Summary of study ST000105

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000097. The data can be accessed directly via it's Project DOI: 10.21228/M8HS3M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000105
Study TitleSCOR Metabolomics
Study TypeMen, control women and PCOS women w/ and w/o OSA. (Untargeted)
Study SummaryPolycystic ovary syndrome (PCOS) affects between 5% and 8% of women, making it one of the most common endocrinopathies in women. The disorder typically has its onset at puberty with evidence of excessive androgen production, obesity, and insulin resistance. Women with PCOS are more insulin resistant than weight-matched controls and have an exceptionally high prevalence of early-onset impaired glucose tolerance (30-40%), and type 2 diabetes (up to 10%). Over the past several years, chronic decreases in sleep duration and/or quality have been identified as a risk for the development of a number of metabolic derangements that are strikingly similar to those seen in PCOS. Specifically, decreased sleep quality due to obstructive sleep apnea (OSA) has been causally linked to insulin resistance, glucose intolerance, dyslipidemia and hypertension independent of body mass index (BMI). Until recently, however, it had not been recognized that OSA is present in a disproportionate number of women with PCOS: the risk for OSA is at least 5- to 10-fold higher compared to the risk in similarly obese women without PCOS. The causes and consequences of OSA in women with PCOS are addressed in this manuscript. Research is NOT published, but project description is relevant: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279609/
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Email mkachman@umich.edu
Submit Date2014-09-30
Num Groups19
Total Subjects112
Raw Data AvailableYes
Raw Data File Type(s).xml,.loG,.stg,
Uploaded File Size8.8 M
Analysis Type DetailLC-MS
Release Date2015-02-03
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8HS3M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000097
Project DOI:doi: 10.21228/M8HS3M
Project Title:Sex, Steroids, Sleep and Metabolic Dysfunction in Women
Project Summary:Gender obstructive sleep apnea studies
Institute:University of Chicago
Department:Medicine/EDM
Laboratory:Ehrmann/Van Cauter Lab
Last Name:Ehrmann
First Name:David
Address:Chicago, IL
Email:dehrmann@uchicago.edu
Phone:773-702-3334

Subject:

Subject ID:SU000124
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Human

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Gender OSA Sampling PCOS CPAP
SA005745S00009922Female Negative After SWS onset No PCOS No CPAP
SA005746S00009923Female Negative After SWS onset No PCOS No CPAP
SA005747S00009921Female Negative After SWS onset No PCOS No CPAP
SA005748S00009920Female Negative After SWS onset No PCOS No CPAP
SA005749S00009918Female Negative After SWS onset No PCOS No CPAP
SA005750S00009924Female Negative After SWS onset No PCOS No CPAP
SA005751S00009919Female Negative After SWS onset No PCOS No CPAP
SA005752S00009925Female Negative After SWS onset No PCOS No CPAP
SA005753S00009926Female Negative After SWS onset No PCOS No CPAP
SA005754S00009946Female Negative After SWS onset PCOS No CPAP
SA005755S00009944Female Negative After SWS onset PCOS No CPAP
SA005756S00009945Female Negative After SWS onset PCOS No CPAP
SA005757S00009942Female Negative After SWS onset PCOS No CPAP
SA005758S00009938Female Negative After SWS onset PCOS No CPAP
SA005759S00009939Female Negative After SWS onset PCOS No CPAP
SA005760S00009943Female Negative After SWS onset PCOS No CPAP
SA005761S00009948Female Negative After SWS onset PCOS No CPAP
SA005762S00009936Female Negative After SWS onset PCOS No CPAP
SA005763S00009935Female Negative After SWS onset PCOS No CPAP
SA005764S00009941Female Negative After SWS onset PCOS No CPAP
SA005765S00009937Female Negative After SWS onset PCOS No CPAP
SA005766S00009947Female Negative After SWS onset PCOS No CPAP
SA005767S00009949Female Negative After SWS onset PCOS No CPAP
SA005768S00009940Female Negative After SWS onset PCOS No CPAP
SA005769S00009859Female Negative Morning fasting No PCOS No CPAP
SA005770S00009860Female Negative Morning fasting No PCOS No CPAP
SA005771S00009861Female Negative Morning fasting No PCOS No CPAP
SA005772S00009862Female Negative Morning fasting No PCOS No CPAP
SA005773S00009868Female Negative Morning fasting No PCOS No CPAP
SA005774S00009863Female Negative Morning fasting No PCOS No CPAP
SA005775S00009865Female Negative Morning fasting No PCOS No CPAP
SA005776S00009864Female Negative Morning fasting No PCOS No CPAP
SA005777S00009867Female Negative Morning fasting No PCOS No CPAP
SA005778S00009866Female Negative Morning fasting No PCOS No CPAP
SA005779S00009879Female Negative Morning fasting PCOS No CPAP
SA005780S00009880Female Negative Morning fasting PCOS No CPAP
SA005781S00009883Female Negative Morning fasting PCOS No CPAP
SA005782S00009881Female Negative Morning fasting PCOS No CPAP
SA005783S00009877Female Negative Morning fasting PCOS No CPAP
SA005784S00009878Female Negative Morning fasting PCOS No CPAP
SA005785S00009882Female Negative Morning fasting PCOS No CPAP
SA005786S00009886Female Negative Morning fasting PCOS No CPAP
SA005787S00009890Female Negative Morning fasting PCOS No CPAP
SA005788S00009889Female Negative Morning fasting PCOS No CPAP
SA005789S00009888Female Negative Morning fasting PCOS No CPAP
SA005790S00009887Female Negative Morning fasting PCOS No CPAP
SA005791S00009885Female Negative Morning fasting PCOS No CPAP
SA005792S00009891Female Negative Morning fasting PCOS No CPAP
SA005793S00009884Female Negative Morning fasting PCOS No CPAP
SA005794S00009933Female Positive After SWS onset No PCOS After CPAP
SA005795S00009932Female Positive After SWS onset No PCOS After CPAP
SA005796S00009934Female Positive After SWS onset No PCOS After CPAP
SA005797S00009931Female Positive After SWS onset No PCOS After CPAP
SA005798S00009927Female Positive After SWS onset No PCOS No CPAP
SA005799S00009930Female Positive After SWS onset No PCOS No CPAP
SA005800S00009928Female Positive After SWS onset No PCOS No CPAP
SA005801S00009929Female Positive After SWS onset No PCOS No CPAP
SA005802S00009954Female Positive After SWS onset PCOS After CPAP
SA005803S00009950Female Positive After SWS onset PCOS No CPAP
SA005804S00009953Female Positive After SWS onset PCOS No CPAP
SA005805S00009952Female Positive After SWS onset PCOS No CPAP
SA005806S00009951Female Positive After SWS onset PCOS No CPAP
SA005807S00009874Female Positive Morning fasting No PCOS After CPAP
SA005808S00009873Female Positive Morning fasting No PCOS After CPAP
SA005809S00009875Female Positive Morning fasting No PCOS After CPAP
SA005810S00009876Female Positive Morning fasting No PCOS After CPAP
SA005811S00009869Female Positive Morning fasting No PCOS No CPAP
SA005812S00009872Female Positive Morning fasting No PCOS No CPAP
SA005813S00009871Female Positive Morning fasting No PCOS No CPAP
SA005814S00009870Female Positive Morning fasting No PCOS No CPAP
SA005815S00009896Female Positive Morning fasting PCOS After CPAP
SA005816S00009894Female Positive Morning fasting PCOS No CPAP
SA005817S00009893Female Positive Morning fasting PCOS No CPAP
SA005818S00009892Female Positive Morning fasting PCOS No CPAP
SA005819S00009895Female Positive Morning fasting PCOS No CPAP
SA005820S00009956Male Negative After SWS onset No PCOS No CPAP
SA005821S00009958Male Negative After SWS onset No PCOS No CPAP
SA005822S00009957Male Negative After SWS onset No PCOS No CPAP
SA005823S00009955Male Negative After SWS onset No PCOS No CPAP
SA005824S00009900Male Negative Morning fasting No PCOS No CPAP
SA005825S00009897Male Negative Morning fasting No PCOS No CPAP
SA005826S00009898Male Negative Morning fasting No PCOS No CPAP
SA005827S00009899Male Negative Morning fasting No PCOS No CPAP
SA005828S00009969Male Positive After SWS onset No PCOS After CPAP
SA005829S00009970Male Positive After SWS onset No PCOS After CPAP
SA005830S00009968Male Positive After SWS onset No PCOS After CPAP
SA005831S00009967Male Positive After SWS onset No PCOS After CPAP
SA005832S00009965Male Positive After SWS onset No PCOS No CPAP
SA005833S00009964Male Positive After SWS onset No PCOS No CPAP
SA005834S00009966Male Positive After SWS onset No PCOS No CPAP
SA005835S00009963Male Positive After SWS onset No PCOS No CPAP
SA005836S00009962Male Positive After SWS onset No PCOS No CPAP
SA005837S00009960Male Positive After SWS onset No PCOS No CPAP
SA005838S00009961Male Positive After SWS onset No PCOS No CPAP
SA005839S00009959Male Positive After SWS onset No PCOS No CPAP
SA005840S00009914Male Positive Morning fasting No PCOS After CPAP
SA005841S00009912Male Positive Morning fasting No PCOS After CPAP
SA005842S00009917Male Positive Morning fasting No PCOS After CPAP
SA005843S00009913Male Positive Morning fasting No PCOS After CPAP
SA005844S00009911Male Positive Morning fasting No PCOS After CPAP
Showing page 1 of 2     Results:    1  2  Next     Showing results 1 to 100 of 112

Collection:

Collection ID:CO000108
Sample Type:Serum

Treatment:

Treatment ID:TR000126

Sample Preparation:

Sampleprep ID:SP000121
Sampleprep Protocol Filename:EX00177-Sample_preparation_protocol.pdf

Combined analysis:

Analysis ID AN000173 AN000174
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent 1200 Agilent 1200
Column Waters Acquity HSS T3 Waters Acquity HSS T3
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF
Ion Mode POSITIVE NEGATIVE
Units Counts Counts

Chromatography:

Chromatography ID:CH000119
Chromatography Summary:AQM003|AQM004
Methods Filename:Column1_solv1_jetstream+_grad9.m
Column1_solv2_jetstream-_grad9.m
Instrument Name:Agilent 1200
Column Name:Waters Acquity HSS T3
Chromatography Type:Reversed phase

MS:

MS ID:MS000136
Analysis ID:AN000173
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
  
MS ID:MS000137
Analysis ID:AN000174
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
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