Summary of Study ST001869

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001180. The data can be accessed directly via it's Project DOI: 10.21228/M85T3V This work is supported by NIH grant, U2C- DK119886.

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Study IDST001869
Study TitleWNK463 Inhibition on Right Ventricular metabolomics
Study SummaryWe investigated the effects of WNK463 treatment on right ventricular metabolism in monocrotaline-induced pulmonary artery hypertension.
Institute
University of Minnesota
Last NamePrins
First NameKurt
Address2231 6th St. SE, 4-145
Emailprin0088@umn.edu
Phone6126257687
Submit Date2021-07-13
Analysis Type DetailLC-MS
Release Date2021-07-26
Release Version1
Kurt Prins Kurt Prins
https://dx.doi.org/10.21228/M85T3V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001180
Project DOI:doi: 10.21228/M85T3V
Project Title:Effects of WNK463 on Right Ventricular Metabolomics in Monocrotaline Rats
Project Summary:We investigated the effects of WNK463 treatment on right ventricular metabolism in monocrotaline-induced pulmonary artery hypertension.
Institute:University of Minnesota
Last Name:Prins
First Name:Kurt
Address:2231 6th St. SE, 4-145
Email:prin0088@umn.edu
Phone:6126257687

Subject:

Subject ID:SU001946
Subject Type:Mammal
Subject Species:Rattus norvegicus
Taxonomy ID:10116
Gender:Male
Animal Animal Supplier:Charles River

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA174682Control 18Control
SA174683Control 20Control
SA174684Control 17Control
SA174685Control11Control
SA174686Control 19Control
SA174687Control 16Control
SA174688Control 13Control
SA174689Control 14Control
SA174690Control 15Control
SA174691Control 12Control
SA174692Vehicle 9Vehicle
SA174693Vehicle 10Vehicle
SA174694Vehicle 13Vehicle
SA174695Vehicle 8Vehicle
SA174696Vehicle 12Vehicle
SA174697Vehicle 11Vehicle
SA174698Vehicle 7Vehicle
SA174699Vehicle 1Vehicle
SA174700Vehicle 6Vehicle
SA174701Vehicle 3Vehicle
SA174702Vehicle 2Vehicle
SA174703Vehicle 5Vehicle
SA174704Vehicle 4Vehicle
SA174705Drug 11WNK463
SA174706Drug 10WNK463
SA174707Drug 12WNK463
SA174708Drug 9WNK463
SA174709Drug 5WNK463
SA174710Drug 2WNK463
SA174711Drug 3WNK463
SA174712Drug 6WNK463
SA174713Drug 7WNK463
SA174714Drug 8WNK463
Showing results 1 to 33 of 33

Collection:

Collection ID:CO001939
Collection Summary:Right ventricular free walls were collected and snap frozen immediately after death.
Sample Type:Heart

Treatment:

Treatment ID:TR001958
Treatment Summary:PBS, WNK-vehicle, or WNK463 at a dose of 3 mg/kg

Sample Preparation:

Sampleprep ID:SP001952
Sampleprep Summary:Samples were frozen and sent to Metabolon

Combined analysis:

Analysis ID AN003031
Analysis type MS
Chromatography type Reversed phase
Chromatography system Waters Acquity
Column Waters Acquity BEH C18 (100 x 2mm,1.7um)
MS Type ESI
MS instrument type Orbitrap
MS instrument name Thermo Q Exactive Orbitrap
Ion Mode POSITIVE
Units relative value

Chromatography:

Chromatography ID:CH002244
Chromatography Summary:Low pH polar
Instrument Name:Waters Acquity
Column Name:Waters Acquity BEH C18 (100 x 2mm,1.7um)
Chromatography Type:Reversed phase

MS:

MS ID:MS002818
Analysis ID:AN003031
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Proprietary analytical software for integration and peak picking
Ion Mode:POSITIVE
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