Data for (Study ST002205)

(Analysis AN003608)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
1-methylnicotinamide 1.7126 1.2807 0.7323 0.2745
2/3-phosphoglycerate 0.8265 0.9270 1.0226 1.2239
2-oxoglutarate 0.5902 0.5981 1.6910 1.1207
3-phosphoserine 0.2858 0.5375 0.9952 2.1814
4-hydroxyphenyllactate 0.5224 0.5217 1.4796 1.4763
4-hydroxyphenylpyruvate 0.9094 0.8957 1.1538 1.0412
4-hydroxyproline 0.9119 0.9538 0.8823 1.2521
5-formamidoimidazole-4-carboxamide ribotide 0.3992 0.3412 1.9417 1.3179
6-phosphogluconate 0.6170 0.8881 1.2736 1.2213
acetyl-CoA 0.7796 0.8797 1.4170 0.9236
aconitate 0.2700 0.3047 1.6537 1.7716
adenine 0.5101 0.7022 1.1227 1.6650
adenosine 1.0263 1.1576 0.7999 1.0162
adenylosuccinate 1.5628 1.7566 0.0053 0.0122
ADP 0.7790 0.9165 1.0338 1.2708
ADP-ribose 0.9212 1.1890 1.0191 0.8706
AICAR NA NA 0.8236 1.1764
alanine 0.7196 0.7424 1.3197 1.2183
aminoimidazole ribonucleotide 1.1259 0.8741 NA NA
AMP 1.1626 1.0522 0.9024 0.8827
arginine 0.8726 0.8064 1.1558 1.1652
argininosuccinate 1.9624 1.9595 0.0338 0.0443
asparagine 0.7328 1.0486 0.8634 1.3552
aspartate 0.2969 0.4327 1.2067 2.0637
ATP 0.4959 0.8079 1.1200 1.5762
beta-alanine 0.9495 1.3214 1.0687 0.6604
beta-citrylglutamate 0.6462 0.6325 1.6945 1.0268
betaine 0.7642 1.1708 1.3651 0.6999
carnitine 0.8773 1.5750 0.8361 0.7115
carnitine C14 0.6081 2.3448 0.5621 0.4850
carnitine C14:1 0.6879 1.2337 0.8943 1.1841
carnitine C16 0.9181 2.0631 0.5294 0.4894
carnitine C16:1 0.6702 2.3903 0.3544 0.5851
carnitine C18 1.8414 0.3113 1.1758 0.6715
carnitine C2 1.1184 1.5888 0.8444 0.4484
carnitine C3 0.1961 0.2465 2.4527 1.1047
carnitine C4 0.5449 0.9620 1.1435 1.3496
carnitine C5 0.4028 0.8047 1.8902 0.9023
carnitine C6 0.9254 1.7310 0.5759 0.7676
carnosine 0.6944 0.8759 1.1795 1.2503
CDP 0.4529 0.7494 1.2203 1.5774
choline 1.1564 1.2928 0.8697 0.6812
citicoline 1.3504 0.9571 1.3395 0.3530
citrate 0.5445 0.5775 1.3153 1.5627
citrulline 0.7561 0.8184 1.0333 1.3923
CMP 0.6538 0.6210 1.4480 1.2772
CMP-acetylneuraminate 0.8176 0.4978 1.6927 0.9918
creatine 0.8322 0.7074 1.1680 1.2924
creatinine 0.6864 0.7896 1.1504 1.3736
CTP 0.3399 0.6636 1.1865 1.8100
cyclic ADP-ribose 0.9730 1.0065 1.1477 0.8727
cyclic AMP 0.9962 1.0900 0.9983 0.9155
cystathionine 0.0731 0.1806 0.3840 3.3624
cysteate 1.0482 1.0140 0.8744 1.0634
cysteinylglycine 1.0195 0.9880 0.6603 1.3322
cytosine 0.5356 0.7352 1.4900 1.2392
dATP 0.0772 0.4536 0.8887 2.5805
dCTP 0.1016 0.4035 1.3516 2.1433
deoxycarnitine 0.7402 1.0192 1.3486 0.8920
dihydroorotate 0.6639 1.0213 0.6957 1.6190
dihydroxyacetone phosphate 0.8141 0.9934 1.1625 1.0301
dTMP 0.4579 0.5903 1.1757 1.7761
dTTP 0.3829 0.5416 1.2045 1.8710
epsilon-(gamma-glutamyl)lysine 1.0193 0.8984 0.9173 1.1650
flavin adenine dinucleotide 0.8847 1.0258 1.3490 0.7404
fructose 6-phosphate 0.9767 1.0193 1.1997 0.8043
fructose bisphosphate 0.8189 0.9383 1.0468 1.1960
fumarate 1.6755 1.8608 0.2482 0.2155
gamma-glutamylalanine 0.9068 1.2331 0.8836 0.9766
gamma-glutamylcysteine 1.0134 0.8325 0.5045 1.6496
gamma-glutamylglutamate 0.5749 0.8346 0.8821 1.7084
gamma-glutamylglycine 0.6186 0.7859 1.4228 1.1727
gamma-glutamylproline 0.7999 0.8162 0.9276 1.4563
GDP 0.6072 1.0783 0.9252 1.3893
GDP-fucose 0.8985 1.2117 0.9459 0.9439
GDP-glucose 1.0477 1.0960 1.1050 0.7513
gluconate 0.5435 0.6488 1.5986 1.2090
glucose 0.5992 0.7943 1.2162 1.3903
glucose 6-phosphate 0.9293 1.1537 1.2291 0.6879
glucuronate 0.9369 1.1571 1.0712 0.8349
glutamate 0.3995 0.3898 1.6392 1.5715
glutamine 0.9334 0.9435 0.9199 1.2033
glutathione reduced 0.9996 1.0703 0.6930 1.2371
glyceraldehyde 3-phosphate 1.2297 1.0520 1.4139 0.3044
glycerol 3-phosphate 0.8806 1.3085 0.8202 0.9907
glycerylphosphorylcholine 0.8213 1.1052 1.3045 0.7691
Glycerylphosphorylethanolamine 0.8432 1.0698 1.6288 0.4583
glycine 0.9401 0.8900 1.1630 1.0069
glycylglycine 0.5979 0.5448 1.1356 1.7217
GMP 0.7375 1.0641 0.9294 1.2689
GTP 0.4312 0.9540 0.9273 1.6875
guanidinoacetate 0.8064 1.0433 1.2731 0.8772
guanosine 0.7100 0.5856 1.4777 1.2267
hippurate 0.7036 0.7636 1.2556 1.2772
histidine 0.7555 0.7905 1.0632 1.3908
homoarginine 0.8492 0.7665 1.1832 1.2011
homocitrulline 0.4323 0.6192 1.4484 1.5001
homocysteine 0.5933 0.4984 1.4190 1.4893
hypotaurine 1.0203 1.3078 0.9630 0.7089
hypoxanthine 0.3621 0.4613 1.6834 1.4931
IMP 0.7840 0.6575 0.8558 1.7028
inosine 0.6605 0.7583 1.0378 1.5435
inositol 0.9047 1.6849 0.6530 0.7574
ketoleucine 0.4964 0.5332 1.4038 1.5666
ketovaline 0.5576 0.5309 1.2024 1.7091
kynurenine 0.6589 0.7070 1.2367 1.3974
lactate 1.1324 1.0324 1.1689 0.6662
leucine+isoleucine 0.7075 0.7867 1.2360 1.2698
lysine 0.7828 0.7862 1.1573 1.2737
malate 0.3189 0.3319 1.8055 1.5437
malonate 1.0985 1.0048 0.9245 0.9722
methionine 0.6814 0.6774 1.0792 1.5619
methionine sulfoxide 0.7828 0.6491 1.2886 1.2795
methylthioadenosine 0.6464 0.6771 0.9839 1.6926
N2-gamma-glutamylglutamine 0.7477 0.8836 0.7828 1.5859
N6,N6,N6-trimethyllysine 1.2247 1.2205 0.7085 0.8463
N-acetylarginine 0.9885 1.0447 0.6250 1.3419
N-acetylasparagine 0.5845 0.7875 1.4002 1.2278
N-acetylaspartate 0.0738 0.0581 3.7408 0.1272
N-acetylaspartylglutamate 0.3614 0.4645 1.6535 1.5205
N-acetylglutamate 0.3205 0.3784 1.8093 1.4918
N-acetylglutamine 0.2484 0.2865 1.8800 1.5850
N-acetylhexosamine phosphate 0.7690 1.0288 1.1641 1.0381
N-acetylhistidine 0.5598 0.7323 1.1929 1.5150
N-acetylmethionine 0.6887 0.8852 0.9372 1.4889
N-acetylneuranimic acid 0.9270 0.7280 1.0654 1.2796
N-acetyltaurine 0.7578 1.1523 1.0894 1.0004
NAD 0.9946 1.0432 1.1337 0.8285
NADH 0.7390 0.9496 0.9324 1.3789
NADP 0.7809 0.9008 1.1246 1.1936
NADPH 0.5455 0.8887 1.1970 1.3688
N-carbamoylaspartate 0.9626 1.1363 0.8686 1.0325
N,N-dimethylarginine 0.9117 0.8389 1.0457 1.2037
ophthalmate 0.1735 0.3231 2.8244 0.6789
ornithine 0.6324 0.4777 1.2718 1.6180
orotate 0.4887 0.7691 1.4006 1.3416
orotidine 0.4837 0.6178 1.7612 1.1372
oxidized glutathione 0.5129 0.8369 0.5016 2.1486
pantothenate 0.9459 0.9980 0.8685 1.1876
pentose 1,5-bisphosphate 0.3765 1.0739 1.7880 0.7616
pentose phosphate 0.8413 0.9740 1.1219 1.0628
phenylalanine 0.6363 0.7324 1.2458 1.3854
phosphocholine 0.7685 1.0110 0.9304 1.2900
phosphocreatine 0.4994 0.6455 1.3502 1.5049
phosphoenolpyruvate 0.3941 0.7498 0.5778 2.2783
proline 0.3342 0.3776 1.6258 1.6624
pyridoxine 0.6864 0.8290 1.1740 1.3106
pyroglutamate 0.7762 0.8833 1.1637 1.1768
pyruvate 0.6367 0.8010 1.2525 1.3098
quinolinate 0.6431 0.7942 1.2114 1.3513
S-(2-succinyl)cysteine 2.2918 1.6848 0.0069 0.0165
S-adenosylhomocysteine 0.6688 0.7733 1.3299 1.2281
S-adenosylmethionine 0.8448 0.9148 1.0484 1.1920
SAICAR 1.7797 2.1475 0.0286 0.0442
sarcosine 0.9816 1.0013 1.0181 0.9990
sedoheptulose 7-phosphate 0.7885 0.7854 1.4337 0.9923
serine 0.9393 1.0085 0.9673 1.0849
S-lactoylglutathione 1.0677 0.9424 0.2865 1.7034
S-Succinylglutathione 1.9096 1.9898 0.0380 0.0626
succinate 1.1236 1.4753 1.1145 0.2866
succinyladenosine 1.9571 1.9779 0.0182 0.0468
taurine 0.8616 1.0345 1.0832 1.0207
thiamine 0.6327 0.7622 1.2213 1.3838
threonine 0.8231 0.8405 1.0235 1.3130
tryptophan 0.6165 0.7257 1.2751 1.3827
tyrosine 0.6391 0.7492 1.2240 1.3877
UDP 0.6139 0.8021 1.2507 1.3333
UDP-GlcNac 0.8808 1.0010 1.0006 1.1176
UDP-glucose 0.7781 0.8005 1.2302 1.1912
UMP 0.9494 0.9893 1.0814 0.9800
uric acid 0.6478 0.8109 0.7698 1.7715
uridine 0.4591 0.6459 1.5991 1.2959
UTP 0.3539 0.6912 1.2589 1.6960
valine 0.7107 0.7895 1.2069 1.2929
xanthine 0.6981 0.8414 1.2605 1.2000
xanthosine 0.6371 0.7683 1.2815 1.3132
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Factors:

F1Genotype:Fh1-/- CL19 | Treatment:Cas9
F2Genotype:Fh1-/- CL19 | Treatment:sg1Hira
F3Genotype:Fh1 fl/fl | Treatment:Cas9
F4Genotype:Fh1 fl/fl | Treatment:sg1Hira
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