Summary of Study ST001935

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001224. The data can be accessed directly via it's Project DOI: 10.21228/M8H12N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST001935
Study Title	Metabolomic profiling of spontaneous macaque model for diabetes mellitus
Study Summary	The prevalence of diabetes mellitus has been increasing for decades worldwide. To develop safe and potent therapeutics, insights into the mechanisms underlying its pathogenesis are urgently needed. We reported the multi-omics profiling of the liver and sera of both peripheral blood and hepatic portal vein blood from Macaca fascicularis with spontaneous diabetes mellitus with a chow diet. The other two groups of the monkeys fed with chow diet and high-sugar high-fat (HSHF) diet, respectively, were included for comparison. These multi-omics datasets can provide a comprehensive picture of the molecular changes caused by diabetes in primates. Analyses of various omics datasets revealed the alterations of high consistency. Correlation between transcripts and proteins derived from the same genes was observed across individuals for most genes, especially the ones of differential expression. As a result, we found that distinct patterns of the metabolome, proteome, and transcriptome between spontaneous diabetes and HSHF diet-induced diabetes compared with healthy individuals.
Institute	Xiamen University
Last Name	Yang
First Name	Zhu
Address	OEW901, Oen Hall Building West Wing,, Ho Sin Hang Campus, Hong Kong Baptist University
Email	yangzhu@gmail.com
Phone	(+852)34115162
Submit Date	2021-09-18
Raw Data Available	Yes
Raw Data File Type(s)	mzXML
Analysis Type Detail	GC-MS
Release Date	2022-02-19
Release Version	1

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Treatment:

Treatment ID:	TR002025
Treatment Summary:	Male Macaca fascicularis of about 18 years old were bought from Huazhen Biosciences (Guangzhou, China). All macaques were born from 16th August 2001 to 11th February 2004 (Supplemental Table S1) and housed in the animal rooms maintained at 16 ~ 26 °C and 40% ~ 70% room humidity on a 12-h/12-h light-dark cycle. All macaques of both NC and sDM groups were fed with the normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), whereas the HFHS monkeys were grown up on the same diet until switching to the high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol) on 1st March 2019 (Fig. 1a). After one year of food change, blood and urine samples were collected.

Treatment ID:

TR002025

Treatment Summary:

Male Macaca fascicularis of about 18 years old were bought from Huazhen Biosciences (Guangzhou, China). All macaques were born from 16th August 2001 to 11th February 2004 (Supplemental Table S1) and housed in the animal rooms maintained at 16 ~ 26 °C and 40% ~ 70% room humidity on a 12-h/12-h light-dark cycle. All macaques of both NC and sDM groups were fed with the normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), whereas the HFHS monkeys were grown up on the same diet until switching to the high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol) on 1st March 2019 (Fig. 1a). After one year of food change, blood and urine samples were collected.