Data for Metabolite changes associated with methionine stress sensitivity of cancer (GC TOF MS analysis) (Study ST000058)

(Analysis AN000096)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7
1-hexadecanol 0.9709 1.1709 1.0095 0.9895 0.9228 0.8415 1.0949
1-monoolein 0.6709 0.7110 0.8618 0.9582 1.1453 0.9550 1.6978
2-aminoadipic acid 1.2805 1.1246 0.8935 1.0449 1.0574 0.7854 0.8138
2-deoxyerythritol 1.0024 1.0243 1.1890 0.9785 1.0760 0.9349 0.7949
2-hydroxyglutaric acid 1.5194 1.5809 1.0545 0.9768 0.6633 0.7792 0.4258
2-ketoisocaproic acid 0.9381 0.8152 0.9705 0.8918 0.9551 1.1391 1.2902
2-monoolein 0.6559 0.6838 0.7373 1.0131 1.1500 1.0145 1.7453
2-monopalmitin 0.6201 0.6062 0.6824 1.1029 1.4949 1.0821 1.4115
3-phosphoglycerate 0.8260 0.8848 0.8454 1.0733 1.4218 0.9808 0.9678
5-aminovaleric acid 0.7366 0.8373 0.8839 1.2299 0.8096 1.2865 1.2161
5b-cholestanol 1.0073 1.1783 1.0564 0.9695 1.1131 0.9449 0.7304
5^-deoxy-5^-methylthioadenosine 2.0402 0.5287 0.5724 0.7326 0.6539 1.1673 1.3050
7-alpha-hydroxycholesterol 1.1336 1.0384 1.2009 1.0727 1.2066 0.6101 0.7377
aconitic acid 1.0915 1.0232 1.0232 1.4089 0.7078 0.9410 0.8045
adenine 1.9657 0.3788 0.4962 0.6882 0.7167 1.4204 1.3341
adenosine 1.4374 1.4647 1.1296 1.0054 0.7233 0.6587 0.5810
adenosine-5-phosphate 1.0058 0.7726 0.9649 1.1258 1.0134 1.1099 1.0075
adipic acid 1.0511 1.1529 0.9730 0.9873 0.9461 0.9830 0.9066
alanine 0.9557 0.4203 0.8838 1.1611 1.0230 1.2305 1.3256
alpha ketoglutaric acid 1.4749 0.8730 0.6812 0.7549 0.6466 1.5976 0.9718
aminomalonic acid 1.1217 0.6745 1.0439 0.9257 0.6551 1.4443 1.1349
arachidic acid 1.1101 1.0705 1.0087 0.9621 0.8476 1.0315 0.9695
asparagine 0.8228 0.6353 0.9658 1.1943 0.9546 1.6510 0.7762
asparagine dehydrated 0.6120 0.4573 0.9724 1.9091 0.9363 1.2751 0.8379
aspartate 1.2152 1.1347 1.2862 1.0275 1.0147 0.5922 0.7295
aspartic acid 0.8049 0.6301 1.2704 2.0255 1.1455 0.5813 0.5422
behenic acid 0.9847 1.0768 1.1077 1.1732 0.9549 0.9352 0.7674
benzoic acid 0.9847 0.9815 1.0638 1.0106 0.9846 0.9883 0.9865
beta alanine 1.5790 1.1783 1.1847 0.7944 0.6711 0.9559 0.6367
butane-2,3-diol 1.0744 0.9052 1.0487 0.8712 1.1281 0.9840 0.9884
capric acid 0.7482 0.9361 0.9107 1.1755 1.1281 0.9418 1.1597
cellobiotol 1.0869 0.8782 1.8824 0.6429 0.5887 0.7512 1.1696
cholesterol 0.9790 1.0031 0.9841 1.2814 0.9787 0.8760 0.8977
citric acid 1.3288 0.9876 0.9722 1.0720 0.7206 1.0829 0.8360
CMP 1.0166 0.7864 1.0704 0.9717 1.0128 0.9717 1.1704
conduritol beta epoxide 1.2291 1.0364 1.1193 1.2079 0.7717 0.7330 0.9027
creatinine 1.1290 0.8928 1.0802 1.0744 0.9154 1.0554 0.8529
cysteine 1.1710 0.8862 1.2390 1.8169 0.8741 0.7212 0.2917
cysteine-glycine 1.8842 0.7045 1.1668 1.5492 0.6803 0.7332 0.2818
cytidine-5^-diphosphate 1.3282 1.4691 1.1976 1.0005 0.7782 0.6855 0.5409
cytidine-5-monophosphate 0.8648 0.8424 0.9634 1.3709 1.0113 0.9354 1.0119
cytosin 1.1648 0.7993 1.0079 1.1630 0.7774 1.2086 0.8791
elaidic acid 0.8384 0.9089 0.8369 0.9543 1.0408 1.0547 1.3660
enolpyruvate NIST 0.7288 0.9149 1.0021 1.2578 1.1559 0.7200 1.2205
erythritol 0.8129 0.8974 0.8706 1.2717 0.9420 1.2753 0.9301
ethanolamine 0.8913 0.8817 1.0131 0.9916 0.8968 0.9711 1.3544
fructose 1.1466 0.9782 0.7697 0.8734 1.2090 1.0005 1.0227
fructose-1,6-bisphosphate 0.9394 1.0110 0.7647 0.8041 1.1964 1.3337 0.9505
fructose 1 phosphate 1.3837 0.6691 0.6232 1.3330 1.2533 1.0925 0.6452
fructose-6-phosphate 1.1101 0.4937 0.6351 0.6007 0.7705 1.1537 2.2364
fumarate 1.3134 0.9092 1.0587 1.3419 1.0026 0.7688 0.6053
GABA 1.4377 1.1344 1.0160 0.7433 0.6711 1.0376 0.9599
galactinol isomer 1.1551 0.9029 0.8714 0.8057 0.9940 1.2042 1.0667
galactose-6-phosphate_200536 0.8989 1.2021 1.0931 1.1223 1.1489 0.6436 0.8910
galacturonic acid 1.4717 1.2591 0.9439 0.8983 0.6377 0.8218 0.9675
gamma glutamyl-valine 0.9323 1.1054 0.9516 0.7977 1.0133 1.3210 0.8787
glucoheptulose 0.6799 1.2310 0.8498 1.0380 0.9191 0.9109 1.3713
glucose 1.0755 1.0258 1.0199 1.3967 0.9621 0.9003 0.6198
glucose-1-phosphate 0.7695 0.9642 0.7894 1.7456 1.1929 0.7982 0.7402
glucose-6-phosphate 0.8056 0.8328 0.7718 0.9842 0.8023 1.5751 1.2282
glutamic acid 1.3081 0.7360 0.9538 1.2347 0.7560 1.2296 0.7817
glutamine 0.8730 1.0531 1.2455 1.3356 0.8570 1.0277 0.6081
glyceric acid 0.8308 0.8627 0.9029 1.6660 0.9987 0.9036 0.8352
glycerol-3-galactoside 1.3294 1.0994 1.0926 1.1146 0.7603 0.8178 0.7858
glycerol-alpha-phosphate 0.6895 0.5022 0.6549 1.0005 0.9615 1.4964 1.6950
glycerol-beta-phosphate 0.8384 0.6205 0.8319 1.0646 0.9238 1.3497 1.3711
glycine 1.0434 0.7563 0.9094 0.9768 0.7389 1.4427 1.1325
glycolic acid 1.0391 0.9571 0.9864 1.1145 0.9594 0.8718 1.0716
guanine 1.0178 1.4773 1.2119 1.1610 0.8452 0.8951 0.3919
guanosine 1.0987 1.9322 1.3387 1.1203 0.6551 0.5826 0.2725
heptadecanoic acid 1.1087 0.9300 0.8686 1.0095 1.0226 1.0502 1.0104
histidine 0.8769 0.4773 0.9258 1.4775 0.6469 1.5706 1.0250
homoserine 2.0400 0.5619 0.5179 0.8149 0.6220 1.2014 1.2420
hydroxycarbamate NIST 0.8280 1.0441 1.2900 0.9338 1.0426 1.0120 0.8496
hydroxylamine 0.9276 1.0619 0.9854 1.1618 0.8458 1.0737 0.9438
hypoxanthine 1.1996 1.3165 1.0867 1.1807 0.7997 0.8957 0.5210
idonic acid NIST 0.9664 0.9704 1.0167 0.9039 1.0086 0.8657 1.2683
inosine 1.1297 1.8658 1.1610 1.1457 0.6803 0.6713 0.3462
inosine 5^-monophosphate 1.4355 1.1493 0.9953 1.0488 1.0450 0.5569 0.7693
inositol-4-monophosphate 1.2805 0.9994 1.0008 1.0096 0.8034 0.8939 1.0124
inositol myo- 1.2590 1.0433 1.2301 1.1945 0.6644 0.7374 0.8713
isocitric acid 1.2965 0.9530 0.9287 1.1653 0.8449 0.9976 0.8139
isoleucine 0.7480 0.5919 0.8578 1.1751 0.9217 1.3012 1.4044
isothreonic acid 1.4031 0.8868 0.9669 0.9643 0.6462 1.2216 0.9111
lactamide 1.2325 0.7915 0.8941 1.0697 1.0354 1.1155 0.8613
lactic acid 1.2955 0.7119 0.7432 1.1312 0.9914 1.2153 0.9116
lauric acid 1.0952 0.7880 0.7713 1.2510 1.0247 0.9847 1.0851
leucine 0.5849 0.5782 1.1825 1.1479 1.0307 1.1859 1.2900
levoglucosan 0.8977 0.8784 0.9213 1.4169 1.2347 0.8128 0.8381
lysine 1.0737 0.7339 1.0428 0.9218 0.8300 1.2368 1.1610
malate 1.2490 0.9418 1.0982 1.2999 1.0345 0.7585 0.6180
maleimide 1.1208 1.0612 0.9276 1.1167 0.9598 0.9211 0.8927
maltose 1.1879 0.5146 3.0088 0.4975 0.6949 0.5653 0.5310
maltotriose minor 2.0011 1.0156 0.7985 0.8231 0.9344 0.6429 0.7843
methanolphosphate 0.9254 0.8426 1.0209 0.8991 1.0199 0.8079 1.4843
methionine 1.4620 1.0057 1.0922 1.0955 0.8387 0.7262 0.7797
monopalmitin-1-glyceride 0.6704 0.7143 0.7672 1.0279 1.3247 1.1094 1.3861
myristic acid 0.9708 0.8316 0.7675 0.9387 1.1391 1.0834 1.2689
N-acetylaspartic acid 1.4106 0.7831 0.9870 1.0381 0.7459 1.0884 0.9469
N-acetyl-D-mannosamine 0.9386 0.8650 1.2023 0.8860 1.4069 0.8650 0.8363
N-acetylgalactosamine 1.1121 0.9985 0.7886 0.9128 1.4173 0.8714 0.8993
nicotinamide 0.6731 0.8129 1.0373 1.2434 1.0293 1.1015 1.1024
ononitol 0.5701 1.2680 0.5977 2.6786 0.7146 0.4575 0.7134
oxalic acid 0.8148 0.9021 1.2040 1.1002 1.0506 0.8259 1.1023
oxoproline 1.0197 0.8849 1.1059 1.3914 0.9002 1.0480 0.6500
palmitic acid 1.0960 0.9898 0.9055 1.0221 0.9812 1.0483 0.9570
palmitoleic acid 1.3165 1.0239 0.9736 1.0589 0.8179 0.7871 1.0220
pantothenic acid 1.0542 1.1372 0.9033 1.1850 1.0097 1.0366 0.6740
pelargonic acid 1.4634 0.8957 0.8900 0.8942 0.7226 1.1061 1.0279
pentadecanoic acid 1.1821 0.9648 0.8661 1.0369 0.9798 0.8504 1.1199
phenylalanine 0.7737 0.6139 0.8337 1.1781 0.8489 1.4162 1.3354
phenylethylamine 0.2591 1.0423 1.1666 1.3547 0.7886 1.2574 1.1314
proline 0.8826 0.7369 1.1587 1.3019 0.9365 1.1486 0.8348
putrescine 0.8045 0.7417 0.9708 0.9023 0.6874 0.6522 2.2412
pyrazine 2,5-dihydroxy NIST 1.2134 0.8311 1.1357 1.5970 0.8962 0.7791 0.5475
pyrophosphate 1.0999 0.6394 0.9637 0.9068 1.0079 1.3045 1.0777
pyruvic acid 1.2708 0.8547 0.9882 1.3993 1.1173 0.7776 0.5922
ribitol 1.7154 0.8101 0.7128 0.8198 0.4348 1.3422 1.1649
ribulose-5-phosphate 0.9034 1.1121 0.9743 1.2084 0.9250 0.8826 0.9943
salicylic acid 0.9686 0.8240 1.1029 1.2518 0.9991 0.8732 0.9803
serine 0.8684 0.7254 0.9918 1.3007 1.0095 1.0512 1.0530
sorbitol 1.1661 0.3419 0.5232 0.8716 0.7053 1.5843 1.8076
spermidine 1.1478 0.9034 1.0649 0.8692 0.9359 1.2204 0.8584
stearic acid 1.1661 0.9923 0.9235 1.0315 0.9574 1.0190 0.9101
stigmasterol 0.9539 1.0194 0.6780 0.8744 0.9586 1.1519 1.3638
succinic acid 1.4402 1.2342 1.2742 1.1979 0.8174 0.5912 0.4448
sucrose 0.9469 1.2807 1.3519 0.8686 0.7199 1.0116 0.8204
taurine 1.4338 1.1279 1.1325 1.1497 0.8294 0.7677 0.5590
threonine 0.7699 0.7396 1.0146 1.2935 0.9564 1.2009 1.0250
thymidine-5-monophosphate 1.0156 0.8581 0.9188 1.1442 1.0075 1.1062 0.9496
thymine 1.4583 1.0056 1.1310 0.7572 0.9716 1.0026 0.6736
tryptophan 0.7647 0.6184 0.8340 1.2093 0.8452 1.3565 1.3720
tyrosine 0.7566 0.5952 0.8011 1.1379 0.8624 1.4316 1.4152
UDP GlcNAc 0.7476 0.5805 0.9310 1.3309 1.0903 1.3605 0.9591
UDP-glucuronic acid 0.9499 1.5064 1.4883 0.8492 0.6001 1.0205 0.5856
uracil 1.2778 1.4644 1.1920 1.1650 0.7315 0.6903 0.4790
urea 0.6737 2.3481 0.7640 0.9708 0.6257 0.4537 1.1640
uridine 1.2642 2.2213 1.2519 0.9404 0.5694 0.4919 0.2608
uridine-5^-monophosphate 1.1996 0.9073 1.3056 1.0440 0.9920 1.2319 0.3196
valine 0.7883 0.5513 0.9859 1.2319 0.9658 1.1825 1.2943
xylulose NIST 0.8976 0.8197 0.8573 1.1741 1.0045 1.3075 0.9392
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Factors:

F1Treatment:Group 1: Methionine Treated - Group 1
F2Treatment:Group 2: Homocysteine Treated-2 hours - Group 2
F3Treatment:Group 3: Homocysteine Treated- 4 hours - Group 3
F4Treatment:Group 4: Homocysteine Treated- 8 hours - Group 4
F5Treatment:Group 5: Homocysteine Treated- 12 hours - Group 5
F6Treatment:Group 6: Homocysteine Treated- 24 hours - Group 6
F7Treatment:Group 7: Homocysteine Treated- 48 hours - Group 7
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