Summary of Study ST002236

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001426. The data can be accessed directly via it's Project DOI: 10.21228/M8D42R This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST002236
Study TitleThe impact of IgE in gut and serum metabolomes in a murine experimental model of allergic enteritis
Study TypeCase-control study
Study SummaryThe pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma, and anaphylaxis, partly due to difficulty in the access to intestinal tissues and because of a highly complex interplay between microbiota and intestinal mucosa. Importantly, a high level of IgE is a poor prognostic factor in gastrointestinal allergies. This study aimed to investigate how IgE influences the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. Ovalbumin-sensitized and egg-white diet fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulation.
Institute
Institute of Applied Molecular Medicine
Last NameZubeldia-Varela
First NameElisa
AddressAvda. Monteprincipe s/n 28668 Boadilla del Monte, Madrid, España
Emailelisa.zubeldiavarela@ceu.es
PhoneTlf: 91 372 47 00 ext. 14675
Submit Date2022-07-19
Num Groups4 groups: BALB/c wild type (WT) and IgE knock-in mice (C.Ighg1tm1.1Pyu) in the BALB/c background, both sensitised and non-sensitised to ovalbumin.
Total Subjects29
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC/LC-MS
Release Date2022-08-10
Release Version1
Elisa Zubeldia-Varela Elisa Zubeldia-Varela
https://dx.doi.org/10.21228/M8D42R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Treatment:

Treatment ID:TR002334
Treatment Summary:Mice  (female, 6 to 8 weeks old) were sensitized by an intraperitoneal injection with 10 µg of ovalbumin (OVA, Sigma-Aldrich) and 1 mg of Alum (ThermoFisher Scientific) in 500 µl of PBS or treated only with PBS twice as non-sensitized controls, at a two-week interval.
  logo