Data for ST004038
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 13C10-Oxidized glutathione | - | 0.04 | - | 51.26 | - | 42.57 | - | - | - | - | - | 34.82 | 31.69 | 18.28 | 6.19 | |
| 13C11-UDP-N-acetylglucosamine | 0.01 | - | 0.01 | - | 0.02 | - | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | - | - | - | - | |
| 13C13-UDP-N-acetylglucosamine | - | - | 0.01 | - | 0.02 | - | 0.02 | 0.01 | - | 0.01 | 0.01 | - | - | - | - | |
| 13C2-2-Oxoglutaric acid | 59.31 | - | 47.89 | - | 33.91 | - | 58.55 | 43.57 | 38.60 | 32.86 | 40.44 | - | - | - | - | |
| 13C2-Acetyl-CoA | 0.35 | 0.18 | 0.42 | 0.18 | 0.32 | 0.20 | 0.38 | 0.34 | 0.18 | 0.54 | 0.10 | 0.15 | 0.13 | 0.14 | 0.16 | |
| 13C2-Aspartic acid | 4.15 | 1.00 | 27.31 | 21.20 | 25.79 | 23.91 | 29.64 | 27.26 | 25.04 | 13.05 | 2.79 | 22.64 | 13.63 | 9.57 | 8.01 | |
| 13C2-cis-Aconitic acid | 0.23 | 0.20 | 1.28 | 1.42 | 1.16 | 1.77 | 0.84 | 0.33 | 1.16 | 0.32 | 0.04 | 0.68 | 0.46 | 0.48 | 0.25 | |
| 13C2-Citric acid/Isocitric acid | 2.34 | 2.33 | 23.29 | 42.43 | 18.06 | 32.57 | 24.29 | 11.75 | 29.53 | 11.36 | 2.76 | 18.37 | 14.73 | 15.30 | 6.91 | |
| 13C2-Fumaric acid | 34.25 | 22.86 | 21.28 | 15.37 | 18.25 | 10.88 | 30.89 | 10.75 | 13.74 | 11.87 | 18.21 | 9.38 | 5.03 | 4.97 | 3.90 | |
| 13C2-Glutamic acid | 47.31 | - | 433.01 | - | 394.05 | - | 408.43 | 199.14 | 297.29 | 122.94 | 28.62 | - | - | - | - | |
| 13C2-Glutamine | 4.29 | - | 6.57 | - | 6.55 | - | 11.56 | 12.49 | 13.98 | 6.01 | 2.10 | - | - | - | - | |
| 13C2-Glutathione | 37.62 | - | 32.12 | - | 19.70 | - | 58.89 | 11.31 | 46.95 | 46.87 | 42.52 | - | - | - | - | |
| 13C2-Itaconic acid | - | 1.58 | - | 0.94 | - | 1.05 | - | - | - | - | - | 0.58 | 0.26 | 0.37 | 0.33 | |
| 13C2-Malic acid | 7.50 | 5.42 | 158.87 | 139.24 | 148.64 | 116.56 | 98.31 | 26.04 | 68.57 | 24.07 | 4.03 | 97.36 | 58.18 | 36.16 | 9.01 | |
| 13C2-N-Acetylglucosamine 1-phosphate/13C6-N-Acetyl-glucosami... | - | 0.10 | - | 0.14 | - | 0.15 | - | - | - | - | - | 0.09 | 0.04 | 0.07 | 0.06 | |
| 13C2-Oxaloacetic acid | 0.21 | 0.18 | 0.20 | 0.20 | 0.20 | 0.23 | 0.48 | 0.10 | 0.26 | 0.07 | 0.06 | 0.14 | 0.11 | 0.08 | 0.07 | |
| 13C2-Succinic acid | 1.31 | 0.74 | 11.83 | 15.87 | 12.21 | 12.37 | 7.99 | 2.49 | 3.93 | 2.21 | 0.84 | 10.21 | 3.13 | 2.40 | 1.52 | |
| 13C2-Succinyl-CoA | 0.13 | 0.12 | 0.02 | 0.14 | 0.01 | 0.12 | 0.06 | 0.05 | 0.15 | 0.04 | 0.05 | 0.09 | 0.07 | 0.08 | 0.07 | |
| 13C2-UDP-N-acetylglucosamine | - | 0.00 | - | 0.03 | - | 0.00 | - | - | - | - | - | 25.44 | 19.54 | 16.47 | 14.04 | |
| 13C3-2-Oxoglutaric acid | 13.10 | 0.11 | 108.74 | 9.40 | 99.82 | 7.86 | 162.40 | 74.01 | 112.17 | 45.30 | 6.62 | 8.84 | 3.62 | 2.46 | 0.60 | |
| 13C3-Aspartic acid | 0.40 | 0.73 | 28.70 | 7.80 | 27.55 | 8.28 | 15.90 | 10.90 | 14.57 | 3.36 | 0.38 | 10.09 | 5.89 | 3.64 | 1.96 | |
| 13C3-cis-Aconitic acid | 0.04 | - | 0.32 | - | 0.39 | - | 0.12 | 0.03 | 0.18 | 0.02 | 0.02 | - | - | - | - | |
| 13C3-Citric acid/Isocitric acid | 0.24 | - | 6.84 | - | 6.64 | - | 3.74 | 1.88 | 4.71 | 1.33 | 0.29 | - | - | - | - | |
| 13C3-Fumaric acid | 0.44 | 1.31 | 4.16 | 5.98 | 4.26 | 4.53 | 1.40 | 0.47 | 0.45 | 0.35 | 0.22 | 2.74 | 1.59 | 1.31 | 1.23 | |
| 13C3-Glutamic acid | 2.47 | 3.50 | 215.87 | 554.31 | 216.66 | 499.14 | 88.79 | 36.72 | 66.65 | 14.89 | 1.83 | 447.08 | 290.57 | 231.69 | 130.13 | |
| 13C3-Glutamine | 0.42 | 1.72 | 3.26 | 37.57 | 3.20 | 38.87 | 1.49 | 1.13 | 2.64 | 0.05 | 0.04 | 13.08 | 7.64 | 5.97 | 7.19 | |
| 13C3-Glutathione | 2.34 | 3.16 | 2.87 | 3.70 | 2.41 | 3.41 | 4.07 | 0.88 | 3.40 | 3.19 | 2.92 | 3.10 | 2.28 | 2.12 | 0.94 | |
| 13C3-Glyceraldehyde 3-phosphate/13C3-Dihydroxyacetone phosph... | 1.31 | - | 2.92 | - | 3.43 | - | 2.78 | 0.45 | 1.65 | 41.32 | 0.51 | - | - | - | - | |
| 13C3-Itaconic acid | - | 2.49 | - | 5.24 | - | 5.06 | - | - | - | - | - | 2.22 | 0.03 | 0.02 | 0.04 | |
| 13C3-Lactic acid | 2.36 | 1.02 | 97.46 | 1.17 | 104.52 | 1.36 | 17.82 | 6.16 | 13.16 | 30.28 | 3.21 | 1.45 | 1.07 | 0.77 | 0.63 | |
| 13C3-Malic acid | 1.00 | 4.91 | 120.33 | 44.71 | 124.22 | 37.42 | 34.09 | 6.78 | 24.61 | 4.47 | 0.52 | 45.33 | 25.58 | 13.68 | 4.72 | |
| 13C3-Oxaloacetic acid | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.01 | 0.05 | 0.02 | 0.05 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | |
| 13C3-Phosphoenolpyruvic acid | 1.42 | - | 2.30 | - | 2.50 | - | 1.73 | 1.30 | 0.15 | 27.67 | 1.86 | - | - | - | - | |
| 13C3-Phosphoglyceric acid | 1.84 | - | 5.19 | - | 7.35 | - | 2.65 | 2.15 | 6.52 | 558.87 | 2.87 | - | - | - | - | |
| 13C3-Succinic acid | 0.05 | 0.27 | 11.75 | 2.62 | 13.79 | 1.47 | 3.33 | 0.63 | 1.56 | 0.36 | 0.02 | 1.52 | 0.68 | 0.45 | 0.16 | |
| 13C3-Succinyl-CoA | 0.55 | 0.51 | 0.12 | 0.66 | 0.08 | 0.66 | 0.12 | 0.38 | 0.11 | 0.04 | 0.09 | 0.44 | 0.25 | 0.29 | 0.29 | |
| 13C4-2-Oxoglutaric acid | 0.55 | - | 70.14 | - | 63.69 | - | 32.43 | 13.48 | 24.02 | 5.83 | 0.39 | - | - | - | - | |
| 13C4-Aspartic acid | 0.10 | 17.99 | 24.38 | 81.79 | 23.08 | 92.48 | 5.25 | 2.19 | 4.82 | 0.46 | 0.07 | 128.60 | 74.71 | 44.62 | 28.96 | |
| 13C4-cis-Aconitic acid | 0.04 | 0.82 | 0.10 | 2.42 | 0.14 | 3.04 | 0.05 | 0.01 | 0.06 | 0.01 | 0.02 | 1.85 | 1.07 | 1.09 | 0.72 | |
| 13C4-Citric acid/Isocitric acid | 0.11 | 2.63 | 16.81 | 53.19 | 15.38 | 39.40 | 7.74 | 2.82 | 10.41 | 1.75 | 0.55 | 33.17 | 23.94 | 22.53 | 7.54 | |
| 13C4-Fumaric acid | 0.32 | 1.05 | 8.09 | 13.08 | 8.56 | 12.22 | 4.14 | 0.96 | 1.88 | 0.73 | 0.11 | 12.31 | 8.48 | 4.47 | 1.30 | |
| 13C4-Glutamic acid | 0.35 | - | 243.20 | - | 240.54 | - | 71.05 | 21.82 | 53.80 | 7.38 | 0.29 | - | - | - | - | |
| 13C4-Glutamine | 0.19 | - | 3.85 | - | 3.69 | - | 1.78 | 1.07 | 2.13 | 0.31 | 0.23 | - | - | - | - | |
| 13C4-Glutathione | 0.60 | - | 2.29 | - | 2.03 | - | 2.23 | 0.47 | 2.22 | 2.22 | 1.31 | - | - | - | - | |
| 13C4-Itaconic acid | - | 0.16 | - | 0.35 | - | 0.33 | - | - | - | - | - | 0.30 | 0.30 | 0.37 | 0.45 | |
| 13C4-Malic acid | 4.09 | 30.96 | 44.86 | 314.81 | 47.41 | 265.23 | 8.45 | 4.30 | 4.06 | 3.70 | 3.91 | 301.85 | 179.10 | 98.89 | 17.63 | |
| 13C4-Oxaloacetic acid | 0.01 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 | 0.14 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| 13C4-Oxidized glutathione | 0.13 | - | 0.96 | - | 0.85 | - | 0.65 | 0.13 | 0.61 | 0.33 | 0.18 | - | - | - | - | |
| 13C4-Succinic acid | 0.01 | 9.28 | 9.42 | 64.93 | 11.24 | 39.24 | 1.15 | 0.11 | 0.56 | 0.03 | 0.01 | 42.27 | 18.46 | 11.33 | 4.73 | |
| 13C4-Succinyl-CoA | 0.13 | 0.12 | 0.04 | 0.24 | 0.04 | 0.23 | 0.05 | 0.07 | 0.04 | 0.02 | 0.06 | 0.13 | 0.12 | 0.11 | 0.12 | |
| 13C5-2-Oxoglutaric acid | - | 5.94 | - | 48.47 | - | 35.76 | - | - | - | - | - | 44.36 | 21.74 | 16.14 | 5.41 | |
| 13C5-cis-Aconitic acid | 0.03 | 0.18 | 0.12 | 0.44 | 0.17 | 0.33 | 0.02 | 0.02 | 0.02 | 0.01 | 0.19 | 0.16 | 0.03 | 0.02 | 0.01 | |
| 13C5-Citric acid/Isocitric acid | 0.07 | 0.30 | 14.06 | 1.04 | 13.26 | 0.84 | 3.16 | 0.87 | 4.40 | 0.36 | 0.21 | 0.67 | 0.45 | 0.41 | 0.16 | |
| 13C5-Glutamic acid | - | 0.06 | - | 0.01 | - | 0.03 | - | - | - | - | - | 937.08 | 1515.18 | 1511.16 | 494.34 | |
| 13C5-Glutamine | - | 1301.18 | - | 2788.88 | - | 2722.49 | - | - | - | - | - | 1922.47 | 1327.63 | 1669.29 | 2138.28 | |
| 13C5-Glutathione | - | 0.24 | - | 11.41 | - | 8.78 | - | - | - | - | - | 10.47 | 9.59 | 6.79 | 2.34 | |
| 13C5-Oxidized glutathione | 0.02 | - | 0.37 | - | 0.41 | - | 0.13 | 0.02 | 0.12 | 0.07 | 0.03 | - | - | - | - | |
| 13C6-cis-Aconitic acid | - | 0.04 | - | 0.10 | - | 0.13 | - | - | - | - | - | 0.06 | 0.03 | 0.02 | 0.03 | |
| 13C6-Citric acid/Isocitric acid | - | 0.75 | - | 2.42 | - | 1.95 | - | - | - | - | - | 1.88 | 1.20 | 0.72 | 0.22 | |
| 13C6-Fructose 1,6-bisphosphate | 0.01 | - | 0.09 | - | 0.09 | - | 2.83 | 3.28 | 5.30 | 728.87 | 1.87 | - | - | - | - | |
| 13C6-Glucosamine 6-phosphate | 0.61 | - | 1.66 | - | 1.32 | - | 0.54 | 0.59 | 0.50 | 10.26 | 0.38 | - | - | - | - | |
| 13C6-Glucose | 2.32 | - | 0.16 | - | 0.06 | - | 0.63 | 0.92 | 0.48 | 4.16 | 1.51 | - | - | - | - | |
| 13C6-Glucose 6-phosphate/13C6-Fructose 6-phosphate | 13.59 | - | 31.35 | - | 26.63 | - | 15.56 | 14.44 | 9.50 | 213.12 | 6.97 | - | - | - | - | |
| 13C6-N-Acetylglucosamine 1-phosphate/13C6-N-Acetyl-glucosami... | 0.05 | - | 0.17 | - | 0.16 | - | 0.11 | 0.03 | 0.10 | 0.03 | 0.06 | - | - | - | - | |
| 13C6-Oxidized glutathione | 0.01 | 0.19 | 0.32 | 9.63 | 0.38 | 10.45 | 0.08 | 0.01 | 0.09 | 0.04 | 0.02 | 3.64 | 3.13 | 2.64 | 1.41 | |
| 13C6-UDP-N-acetylglucosamine | 0.01 | - | 0.02 | - | 0.02 | - | 0.03 | 0.01 | 0.02 | 0.03 | 0.01 | - | - | - | - | |
| 13C7-Oxidized glutathione | - | - | 0.10 | - | 0.15 | - | 0.02 | 0.00 | 0.01 | 0.01 | 0.01 | - | - | - | - | |
| 13C8-N-Acetylglucosamine 1-phosphate/13C8-N-Acetyl-glucosami... | 0.06 | - | 0.07 | - | 0.07 | - | 0.04 | 0.01 | 0.03 | 0.02 | 0.01 | - | - | - | - | |
| 13C8-Oxidized glutathione | 0.00 | 0.08 | 0.11 | 23.75 | 0.18 | 22.62 | 0.02 | 0.01 | 0.03 | 0.01 | 0.01 | 10.88 | 10.20 | 6.83 | 3.13 | |
| 13C8-UDP-N-acetylglucosamine | 0.03 | - | 0.05 | - | 0.07 | - | 0.03 | 0.01 | 0.04 | 0.02 | 0.01 | - | - | - | - | |
| 2-Oxoglutaric acid | 9.66 | 20.33 | 6.52 | 13.21 | 5.68 | 11.38 | 8.88 | 5.17 | 7.13 | 5.87 | 5.24 | 12.17 | 5.64 | 5.57 | 2.16 | |
| Acetyl-CoA | 1.42 | 1.57 | 0.18 | 0.93 | 0.14 | 1.30 | 0.35 | 0.28 | 0.15 | 1.02 | 0.43 | 0.54 | 0.40 | 0.62 | 0.98 | |
| Aspartic acid | 447.28 | 358.82 | 87.49 | 67.46 | 77.38 | 75.93 | 226.72 | 298.11 | 187.88 | 224.99 | 522.60 | 72.91 | 44.62 | 45.21 | 56.35 | |
| cis-Aconitic acid | 1.41 | 3.84 | 0.47 | 2.19 | 0.43 | 2.55 | 0.69 | 0.49 | 0.82 | 0.47 | 0.47 | 1.10 | 0.79 | 1.15 | 1.01 | |
| Citric acid/Isocitric acid | 30.18 | 82.93 | 14.99 | 94.93 | 11.07 | 68.79 | 31.13 | 23.95 | 36.42 | 27.77 | 23.69 | 43.27 | 34.68 | 55.41 | 26.76 | |
| Fructose 1,6-bisphosphate | 0.07 | - | 0.07 | - | 0.06 | - | 1.34 | 2.83 | 2.58 | 17.49 | 0.63 | - | - | - | - | |
| Fumaric acid | 16.19 | 14.16 | 9.33 | 6.09 | 7.76 | 6.45 | 11.21 | 4.25 | 5.99 | 4.32 | 4.83 | 4.65 | 3.64 | 3.29 | 1.18 | |
| Glucosamine 6-phosphate | 0.33 | 0.32 | 0.20 | 0.15 | 0.13 | 0.23 | 0.14 | 0.17 | 0.10 | 0.25 | 0.06 | 0.14 | 0.05 | 0.05 | 0.11 | |
| Glucose | 4.01 | - | 2.23 | - | 2.14 | - | 1.62 | 0.19 | 0.20 | 0.56 | 0.15 | - | - | - | - | |
| Glucose 6-phosphate/Fructose 6-phosphate | 39.39 | - | 25.54 | - | 17.29 | - | 10.88 | 346.34 | 4.08 | 12.39 | 1.42 | - | - | - | - | |
| Glutamic acid | 2225.93 | 2917.14 | 669.21 | 720.60 | 512.07 | 653.84 | 1445.79 | 904.49 | 959.28 | 848.41 | 1405.43 | 459.30 | 0.02 | 0.02 | 0.03 | |
| Glutamine | 553.33 | 243.57 | 30.65 | 99.32 | 30.78 | 105.56 | 270.95 | 505.38 | 321.30 | 535.05 | 254.43 | 46.06 | 24.32 | 30.20 | 41.49 | |
| Glutathione | 687.30 | 718.14 | 240.50 | 212.09 | 125.27 | 133.29 | 581.30 | 120.40 | 383.51 | 218.08 | 472.08 | 349.62 | 161.09 | 212.41 | 72.07 | |
| Glyceraldehyde 3-phosphate/Dihydroxyacetone phosphate | 3.97 | - | 1.97 | - | 1.80 | - | 2.21 | 0.38 | 1.04 | 4.94 | 0.54 | - | - | - | - | |
| Itaconic acid | - | 0.46 | - | 0.56 | - | 0.48 | - | - | - | - | - | 0.46 | 0.32 | 0.27 | 0.44 | |
| Lactic acid | 96.79 | 33.00 | 63.27 | 81.37 | 50.65 | 70.59 | 51.99 | 4.91 | 12.10 | 7.90 | 5.43 | 42.82 | 29.26 | 27.50 | 20.60 | |
| Malic acid | 468.97 | 457.36 | 268.65 | 247.50 | 213.97 | 198.38 | 371.41 | 133.34 | 233.77 | 179.91 | 139.80 | 161.60 | 96.50 | 91.69 | 35.10 | |
| N-Acetylglucosamine | 0.27 | 0.26 | 0.10 | 0.43 | 0.12 | 0.46 | 0.10 | 0.13 | 0.10 | 0.11 | 0.15 | 0.25 | 0.19 | 0.17 | 0.18 | |
| N-Acetylglucosamine 1-phosphate/N-Acetyl-glucosamine 6-phosp... | 3.22 | 2.97 | 2.21 | 7.65 | 1.49 | 7.01 | 2.36 | 1.65 | 1.26 | 4.26 | 1.83 | 3.15 | 2.58 | 2.92 | 2.12 | |
| Oxaloacetic acid | 1.74 | 1.10 | 0.23 | 0.29 | 0.17 | 0.25 | 0.34 | 0.17 | 0.20 | 0.35 | 0.34 | 0.48 | 0.30 | 0.49 | 0.16 | |
| Oxidized glutathione | 610.98 | 436.01 | 104.47 | 42.96 | 40.93 | 21.35 | 287.35 | 39.42 | 133.72 | 77.71 | 229.62 | 119.44 | 24.33 | 42.18 | 13.31 | |
| Phosphoenolpyruvic acid | 5.47 | - | 1.86 | - | 1.72 | - | 2.11 | 1.05 | 2.71 | 3.75 | 2.12 | - | - | - | - | |
| Phosphoglyceric acid | 9.57 | - | 3.60 | - | 4.12 | - | 3.43 | 1.32 | 5.11 | 81.02 | 3.21 | - | - | - | - | |
| Succinic acid | 64.18 | 45.57 | 37.20 | 27.05 | 30.53 | 18.28 | 56.10 | 19.06 | 23.62 | 21.75 | 32.13 | 15.47 | 7.81 | 8.08 | 6.77 | |
| Succinyl-CoA | 0.21 | 0.22 | 0.06 | 0.17 | 0.03 | 0.12 | 0.17 | 0.13 | 0.13 | 0.09 | 0.17 | 0.14 | 0.09 | 0.15 | 0.13 | |
| UDP-N-acetylglucosamine | 376.94 | 377.42 | 17.80 | 199.48 | 9.87 | 192.12 | 70.25 | 80.14 | 49.04 | 79.62 | 53.57 | 158.39 | 91.90 | 114.87 | 154.16 |
Factors:
| F1 | Sample source:HEK293FT cells | Time Point:0.25 hours | Treatment:11mM U-13C-glucose |
| F2 | Sample source:HEK293FT cells | Time Point:0.25 hours | Treatment:4mM U-13C-glutamine |
| F3 | Sample source:HEK293FT cells | Time Point:16 hours | Treatment:11mM U-13C-glucose |
| F4 | Sample source:HEK293FT cells | Time Point:16 hours | Treatment:4mM U-13C-glutamine |
| F5 | Sample source:HEK293FT cells | Time Point:24 hours | Treatment:11mM U-13C-glucose |
| F6 | Sample source:HEK293FT cells | Time Point:24 hours | Treatment:4mM U-13C-glutamine |
| F7 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:11mM U-13C-glucose |
| F8 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:11mM U-13C-glucose + 11mM 2-DG |
| F9 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:11mM U-13C-glucose 1mM malonate |
| F10 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:11mM U-13C-glucose + 2uM POMHEX |
| F11 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:11mM U-13C-glucose + 300nM KL-11743 |
| F12 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:4mM U-13C-glutamine |
| F13 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:4mM U-13C-glutamine + 1mM malonate |
| F14 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:4mM U-13C-glutamine + 1uM CB-839 |
| F15 | Sample source:HEK293FT cells | Time Point:6 hours | Treatment:4mM U-13C-glutamine + 50uM V-9302 |