Data for ST000271
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 or 3-phosphoglycerate_13C_1 | - | - | - | - | 1202.18 | 3004.28 | - | 1155.99 | - | - | |
| 2 or 3-phosphoglycerate_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| 2 or 3-phosphoglycerate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| 2 or 3-phosphoglycerate_2PG/3PG | 116040.60 | 86268.87 | 31598.95 | 39515.79 | 175095.20 | 150750.30 | 136820.70 | 137607.30 | 77295.57 | 91907.98 | |
| 3-Glycerophosphate | 45625.86 | 43322.07 | 53448.32 | 48902.05 | 59699.84 | 37293.60 | 39146.65 | 31100.73 | 94861.57 | 79397.41 | |
| 3-Glycerophosphate_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| 3-Glycerophosphate_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| 3-Glycerophosphate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| 3-phosphoglyceraldehyde | 5231.92 | 6853.54 | 4756.58 | 4912.81 | 5491.00 | 7371.69 | 4269.09 | 6787.99 | 6129.63 | 4533.99 | |
| 3-phosphoglyceraldehyde_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| 3-phosphoglyceraldehyde_13C_2 | - | 681.53 | - | - | 858.15 | 1725.11 | 1111.24 | 231.69 | - | - | |
| 3-phosphoglyceraldehyde_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| 6-Phosphogluconate | 523877.60 | 571369.40 | 214592.60 | 197255.40 | 376502.60 | 493988.10 | 465224.30 | 438344.10 | 240190.60 | 215826.10 | |
| 6-Phosphogluconate_13C_1 | 3671.04 | 11184.27 | - | 2110.21 | 4771.32 | 5186.39 | - | 5850.64 | 1283.57 | 1552.00 | |
| 6-Phosphogluconate_13C_2 | 2866.26 | - | 640.54 | 1961.59 | 1150.76 | 2719.07 | 917.48 | 1161.51 | 2625.85 | 560.76 | |
| 6-Phosphogluconate_13C_3 | - | - | - | - | - | - | - | - | - | 618.55 | |
| 6-Phosphogluconate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| 6-Phosphogluconate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| 6-Phosphogluconate_13C_6 | - | - | - | - | - | - | - | - | - | - | |
| Acetyl-CoA | 31046.19 | 22957.60 | 21227.91 | 10115.62 | 38237.07 | 35423.60 | 39232.04 | 34334.73 | 47310.94 | 32283.91 | |
| Acetyl-CoA_13C_1 | - | - | - | 1002.03 | - | - | - | - | - | 8510.14 | |
| Acetyl-CoA_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| Adenosine diphosphate_13C_1 | - | 14880.99 | - | 4468.60 | 11351.27 | - | 13773.78 | - | 40623.26 | 44566.11 | |
| Adenosine diphosphate_13C_2 | 6442.39 | 7350.27 | 9861.05 | 6599.81 | 8826.62 | 1522.34 | 14469.41 | 24713.29 | 9764.27 | - | |
| Adenosine diphosphate_13C_3 | 1556.56 | 240.77 | - | 1263.83 | 4396.81 | 3074.53 | 3261.49 | 5407.37 | 5267.20 | 5408.45 | |
| Adenosine diphosphate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| Adenosine diphosphate_13C_5 | - | - | - | - | - | 131.08 | 10.80 | 113.15 | - | - | |
| Adenosine monophosphate_13C_1 | 13059.91 | 11267.99 | 19075.48 | - | - | 1143.88 | - | 5064.18 | - | - | |
| Adenosine monophosphate_13C_2 | - | - | 1722.46 | 147.81 | 2831.19 | 2346.60 | - | - | 813.82 | 730.40 | |
| Adenosine monophosphate_13C_3 | - | 1180.32 | 4636.28 | 683.51 | 3487.37 | 2781.63 | 1766.32 | - | 7661.74 | 12538.00 | |
| Adenosine monophosphate_13C_4 | - | - | - | - | - | - | - | 16.00 | - | - | |
| Adenosine monophosphate_13C_5 | - | - | - | - | 689.93 | - | - | 264.58 | 416.14 | - | |
| Adenosine triphosphate_13C_1 | - | 1803.72 | - | - | 61044.00 | 11393.66 | 54358.82 | 9802.07 | 40396.23 | 27199.89 | |
| Adenosine triphosphate_13C_2 | 59947.66 | 67682.59 | 29764.31 | 29787.36 | 66250.36 | 64411.98 | 87120.77 | 68805.54 | 44024.35 | 44982.08 | |
| Adenosine triphosphate_13C_3 | 13521.61 | 9837.78 | 7340.99 | 5347.24 | 16131.95 | 9898.46 | 15999.50 | 12143.61 | 7934.39 | 5042.35 | |
| Adenosine triphosphate_13C_4 | 2142.46 | - | 506.91 | - | 809.98 | 2326.56 | - | - | - | 1116.03 | |
| Adenosine triphosphate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| ADP | 4004852.00 | 3603645.00 | 3693421.00 | 3397115.00 | 5067266.00 | 5636986.00 | 4849468.00 | 4963364.00 | 5757836.00 | 5871313.00 | |
| AMP | 942017.10 | 823348.80 | 1493220.00 | 1749142.00 | 2413976.00 | 1463980.00 | 1999974.00 | 1550874.00 | 3948148.00 | 3497609.00 | |
| Aspartate | 1720892.00 | 1817803.00 | 1071703.00 | 1107433.00 | 2296101.00 | 2672124.00 | 1865306.00 | 2170392.00 | 1351105.00 | 1546595.00 | |
| Aspartate_13C_1 | 215165.75 | 399558.07 | 84275.86 | 190082.18 | 300762.34 | 554526.32 | 235176.60 | 492147.59 | 120534.75 | 253718.00 | |
| Aspartate_13C_2 | 6748.55 | 13161.80 | 285.14 | 10121.74 | 5287.67 | 13387.74 | 3260.50 | 12014.43 | 735.20 | 10160.84 | |
| Aspartate_13C_3 | - | - | - | - | 1395.62 | 395.72 | - | - | 151.78 | 2432.89 | |
| Aspartate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| ATP | 3744498.00 | 3796626.00 | 2654922.00 | 2346824.00 | 3496324.00 | 3731951.00 | 3403502.00 | 3993507.00 | 3285811.00 | 3149156.00 | |
| Citrate or Isocitrate | 1416013.00 | 1555231.00 | 1896825.00 | 1331325.00 | 2082593.00 | 1891288.00 | 1357531.00 | 1474581.00 | 4540850.00 | 3047324.00 | |
| Citrate or Isocitrate_13C_1 | 127863.07 | 324339.17 | 118979.78 | 316515.87 | 198245.21 | 432132.38 | 137584.71 | 375927.96 | 409402.08 | 808198.66 | |
| Citrate or Isocitrate_13C_2 | 11133.23 | 67389.62 | 3484.46 | 78459.84 | 18836.47 | 73772.46 | 8254.10 | 87478.25 | 17146.54 | 160510.23 | |
| Citrate or Isocitrate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Citrate or Isocitrate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| Citrate or Isocitrate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Citrate or Isocitrate_13C_6 | - | - | - | - | - | - | - | - | - | - | |
| Erythrose 4-phosphate | 9190.37 | 16045.67 | - | 5070.10 | 22705.71 | 21333.66 | 21652.28 | 23562.50 | - | 11220.39 | |
| Erythrose 4-phosphate_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| Erythrose 4-phosphate_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| Erythrose 4-phosphate_13C_3 | - | - | - | - | - | - | 7.58 | 12.03 | - | - | |
| Erythrose 4-phosphate_13C_4 | - | - | - | - | - | - | 232.15 | - | - | - | |
| Fructose 1,6-bisphosphate | 622837.90 | 680157.50 | 496621.70 | 498169.60 | 563572.70 | 634831.50 | 561795.10 | 703860.50 | 623638.30 | 610031.90 | |
| Fructose 1,6-bisphosphate_13C_1 | 4086.12 | 12383.54 | 704.80 | 1128.10 | 5921.48 | 12682.80 | 3724.03 | 10001.73 | 5283.94 | 1880.81 | |
| Fructose 1,6-bisphosphate_13C_2 | 1341.04 | 3181.37 | 1421.65 | 4108.24 | 5697.85 | 1840.58 | 3110.05 | 3683.30 | 2187.64 | 1791.65 | |
| Fructose 1,6-bisphosphate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Fructose 1,6-bisphosphate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| Fructose 1,6-bisphosphate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Fructose 1,6-bisphosphate_13C_6 | - | - | - | - | - | - | - | - | - | - | |
| Glucose 6-phosphate or fructose-6-phosphate | 237210.80 | 265402.70 | 176545.60 | 171233.90 | 300947.00 | 261116.20 | 209790.70 | 270044.60 | 224640.00 | 219876.70 | |
| Glucose 6-phosphate or fructose-6-phosphate_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| Glucose 6-phosphate or fructose-6-phosphate_13C_2 | 9713.79 | 11724.94 | 8141.95 | 5523.77 | 15299.11 | 17831.61 | 12271.48 | 13841.60 | 10515.09 | 11881.95 | |
| Glucose 6-phosphate or fructose-6-phosphate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Glucose 6-phosphate or fructose-6-phosphate_13C_4 | 4088.78 | - | 4566.68 | - | - | - | - | - | 4621.19 | 3036.34 | |
| Glucose 6-phosphate or fructose-6-phosphate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Glucose 6-phosphate or fructose-6-phosphate_13C_6 | - | - | - | - | - | - | - | - | - | - | |
| Glutamate | 12126695.00 | 9565190.00 | 10355904.00 | 8756990.00 | 14898861.00 | 12433706.00 | 11284725.00 | 10262657.00 | 11785458.00 | 11819261.00 | |
| Glutamate_13C_1 | 145517.20 | 770871.00 | 73985.25 | 514201.70 | 224316.00 | 986006.10 | 218056.70 | 1156682.00 | 169211.70 | 910561.90 | |
| Glutamate_13C_2 | 4510.17 | 151626.90 | 200.44 | 102518.50 | 5498.99 | 152939.90 | - | 205904.50 | 7860.18 | 161775.10 | |
| Glutamate_13C_3 | - | 1257.48 | - | 1514.77 | - | 821.80 | - | 7104.21 | - | 3215.37 | |
| Glutamate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| Glutamate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Lactate | - | - | - | - | - | - | - | - | - | - | |
| Lactate_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| Lactate_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| Lactate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Malate | 664439.20 | 820941.50 | 818898.30 | 941954.50 | 846377.30 | 724122.90 | 432403.00 | 520347.60 | 752838.30 | 829105.20 | |
| Malate_13C_1 | 130468.51 | 249553.55 | 99452.67 | 260146.17 | 140792.24 | 209538.64 | 92474.55 | 173538.11 | 93894.12 | 181943.19 | |
| Malate_13C_2 | 18662.22 | 23703.71 | 17863.86 | 26554.42 | 16384.74 | 19905.60 | 14352.65 | 16616.01 | 13844.92 | 18704.72 | |
| Malate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Malate_13C_4 | - | - | - | - | - | - | - | - | - | 899.10 | |
| Malonyl-CoA | - | - | - | - | - | - | - | - | - | - | |
| Malonyl-CoA_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| Malonyl-CoA_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| Malonyl-CoA_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Nicotinamide Adenine Dinucleotide oxidized | 939782.30 | 884574.60 | 741389.90 | 725935.70 | 1377808.00 | 1473510.00 | 1368242.00 | 1332308.00 | 1140827.00 | 1244187.00 | |
| Nicotinamide Adenine Dinucleotide oxidized_13C_1 | 11449.56 | 23141.78 | 1765.32 | 948.25 | 34136.77 | 27889.60 | 17975.86 | 10871.48 | 4658.22 | 16125.75 | |
| Nicotinamide Adenine Dinucleotide oxidized_13C_2 | 8459.48 | 8761.68 | 6710.67 | 5788.40 | 12852.43 | 8409.91 | 12947.95 | 9903.97 | 5410.37 | 6389.17 | |
| Nicotinamide Adenine Dinucleotide oxidized_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Nicotinamide Adenine Dinucleotide oxidized_13C_4 | - | 175.96 | - | - | - | - | - | - | - | - | |
| Nicotinamide Adenine Dinucleotide oxidized_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Nicotinamide Adenine Dinucleotide reduced | 54095.19 | 13505.75 | 50692.79 | 20151.97 | 8355.83 | 42133.59 | 71741.81 | 46350.86 | 76724.84 | 41087.40 | |
| Nicotinamide Adenine Dinucleotide reduced_13C_1 | 3198.86 | - | 1143.04 | 4009.63 | - | 1024.71 | 2989.82 | 1191.74 | 825.21 | 1610.97 | |
| Nicotinamide Adenine Dinucleotide reduced_13C_2 | - | - | - | - | - | - | - | - | - | - | |
| Nicotinamide Adenine Dinucleotide reduced_13C_3 | - | - | 821.59 | - | - | 1361.45 | - | 619.01 | 524.11 | - | |
| Nicotinamide Adenine Dinucleotide reduced_13C_4 | 2765.22 | 8.27 | 151.75 | - | - | 626.97 | 411.96 | 1122.54 | 165.95 | 408.11 | |
| Nicotinamide Adenine Dinucleotide reduced_13C_5 | - | 1199.02 | - | - | - | 638.03 | - | - | - | - | |
| Phosphoenolpyruvate | 29699.03 | 20440.76 | 4245.28 | 8892.64 | 50635.87 | 37995.79 | 37688.83 | 35349.07 | 15279.15 | 22762.25 | |
| Phosphoenolpyruvate_13C_1 | - | - | - | - | - | - | - | - | - | - | |
| Phosphoenolpyruvate_13C_2 | - | - | - | 107.66 | - | - | 2.66 | 33.83 | 390.19 | - | |
| Phosphoenolpyruvate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Ribose-5-phosphate or xylulose 5-phosphate | 110753.10 | 94822.86 | 93922.49 | 108381.00 | 185530.70 | 145463.30 | 129810.70 | 111363.40 | 178130.20 | 171701.20 | |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_1 | - | - | 1694.41 | 338.12 | 745.64 | 522.78 | - | 1504.92 | 524.86 | 3370.46 | |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_2 | 19251.80 | 17909.20 | 14390.36 | 13434.19 | 19816.18 | 20524.82 | 16041.05 | 20184.11 | 18216.97 | 18988.94 | |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_4 | - | 2258.93 | - | - | - | - | 3693.22 | 3214.04 | - | - | |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Sedoheptulose 7-phosphate | 166660.70 | 234417.00 | 63985.45 | 77925.20 | 138286.50 | 213425.80 | 182280.20 | 289421.80 | 108779.20 | 96989.36 | |
| Sedoheptulose 7-phosphate_13C_1 | 3586.79 | 8191.15 | 732.00 | 2025.63 | 3746.58 | 11153.21 | 3868.08 | 12477.86 | 1179.31 | 365.43 | |
| Sedoheptulose 7-phosphate_13C_2 | - | 272.55 | - | - | - | - | - | - | - | - | |
| Sedoheptulose 7-phosphate_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Sedoheptulose 7-phosphate_13C_4 | - | - | - | - | - | - | - | - | - | - | |
| Sedoheptulose 7-phosphate_13C_5 | - | - | - | - | - | - | - | - | - | - | |
| Sedoheptulose 7-phosphate_13C_6 | - | - | - | - | - | - | - | - | - | - | |
| Sedoheptulose 7-phosphate_13C_7 | - | - | - | - | - | - | - | - | - | - | |
| Sucrose | 254695.40 | 259674.80 | 161175.90 | 190833.20 | 418635.10 | 413986.90 | 333143.80 | 383096.20 | 345494.40 | 320197.20 | |
| Sucrose_13C_1 | - | 10238.23 | - | 6142.22 | - | 10049.14 | - | 14791.39 | - | 7300.13 | |
| Sucrose_13C_2 | - | 2542.00 | - | - | - | - | 296.54 | 746.32 | - | - | |
| Sucrose_13C_3 | - | - | - | - | - | - | - | - | - | - | |
| Sucrose_13C_4 | - | - | - | - | - | - | - | - | - | - |
Factors:
| F1 | Drug combination:Isoproterenol | 13C-label position in pyruvate:C1 |
| F2 | Drug combination:Isoproterenol | 13C-label position in pyruvate:C2 |
| F3 | Drug combination:Isoproterenol + Leelamine | 13C-label position in pyruvate:C1 |
| F4 | Drug combination:Isoproterenol + Leelamine | 13C-label position in pyruvate:C2 |
| F5 | Drug combination:None | 13C-label position in pyruvate:C1 |
| F6 | Drug combination:None | 13C-label position in pyruvate:C2 |
| F7 | Drug combination:Rosiglitazone | 13C-label position in pyruvate:C1 |
| F8 | Drug combination:Rosiglitazone | 13C-label position in pyruvate:C2 |
| F9 | Drug combination:Rosiglitazone + Leelamine | 13C-label position in pyruvate:C1 |
| F10 | Drug combination:Rosiglitazone + Leelamine | 13C-label position in pyruvate:C2 |
