Data for SIRM Analysis of human P493 cells under hypoxia in [U-13C] labeled Glucose medium (Study ST000114)
(Analysis AN000194)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| a-glycerol-3P_1-13C0 | 1.3904 | 0.9196 | 0.8651 | 0.8248 |
| a-glycerol-3P_1-13C1 | 1.0000 | NA | NA | NA |
| a-glycerol-3P_1-13C2 | 1.2643 | 0.9558 | 0.8334 | 0.9465 |
| a-glycerol-3P_1-13C3 | 1.8232 | 0.7960 | 0.9782 | 0.4025 |
| a-glycerol-3P_1-ALL | NA | NA | NA | NA |
| a-glycerol-3P_2-13C0 | 1.3593 | 0.8913 | 0.8344 | 0.9151 |
| a-glycerol-3P_2-13C1 | 0.8654 | 0.5959 | 0.5766 | 1.7601 |
| a-glycerol-3P_2-13C2 | 1.8968 | 0.7909 | 0.9986 | 0.3137 |
| a-glycerol-3P_2-13C3 | 1.8398 | 0.7372 | 1.0353 | 0.3876 |
| a-glycerol-3P_2-ALL | 1.4950 | 0.8356 | 0.8885 | 0.7809 |
| a-ketoglutarate-13C0 | 1.5968 | 0.1054 | 0.8505 | NA |
| a-ketoglutarate-13C1 | 1.4146 | NA | 0.7927 | NA |
| a-ketoglutarate-13C2 | 0.6601 | NA | 1.3399 | NA |
| a-ketoglutarate-13C3 | 0.6459 | NA | 1.3541 | NA |
| a-ketoglutarate-13C4 | 0.4088 | 0.7911 | 1.6956 | NA |
| a-ketoglutarate-13C5 | NA | 0.5359 | 1.2320 | NA |
| a-ketoglutarate-ALL | 1.2082 | 0.1914 | 1.1961 | NA |
| Ala-13C0 | 1.2298 | 0.8610 | 0.7952 | 1.1141 |
| Ala-13C1 | 1.7495 | 0.4807 | 1.4967 | 0.2732 |
| Ala-13C2 | 1.2579 | 0.5706 | 1.6785 | 0.4931 |
| Ala-13C3 | 2.0004 | 0.4362 | 1.3512 | 0.2123 |
| Ala-ALL | 1.8477 | 0.5112 | 1.2702 | 0.3708 |
| Arg-13C0 | 1.2628 | 0.6547 | 1.1620 | 0.9205 |
| Arg-13C1 | 1.6360 | 0.4590 | 1.1652 | 0.7397 |
| Arg-13C2 | NA | NA | NA | NA |
| Arg-13C3 | 1.0000 | NA | NA | NA |
| Arg-13C4 | NA | NA | NA | NA |
| Arg-13C5 | NA | NA | NA | NA |
| Arg-13C6 | NA | NA | NA | NA |
| Arg-ALL | 1.2812 | 0.6454 | 1.1616 | 0.9118 |
| ascorbate-13C0 | NA | NA | NA | NA |
| ascorbate-13C1 | NA | NA | NA | NA |
| ascorbate-13C2 | NA | NA | NA | NA |
| ascorbate-13C3 | NA | NA | NA | NA |
| ascorbate-13C4 | NA | NA | NA | NA |
| ascorbate-13C5 | NA | NA | NA | NA |
| ascorbate-ALL | NA | NA | NA | NA |
| Asn-13C0 | 1.0625 | 0.7316 | 1.1529 | 1.0530 |
| Asn-13C1 | 1.2166 | 0.6580 | 0.9216 | 1.2038 |
| Asn-13C2 | 0.8368 | 0.3589 | 1.9674 | NA |
| Asn-13C3 | 0.6415 | 1.3997 | 1.2847 | 0.3894 |
| Asn-13C4 | NA | 1.0000 | NA | NA |
| Asn-ALL | 1.0666 | 0.7301 | 1.1487 | 1.0546 |
| Asp-13C0 | 0.4685 | 0.8822 | 0.3469 | 2.3024 |
| Asp-13C1 | 0.5291 | 0.6218 | 0.4510 | 2.3980 |
| Asp-13C2 | 0.1152 | 0.4876 | 0.3446 | 3.0526 |
| Asp-13C3 | 0.0790 | 0.4462 | 0.4186 | 3.0561 |
| Asp-13C4 | 0.0529 | 0.3610 | 0.4749 | 3.1111 |
| Asp-ALL | 0.3335 | 0.6809 | 0.3791 | 2.6065 |
| bOHbutyrate-13C0 | 1.3898 | 0.5781 | 1.3591 | 0.6731 |
| bOHbutyrate-13C1 | 1.5442 | 0.6052 | 1.1983 | 0.6524 |
| bOHbutyrate-13C2 | 0.9680 | 0.5639 | 1.5552 | 0.9129 |
| bOHbutyrate-13C3 | 0.8516 | NA | 1.0742 | NA |
| bOHbutyrate-13C4 | NA | NA | NA | NA |
| bOHbutyrate-ALL | 1.3896 | 0.5787 | 1.3516 | 0.6801 |
| [calc GSH-13C] | 1.2443 | 0.6193 | 1.4742 | 0.6622 |
| citrate-13C0 | 1.4578 | 0.6346 | 1.2232 | 0.6844 |
| citrate-13C1 | 0.7943 | 0.4457 | 1.7584 | 1.0016 |
| citrate-13C2 | 0.9217 | 0.3633 | 1.9201 | 0.7949 |
| citrate-13C3 | 0.3876 | 0.4707 | 2.0135 | 1.1282 |
| citrate-13C4 | 0.3240 | 0.2830 | 2.4715 | 0.9215 |
| citrate-13C5 | 0.2900 | 0.1669 | 2.7172 | 0.8259 |
| citrate-13C6 | NA | 0.0808 | 1.9185 | 0.5411 |
| citrate-ALL | 0.9248 | 0.4451 | 1.8099 | 0.8202 |
| Cys-13C0 | 1.1889 | 0.7517 | 0.7744 | 1.2850 |
| Cys-13C1 | 1.7199 | 0.2129 | 1.5256 | 0.5417 |
| Cys-13C2 | 1.1303 | 0.7303 | 1.0276 | 1.1118 |
| Cys-13C3 | 0.4934 | NA | 1.3430 | 1.3271 |
| Cys-ALL | 1.2163 | 0.7184 | 0.8288 | 1.2365 |
| fumarate-13C0 | 1.6338 | 0.7634 | 0.9910 | 0.6118 |
| fumarate-13C1 | 1.2655 | 0.7042 | 1.1124 | 0.9179 |
| fumarate-13C2 | 0.7874 | 0.6752 | 1.9794 | 0.5580 |
| fumarate-13C3 | 0.4106 | 0.5887 | 2.2911 | 0.7096 |
| fumarate-13C4 | 0.1560 | 0.2201 | 2.9067 | 0.7172 |
| fumarate-ALL | 1.4201 | 0.7303 | 1.2180 | 0.6317 |
| GAB-13C0 | 1.0021 | 0.9979 | NA | NA |
| GAB-13C1 | NA | NA | NA | NA |
| GAB-13C2 | NA | NA | NA | NA |
| GAB-13C3 | NA | NA | NA | NA |
| GAB-13C4 | NA | NA | NA | NA |
| GAB-ALL | 1.0021 | 0.9979 | NA | NA |
| Gln-13C0 | 0.3867 | 0.9868 | 0.8645 | 1.7619 |
| Gln-13C1 | 0.3658 | 0.9517 | 0.8679 | 1.8146 |
| Gln-13C2 | 0.2492 | 0.8563 | 1.3601 | 1.5344 |
| Gln-13C3 | 0.2974 | 0.5358 | 0.9454 | 1.8701 |
| Gln-13C4 | 0.0325 | 0.6061 | 1.4698 | 1.4219 |
| Gln-13C5 | NA | 0.9315 | 1.5313 | 0.0059 |
| Gln-ALL | 0.3835 | 0.9824 | 0.8718 | 1.7624 |
| Glu-13C0 | 1.3188 | 1.1584 | 0.7523 | 0.7704 |
| Glu-13C1 | 1.5967 | 0.6143 | 1.1500 | 0.6391 |
| Glu-13C2 | 0.4984 | 0.9691 | 1.0621 | 1.4704 |
| Glu-13C3 | 0.3878 | 0.6933 | 1.3879 | 1.5310 |
| Glu-13C4 | 0.1888 | 0.6187 | 1.5331 | 1.6594 |
| Glu-13C5 | 0.1319 | 0.5605 | 1.7652 | 1.5424 |
| Glu-ALL | 1.0011 | 0.9479 | 1.0127 | 1.0382 |
| Gly-13C0 | 0.8183 | 1.0895 | 0.6735 | 1.4186 |
| Gly-13C1 | 0.8805 | 1.2693 | 0.9424 | 0.9077 |
| Gly-13C2 | 0.9923 | 1.4470 | 0.7472 | 0.8136 |
| Gly-ALL | 0.8372 | 1.1306 | 0.6923 | 1.3399 |
| His-13C0 | 0.9259 | NA | 1.1483 | NA |
| His-13C1 | NA | NA | NA | NA |
| His-13C2 | NA | NA | NA | NA |
| His-13C3 | NA | NA | NA | NA |
| His-13C4 | NA | NA | NA | NA |
| His-13C5 | NA | NA | NA | NA |
| His-13C6 | NA | NA | NA | NA |
| His-ALL | 0.9259 | NA | 1.1483 | NA |
| Ile-13C0 | 0.9341 | 0.9534 | 0.7613 | 1.3512 |
| Ile-13C1 | 1.6482 | 0.4480 | 1.4981 | 0.4057 |
| Ile-13C2 | 0.9753 | 0.5975 | 1.4273 | NA |
| Ile-13C3 | NA | NA | NA | NA |
| Ile-13C4 | NA | NA | NA | NA |
| Ile-13C5 | NA | NA | NA | NA |
| Ile-13C6 | NA | NA | NA | NA |
| Ile-ALL | 1.0936 | 0.8409 | 0.9291 | 1.1364 |
| lactate-13C0 | 0.8062 | 0.9526 | 0.9286 | 1.3126 |
| lactate-13C1 | 1.1721 | 1.2928 | 0.8275 | 0.7076 |
| lactate-13C2 | 1.0632 | 1.3108 | 0.7545 | 0.8715 |
| lactate-13C3 | 1.3196 | 1.1393 | 0.9245 | 0.6166 |
| lactate-ALL | 1.1939 | 1.1159 | 0.9124 | 0.7778 |
| Leu-13C0 | 0.9302 | 0.9348 | 0.7975 | 1.3375 |
| Leu-13C1 | 1.7513 | 0.4854 | 1.4933 | 0.2700 |
| Leu-13C2 | 1.1444 | 0.4413 | 1.2699 | NA |
| Leu-13C3 | 1.0000 | NA | NA | NA |
| Leu-13C4 | NA | NA | NA | NA |
| Leu-13C5 | NA | NA | NA | NA |
| Leu-13C6 | NA | NA | NA | NA |
| Leu-ALL | 1.1056 | 0.8401 | 0.9422 | 1.1122 |
| Lys-13C0 | 1.0253 | 0.8897 | 0.8267 | 1.2583 |
| Lys-13C1 | NA | 0.4291 | 2.5762 | 0.5657 |
| Lys-13C2 | NA | NA | NA | NA |
| Lys-13C3 | NA | NA | NA | NA |
| Lys-13C4 | NA | NA | NA | NA |
| Lys-13C5 | NA | NA | NA | NA |
| Lys-13C6 | NA | NA | NA | NA |
| Lys-ALL | 1.0077 | 0.8892 | 0.8567 | 1.2464 |
| Malate-13C0 | 1.9973 | 0.6650 | 1.0298 | 0.3079 |
| Malate-13C1 | 0.8347 | 0.9047 | 1.3242 | 0.9364 |
| Malate-13C2 | 0.6950 | 0.6367 | 2.0109 | 0.6574 |
| Malate-13C3 | 0.5037 | 0.6585 | 2.0701 | 0.7677 |
| Malate-13C4 | 0.0629 | 0.5049 | 2.5084 | 0.9238 |
| Malate-ALL | 1.5295 | 0.6712 | 1.3365 | 0.4629 |
| Met-13C0 | 0.9714 | 0.8581 | 0.7927 | 1.3778 |
| Met-13C1 | 1.7967 | 0.3552 | 1.2085 | 0.6396 |
| Met-13C2 | 0.6415 | 0.1391 | 1.7889 | NA |
| Met-13C3 | 1.0083 | NA | 0.9835 | NA |
| Met-13C4 | NA | NA | NA | NA |
| Met-13C5 | NA | 1.1161 | 0.8839 | NA |
| Met-ALL | 0.9533 | 0.9652 | 1.0568 | 1.0247 |
| Norleu-ALL | NA | NA | NA | NA |
| OHPro-13C0 | 1.3405 | 0.6980 | 1.2409 | 0.7206 |
| OHPro-13C1 | 0.8519 | 0.7178 | 1.4535 | 0.9768 |
| OHPro-13C2 | NA | 0.0169 | NA | 1.9831 |
| OHPro-13C3 | NA | NA | NA | NA |
| OHPro-13C4 | NA | NA | NA | NA |
| OHPro-13C5 | NA | NA | NA | NA |
| OHPro-ALL | 1.3199 | 0.6986 | 1.2493 | 0.7321 |
| Orn-13C0 | 1.2641 | 0.8777 | 0.9006 | 0.9576 |
| Orn-13C1 | 0.6675 | 1.0610 | 0.8854 | 1.3860 |
| Orn-13C2 | 0.6433 | 0.4560 | 1.4284 | 1.9445 |
| Orn-13C3 | NA | 1.0000 | NA | NA |
| Orn-13C4 | NA | NA | NA | NA |
| Orn-13C5 | NA | NA | NA | NA |
| Orn-ALL | 1.0563 | 0.9278 | 0.9677 | 1.0482 |
| Phe-13C0 | 1.1360 | 0.7887 | 1.0248 | 1.0505 |
| Phe-13C1 | 1.3518 | 0.6571 | 1.0771 | 0.9140 |
| Phe-13C2 | NA | NA | NA | NA |
| Phe-13C3 | NA | NA | NA | NA |
| Phe-13C4 | NA | NA | NA | NA |
| Phe-13C5 | NA | NA | NA | 1.0000 |
| Phe-13C6 | 0.8407 | NA | NA | 1.1593 |
| Phe-13C7 | 0.6805 | NA | 1.1217 | 1.1978 |
| Phe-13C8 | NA | 1.2958 | 0.7042 | NA |
| Phe-13C9 | NA | NA | 0.9548 | 1.0452 |
| Phe-ALL | 1.1173 | 0.7310 | 1.0059 | 1.1458 |
| PO4-ALL | NA | NA | NA | NA |
| Pro258-13C0 | 1.9618 | 0.6227 | 1.1241 | 0.2913 |
| Pro258-13C1 | 1.4438 | 0.8003 | 1.3781 | 0.3778 |
| Pro258-13C2 | 1.0169 | 0.6022 | 2.0868 | 0.2941 |
| Pro258-13C3 | 0.3567 | 0.4260 | 2.8110 | 0.4062 |
| Pro258-13C4 | 0.2576 | 0.3963 | 2.9680 | 0.3780 |
| Pro258-13C5 | 1.6321 | 1.0860 | 0.5114 | 0.7705 |
| Pro258-ALL | 1.6973 | 0.6239 | 1.3659 | 0.3129 |
| SeMet-ALL | NA | NA | NA | NA |
| Ser-13C0 | 0.9358 | 0.9055 | 0.8317 | 1.3270 |
| Ser-13C1 | 1.2301 | 1.0909 | 0.8614 | 0.8177 |
| Ser-13C2 | 1.2467 | 1.1336 | 0.9794 | 0.6403 |
| Ser-13C3 | 0.9969 | 1.2507 | 0.9157 | 0.8367 |
| Ser-ALL | 1.0121 | 0.9692 | 0.8518 | 1.1669 |
| Succinate-13C0 | 1.2891 | 1.0109 | 0.9846 | 0.7154 |
| Succinate-13C1 | 1.2028 | 0.8341 | 1.1217 | 0.8414 |
| Succinate-13C2 | 0.7556 | 0.8359 | 1.7785 | 0.6301 |
| Succinate-13C3 | 0.3246 | 0.7613 | 2.2486 | 0.6655 |
| Succinate-13C4 | 0.2494 | 0.4185 | 2.5478 | 0.7843 |
| Succinate-ALL | 1.1827 | 0.9668 | 1.1366 | 0.7139 |
| t-aconitate-13C0 | 1.3159 | 0.5734 | 0.7948 | NA |
| t-aconitate-13C1 | NA | NA | NA | NA |
| t-aconitate-13C2 | 0.6786 | 0.7679 | 1.8749 | NA |
| t-aconitate-13C3 | 1.0000 | NA | NA | NA |
| t-aconitate-13C4 | NA | NA | NA | NA |
| t-aconitate-13C5 | NA | NA | NA | NA |
| t-aconitate-13C6 | NA | NA | NA | NA |
| t-aconitate-ALL | 0.9886 | 0.6690 | 1.3538 | NA |
| Thr-13C0 | 1.1622 | 0.8138 | 1.0553 | 0.9687 |
| Thr-13C1 | 1.9891 | 0.5522 | 0.7196 | 0.7391 |
| Thr-13C2 | 1.0000 | NA | NA | NA |
| Thr-13C3 | NA | NA | 1.0000 | NA |
| Thr-13C4 | NA | NA | NA | NA |
| Thr-ALL | 1.1743 | 0.8100 | 1.0505 | 0.9652 |
| Trp-13C0 | NA | NA | NA | NA |
| Trp-13C1 | NA | NA | NA | NA |
| Trp-13C10 | NA | NA | NA | NA |
| Trp-13C11 | NA | NA | NA | NA |
| Trp-13C2 | NA | NA | NA | NA |
| Trp-13C3 | NA | NA | NA | NA |
| Trp-13C4 | NA | NA | NA | NA |
| Trp-13C5 | NA | NA | NA | NA |
| Trp-13C6 | NA | NA | NA | NA |
| Trp-13C7 | NA | NA | NA | NA |
| Trp-13C8 | NA | NA | NA | NA |
| Trp-13C9 | NA | NA | NA | NA |
| Trp-ALL | NA | NA | NA | NA |
| Tyr-13C0 | 1.1334 | 0.7823 | 1.0121 | 1.0722 |
| Tyr-13C1 | 1.6269 | 0.4908 | 0.6827 | 0.9450 |
| Tyr-13C2 | NA | 1.0000 | NA | NA |
| Tyr-13C3 | NA | NA | NA | NA |
| Tyr-13C4 | NA | NA | NA | NA |
| Tyr-13C5 | NA | NA | NA | NA |
| Tyr-13C6 | NA | NA | NA | NA |
| Tyr-13C7 | NA | NA | NA | 1.0000 |
| Tyr-13C8 | NA | NA | NA | NA |
| Tyr-13C9 | NA | NA | NA | NA |
| Tyr-ALL | 1.1697 | 0.7555 | 0.9989 | 1.0760 |
| Val-13C0 | 1.0070 | 0.9793 | 0.7689 | 1.2449 |
| Val-13C1 | 1.7765 | 0.2668 | 1.6328 | 0.3239 |
| Val-13C2 | NA | NA | NA | NA |
| Val-13C3 | NA | NA | NA | NA |
| Val-13C4 | NA | NA | NA | NA |
| Val-13C5 | NA | NA | NA | NA |
| Val-ALL | 1.0629 | 0.9276 | 0.8316 | 1.1780 |
Factors:
| F1 | Oxygen Condition:hypoxia | Treatment:None |
| F2 | Oxygen Condition:hypoxia | Treatment:Tetracycline |
| F3 | Oxygen Condition:normoxia | Treatment:None |
| F4 | Oxygen Condition:normoxia | Treatment:Tetracycline |
