Data for Metabolite changes associated with methionine stress sensitivity of cancer (CSH QTOF MS analysis) (Study ST000077)
(Analysis AN000124)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
---|---|---|---|---|---|---|---|---|
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1^-sn-glycerol) | 1.4797 | 0.8838 | 0.7350 | 1.1418 | 1.3590 | 1.0433 | 1.1223 | 0.0210 |
Cer (d32:1) | 0.8688 | 1.2196 | 1.1266 | 1.0101 | 0.9704 | 1.1719 | 1.4730 | 0.0371 |
Cer (d34:0) | 1.2907 | 1.1774 | 1.0387 | 0.9483 | 1.1170 | 0.9400 | 1.1736 | 0.1435 |
Cer (d34:1) | 0.8388 | 1.2631 | 1.2631 | 0.8897 | 1.0422 | 1.0813 | 1.4318 | 0.0639 |
Cer (d34:2) | 1.1963 | 1.2291 | 0.9813 | 0.9607 | 0.8828 | 1.0901 | 1.4534 | 0.0929 |
Cer (d36:1) | 0.5536 | 1.6376 | 1.4336 | 0.5219 | 1.0269 | 0.9789 | 1.7822 | 0.0145 |
Cer (d38:1) | 0.6786 | 1.5851 | 1.4924 | 0.5171 | 1.2364 | 0.8801 | 1.4538 | 0.0265 |
Cer (d39:1) | 0.8796 | 1.5251 | 1.1526 | 0.5265 | 1.2201 | 0.8856 | 1.6787 | 0.0687 |
Cer (d40:1) | 0.9095 | 1.2936 | 1.4334 | 0.5240 | 1.5909 | 0.7671 | 1.2029 | 0.1059 |
Cer (d40:2) | 1.0455 | 1.3522 | 1.0260 | 0.8025 | 0.9924 | 1.0994 | 1.5238 | 0.0521 |
Cer (d41:1) | 1.0625 | 1.2324 | 1.1486 | 0.6188 | 1.2655 | 0.9212 | 1.4323 | 0.2357 |
Cer (d42:1) | 1.1913 | 1.0472 | 1.1798 | 0.7125 | 1.5289 | 0.8565 | 1.1128 | 0.1990 |
Cer (d42:2) | 1.1191 | 1.2850 | 0.9930 | 0.8035 | 0.9799 | 1.1350 | 1.5610 | 0.0182 |
Cer (d43:1) | 1.4944 | 1.0465 | 0.8587 | 0.8750 | 1.0607 | 0.9994 | 1.2289 | 0.3248 |
Cer (d44:1) | 1.2623 | 0.8222 | 1.1030 | 0.7273 | 1.9803 | 0.7852 | 0.8979 | 0.1951 |
FA (18:1) | 0.9950 | 0.9119 | 0.9479 | 0.8275 | 1.2901 | 0.6852 | 1.1066 | 1.3499 |
GlcCer (d34:1) | 0.8675 | 1.1636 | 1.5252 | 0.7210 | 1.3960 | 0.7545 | 1.1805 | 0.2490 |
GlcCer (d38:1) | 0.9943 | 1.2958 | 1.4592 | 0.7081 | 1.4067 | 0.7619 | 1.1196 | 0.0456 |
GlcCer (d40:1) | 1.1162 | 1.0813 | 1.2984 | 0.6996 | 1.7781 | 0.6959 | 1.0207 | 0.0865 |
GlcCer (d41:1) | 1.2335 | 1.1095 | 1.2838 | 0.7195 | 1.4548 | 0.7230 | 1.1487 | 0.1524 |
GlcCer (d42:1) | 1.2610 | 0.9589 | 1.0339 | 0.9685 | 1.5248 | 0.8975 | 1.0504 | 0.0902 |
GlcCer (d42:2) | 1.3929 | 1.1323 | 1.0925 | 0.9176 | 1.0455 | 0.9449 | 1.2732 | 0.0259 |
LPC (16:0) | 0.3147 | 0.1988 | 0.2116 | 0.3060 | 0.2915 | 0.2332 | 0.2440 | 7.6813 |
LPC (18:1) | 0.8433 | 0.8733 | 0.5598 | 0.8796 | 0.9284 | 0.7258 | 0.8004 | 2.7860 |
LPE (20:4) | 1.1061 | 1.0519 | 0.7646 | 1.0198 | 1.5404 | 0.9926 | 1.1490 | 0.2171 |
LPE (22:6) | 1.1617 | 1.1413 | 0.8047 | 0.9884 | 1.4036 | 0.9229 | 1.2108 | 0.2258 |
PC (30:0) | 1.5443 | 0.8684 | 0.8080 | 1.2207 | 0.9498 | 1.1884 | 1.2077 | 0.0196 |
PC (32:0) | 1.4091 | 1.0045 | 0.7550 | 1.1621 | 0.7626 | 1.3140 | 1.3667 | 0.0903 |
PC (32:1) | 1.4086 | 1.0061 | 0.8856 | 1.1395 | 1.0915 | 1.1166 | 1.1117 | 0.0244 |
PC (33:1) | 1.3760 | 0.9801 | 0.9576 | 0.9749 | 1.3564 | 1.0020 | 1.1145 | 0.0228 |
PC (33:2) | 1.7504 | 0.9348 | 0.6583 | 1.2338 | 0.6919 | 1.1530 | 1.1262 | 0.3108 |
PC (34:0) | 1.2224 | 1.1007 | 0.9558 | 1.0118 | 1.0868 | 1.0785 | 1.2893 | 0.1026 |
PC (34:1) | 1.1684 | 1.0555 | 1.0351 | 1.0571 | 1.1619 | 1.0616 | 1.0918 | 0.1889 |
PC (34:2) | 1.2777 | 0.8205 | 0.6467 | 1.0876 | 0.5900 | 1.0172 | 0.9923 | 1.7547 |
PC (34:4) | 1.2486 | 0.9012 | 0.7519 | 1.0582 | 1.3704 | 1.0563 | 1.0994 | 0.3852 |
PC (35:2) | 1.4876 | 1.0552 | 0.8648 | 1.1071 | 0.8705 | 1.1052 | 1.1525 | 0.1935 |
PC (36:1) | 1.1042 | 0.9949 | 1.0600 | 0.9280 | 1.5744 | 0.9443 | 1.0746 | 0.1175 |
PC (36:2) | 1.3202 | 1.0251 | 0.9172 | 1.1085 | 0.7888 | 1.0893 | 1.1393 | 0.5287 |
PC (36:3) | 1.3557 | 1.0403 | 0.8599 | 0.9332 | 0.6530 | 1.0085 | 1.1855 | 1.0138 |
PC (36:4) A | 0.5255 | 0.4764 | 0.3885 | 0.4757 | 0.7007 | 0.5359 | 0.6412 | 5.2218 |
PC (36:5) | 1.1087 | 0.6404 | 0.4669 | 1.1906 | 0.8082 | 1.0871 | 0.9548 | 1.9760 |
PC (37:4) | 0.9687 | 1.1193 | 1.2269 | 0.7029 | 1.2842 | 0.7767 | 1.1036 | 0.7915 |
PC (38:2) | 1.4975 | 1.1429 | 0.8532 | 1.2475 | 0.6071 | 1.2032 | 1.2232 | 0.0418 |
PC (38:3) | 1.1132 | 0.8271 | 0.6790 | 0.7893 | 0.6966 | 0.8091 | 0.9678 | 2.4799 |
PC (38:4) | 0.3733 | 0.3326 | 0.2174 | 0.3726 | 0.3976 | 0.4777 | 0.5228 | 6.5822 |
PC (38:5) | 1.2213 | 0.9284 | 0.5547 | 1.1568 | 0.7356 | 1.3049 | 1.3778 | 0.7531 |
PC (38:6) | 0.8671 | 0.6249 | 0.5688 | 0.5635 | 1.0592 | 0.6497 | 0.8395 | 3.3830 |
PC (40:5) | 1.1295 | 0.8205 | 0.5805 | 0.9177 | 0.9470 | 1.0758 | 1.1388 | 1.5666 |
PC (40:6) | 0.7807 | 0.5398 | 0.4335 | 0.6462 | 0.8294 | 0.8099 | 0.8719 | 3.7421 |
PE (34:1) B | 1.4193 | 0.9490 | 0.8925 | 1.1876 | 1.0463 | 1.1296 | 1.1647 | 0.0029 |
PE (34:2) B | 1.6893 | 1.0760 | 0.7437 | 1.2553 | 0.5628 | 1.2027 | 1.2736 | 0.0200 |
PE (35:2) | 1.4081 | 1.0809 | 0.8863 | 1.1934 | 0.7979 | 1.1953 | 1.2346 | 0.0159 |
PE (36:2) A | 1.2755 | 0.8591 | 0.6722 | 1.0854 | 0.6342 | 1.0283 | 0.9901 | 1.6035 |
PE (36:2) B | 1.3695 | 1.1004 | 1.0124 | 1.1593 | 0.8197 | 1.1239 | 1.2081 | 0.0118 |
PE (36:3) B | 1.6528 | 1.1052 | 0.8822 | 1.0291 | 0.8011 | 1.0408 | 1.2887 | 0.0297 |
PE (36:4) | 1.6690 | 1.0070 | 0.7048 | 1.0988 | 0.6986 | 1.0763 | 1.3111 | 0.3497 |
PE (36:4) B | 1.5916 | 0.9322 | 0.7421 | 1.0165 | 1.1774 | 1.0114 | 1.2528 | 0.1189 |
PE (38:1) A | 1.1783 | 0.9952 | 1.0340 | 0.8579 | 1.6303 | 0.9235 | 1.0837 | 0.0906 |
PE (38:2) A | 1.3320 | 1.0166 | 0.9187 | 1.0976 | 0.8129 | 1.0723 | 1.1184 | 0.5481 |
PE (38:4) B | 1.2704 | 0.9571 | 0.9468 | 1.0499 | 1.3654 | 1.0179 | 1.1398 | 0.0502 |
PE (40:2) A | 1.4204 | 1.0603 | 0.9122 | 1.1330 | 0.9479 | 1.0774 | 1.1925 | 0.0726 |
PE (44:3) A | 1.2620 | 1.1294 | 1.1803 | 0.8973 | 1.1377 | 0.9298 | 1.2396 | 0.0451 |
PG (34:1) | 2.0748 | 0.6222 | 0.5510 | 1.2562 | 1.2497 | 1.0210 | 0.9574 | 0.0094 |
PG (34:2) | 2.3167 | 0.6424 | 0.3137 | 1.6625 | 0.4716 | 1.2801 | 1.0121 | 0.0720 |
PG (36:2) | 1.5025 | 1.1892 | 0.9456 | 0.9064 | 0.9972 | 0.9760 | 1.2835 | 0.0273 |
PG (36:3) | 1.6175 | 1.0785 | 0.7952 | 1.0597 | 0.7699 | 1.0945 | 1.3487 | 0.0977 |
PG (40:7) | 1.6325 | 0.9849 | 0.6637 | 1.0766 | 0.8833 | 1.1523 | 1.4641 | 0.0115 |
PG (44:1) | 1.2042 | 1.0577 | 1.0911 | 1.0093 | 0.9134 | 1.0058 | 1.1214 | 0.5034 |
PI (32:0) (16:0/16:0) | 1.7167 | 1.1723 | 1.1714 | 0.4781 | 1.8585 | 0.5379 | 0.7471 | 0.0061 |
PI (32:1) | 1.9714 | 0.9027 | 0.7501 | 1.0873 | 1.0529 | 0.9988 | 0.9735 | 0.0089 |
PI (34:1) | 1.4585 | 1.0045 | 0.8883 | 1.0510 | 1.1500 | 1.0680 | 1.1707 | 0.0021 |
PI (34:2) | 1.9396 | 0.9803 | 0.4853 | 1.4332 | 0.4953 | 1.2688 | 1.1544 | 0.0422 |
PI (36:1) | 1.4076 | 1.0462 | 1.2125 | 0.8325 | 1.4802 | 0.8202 | 0.9092 | 0.0254 |
PI (36:2) | 1.7061 | 1.0386 | 0.6738 | 1.2772 | 0.6276 | 1.2265 | 1.2375 | 0.0294 |
PI (36:3) | 1.3810 | 1.0542 | 1.0589 | 0.9619 | 1.1649 | 0.9466 | 1.1299 | 0.1134 |
PI (36:4) | 1.4154 | 1.0925 | 1.0457 | 0.8127 | 1.3112 | 0.8907 | 1.1397 | 0.1027 |
PI (38:3) | 1.2491 | 1.1275 | 1.1984 | 0.7791 | 1.3745 | 0.8412 | 1.0543 | 0.1859 |
PI (38:4) | 1.2845 | 1.1438 | 1.1447 | 0.7176 | 1.3351 | 0.8131 | 1.1583 | 0.2566 |
PI (38:5) | 1.5961 | 1.2528 | 0.7392 | 1.0861 | 0.5291 | 1.2096 | 1.4396 | 0.0099 |
PI (38:6) | 1.5582 | 0.9588 | 0.8024 | 0.8239 | 1.4180 | 0.9154 | 1.1396 | 0.2248 |
PI (40:6) | 1.6070 | 1.3966 | 0.9423 | 0.6611 | 1.2745 | 0.7102 | 0.9459 | 0.2651 |
plasmenyl-PC (32:0) | 1.2348 | 1.1096 | 1.0645 | 1.0749 | 0.9718 | 1.0841 | 1.2330 | 0.0474 |
plasmenyl-PC (34:0) | 1.2787 | 1.1360 | 1.0634 | 1.1383 | 0.8381 | 1.1143 | 1.2312 | 0.0103 |
plasmenyl-PC (34:1) | 1.4305 | 1.1096 | 1.0234 | 1.1549 | 0.6969 | 1.0740 | 1.1202 | 0.2275 |
plasmenyl-PC (36:0) | 1.1601 | 0.9960 | 1.3134 | 0.7749 | 1.7739 | 0.7186 | 0.9182 | 0.0992 |
plasmenyl-PC (36:1) | 1.2674 | 1.1003 | 1.2713 | 0.9955 | 1.0861 | 0.9492 | 1.0863 | 0.0206 |
plasmenyl-PC (36:3) | 1.0655 | 1.2668 | 1.1681 | 0.7905 | 1.0642 | 0.9251 | 1.2770 | 0.3495 |
plasmenyl-PC (36:4) | 0.8914 | 1.0974 | 0.9006 | 0.6833 | 1.2396 | 0.9001 | 1.2444 | 1.1392 |
plasmenyl-PC (38:0) | 1.3582 | 0.8918 | 0.9917 | 1.1084 | 1.5127 | 0.8648 | 0.8924 | 0.1374 |
plasmenyl-PC (38:4) | 1.1402 | 1.2838 | 1.2827 | 0.7872 | 0.9528 | 0.8949 | 1.2495 | 0.2950 |
plasmenyl-PC (40:4) | 1.0374 | 1.1156 | 1.3700 | 0.7725 | 1.2755 | 0.7923 | 1.1187 | 0.3968 |
plasmenyl-PE 34:0; | 1.3171 | 1.2293 | 1.1679 | 0.8388 | 1.1117 | 0.8917 | 1.2123 | 0.0456 |
plasmenyl-PE (34:1) | 1.1772 | 1.0034 | 1.2162 | 0.9088 | 1.4750 | 0.9265 | 1.0547 | 0.0025 |
plasmenyl-PE (34:2) | 1.2139 | 0.8871 | 1.0347 | 0.9170 | 1.6689 | 0.9354 | 1.0374 | 0.0864 |
plasmenyl-PE (36:1) | 1.1210 | 0.9468 | 1.1975 | 0.8744 | 1.7822 | 0.8600 | 0.9478 | 0.0098 |
plasmenyl-PE (36:2) | 1.2290 | 1.0014 | 1.2369 | 0.9190 | 1.3817 | 0.9252 | 1.0525 | 0.0233 |
plasmenyl-PE (36:4) | 1.2513 | 0.9964 | 1.1881 | 0.8382 | 1.4744 | 0.8816 | 1.1095 | 0.0503 |
plasmenyl-PE (36:5) | 1.1218 | 0.9081 | 1.2530 | 0.8612 | 1.5365 | 0.9225 | 1.1642 | 0.0317 |
plasmenyl-PE (38:6) | 1.4310 | 1.0429 | 1.1011 | 0.8116 | 1.2661 | 0.8979 | 1.2454 | 0.0205 |
plasmenyl-PE (40:5) | 1.1467 | 0.9510 | 1.1647 | 0.8005 | 1.7850 | 0.8300 | 1.0475 | 0.0486 |
plasmenyl-PE (40:6) | 1.1554 | 0.9319 | 1.3196 | 0.7338 | 1.7785 | 0.7653 | 1.0315 | 0.0558 |
plasmenyl-PE (40:7) | 1.4710 | 1.0168 | 1.2498 | 0.8169 | 1.1630 | 0.8896 | 1.1717 | 0.0189 |
PS (36:2) | 1.2090 | 1.0598 | 0.8114 | 1.2236 | 0.7673 | 1.2871 | 1.2620 | 0.2604 |
PS (39:3) | 0.9169 | 0.9914 | 1.0621 | 1.0546 | 0.9722 | 1.0519 | 1.0102 | 0.9245 |
SM (d32:1) | 1.4763 | 1.0540 | 0.9270 | 1.0587 | 0.8018 | 1.0283 | 1.1520 | 0.3865 |
SM (d33:1) | 1.3281 | 0.9825 | 0.9874 | 0.8901 | 1.0622 | 0.9060 | 1.0879 | 0.7039 |
SM (d34:1) | 1.2861 | 0.9687 | 0.9410 | 0.9461 | 0.9739 | 0.9333 | 1.0817 | 0.8529 |
SM (d36:1) | 1.1902 | 1.0313 | 1.0767 | 0.9470 | 1.1644 | 0.9419 | 1.0870 | 0.4443 |
SM (d38:1) | 1.1502 | 1.0223 | 1.0590 | 0.9322 | 1.2024 | 0.9046 | 1.0539 | 0.5853 |
SM (d38:2) | 1.0317 | 0.8894 | 0.9849 | 0.8237 | 0.8669 | 0.7808 | 0.8381 | 1.9921 |
SM (d40:1) | 1.0494 | 0.8926 | 1.0260 | 0.8485 | 1.5620 | 0.8214 | 0.9445 | 0.7889 |
SM (d40:2) | 1.1676 | 0.9347 | 0.8223 | 0.9874 | 0.7586 | 0.9318 | 1.0414 | 1.4887 |
SM (d42:1) | 0.9956 | 0.9363 | 1.0470 | 0.8845 | 1.7629 | 0.8578 | 0.9646 | 0.3901 |
SM (d42:2) | 1.2728 | 1.0440 | 0.9982 | 1.0623 | 1.0049 | 1.0392 | 1.1456 | 0.2926 |
SM (d42:3) | 1.1488 | 0.8761 | 0.8177 | 0.9307 | 0.6451 | 0.8546 | 0.9308 | 2.0384 |
Factors:
F1 | Treatment:100uM Met | Timepoint:0 hours |
F2 | Treatment:370uM Hcy | Timepoint:12 hours |
F3 | Treatment:370uM Hcy | Timepoint:24 hours |
F4 | Treatment:370uM Hcy | Timepoint:2 hours |
F5 | Treatment:370uM Hcy | Timepoint:48 hours |
F6 | Treatment:370uM Hcy | Timepoint:4 hours |
F7 | Treatment:370uM Hcy | Timepoint:8 hours |
F8 | Treatment:quality check | Timepoint:quality check |