Summary of Study ST001953
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001240. The data can be accessed directly via it's Project DOI: 10.21228/M8F121 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001953 |
| Study Title | Identifying metabolite changes in human islets treated with Phospho-BAD mimicry and Inflammatory cytokines |
| Study Summary | The goal of this study was to associate metabolite changes with protection of human islets from cell death induced by the diabetogenic stress of inflammatory cytokines. Protection of human islet viability was accomplished via enhanced glucose metabolism using phospho-BAD mimicry peptide treatment. |
| Institute | Harvard University |
| Department | Dana-Farber Cancer Institute |
| Laboratory | Nika N. Danial |
| Last Name | Fu |
| First Name | Accalia |
| Address | 360 Longwood Ave., Boston, MA, 02215 |
| accalia_fu@dfci.harvard.edu | |
| Phone | 617-632-3000 |
| Submit Date | 2021-10-18 |
| Num Groups | 4 |
| Total Subjects | 32 |
| Publications | Fu et al. 2020, Fu et al. in press |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | MS(Dir. Inf.) |
| Release Date | 2021-11-12 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR002043 |
| Treatment Summary: | Human islets were treated with vehicle DMSO 0.5% or 5uM peptide BAD SAHBa SD for 5 hours, then treated with PBS as control and inflammatory cytokines as experimental groups. |
| Treatment Protocol Filename: | Methods Fu et al. FIA_MS |
| Treatment Compound: | BAD SAHB SD peptide, inflammatory cytokines |
| Treatment Dose: | 5 uM peptide, 10 ng/ml TNF-α, 10 ng/ml IL-1β, and 100 ng/ml IFN |
| Treatment Doseduration: | 24 hours |
| Treatment Vehicle: | DMSO and PBS |
| Cell Media: | PIMS, Prodo Labs |
