Summary of Study ST000855
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000601. The data can be accessed directly via it's Project DOI: 10.21228/M8067M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000855 |
Study Title | Urine metabolic profiles of pregnant women in relation to environmental exposures |
Study Type | MS analysis |
Study Summary | The purpose of this study is to broaden our understanding of how trace metals alone and in combination with other chemical exposures contribute to these adverse pregnancy outcomes that can have significant repercussive effects in the life of the child. Additionally, our aim is to use cutting-edge metabolomics techniques to better understand mechanisms underlying these associations in order to identify opportunities for prevention when reducing exposure is difficult or impossible. Utilizing the CHEAR resources, we plan to measure trace metal concentrations in urine from the third trimester of pregnancy along with metabolomics profiles from the same time point. Doing so will allow us to address the following specific aims: SEE NOTES |
Institute | University of Michigan |
Department | Biomedical Research Core Facilities |
Laboratory | Metabolomics core |
Last Name | Kachman |
First Name | Maureen |
Address | 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 |
mkachman@med.umich.edu | |
Phone | (734) 232-8175 |
Submit Date | 2017-07-21 |
Num Groups | 1159 |
Total Subjects | 390 |
Study Comments | SPECIFIC AIM 1: Assess the impact of urinary trace metal concentrations from the 3rd trimester of pregnancy on birth outcomes, including spontaneous and placentally-mediated preterm delivery as well as fetal growth as characterized by repeated ultrasound measures. SPECIFIC AIM 2: Investigate the cumulative association between trace metal and phthalate exposures during pregnancy on birth outcomes. SPECIFIC AIM 3: Explore metabolomics profiles in urine from the third trimester of pregnancy in relation to: environmental exposures individually and in mixtures; birth outcomes; and previously measured oxidative stress biomarkers. |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Chear Study | Yes |
Analysis Type Detail | LC-MS |
Release Date | 2024-12-31 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
Project ID: | PR000601 |
Project DOI: | doi: 10.21228/M8067M |
Project Title: | META Studies |
Project Type: | MS analysis |
Project Summary: | Metabolic profiling in pregnancy to identify mechanisms of preterm birth and fetal growth restriction in the context of environmental trace metal exposures |
Institute: | National Institute of Environmental Health Sciences |
Department: | Epidemiology Branch |
Laboratory: | Ferguson Lab |
Last Name: | Ferguson |
First Name: | Kelly |
Address: | Research Triangle Park, NC |
Email: | kelly.ferguson2@nih.gov |
Phone: | 919-699-4827 |
Subject:
Subject ID: | SU000909 |
Subject Type: | HUMAN |
Subject Species: | Homo sapiens |
Taxonomy ID: | 9606 |
Species Group: | Mammals |
Factors:
Subject type: HUMAN; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Alcohol use in pregnancy | Smoking status in pregnancy | Parity | Preterm |
---|---|---|---|---|---|
SA050439 | S00028571 | NA | NA | nulliparous | term |
SA050440 | S00028547 | NA | NA | nulliparous | term |
SA050441 | S00028448 | NA | NA | parous | term |
SA050442 | S00028572 | NA | NA | parous | term |
SA050443 | S00028558 | NA | NA | parous | term |
SA050444 | S00028359 | NA | No | nulliparous | preterm |
SA050445 | S00028271 | NA | No | parous | preterm |
SA050446 | S00028229 | NA | No | parous | preterm |
SA050447 | S00028381 | NA | No | parous | term |
SA050448 | S00028379 | No | No | nulliparous | preterm |
SA050449 | S00028376 | No | No | nulliparous | preterm |
SA050450 | S00028391 | No | No | nulliparous | preterm |
SA050451 | S00028392 | No | No | nulliparous | preterm |
SA050452 | S00028373 | No | No | nulliparous | preterm |
SA050453 | S00028387 | No | No | nulliparous | preterm |
SA050454 | S00028323 | No | No | nulliparous | preterm |
SA050455 | S00028289 | No | No | nulliparous | preterm |
SA050456 | S00028287 | No | No | nulliparous | preterm |
SA050457 | S00028615 | No | No | nulliparous | preterm |
SA050458 | S00028307 | No | No | nulliparous | preterm |
SA050459 | S00028309 | No | No | nulliparous | preterm |
SA050460 | S00028351 | No | No | nulliparous | preterm |
SA050461 | S00028328 | No | No | nulliparous | preterm |
SA050462 | S00028360 | No | No | nulliparous | preterm |
SA050463 | S00028456 | No | No | nulliparous | preterm |
SA050464 | S00028549 | No | No | nulliparous | preterm |
SA050465 | S00028541 | No | No | nulliparous | preterm |
SA050466 | S00028531 | No | No | nulliparous | preterm |
SA050467 | S00028552 | No | No | nulliparous | preterm |
SA050468 | S00028563 | No | No | nulliparous | preterm |
SA050469 | S00028582 | No | No | nulliparous | preterm |
SA050470 | S00028565 | No | No | nulliparous | preterm |
SA050471 | S00028564 | No | No | nulliparous | preterm |
SA050472 | S00028500 | No | No | nulliparous | preterm |
SA050473 | S00028493 | No | No | nulliparous | preterm |
SA050474 | S00028460 | No | No | nulliparous | preterm |
SA050475 | S00028275 | No | No | nulliparous | preterm |
SA050476 | S00028452 | No | No | nulliparous | preterm |
SA050477 | S00028470 | No | No | nulliparous | preterm |
SA050478 | S00028471 | No | No | nulliparous | preterm |
SA050479 | S00028475 | No | No | nulliparous | preterm |
SA050480 | S00028591 | No | No | nulliparous | preterm |
SA050481 | S00028425 | No | No | nulliparous | preterm |
SA050482 | S00028406 | No | No | nulliparous | preterm |
SA050483 | S00028231 | No | No | nulliparous | preterm |
SA050484 | S00028239 | No | No | nulliparous | preterm |
SA050485 | S00028234 | No | No | nulliparous | preterm |
SA050486 | S00028240 | No | No | nulliparous | preterm |
SA050487 | S00028258 | No | No | nulliparous | term |
SA050488 | S00028529 | No | No | nulliparous | term |
SA050489 | S00028530 | No | No | nulliparous | term |
SA050490 | S00028587 | No | No | nulliparous | term |
SA050491 | S00028476 | No | No | nulliparous | term |
SA050492 | S00028534 | No | No | nulliparous | term |
SA050493 | S00028533 | No | No | nulliparous | term |
SA050494 | S00028384 | No | No | nulliparous | term |
SA050495 | S00028527 | No | No | nulliparous | term |
SA050496 | S00028519 | No | No | nulliparous | term |
SA050497 | S00028404 | No | No | nulliparous | term |
SA050498 | S00028518 | No | No | nulliparous | term |
SA050499 | S00028520 | No | No | nulliparous | term |
SA050500 | S00028526 | No | No | nulliparous | term |
SA050501 | S00028517 | No | No | nulliparous | term |
SA050502 | S00028371 | No | No | nulliparous | term |
SA050503 | S00028257 | No | No | nulliparous | term |
SA050504 | S00028611 | No | No | nulliparous | term |
SA050505 | S00028357 | No | No | nulliparous | term |
SA050506 | S00028612 | No | No | nulliparous | term |
SA050507 | S00028262 | No | No | nulliparous | term |
SA050508 | S00028356 | No | No | nulliparous | term |
SA050509 | S00028355 | No | No | nulliparous | term |
SA050510 | S00028546 | No | No | nulliparous | term |
SA050511 | S00028545 | No | No | nulliparous | term |
SA050512 | S00028542 | No | No | nulliparous | term |
SA050513 | S00028362 | No | No | nulliparous | term |
SA050514 | S00028537 | No | No | nulliparous | term |
SA050515 | S00028368 | No | No | nulliparous | term |
SA050516 | S00028405 | No | No | nulliparous | term |
SA050517 | S00028538 | No | No | nulliparous | term |
SA050518 | S00028539 | No | No | nulliparous | term |
SA050519 | S00028241 | No | No | nulliparous | term |
SA050520 | S00028540 | No | No | nulliparous | term |
SA050521 | S00028536 | No | No | nulliparous | term |
SA050522 | S00028588 | No | No | nulliparous | term |
SA050523 | S00028251 | No | No | nulliparous | term |
SA050524 | S00028490 | No | No | nulliparous | term |
SA050525 | S00028489 | No | No | nulliparous | term |
SA050526 | S00028594 | No | No | nulliparous | term |
SA050527 | S00028597 | No | No | nulliparous | term |
SA050528 | S00028441 | No | No | nulliparous | term |
SA050529 | S00028496 | No | No | nulliparous | term |
SA050530 | S00028445 | No | No | nulliparous | term |
SA050531 | S00028488 | No | No | nulliparous | term |
SA050532 | S00028487 | No | No | nulliparous | term |
SA050533 | S00028480 | No | No | nulliparous | term |
SA050534 | S00028473 | No | No | nulliparous | term |
SA050535 | S00028474 | No | No | nulliparous | term |
SA050536 | S00028481 | No | No | nulliparous | term |
SA050537 | S00028467 | No | No | nulliparous | term |
SA050538 | S00028461 | No | No | nulliparous | term |
Collection:
Collection ID: | CO000903 |
Collection Summary: | - |
Sample Type: | Urine |
Treatment:
Treatment ID: | TR000923 |
Treatment Summary: | - |
Sample Preparation:
Sampleprep ID: | SP000916 |
Sampleprep Summary: | - |
Sampleprep Protocol Filename: | EX00708_Untargeted_Metabolomics.pdf |
Combined analysis:
Analysis ID | AN001422 | AN001423 |
---|---|---|
Analysis type | MS | MS |
Chromatography type | Reversed phase | Reversed phase |
Chromatography system | Agilent | Agilent |
Column | Waters Acquity HSS T3 (50 x 2.1mm,1.8um) | Waters Acquity HSS T3 (50 x 2.1mm,1.8um) |
MS Type | ESI | ESI |
MS instrument type | QTOF | QTOF |
MS instrument name | Agilent 6530 QTOF | Agilent 6530 QTOF |
Ion Mode | NEGATIVE | POSITIVE |
Units | peak area normalized | peak area normalized |
Chromatography:
Chromatography ID: | CH000994 |
Instrument Name: | Agilent |
Column Name: | Waters Acquity HSS T3 (50 x 2.1mm,1.8um) |
Chromatography Type: | Reversed phase |
MS:
MS ID: | MS001312 |
Analysis ID: | AN001422 |
Instrument Name: | Agilent 6530 QTOF |
Instrument Type: | QTOF |
MS Type: | ESI |
Ion Mode: | NEGATIVE |
Analysis Protocol File: | EX00708 - Untargeted Metabolomics.pdf |
MS ID: | MS001313 |
Analysis ID: | AN001423 |
Instrument Name: | Agilent 6530 QTOF |
Instrument Type: | QTOF |
MS Type: | ESI |
Ion Mode: | POSITIVE |
Analysis Protocol File: | EX00708 - Untargeted Metabolomics.pdf |