Data for Identification of altered metabolic pathways in Alzheimer's disease, mild cognitive impairment and cognitively normals using Metabolomics (CSF) (Study ST000047)

(Analysis AN000083)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
12-oxo-10Z-dodecenoicacid 0.9810 1.1380 0.8531
13-ethyl-2,17-dihydroxy-18,19-Dinorpregna-4,9,11-trien-20-yn-3-one 1.0207 0.9512 1.0509
1,3-Glyceryldinitrate 0.7776 1.3195 0.9799
14-pentadecynoicacid 1.0926 0.9198 1.0695
1alpha,25-dihydroxy-24-oxovitaminD_3/1alpha,25-dihydroxy-24-oxocholecalciferol 1.0208 1.0336 0.9456
1beta,25-dihydroxy-3-deoxy-3-thiavitaminD3/1beta,25-dihydroxy-3-deoxy-3-thiacholecalciferol 0.9693 1.0202 1.0105
1-Hydroxy-2-naphthoicacid 0.6471 1.3494 1.0301
1-Methylguanine 1.0210 0.9695 1.0102
20-ethyl-PGE2 1.1921 0.9229 0.8890
(22E,24E)-1alpha,25-dihydroxy-22,23,24,24a-tetradehydro-24a-homovitaminD3/(22E,24E)-1alpha,25-dih 0.5005 2.4161 0.3026
(22R)-1alpha,22,25-trihydroxy-23,24-tetradehydro-24a,24b-dihomo-20-epivitaminD3/(22R)-1alpha,22,2 0.4892 1.8796 0.6779
2,3-Dihydroxy-3-methylvalericacid 0.8912 1.0574 1.0651
2,3-Dioxogulonicacid 1.0549 0.8564 1.0744
2,4-DINITROPHENOL 1.0340 0.9635 1.0026
2,5-Dimethoxycinnamicacid 0.7604 1.1662 1.0595
2-Amino-4-chloro-6-methylpyrimidine 1.0399 1.0106 0.9372
2-BENZOYL-5-METHOXYBENZOQUINONE 0.8417 1.0343 1.1148
2^-Deoxyuridine5^-diphosphate(dUDP) 1.1718 0.9700 0.9582
2-Furoylglycine 0.8807 1.3021 0.5860
2H-1-Benzopyran-6-aceticacid,7-hydroxy-8-methoxy-2-oxo- 0.9781 0.8923 1.0877
2-Heptenedioicacid,4-oxo- 0.9632 1.0298 1.0073
2-Hydroxy-3-(4-methoxyethylphenoxy)-propanoicacid 0.5570 1.2813 0.8329
2-Hydroxyethanesulfonate 0.9631 1.0484 0.9885
2-Hydroxyethinylestradiol 0.8031 0.9886 1.2082
2-Hydroxyethinylestradiol-1.1476005 0.7019 0.7807 1.5236
2-Hydroxyethinylestradiol-1.305595 0.9852 0.9659 1.0450
2-Hydroxyethinylestradiol-1.9728087 1.0505 0.9521 0.9973
2-Hydroxyethinylestradiol-2.0906997 1.0481 0.8912 1.0627
2-Hydroxyethinylestradiol-2.8964827 1.0196 0.9243 1.0562
2-ISOPROPYL-3-METHOXYCINNAMICACID 1.3197 0.7625 0.8654
2-Methoxy-estradiol-17beta3-glucuronide 1.0275 0.8939 1.0739
2-Naphthaleneaceticacid,6-hydroxy- 0.9782 1.0587 0.9590
2-Naphthaleneaceticacid,6-hydroxy--3.1083467 0.8955 1.1753 0.9128
2-Naphthaleneaceticacid,6-hydroxy--3.220013 0.8825 1.2933 1.0001
2-Oxo-4-methylthiobutanoicacid 0.9632 0.9842 1.0749
2-Propylglutaricacid 0.9138 1.0474 1.0404
2-propyl-tridecanoicacid 0.9591 1.0528 0.9881
2-propyl-tridecanoicacid-1.9754443 1.1670 0.9798 0.8532
3,4,5-Trihydroxystilbene 1.0538 0.9670 0.9600
3alpha-HYDROXY-3-DEOXYANGOLENSICACIDMETHYLESTER 1.0608 0.9368 0.9736
3-Amino-3-(4-hydroxyphenyl)propanoate 0.8372 0.9993 1.1526
3-(a-Naphthoxy)lacticacid 0.9669 1.0391 0.9888
3D,7D,11D-Phytanicacid 0.9897 1.0207 0.9896
3-Dehydroquinicacid 0.9844 1.1663 0.7753
3-DESMETHYL-5-DESHYDROXYSCLEROIN 0.8068 0.8577 1.4016
3-dodecynoicacid 0.9945 1.1032 0.9099
3E,5E-tridecadienoicacid 1.0111 1.1860 0.8033
3-Furoicacid 1.1139 0.9060 0.9697
3-Hydroxy-2-methyl-[R-(R,S)]-butanoicacid 0.9947 1.0247 0.9807
3-Hydroxydodecanedioicacid 1.0522 1.0586 0.7986
3-Hydroxyphenytoin 0.8274 1.3104 0.9580
3-Methylsubericacid 0.8891 0.8349 1.3981
3-oxo-dodecanoicacid 1.0878 1.0038 0.9586
4,8-dimethyl-dodecanoicacid 1.1675 0.9756 0.8569
4-amino-4-cyano-butanoicacid 1.0185 0.9419 1.0161
4-hydroxypelargonicacid 1.0165 0.9201 1.0669
5-[2-(hydroxymethyl)-5-methylphenoxy]-2,2-dimethyl-Pentanoicacid(GemfibrozilM4) 1.0522 0.9244 1.0209
5-(4-hydroxy-2,5-dimethylphenoxy)-2,2-dimethyl-Pentanoicacid(GemfibrozilM1) 1.0252 1.4105 0.5643
5,6-Dihydrouridine 1.0793 0.9697 0.9509
5-Acetyl-4-methylthiazole 1.0856 0.9666 0.9478
5-Hydroxyindol-2-carboxylicacid 0.9093 0.9720 1.1150
5-Hydroxyindoleaceticacid 0.9780 0.9061 1.0987
5-Hydroxyindoleaceticacid-1.9673504 1.4229 0.9161 0.6453
5-Hydroxymethyluracil 0.8736 1.1775 0.9489
6b,11b,16a,17a,21-Pentahydroxypregna-1,4-diene-3,20-dione16,17-acetonide 0.9743 0.9439 1.0809
6b,11b,16a,17a,21-Pentahydroxypregna-1,4-diene-3,20-dione16,17-acetonide-1.9632031 0.6638 1.2750 1.0633
6-Hydroxynicotinicacid 0.9939 1.0547 0.9514
(+)-6-methylcaprylicacid 0.9940 0.8764 1.1031
7-Acetamidonitrazepam 0.9771 0.9910 1.0408
7-Aminonitrazepam 0.9740 1.1040 0.9220
7E-decen-1-ol 0.6473 1.1828 0.9742
7-Ethoxycoumarin 0.9137 0.7767 1.4881
7-Hydroxyoctanoicacid 0.9326 0.9395 1.1374
7-hydroxyTetranorIloprost 0.5431 1.6734 0.7761
9-hydroxy-5Z-nonenoicacid 1.0054 0.9055 1.0873
9-lauroleicacid 1.1646 1.1234 0.7119
9(S)-HODE-d4 0.8824 1.1377 0.9279
Acetoaceticacid 0.5467 1.3776 0.4910
Acetoaceticacid-2.7565882 0.8662 1.0391 1.0927
Acetoin 0.9959 0.9981 1.0060
Acetoin-1.7186093 0.7530 1.1365 1.0630
Acetoin-1.7995661 0.8824 1.2195 0.9626
Acipimox 1.0892 0.9377 0.9731
Acrylicacid 1.1080 0.9113 0.9746
Acrylicacid-2.8973038 0.9924 1.1965 0.8969
Adriamycinone 1.0303 0.7956 1.1156
a-hydroxybutyrate 0.9233 1.1146 0.9621
a-hydroxybutyrate-1.537142 0.9768 0.8630 1.1602
a-hydroxyisovalerate 0.9860 1.0065 1.0075
a-hydroxyisovalerate-2.912282 1.1220 1.0606 0.8144
AlaMetLys 0.9538 1.1227 0.9000
Alfentanil 0.7909 1.2280 0.9925
Allantoin 1.0227 0.8711 1.1018
Allantoin-2.1088858 0.8612 1.2262 0.9710
alpha-hydroxyisobutyrate 0.9955 1.0313 0.9733
alpha-ketoglutarate 0.6909 1.4746 0.4239
aminohippuricacid 1.0777 1.0181 0.9089
ArgCysCys 0.7655 1.1990 0.9926
AspAsp 0.9330 1.0795 0.9922
AspGlu 0.8388 1.0874 0.9999
AspThr 0.9021 1.0659 1.0320
Benazeprilat 1.2064 0.7949 1.0461
Benzaldehyde,p-amino-,thiosemicarbazone 0.7944 1.1971 0.9101
beta-Alanine 1.0062 0.9375 1.0526
beta-Alanine-6.9398165 0.8252 1.1832 0.9916
Bilirubin 0.8412 1.1660 1.0163
(+)-Bornane-2,5-dione 0.9688 1.1303 0.8398
B-ureidoisobutyricacid 0.6641 1.3584 0.9775
Carboxyltolmetin 0.9510 0.9981 1.0948
Catalpol 0.8868 1.0553 0.9353
CEFTIBUTEN 1.0063 1.1005 0.8925
Citraconicacid 1.1939 0.8590 0.9421
Citraconicacid-1.722686 0.9594 0.8808 1.1569
Citraconicacid-2.040095 1.1818 0.8438 0.9735
CITROPTEN 0.8250 1.3106 0.8643
clavuloneI 0.9797 0.9407 1.0765
clavuloneIII 0.9380 0.9631 1.0965
ClonidineMetabolite3 0.8255 1.1679 0.9735
ClonidineMetabolite3-3.0479238 1.0663 0.9135 1.0295
Clorazepate 0.9885 1.0821 0.9293
COTARNINE 1.4156 1.0091 0.9185
Creatine 0.8199 1.0207 1.1101
Creatinine 1.0595 0.9503 0.9903
Crotonicacid 1.0439 1.1934 0.7293
CysCysTyr 0.8380 1.1421 1.0199
D1-2-Hydroxymethylethisterone 0.8667 0.9336 1.1998
D1-2-Hydroxymethylethisterone-1.0877049 1.0916 0.8937 1.0257
D1-2-Hydroxymethylethisterone-1.2925578 1.0075 0.9147 1.0747
D1-2-Hydroxymethylethisterone-1.9729636 1.0472 0.9645 0.9883
D1-2-Hydroxymethylethisterone-2.0888731 1.0425 0.8846 1.0769
D1-2-Hydroxymethylethisterone-2.898744 1.0616 0.9297 1.0063
Dehydroascorbicacid 1.4488 0.6313 0.9015
Dehydroascorbicacid-1.13851 1.1165 0.9649 0.9153
Dehydroascorbicacid-2.0140483 1.2823 0.7927 0.9601
Dehydroascorbicacid-2.9501877 1.3235 0.6877 0.9883
desmethylnortriptylineglucuronide 0.9178 0.9245 1.1930
D-Glucose 1.0048 1.0200 0.9748
D-Glucoside 0.6870 0.7629 1.6459
Diacetyl 1.1453 0.7789 1.0684
Diacetyl-1.7367859 0.8278 0.9684 1.2038
Diacetyl-1.9789566 0.8020 0.9944 1.2032
Diacetyl-2.955511 0.9561 1.3050 0.7608
DIBENZOTHIOPHENE 0.9834 1.1350 0.8805
Dihydrokaempferol 0.6297 1.1348 1.2970
Dihydrolipoamide 0.9387 0.9818 1.0893
Dihydroxyacetone(glycerone) 0.8235 0.9694 1.1817
dihydroxyacetonephosphate(DHAP) 1.0464 0.9742 0.9794
Dihydroxyfumarate 0.7933 0.9991 1.1828
DL-erythronicacid 0.9294 1.0487 1.0217
D-Leucicacid 0.9876 0.9820 1.0304
Dodecanedioicacid 0.9899 1.0296 0.9794
Ellagicacid 1.0810 0.9282 0.9908
Embelin 1.0295 1.0267 0.9482
Embelin-0.8153355 0.9197 1.2784 0.7878
Embelin-0.9982194 0.9884 1.1275 0.8534
Embelin-1.1001831 1.0153 1.0208 0.9639
Embelin-1.2925849 0.9953 0.9372 1.0526
Embelin-1.9750104 1.0355 0.9988 0.9657
Erythrono-1,4-lactone 0.2923 0.4329 2.2943
ETHOPROPAZINE 1.0992 0.7317 1.0670
ethylmalonicacid 0.8658 0.8999 1.2479
EUGENITOL 0.9048 1.1348 1.0097
Fosfomycin 1.0740 0.9216 1.0504
Fumaricacid 0.9129 1.4715 0.6066
FUMARPROTOCETRARICACID 0.9530 0.9830 1.0642
gamma-Hydroxyphenylbutazoneglucuronide 1.1383 0.9273 0.9221
Gemfibrozil 1.0139 1.1519 0.8356
GENKWANIN 0.7728 1.1292 1.1559
GlnTrpGln 0.9759 1.0444 0.9798
Glucosylgalactosylhydroxylysine 1.0823 0.9298 0.9447
GluSer 0.9207 1.1856 0.9189
Glutaconicacid 1.0479 0.9432 1.0126
Glutamicacidg-semialdehyde 1.0036 0.9464 1.0499
Glutaral(Glutaraldehyde) 0.9517 1.0941 0.9257
GluTyrThr 0.9878 0.9556 1.0566
Glycolate 1.0924 0.9538 0.9192
Glyoxylicacid 0.8769 0.9374 1.1630
griseorhodinA 0.8623 1.0439 1.1116
Gualenate(SodiumGualenate) 0.8395 1.3445 0.7710
HisCys 0.9744 1.0319 0.9914
HisLeuLys 1.1982 0.9095 0.8923
Hypoxanthine 1.0187 0.9606 1.0207
Iduronicacid 0.7029 0.6507 1.4848
Imidazolone 0.9858 0.9452 1.0642
Imidazolone-0.8470633 0.9199 1.0957 0.9962
Imidazolone-1.0847108 0.9913 0.9817 1.0255
Imidazolone-1.1732987 1.0114 0.9601 1.0302
Imidazolone-1.9679021 1.0339 1.0252 0.9418
Imidazolone-5.591784 1.1325 0.9543 0.9253
Imidazolone-5.7556376 1.1088 1.0409 0.8785
Indoxylsulfuricacid 1.2146 0.9376 0.8334
Inosine 1.0212 1.0521 0.9268
Isoacitretin 0.7956 0.9628 1.2416
Isoacitretin-1.116818 1.2141 0.8740 0.9497
Isoacitretin-1.1998972 1.0040 0.9466 1.0501
Isoacitretin-1.3034887 0.9227 0.9151 1.1735
Isoacitretin-1.9727861 1.0402 0.9580 1.0018
Isoacitretin-2.0889266 1.0405 0.8956 1.0671
Isoacitretin-2.8948605 1.0657 0.9243 1.0099
Isobutyrylglycinemethylester 0.9608 0.9304 1.1088
Isoleucine 0.9611 0.9415 1.0994
KINETIN 0.9911 1.0850 0.9149
KOBUSONE 0.9435 1.2093 0.8083
KOBUSONE-1.0965811 0.9863 0.9719 1.0445
Lactaldehyde 0.9302 1.0936 0.9762
Lactaldehyde-1.8849502 0.2489 0.3307 2.5986
Lactate 1.0029 1.0505 0.9483
Lactate-5.6089334 0.9596 1.0734 0.9659
Lactate-5.7357388 0.8747 1.1800 0.9346
Lacticacid 1.0144 0.7163 1.2573
Lauricacid 1.0810 0.9819 0.9156
L-DOPA 1.0043 0.8492 1.1416
Lecanoricacid 1.1029 0.8605 1.0366
Leucine 0.9295 1.0213 1.0492
L-Fucose1-phosphate 0.9958 1.0863 0.9179
L-Galactose 0.8576 1.1779 0.9670
Loratadine 0.9700 0.8012 1.3405
Lorazepam 0.8507 1.2438 0.9270
Lorazepam-2.4245577 0.9059 1.0835 1.0078
Lorazepam-2.8229904 1.0208 0.8353 1.1488
Lorazepam-2.8873434 1.1038 1.1361 0.7024
Losartan 0.9870 0.9283 1.0847
LUPININE 0.7658 1.0202 1.2428
LysPhe 0.8380 1.0989 1.0631
Mannitol 0.8606 1.1113 1.0281
MERBROMIN 0.9126 1.0942 0.9932
MethoxsalenMetabolite 0.5096 1.4753 0.8184
METHYL7-DESHYDROXYPYROGALLIN-4-CARBOXYLATE 0.7017 1.2787 0.7808
methyl8-[2-(2-formyl-vinyl)-3-hydroxy-5-oxo-cyclopentyl]-octanoate 1.3311 0.9634 0.5988
Methylglyoxal 0.8745 1.4676 0.6580
Methylglyoxal-1.3239123 0.8217 1.1490 0.9731
Methylglyoxal-1.6264697 1.0539 0.8842 1.0246
Methylglyoxal-2.3959143 0.8991 0.9389 1.1498
MetMetTrp 1.0007 0.9854 1.0209
Mitotane 0.5057 0.4523 1.9014
Mono-N-depropylprobenecid 0.8734 1.1341 0.9920
m-Salicylicacid 1.1432 1.3593 0.6452
myo-Inositol 0.8402 1.1788 0.9876
myo-Inositol-2.6662457 0.9910 1.1354 0.8471
N-Acetyl-5-hydroxysulfapyridine 0.9886 0.9420 1.0956
N-Acetylgalactosamine4-sulphate 0.9057 1.0709 1.0235
Naltrexone-3-glucuronide 1.0289 0.8687 1.0454
Naproxen 0.9913 1.0805 0.9306
Naproxen-3.0620813 1.1602 1.0361 0.8098
N-gamma-Acetyl-N-2-formyl-5-methoxykynurenamine 0.9937 1.0234 0.9917
n-HexanoicAcid 1.1167 0.8897 0.9860
Nicorandil 0.9702 0.9431 1.0962
N,N-HEXAMETHYLENEAMILORIDE 0.9544 1.0853 0.8830
O-BENZYL-l-SERINE 0.7121 1.3641 0.9525
O-Desmethylnaproxen 0.9772 1.1387 0.8841
O-Desmethylnaproxen-1.3967192 0.7996 1.2304 0.9634
O-Desmethylnaproxen-3.1314578 0.8650 1.1364 1.0234
O-Desmethylquinidine 0.9191 1.0926 1.0269
Oroticacid 0.7995 1.0893 1.1403
Oxazepam 0.7579 1.2639 0.9870
Oxipurinol 1.0068 0.9700 1.0232
PantothenicAcid 0.8897 0.9466 1.1637
PenicillinG 0.7570 0.8500 1.3877
pentanamide 1.0328 0.9092 1.0589
PheArgSer 1.1045 0.9344 0.9720
Phenylalanine 0.9665 1.0445 0.9890
Phenylsulfate 1.4819 0.8380 0.6802
Phosphatidylglycerol 0.7257 1.1013 1.1731
Pirenzepine 0.8485 1.3092 0.8360
Procarbazine 1.0341 1.2927 0.6732
Procarbazine-1.0827432 0.8744 1.2009 0.9103
Propanoicacid,2-hydroxy-3-[(4-hydroxy-1-naphthalenyl)oxy]- 1.1243 0.7795 1.4020
Propionylglycinemethylester 1.0330 0.8950 1.0720
ProTyrTrp 1.0537 0.8917 1.0509
Pseudouridine 1.0956 0.9388 0.9656
Purine 0.9532 1.0756 0.9741
Purine-1.0687234 0.9401 1.1029 0.9494
Purine-1.994147 0.9504 1.0199 1.0298
Pyrazinoicacid 0.8950 1.0778 1.0371
Pyrimethamine 0.7951 1.3076 0.9031
Pyrocatecholsulfate 0.9500 0.9173 1.1272
PYROGALLIN 0.5932 1.4916 0.8831
Pyroglutamicacid 0.8146 1.1184 1.0669
Pyrophosphate 0.9967 0.9397 1.0616
Pyrophosphate-4.160074 1.0326 1.0259 0.9452
Pyrophosphate-6.828654 0.9045 1.0644 0.9466
Pyrrole-2-carboxylicacid 0.8945 1.0142 1.0843
Pyrrole-2-carboxylicacid-1.9725019 0.9647 1.0569 0.9768
Pyrrole-2-carboxylicacid-2.172489 1.1340 0.9505 0.9059
Pyruvicacid 0.9400 0.8881 1.1547
Pyruvicacid-2.0019042 1.2136 0.9357 0.8508
Pyruvicacid-3.3105016 1.1115 0.8517 0.9366
Ribothymidine 0.9625 1.0189 1.0213
Sedoheptulose 0.9703 1.0519 0.9745
Sedoheptulose-2.968789 0.8316 1.1019 1.0756
SerLysMet 0.9829 1.0190 0.9981
Stearicacid 0.9631 1.0538 0.9831
Stearicacid-1.975433 1.1691 0.9664 0.8644
Succinicanhydride 1.1121 1.2095 0.6944
Succinicanhydride-1.1389956 1.1358 0.9765 0.8864
Succinicanhydride-1.6393243 1.2324 0.9016 0.8710
Succinicanhydride-3.020823 1.3795 0.8485 0.8170
SULBACTAM 0.5042 0.7182 1.6617
Sulfadoxinesuflate 1.0004 0.9764 1.0232
Sulfaphenazole 1.0105 1.0708 0.9269
Taurine 0.8716 1.1068 1.0238
Terephthalicacid 0.8609 1.2314 1.1201
Testosteronesulfate 1.0121 1.2485 0.7304
Tetracaine 1.0709 0.9287 0.9616
Thioguanine 0.9129 1.0911 0.9467
threo-Isocitricacid 1.1959 0.8235 0.9883
ThrGly 0.8522 1.0902 1.0873
Triprolidine 0.8258 0.9424 1.3003
TrpTyrGlu 1.0123 0.8562 1.0969
Tryptophan 1.0160 0.9469 1.0188
TUBAICACID 0.9111 1.1898 0.9117
Uricacid 0.9556 1.0826 0.9634
Uricacid-2.925639 0.9852 0.9758 1.0209
Uridine 0.8891 1.0230 1.0879
Valine 0.8755 1.0527 1.0763
Veratricacid 1.0270 1.1096 0.8857
Veratricacid-3.0931485 0.9654 0.9576 1.0796
Xanthine 1.0009 1.0002 0.9990
Xanthosine 1.0281 1.0581 0.9056
Zalcitabinemonophosphate 0.9850 1.0809 0.8995
Zearalenone 0.9999 0.9515 1.0544
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Factors:

F1Cognitive Status:AD
F2Cognitive Status:CN
F3Cognitive Status:MCI
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