Data for ST003501
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| 1,3-15N2-Uric acid | - | - | - | - | - | - | |
| 13C10,15N5-Adenosine | - | - | - | - | - | - | |
| 13C3-Thiamine | 25.31 | 25.35 | 25.28 | 25.54 | 25.13 | 25.31 | |
| 13C5-Hypoxanthine | 14.78 | 14.74 | 14.67 | 14.67 | 14.91 | 14.65 | |
| 13C5-Xanthosine | - | - | - | - | - | - | |
| 15N4-Inosine | - | - | - | - | - | - | |
| 1-Methylhistidine | - | - | - | - | - | - | |
| 1-Methylnicotinamide | 16.47 | 17.21 | 17.72 | 17.20 | 16.67 | 17.86 | |
| 1-Methylxanthine | - | - | - | - | - | - | |
| 1-Methylxanthosine | - | - | - | - | - | - | |
| 2-Aminobenzoic acid | - | - | - | - | - | - | |
| 3-Hydroxybutyric acid | - | - | - | - | - | - | |
| 3-Hydroxykynurenine | 16.15 | 16.43 | 16.55 | 16.64 | 16.37 | 15.06 | |
| 3-Hydroxy-N6,N6,N6-Trimethyllysine | - | - | - | - | - | - | |
| 3-Hydroxytyrosol | 15.67 | 16.15 | 16.82 | 16.53 | 15.68 | 16.71 | |
| 3-Methoxytyrosine | - | - | - | - | - | - | |
| 3-Methylxanthine | - | - | - | - | - | - | |
| 3-Methylxanthosine | - | - | - | - | - | - | |
| 4-Hydroxyproline | - | - | - | - | - | - | |
| 4-Trimethylammoniobutanal | - | - | - | - | - | - | |
| 5-Glutamylalanine | - | - | - | - | - | - | |
| 5-Hydroxyindoleacetic acid | - | - | - | - | - | - | |
| 5-Hydroxytryptophan | - | - | - | - | - | - | |
| 5^-Methylthioadenosine | 19.36 | 17.43 | 18.61 | 18.45 | 16.75 | 17.56 | |
| 6-Aminouracil | - | - | - | - | - | - | |
| 6C13-Phenylalanine | 27.34 | 27.59 | 27.58 | 27.54 | 27.62 | 27.59 | |
| 6C13-Tyrosine | 20.34 | 20.58 | 20.49 | 20.44 | 20.59 | 20.71 | |
| 7-alpha-Hydroxy-3-oxo-4-cholestenoate | - | - | - | - | - | - | |
| 7-Methylguanine | - | - | - | - | - | - | |
| 7-Methylguanosine | - | - | - | - | - | - | |
| 7-Methylxanthine | - | - | - | - | - | - | |
| 7-Methylxanthosine | - | - | - | - | - | - | |
| 8-Hydroxy-deoxyguanosine | - | - | - | - | - | - | |
| 8-Hydroxyguanosine | - | - | - | - | - | - | |
| 8-Oxo-deoxyguanosine-13C,15N2 | - | - | - | - | - | - | |
| 9-Hexadecenoylcarnitine | 13.28 | 12.58 | 12.84 | 13.58 | 13.41 | 13.23 | |
| Acetylcarnitine | 19.37 | 19.64 | 19.23 | 19.70 | 19.78 | 18.77 | |
| Acetylcarnitine-d3 | 28.83 | 28.93 | 28.83 | 28.82 | 28.85 | 28.92 | |
| Adenine | - | - | - | - | - | - | |
| Adenosine | 22.21 | 19.31 | 22.44 | 21.09 | 18.67 | 21.42 | |
| Adenosine diphosphate ribose | - | - | - | - | - | - | |
| Adenosylcobalamin | - | - | - | - | - | - | |
| AICA-riboside | - | - | - | - | - | - | |
| Alanine | 13.54 | 12.59 | 13.58 | 13.72 | 13.39 | 13.38 | |
| Alanine-d4 | 22.23 | 22.25 | 22.28 | 22.29 | 22.26 | 22.27 | |
| alpha-Tocopherol | 15.05 | 14.67 | 14.78 | 14.97 | 14.78 | 14.74 | |
| Arabitol | 25.06 | 25.12 | 25.07 | 25.11 | 25.13 | 25.11 | |
| Arginine | 20.18 | 19.22 | 19.67 | 20.03 | 19.24 | 19.56 | |
| Arginine-d4C13 | 28.74 | 28.40 | 28.43 | 28.46 | 28.47 | 28.32 | |
| Ascorbate | - | - | - | - | - | - | |
| Asparagine | - | - | - | - | - | - | |
| Aspartic acid | 16.29 | 15.48 | 15.99 | 16.15 | 15.38 | 15.39 | |
| Aspartic acid-d3 | 22.15 | 22.12 | 22.13 | 22.17 | 22.17 | 22.15 | |
| Asymmetric dimethylarginine | 16.68 | 15.72 | 16.30 | 16.82 | 15.71 | 16.12 | |
| Betaine | - | - | - | - | - | - | |
| Betaine-d11 | 23.46 | 23.70 | 23.76 | 23.72 | 23.73 | 23.84 | |
| Bilirubin | - | - | - | - | - | - | |
| Butyrobetaine | 14.55 | 14.35 | 14.54 | 14.45 | 14.55 | 14.17 | |
| Butyrylcarnitine | 16.37 | 16.67 | 16.44 | 16.87 | 16.96 | 16.13 | |
| Butyrylcarnitine-d3 | 27.82 | 27.91 | 27.89 | 27.87 | 27.91 | 27.95 | |
| Cadaverine | - | - | - | - | - | - | |
| cADPRibose | - | - | - | - | - | - | |
| Caffeine | - | - | - | - | - | - | |
| Capsaicin | - | - | - | - | - | - | |
| Carnitine | 16.82 | 15.94 | 16.99 | 16.99 | 16.26 | 16.65 | |
| Carnitine-d9 | 26.21 | 26.21 | 26.31 | 26.34 | 26.29 | 26.30 | |
| Choline | 23.37 | 22.24 | 23.38 | 22.97 | 21.70 | 22.71 | |
| Citrulline | - | - | - | - | - | - | |
| Citrulline-d2 | 21.02 | 21.02 | 21.02 | 20.99 | 21.05 | 21.02 | |
| Cotinine | - | - | - | - | - | - | |
| Creatine | 21.92 | 19.54 | 21.11 | 20.93 | 19.03 | 19.77 | |
| Creatinine | - | - | - | - | - | - | |
| Creatinine-d3 | 16.28 | 15.54 | 17.85 | 16.66 | 14.91 | 17.48 | |
| Curcumin | 16.35 | 16.38 | 15.93 | 15.70 | 16.26 | 16.26 | |
| Cyanocobalamin | - | - | - | - | - | - | |
| Cystathionine | - | - | - | - | - | - | |
| Cysteine | - | - | - | - | - | - | |
| Cysteinylglycine | 22.29 | 22.05 | 22.06 | 22.11 | 22.12 | 21.98 | |
| Cystine | - | - | - | - | - | - | |
| Cytosine | - | - | - | - | - | - | |
| Decanoylcarnitine | 14.40 | 14.32 | 14.77 | 14.51 | 14.36 | 14.67 | |
| Demethoxycurcumin | - | - | - | - | - | - | |
| Deoxyadenosine | - | - | - | - | - | - | |
| Deoxyguanosine | - | - | - | - | - | - | |
| Deoxyinosine | - | - | - | - | - | - | |
| Dimethylethanolamine | 18.32 | 18.19 | 18.31 | 18.50 | 18.23 | 18.34 | |
| Dimethylglycine | - | - | - | - | - | - | |
| DNL201 | - | - | - | - | - | - | |
| Dodecanoylcarnitine | - | - | - | - | - | - | |
| Dopa | - | - | - | - | - | - | |
| Dopamine | 17.71 | 18.04 | 17.95 | 17.95 | 18.03 | 17.92 | |
| Dopamine 3-o-sulfate | - | - | - | - | - | - | |
| Dopamine 4-o-sulfate | - | - | - | - | - | - | |
| Epinephrine | - | - | - | - | - | - | |
| Ergothioneine | 11.84 | 16.56 | 13.14 | 15.94 | 16.88 | 11.88 | |
| Ethanolamine | 13.73 | 13.77 | 13.73 | 12.77 | 13.78 | 13.57 | |
| Formylanthranilic acid | - | - | - | - | - | - | |
| gamma-Aminobutyric acid | 12.93 | 12.22 | 13.41 | 12.65 | 12.07 | 12.46 | |
| Gamma-Glutamylcysteine | - | - | - | - | - | - | |
| Glucosamine | - | - | - | - | - | - | |
| Glucose | 20.93 | 20.65 | 20.88 | 20.93 | 20.87 | 20.72 | |
| Glutamic acid | 18.26 | 17.43 | 18.08 | 18.26 | 17.36 | 17.73 | |
| Glutamic acid-d3 | 21.65 | 21.66 | 21.66 | 21.63 | 21.67 | 21.69 | |
| Glutamine | 14.87 | 14.47 | 15.32 | 15.68 | 14.35 | 15.11 | |
| Glutathione | 18.29 | 16.86 | 17.77 | 17.47 | 16.83 | 16.86 | |
| Glutathione disulfide | - | - | - | - | - | - | |
| Glutathione-(glycine-13C2,15N) | - | - | - | - | - | - | |
| Glycerophosphocholine | 23.01 | 22.14 | 23.32 | 23.06 | 21.48 | 23.35 | |
| Glycine | 11.80 | 11.08 | 12.21 | 11.15 | 11.54 | - | |
| Guanine | - | - | - | - | - | - | |
| Guanosine | - | - | - | - | - | - | |
| Hexanoylcarnitine | 17.76 | 17.08 | 17.65 | 17.46 | 16.76 | 17.16 | |
| Histamine | 16.19 | 13.12 | 15.08 | 16.72 | 16.48 | 15.76 | |
| Histidine | 19.50 | 18.23 | 18.77 | 20.21 | 18.79 | 19.23 | |
| Homocysteine | 21.96 | 22.00 | 22.01 | 22.01 | 22.03 | 22.03 | |
| Homoserine | 13.70 | 13.29 | 13.77 | 13.96 | 13.62 | 13.86 | |
| Hydroxybutyrylcarnitine | 18.40 | 17.73 | 18.27 | 18.47 | 17.98 | 16.96 | |
| Hydroxyhexanoylcarnitine | 13.61 | 12.90 | 13.59 | 14.43 | 13.43 | 14.14 | |
| Hydroxyisovaleroyl carnitine | 15.80 | 14.74 | 15.45 | 15.39 | 14.79 | 14.60 | |
| Hydroxypropionylcarnitine | - | - | - | - | - | - | |
| Hypoxanthine | 15.33 | 15.67 | 16.55 | 16.22 | 15.33 | 17.13 | |
| Imidazoleacetic acid | 18.73 | 19.47 | 19.04 | 18.71 | 19.38 | 19.49 | |
| Indole | - | - | - | - | - | - | |
| Inosine | 13.55 | 14.41 | 15.22 | 14.40 | 13.87 | 15.38 | |
| Isovalerylcarnitine | 14.56 | 14.21 | 14.86 | 15.06 | 14.44 | 14.85 | |
| Isovalerylcarnitine-d9 | 28.13 | 28.18 | 28.18 | 28.18 | 28.21 | 28.20 | |
| Kynurenic acid | - | - | - | - | - | - | |
| Kynurenine | - | - | - | - | - | - | |
| Leucine | 17.50 | 17.23 | 17.77 | 17.88 | 17.33 | 17.39 | |
| Leucine-d3 | 27.18 | 27.42 | 27.39 | 27.36 | 27.46 | 27.45 | |
| Linoleyl carnitine | - | - | - | - | - | - | |
| LPC(18:1(d7)) | 26.91 | 26.96 | 27.03 | 27.00 | 26.99 | 27.05 | |
| Lysine | 16.15 | 15.47 | 16.00 | 16.64 | 15.30 | 15.92 | |
| Mannitol | - | - | - | - | - | - | |
| Mannose | - | - | - | - | - | - | |
| Melatonin | - | - | - | - | - | - | |
| Methionine | 14.28 | 14.39 | 14.52 | 14.76 | 14.56 | 14.71 | |
| Methionine-d3 | 23.11 | 23.15 | 23.17 | 23.16 | 23.20 | 23.18 | |
| Methionine S-oxide | 13.04 | 12.30 | 12.84 | 13.17 | 12.36 | 12.58 | |
| Methylcobalamin | - | - | - | - | - | - | |
| Myristoylcarnitine | - | - | - | - | - | - | |
| Myristoylcarnitine-d9 | 26.00 | 26.04 | 26.03 | 26.03 | 26.03 | 26.03 | |
| N15C13-Glycine | 19.53 | 19.62 | 19.58 | 19.67 | 19.60 | 19.58 | |
| N1-Acetylspermidine | - | - | - | - | - | - | |
| N1-Acetylspermidine-d6 | - | - | - | - | - | - | |
| N1-Acetylspermine | - | - | - | - | - | - | |
| N1-N12-Diacetylspermine | - | - | - | - | - | - | |
| N1-N8-Diacetylspermidine | - | - | - | - | - | - | |
| N1-N8-Diacetylspermidine-d6 | - | - | - | - | - | - | |
| N6,N6,N6-Trimethyllysine | 17.47 | 16.54 | 17.05 | 17.36 | 16.35 | 16.51 | |
| N-Acetylalanine | - | - | - | - | - | - | |
| N-Acetylaspartic acid | 20.40 | 20.34 | 20.46 | 20.40 | 20.29 | 20.39 | |
| N-Acetylcysteine | - | - | - | - | - | - | |
| N-Acetylglutamic acid | - | - | - | - | - | - | |
| N-Acetylneuraminic acid | - | - | - | - | - | - | |
| N-Acetylputrescine | - | - | - | - | - | - | |
| N-Acetylserine | - | - | - | - | - | - | |
| NAD | - | - | - | - | - | - | |
| N-Alpha-acetyllysine | - | - | - | - | - | - | |
| Niacinamide | 16.79 | 17.49 | 17.81 | 17.87 | 17.47 | 17.60 | |
| Niacinamide-d4 | - | - | - | - | - | - | |
| Nicotinamide mononucleotide | - | - | - | - | - | - | |
| Nicotinamide riboside | - | - | - | - | - | - | |
| Nicotinic acid | - | - | - | - | - | - | |
| Nitrotyrosine | - | - | - | - | - | - | |
| N,N^-Bis(gamma-glutamyl)cystine | - | - | - | - | - | - | |
| Nonanoylcarnitine | - | - | - | - | - | - | |
| Norepinephrine | 13.89 | 14.21 | 13.98 | 13.97 | 13.81 | 14.00 | |
| Octanoylcarnitine | 16.91 | 16.89 | 16.79 | 16.72 | 16.76 | 16.88 | |
| Octanoylcarnitine-d3 | 27.22 | 27.35 | 27.28 | 27.33 | 27.37 | 27.33 | |
| Ornithine | 14.06 | 13.07 | 12.99 | 15.14 | 13.58 | 14.19 | |
| Ornithine-d2 | 23.21 | 22.94 | 22.90 | 22.88 | 23.03 | 22.76 | |
| Palmitoylcarnitine | 14.69 | 15.09 | 14.58 | 15.21 | 15.33 | 14.45 | |
| Palmitoylcarnitine-d3 | 24.99 | 25.08 | 25.05 | 25.08 | 25.10 | 25.11 | |
| Paraxanthine | - | - | - | - | - | - | |
| Phenylalanine | 18.37 | 17.55 | 18.50 | 18.70 | 17.62 | 17.92 | |
| Piperanine | - | - | - | - | - | - | |
| Piperine | - | - | - | - | - | - | |
| Pipernonaline | - | - | - | - | - | - | |
| Piperyline | - | - | - | - | - | - | |
| Proline | - | - | - | - | - | - | |
| Propionylcarnitine | 17.24 | 17.59 | 17.50 | 17.73 | 17.70 | 17.53 | |
| Propionylcartinine-d3 | 27.82 | 27.86 | 27.85 | 27.85 | 27.86 | 27.88 | |
| Putrescine | - | - | - | - | - | - | |
| Pyridoxamine | 16.65 | 16.86 | 16.99 | 16.62 | 16.59 | 16.78 | |
| Pyroglutamic acid | 20.05 | 19.53 | 20.48 | 21.03 | 19.89 | 20.28 | |
| S-Adenosylhomocysteine | - | - | - | - | - | - | |
| S-Adenosylmethionine | 19.86 | 17.50 | 18.80 | 18.44 | 17.43 | 17.76 | |
| Sarcosine | 14.65 | 13.38 | 14.07 | 13.75 | 12.77 | 13.06 | |
| Serine | 15.96 | 14.95 | 15.89 | 16.39 | 15.36 | 15.95 | |
| Serotonin | - | - | - | - | - | - | |
| Spermidine | - | - | - | - | - | - | |
| Spermine | - | - | - | - | - | - | |
| Stearoylcarnitine | 14.92 | 15.13 | 14.39 | 15.18 | 15.24 | 15.19 | |
| Sucrose | 21.57 | 20.70 | 22.69 | 22.35 | 21.10 | 22.23 | |
| Taurine | 23.19 | 23.97 | 23.60 | 23.32 | 23.93 | 24.04 | |
| Tetrahydrocurcumin | - | - | - | - | - | - | |
| Theobromine | - | - | - | - | - | - | |
| Theophylline | - | - | - | - | - | - | |
| Thiamine | 12.44 | 12.55 | 12.01 | 12.29 | 12.53 | 12.36 | |
| Threonine | 13.49 | 12.83 | 13.08 | 13.63 | 13.37 | 13.23 | |
| Trigonelline | - | - | - | - | - | - | |
| Trimethylamine-d9 N-oxide | 27.32 | 27.35 | 27.32 | 27.31 | 27.31 | 27.34 | |
| Trimethylamine-N-oxide | 17.45 | 17.44 | 17.27 | 17.42 | 17.39 | 17.23 | |
| Tryptophan | 13.77 | 13.02 | 14.08 | 14.93 | 13.73 | 13.84 | |
| Tyrosine | - | - | - | - | - | - | |
| Uracil | - | - | - | - | - | - | |
| Ureidopropionic acid | - | - | - | - | - | - | |
| Uric acid | - | - | - | - | - | - | |
| Uridine | - | - | - | - | - | - | |
| Valerobetaine | 18.86 | 18.31 | 18.86 | 19.23 | 18.80 | 18.49 | |
| Valerobetaine-d9 | 25.97 | 26.03 | 26.00 | 26.01 | 26.03 | 26.02 | |
| Valine | - | - | - | - | - | - | |
| Valine-d8 | 23.19 | 23.97 | 23.60 | 23.32 | 23.93 | 24.04 | |
| Xanthine | - | - | - | - | - | - | |
| Xanthosine | 18.82 | 18.92 | 18.88 | 18.89 | 18.98 | 18.93 |
Factors:
| F1 | genotype:APP | condition:high | group:high_disease |
| F2 | genotype:APP | condition:low | group:low_disease |
| F3 | genotype:APP | condition:mid | group:mid_disease |
| F4 | genotype:NA | condition:NA | group:NA |
| F5 | genotype:WT | condition:low | group:low_healthy |
| F6 | genotype:WT | condition:mid | group:mid_healthy |
