Summary of Study ST001383

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000947. The data can be accessed directly via it's Project DOI: 10.21228/M88T2D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001383
Study TitleInvestigating exposures and health impacts of endocrine disrupting chemicals among inner-city children.
Study TypeObservational study
Study SummaryOur CHEAR project will conduct untargeted metabolomics analyses among children with and without asthma to gain insight into potential mechanisms related to asthma development. Metabolomics analysis will be conducted in a subset of participants from DISCOVER, a panel study enriched with low-income African American children in Baltimore, MD enrolled from 2009 to 2013. We will conduct untargeted metabolomics in serum collected from 15 children with non-atopic asthma and 22 non-atopic children without asthma. For each child, we will conduct analyses in two serum samples collected 3-9 months apart (total = 74 samples). We will use these pilot data to explore differences in metabolomic profiles among non-atopic children with asthma compared to non-asthmatic controls, and leverage repeated sample measures to assess differences in metabolomic profiles among asthmatic children by symptom frequency or severity. Finally, these data will be used to explore differences in metabolomic profiles by exposure status after urinary organophosphate flame retardant biomarkers have been quantified by CHEAR. Together, these analyses will provide pilot data for future work in our Center to assess potential mechanisms related to asthma development and severity as well as effects of organophoshate flame retardant exposures.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI
Emailmkachman@med.umich.edu
Phone734-232-0842
Submit Date2020-03-18
Raw Data AvailableYes
Raw Data File Type(s)d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M88T2D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000947
Project DOI:doi: 10.21228/M88T2D
Project Title:Health impacts of endocrine disrupting chemicals
Project Type:Observational study
Project Summary:Investigating exposures and health impacts of endocrine disrupting chemicals among inner-city children.
Institute:University of Michigan
Department:Nutritional Sciences
Laboratory:Meeker Lab
Last Name:Meeker
First Name:John
Address:Ann Arbor, MI
Email:meekerj@umich.edu
Phone:734-764-7184

Subject:

Subject ID:SU001457
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Gender Condition
SA100979R00CHRPL1-3CHEAR CHEAR
SA100980R00CHRPL1-2CHEAR CHEAR
SA100981R00CHRPL1-4CHEAR CHEAR
SA100982R00CHRPL1-1CHEAR CHEAR
SA100983C-1NYP2-S-00Female asthmatic
SA100984C-1NYQ0-S-00Female asthmatic
SA100985C-1NYR8-S-00Female asthmatic
SA100986C-1NYJ5-S-00Female asthmatic
SA100987C-1NYK3-S-00Female asthmatic
SA100988C-1NYU1-S-00Female asthmatic
SA100989C-1NY93-S-00Female asthmatic
SA100990C-1NY44-S-00Female asthmatic
SA100991C-1NYX4-S-00Female asthmatic
SA100992C-1NZ76-S-00Female asthmatic
SA100993C-1NZ68-S-00Female asthmatic
SA100994C-1NY51-S-00Female asthmatic
SA100995C-1NYW7-S-00Female asthmatic
SA100996C-1NYN6-S-00Female asthmatic
SA100997C-1NY85-S-00Female asthmatic
SA100998C-1NYV9-S-00Female asthmatic
SA100999C-1P025-S-00Female control
SA101000C-1P017-S-00Female control
SA101001C-1NZD7-S-00Female control
SA101002C-1NZN5-S-00Female control
SA101003C-1NZM8-S-00Female control
SA101004C-1NZP1-S-00Female control
SA101005C-1NZS4-S-00Female control
SA101006C-1NZT2-S-00Female control
SA101007C-1NZL0-S-00Female control
SA101008C-1NZK2-S-00Female control
SA101009C-1NZ50-S-00Female control
SA101010C-1NZG1-S-00Female control
SA101011C-1NZH9-S-00Female control
SA101012C-1NZJ4-S-00Female control
SA101013C-1NZC0-S-00Female control
SA101014C-1NYT3-S-00Female control
SA101015C-1NYF4-S-00Female control
SA101016C-1NZ43-S-00Female control
SA101017C-1NYS5-S-00Female control
SA101018C-1NYE6-S-00Female control
SA101019C-1NY77-S-00Male asthmatic
SA101020C-1NYA5-S-00Male asthmatic
SA101021C-1NYB3-S-00Male asthmatic
SA101022C-1NY69-S-00Male asthmatic
SA101023C-1NY36-S-00Male asthmatic
SA101024C-1NXY3-S-00Male asthmatic
SA101025C-1NY28-S-00Male asthmatic
SA101026C-1NYD8-S-00Male asthmatic
SA101027C-1NYC1-S-00Male asthmatic
SA101028C-1NXX5-S-00Male asthmatic
SA101029C-1P009-S-00Male asthmatic
SA101030C-1NZY1-S-00Male asthmatic
SA101031C-1NZW6-S-00Male control
SA101032C-1P033-S-00Male control
SA101033C-1NZX3-S-00Male control
SA101034C-1P058-S-00Male control
SA101035C-1P041-S-00Male control
SA101036C-1NZV8-S-00Male control
SA101037C-1P066-S-00Male control
SA101038C-1NZB2-S-00Male control
SA101039C-1NYL1-S-00Male control
SA101040C-1NYM9-S-00Male control
SA101041C-1NZ27-S-00Male control
SA101042C-1NZU0-S-00Male control
SA101043C-1NYG2-S-00Male control
SA101044C-1NY02-S-00Male control
SA101045C-1NY10-S-00Male control
SA101046C-1NZ35-S-00Male control
SA101047C-1NYH0-S-00Male control
SA101048C-1NZR7-S-00Male control
SA101049C-1NZ84-S-00Male control
SA101050C-1NZF3-S-00Male control
SA101051C-1NZQ9-S-00Male control
SA101052C-1NZ92-S-00Male control
SA101053C-1NZE5-S-00Male control
SA101054C-1NZA4-S-00Male control
SA101055Master pool-08POOL POOL
SA101056Master pool-09POOL POOL
SA101057Master pool-10POOL POOL
SA101058Master pool-07POOL POOL
SA101059Master pool-03POOL POOL
SA101060Master pool-01POOL POOL
SA101061Master pool-02POOL POOL
SA101062Master pool-04POOL POOL
SA101063Master pool-05POOL POOL
SA101064Master pool-06POOL POOL
Showing results 1 to 86 of 86

Collection:

Collection ID:CO001452
Collection Summary:Standard blood serum collection protocol
Sample Type:Blood (serum)
Storage Conditions:-80℃

Treatment:

Treatment ID:TR001472
Treatment Summary:This is observational study

Sample Preparation:

Sampleprep ID:SP001465
Sampleprep Summary:Standard untargeted metabolomics sample preparation (see enclosed protocol)

Combined analysis:

Analysis ID AN002304 AN002305 AN002306 AN002307
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II
Column Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF QTOF QTOF
MS instrument name Agilent 6540 QTOF Agilent 6540 QTOF Agilent 6540 QTOF Agilent 6540 QTOF
Ion Mode POSITIVE NEGATIVE POSITIVE NEGATIVE
Units Peak area normalized Peak area normalized Peak area normalized Peak area normalized

Chromatography:

Chromatography ID:CH001693
Chromatography Summary:RP-LCMS-Positive
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH001694
Chromatography Summary:RP-LCMS-Negative
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS002147
Analysis ID:AN002304
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Untargeted recursive search (Agilent Qual/MPP/In-house software)
Ion Mode:POSITIVE
  
MS ID:MS002148
Analysis ID:AN002305
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Untargeted recursive search (Agilent Qual/MPP/In-house software)
Ion Mode:NEGATIVE
  
MS ID:MS002149
Analysis ID:AN002306
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Targeted search (Agilent ProFinder)
Ion Mode:POSITIVE
  
MS ID:MS002150
Analysis ID:AN002307
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Targeted search (Agilent ProFinder)
Ion Mode:NEGATIVE
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