Summary of study ST000669

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000472. The data can be accessed directly via it's Project DOI: 10.21228/M82028 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000669
Study TitleCharacterization of Retinal Exudates in Coats Disease - lipid profile
Study TypeMS analysis
Study SummaryThe aim of our study is to characterize the retinal lipid exudates through lipidomic assays. Lipidomic analysis will quantify and identify the retinal lipid exudates and provide a `lipid profile? of the exudates. The characterization of the retinal lipids will help in further understanding the pathogenesis of Coat?s disease. It may allow us to identify and therapeutically target a metabolic pathway to prevent retinal exudation abnormal in Coat?s disease.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-05
Num Groups11
Total Subjects4
Raw Data AvailableYes
Raw Data File Type(s).wiff
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M82028
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000472
Project DOI:doi: 10.21228/M82028
Project Title:Characterization of Retinal Exudates in Coats Disease
Project Type:MS analysis
Project Summary:The aim of our study is to characterize the retinal lipid exudates through lipidomic assays
Institute:University of Michigan
Department:Ophthalmology and Visual Sciences
Laboratory:Besirli Lab
Last Name:Besirli
First Name:Cagri
Address:Ann Arbor, MI
Email:cbesirli@umich.edu
Phone:734-615-6099

Subject:

Subject ID:SU000692
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Human

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Disease Matrix Sample type
SA038496S00019676AS-Control-P Plasma Plasma
SA038497S00019675AS-Control-S SRF Fluids and Secretions
SA038498S00019672Coats CB Fluids and Secretions
SA038499S00019673Coats CB Fluids and Secretions
SA038500S00019674JB-Coats-P Plasma Plasma
Showing results 1 to 5 of 5

Collection:

Collection ID:CO000686
Collection Summary:-
Sample Type:Retina

Treatment:

Treatment ID:TR000706
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000699
Sampleprep Summary:-
Sampleprep Protocol Filename:A004_-_Shotgun_Lipidomics.pdf

Combined analysis:

Analysis ID AN001024 AN001025
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Shimadzu CTO-20A Nexera X2 Shimadzu CTO-20A Nexera X2
Column Waters Acquity HSS T3 (50 x 2.1mm, 1.8um) Waters Acquity HSS T3 (50 x 2.1mm, 1.8um)
MS Type ESI ESI
MS instrument type Triple TOF Triple TOF
MS instrument name ABI Sciex 5600+ TripleTOF ABI Sciex 5600+ TripleTOF
Ion Mode NEGATIVE POSITIVE
Units peak area peak area

Chromatography:

Chromatography ID:CH000732
Instrument Name:Shimadzu CTO-20A Nexera X2
Column Name:Waters Acquity HSS T3 (50 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS000919
Analysis ID:AN001024
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
Ion Mode:NEGATIVE
  
MS ID:MS000920
Analysis ID:AN001025
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
Ion Mode:POSITIVE
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