Summary of Study ST001940

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001228. The data can be accessed directly via it's Project DOI: 10.21228/M80120 This work is supported by NIH grant, U2C- DK119886.

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Study ID	ST001940
Study Title	Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement
Study Summary	34 Rome III-diagnosed IBS patients receiving CBT were drawn from the Irritable Bowel Syndrome Outcome Study (IBSOS; ClinicalTrials.gov NCT00738920). Fecal samples were collected at baseline and post-treatment for 16S rRNA gene sequencing, untargeted metabolomics, and measurement of short chain fatty acids. Multimodal neuroimaging was performed at baseline and post-treatment.
Institute	University of California, Los Angeles
Department	Division of Digestive Diseases
Laboratory	Jacobs Laboratory
Last Name	Jacobs
First Name	Jonathan
Address	10833 Le Conte Ave, Los Angeles, CA 90095
Email	JJacobs@mednet.ucla.edu
Phone	310-825-9333
Submit Date	2021-09-01
Total Subjects	34
Num Males	6
Num Females	28
Raw Data Available	Yes
Analysis Type Detail	LC-MS
Release Date	2022-03-01
Release Version	1

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Treatment:

Treatment ID:	TR002030
Treatment Summary:	Eligible patients received 10 sessions of clinic-based CBT or 4 sessions of largely home-based CBT with minimal therapist contact over a 10-week acute phase. The 10 session version was delivered once a week for 10 weeks, while the 4 session version was delivered at week 1, week 3, week 5, and week 10. For these analyses, the two CBT protocols were combined as they are technically identical (patient education, self-monitoring, muscle relaxation, worry control, flexible problem solving, relapse prevention) and have efficacy equivalence.

Treatment ID:

TR002030

Treatment Summary:

Eligible patients received 10 sessions of clinic-based CBT or 4 sessions of largely home-based CBT with minimal therapist contact over a 10-week acute phase. The 10 session version was delivered once a week for 10 weeks, while the 4 session version was delivered at week 1, week 3, week 5, and week 10. For these analyses, the two CBT protocols were combined as they are technically identical (patient education, self-monitoring, muscle relaxation, worry control, flexible problem solving, relapse prevention) and have efficacy equivalence.