Summary of Study ST002337

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001500. The data can be accessed directly via it's Project DOI: 10.21228/M8SX3G This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002337
Study TitleGuangzhou Nutrition and Health Study (GNHS)
Study TypeObservational study
Study SummaryThe GNHS was an onging community-based prospective cohort study.In GNHS,a total of 4,048 Chinese participants aged 40-75 years living in the urban area of Guangzhou, China, for at least 5 years were recruited between 2008-2013. Participants were followed up every three years. During the period 2008-2019, blood samples were collected at up to three time points. In 2014-2019 follow-up visits, stool samples were collected at up to two time points.The information of diet, sociodemographic factors, lifestyle factors, and medications, etc. was collected at the baseline and follow-up visits. The aim of this study was to investigate the relationships among human nutrition, enviromental factors, gut microbiome and human diseases.
Institute
Westlake University
Last NameJu-Sheng
First NameZheng
AddressWestlake University,18 Shilongshan Rd, Cloud Town, Hangzhou, China
Emailzhengjusheng@westlake.edu.cn
Phone+8657186915303
Submit Date2022-10-11
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailLC-MS
Release Date2022-11-21
Release Version1
Zheng Ju-Sheng Zheng Ju-Sheng
https://dx.doi.org/10.21228/M8SX3G
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001500
Project DOI:doi: 10.21228/M8SX3G
Project Title:Fecal metabolome of Guangzhou Nutrition and Health Study (GNHS)
Project Type:Observational study
Project Summary:Our study was based on the Guangzhou Nutrition and Health Study (GNHS). This study aims to investigate the relationships among human nutrition, environmental factors, gut microbiome and human diseases.The data from the control arm of a case-control study for hip fraction was also included in this project to replicate our findings.
Institute:Westlake University
Last Name:Zheng
First Name:Ju-Sheng
Address:Westlake University,18 Shilongshan Rd, Cloud Town, Hangzhou, China, Hangzhou, Zhejiang, 310000, China
Email:zhengjusheng@westlake.edu.cn
Phone:057186915303

Subject:

Subject ID:SU002426
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sex
SA233886FB0327Female
SA233887FB0326Female
SA233888FB0329Female
SA233889FB0331Female
SA233890FB0332Female
SA233891FB0325Female
SA233892FB0323Female
SA233893FB0316Female
SA233894FB0315Female
SA233895FB0317Female
SA233896FB0321Female
SA233897FB0334Female
SA233898FB0324Female
SA233899FB0337Female
SA233900FB0348Female
SA233901FB0347Female
SA233902FB0350Female
SA233903FB0351Female
SA233904FB0352Female
SA233905FB0346Female
SA233906FB0345Female
SA233907FB0338Female
SA233908FB0314Female
SA233909FB0340Female
SA233910FB0341Female
SA233911FB0342Female
SA233912FB0336Female
SA233913FB0312Female
SA233914FB0289Female
SA233915FB0288Female
SA233916FB0290Female
SA233917FB0291Female
SA233918FB0292Female
SA233919FB0287Female
SA233920FB0286Female
SA233921FB0281Female
SA233922FB0279Female
SA233923FB0282Female
SA233924FB0283Female
SA233925FB0284Female
SA233926FB0293Female
SA233927FB0296Female
SA233928FB0309Female
SA233929FB0308Female
SA233930FB0310Female
SA233931FB0311Female
SA233932FB0353Female
SA233933FB0305Female
SA233934FB0304Female
SA233935FB0300Female
SA233936FB0298Female
SA233937FB0301Female
SA233938FB0302Female
SA233939FB0303Female
SA233940FB0313Female
SA233941FB0355Female
SA233942FB0401Female
SA233943FB0400Female
SA233944FB0402Female
SA233945FB0403Female
SA233946FB0404Female
SA233947FB0399Female
SA233948FB0398Female
SA233949FB0392Female
SA233950FB0391Female
SA233951FB0394Female
SA233952FB0396Female
SA233953FB0397Female
SA233954FB0405Female
SA233955FB0406Female
SA233956FB0419Female
SA233957FB0418Female
SA233958FB0420Female
SA233959FB0421Female
SA233960FB0423Female
SA233961FB0417Female
SA233962FB0415Female
SA233963FB0408Female
SA233964FB0407Female
SA233965FB0410Female
SA233966FB0411Female
SA233967FB0412Female
SA233968FB0389Female
SA233969FB0388Female
SA233970FB0366Female
SA233971FB0365Female
SA233972FB0367Female
SA233973FB0368Female
SA233974FB0369Female
SA233975FB0364Female
SA233976FB0363Female
SA233977FB0357Female
SA233978FB0278Female
SA233979FB0359Female
SA233980FB0360Female
SA233981FB0361Female
SA233982FB0372Female
SA233983FB0373Female
SA233984FB0384Female
SA233985FB0383Female
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Collection:

Collection ID:CO002419
Collection Summary:Fecal samples from all participants were collected on the examination day, and then stored at -80℃ within four hours.
Sample Type:Feces

Treatment:

Treatment ID:TR002438
Treatment Summary:N/A

Sample Preparation:

Sampleprep ID:SP002432
Sampleprep Summary:The order of all test samples is randomly selected before the preparation. 10 mg lyophilized feces were homogenized with 25μL water and extracted with 185μL cold ACN-Methanol (8/2, v/v). After centrifugation, 30 μL supernatant was used to derivatization with 20 μL freshly prepared derivative reagents on a Biomek 4000 workstation (Biomek 4000, Beckman Coulter, Inc., Brea, California, USA), followed by mixing with internal standards. Subsequently, the derivatized samples and serial dilutions of derivatized stock standards were randomly analyzed and quantitated by an ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) system (ACQUITY UPLC-Xevo TQ-S, Waters Corp., Milford, MA, USA).

Combined analysis:

Analysis ID AN003819
Analysis type MS
Chromatography type Reversed phase
Chromatography system Waters Acquity
Column Waters Acquity BEH C18 (100 x 2.1mm,1.7um)
MS Type ESI
MS instrument type QTOF
MS instrument name Waters Xevo-TQ-S
Ion Mode UNSPECIFIED
Units umol/L

Chromatography:

Chromatography ID:CH002826
Instrument Name:Waters Acquity
Column Name:Waters Acquity BEH C18 (100 x 2.1mm,1.7um)
Chromatography Type:Reversed phase

MS:

MS ID:MS003561
Analysis ID:AN003819
Instrument Name:Waters Xevo-TQ-S
Instrument Type:QTOF
MS Type:ESI
MS Comments:Capillary (Kv):1.5 (ESI+), 2.0 (ESI-) Source Temp (°C):150 Desolvation Temp(°C):550 Desolvation Gas Flow (L/Hr):1000 MS acquisition software: QuanMET software (v2.0, Metabo-Profile, Shanghai, China)
Ion Mode:UNSPECIFIED
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