Data for Disruption of Zinc homeostasis can impair maternal glucocorticoid metabolism: consequences on the developing fetus (Study ST000120)
(Analysis AN000202)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 | F31 | F32 | F33 | F34 | F35 | F36 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11-Dehydrocorticosterone | 9.0392 | 4.5882 | 7.4532 | 6.5493 | NA | NA | NA | NA | 0.0038 | 0.0003 | 0.0005 | 0.0036 | 0.0053 | 0.0041 | 0.0013 | 0.0102 | 0.0049 | 0.0025 | 0.0005 | 0.0025 | 0.0060 | 0.0032 | 0.0034 | 0.0080 | 0.0015 | 0.0015 | 0.0023 | 0.0016 | 0.0294 | 0.0175 | 0.0302 | 0.0275 | 0.0953 | 0.0652 | 0.0738 | 0.0666 |
| 17-hydroxypregnenolone | 3.9960 | 1.9871 | 4.9813 | 3.7668 | NA | NA | NA | NA | 0.0662 | 0.0813 | 0.0604 | 0.0819 | 0.1586 | 0.1496 | 0.1306 | 0.3485 | 0.2067 | 0.4064 | 0.2352 | 0.2523 | 0.3864 | 0.2625 | 0.1620 | 0.2330 | 0.9367 | 0.2791 | 0.4173 | 0.3910 | 3.0868 | 0.9996 | 3.4048 | 0.8429 | 0.2003 | 0.1493 | 0.1433 | 0.1185 |
| 17-hydroxyprogesterone | NA | NA | NA | NA | NA | NA | NA | NA | 1.0703 | 1.2722 | 1.6541 | 0.9534 | 0.2950 | 0.3792 | 0.5176 | 0.4627 | 1.5464 | 1.0554 | 1.1942 | 1.8626 | 0.6642 | 0.2966 | 0.6444 | 0.4702 | 0.4184 | 0.6252 | 0.3270 | 0.4190 | 2.4238 | 1.2935 | 2.3690 | 1.3102 | 0.3465 | 3.0327 | 0.2001 | 0.2831 |
| Aldosterone | 6.3864 | 8.3395 | 6.0785 | 9.3133 | NA | NA | NA | NA | 0.0219 | 0.0099 | 0.0100 | 0.0109 | 0.0459 | 0.0189 | 0.0285 | 0.0401 | 0.0255 | 0.0233 | 0.0209 | 0.0168 | 0.0499 | 0.0247 | 0.0441 | 0.0417 | 0.0108 | 0.0083 | 0.0116 | 0.0071 | 0.0106 | 0.0090 | 0.0140 | 0.0198 | 0.0271 | 0.0096 | 0.0179 | 0.0321 |
| Allodihydrotestosterone | 1.8778 | 2.1658 | 2.4508 | 1.3061 | NA | NA | NA | NA | 1.1480 | 2.2040 | 0.9100 | 1.0520 | NA | NA | NA | NA | 1.2311 | 1.1010 | 0.7156 | 1.0618 | NA | NA | NA | NA | 0.2471 | 0.2027 | 0.2736 | 0.3151 | 0.2649 | 0.1782 | 0.2952 | 0.2302 | NA | NA | NA | NA |
| Androstenedione | 3.2846 | 3.9658 | 3.6941 | 2.8953 | NA | NA | NA | NA | NA | NA | NA | NA | 0.5943 | 0.3633 | 0.5531 | 0.3059 | NA | NA | NA | NA | 0.5715 | 0.2854 | 0.8213 | 0.2535 | 0.1823 | 0.1873 | 0.2331 | 0.0785 | 0.6008 | 0.3651 | 0.5838 | 0.3663 | 0.9291 | 1.2570 | 0.8243 | 0.8469 |
| Androstenolone (DHEA) | 2.0706 | 2.1330 | 2.3469 | 1.7454 | NA | NA | NA | NA | 0.4447 | 0.5819 | 0.2781 | 0.7483 | 0.9009 | 1.0020 | 1.6735 | 1.0678 | 0.5695 | 2.1964 | 0.4832 | 0.7368 | 1.2716 | 0.7022 | 0.7633 | 0.6238 | 0.3634 | 0.1632 | 0.3010 | 0.5179 | 1.0291 | 1.5491 | 0.6044 | 1.0782 | 1.2932 | 1.0628 | 0.8267 | 0.9728 |
| Cortexolone | NA | NA | NA | NA | NA | NA | NA | NA | 0.1607 | 0.0384 | 0.0227 | 0.0145 | 0.2526 | 0.2516 | 0.1599 | 0.5067 | 0.3751 | 0.1282 | 0.1667 | 0.1894 | 0.7121 | 0.1643 | 0.3087 | 0.6001 | 0.0575 | 0.0380 | 0.0225 | 0.0388 | 0.8543 | 1.0661 | 0.9016 | 0.8687 | 4.5887 | 2.7442 | 3.7505 | 3.6016 |
| Cortexone | 8.6890 | 3.8196 | 11.3844 | 6.8197 | NA | NA | NA | NA | 0.0011 | 0.0002 | 0.0002 | 0.0002 | 0.0006 | 0.0001 | 0.0005 | 0.0009 | 0.0015 | 0.0013 | 0.0004 | 0.0005 | 0.0165 | 0.0001 | 0.0003 | 0.0008 | 0.0004 | 0.0002 | 0.0002 | 0.0002 | 0.0072 | 0.0068 | 0.0052 | 0.0075 | 0.0092 | 0.0067 | 0.0047 | 0.0066 |
| Corticosterone, DOC | 8.8437 | 5.9919 | 7.8221 | 7.8771 | NA | NA | NA | NA | 0.0069 | 0.0043 | 0.0062 | 0.0058 | 0.0364 | 0.0445 | 0.0398 | 0.0483 | 0.0087 | 0.0071 | 0.0070 | 0.0054 | 0.0595 | 0.0299 | 0.0372 | 0.0521 | 0.0014 | 0.0007 | 0.0008 | 0.0016 | 0.0386 | 0.0273 | 0.0393 | 0.0404 | 0.0203 | 0.0168 | 0.0177 | 0.0206 |
| Cortisol | 2.1892 | 1.4382 | 2.2998 | 13.5301 | NA | NA | NA | NA | 0.8303 | 0.4431 | NA | 0.8249 | 0.0585 | 0.0233 | 0.0733 | 0.1021 | 0.8364 | 0.2600 | 0.2273 | 0.4695 | 0.2222 | 0.2915 | 0.3374 | 0.1633 | 0.7474 | 0.3552 | 0.3489 | 0.3151 | 0.2275 | 0.0736 | 0.1778 | 0.2846 | 0.6320 | 0.6087 | 0.3863 | 0.1048 |
| Cortisone | 5.4386 | 5.2527 | 17.7254 | 5.9045 | NA | NA | NA | NA | 0.2611 | 0.3132 | 0.6235 | 0.2694 | 0.6048 | 0.0517 | 0.6376 | 0.8634 | 0.4138 | 0.2422 | 0.1487 | 0.2409 | 0.4473 | 0.1305 | 0.5675 | 0.4241 | 0.3619 | 0.3233 | 0.2118 | 0.1967 | 0.1460 | 0.3769 | 0.2034 | 0.2246 | 0.3000 | 0.0844 | 0.8301 | 0.2289 |
| Estradiol | 1.9485 | 2.4902 | 4.2766 | 0.6311 | NA | NA | NA | NA | 0.2559 | 0.5382 | 0.2554 | 0.2209 | 0.3204 | 0.3023 | 0.5590 | 1.2258 | 0.4058 | 0.8917 | 0.3555 | 1.3981 | 0.2635 | 0.1766 | 1.3447 | 0.4334 | 1.8936 | 0.9259 | 5.2084 | 0.4845 | 0.4976 | 0.1995 | 0.2176 | 0.1784 | 0.8313 | 1.0621 | 2.1750 | 0.6719 |
| Estrone | 0.8898 | 4.5321 | 7.4446 | 0.6726 | NA | NA | NA | NA | 0.4065 | 1.0899 | 0.1135 | 0.7023 | 0.0705 | 0.1124 | 0.1161 | 0.0964 | 1.3494 | 3.1563 | 1.2159 | 11.6164 | 0.1814 | 0.0724 | 0.0971 | 0.0962 | 0.0794 | 0.0814 | 0.1056 | 0.0924 | 0.0174 | 0.0158 | 0.0197 | 0.0113 | 0.0395 | 0.0644 | 0.0939 | 0.0298 |
| Mono-(2-ethylhexyl) phthalate | NA | 0.7961 | NA | 0.9312 | NA | NA | NA | NA | NA | 0.1711 | NA | 0.2901 | NA | 0.1894 | NA | 0.4906 | NA | 0.1374 | NA | 0.2432 | NA | 0.1209 | NA | 0.2996 | NA | 4.7462 | NA | 5.5844 | NA | 0.3583 | NA | 0.6474 | NA | 0.2566 | NA | 0.4315 |
| Pregnenolone | 9.1932 | 4.2706 | 7.7918 | 5.5125 | NA | NA | NA | NA | 0.0950 | 0.0360 | 0.0482 | 0.0494 | 0.2849 | 0.3571 | 0.3137 | 0.2238 | 0.0669 | 0.0833 | 0.0560 | 0.0273 | 0.4201 | 0.2747 | 0.2929 | 0.2741 | 0.0491 | 0.0277 | 0.0364 | 0.0293 | 0.0137 | 0.0062 | 0.0064 | 0.0099 | 0.0283 | 0.0187 | 0.0244 | 0.0241 |
| Progesterone | 8.8930 | 6.2021 | 8.5693 | 7.4938 | NA | NA | NA | NA | 0.0032 | 0.0034 | 0.0025 | 0.0034 | 0.0010 | 0.0013 | 0.0010 | 0.0012 | 0.0043 | 0.0040 | 0.0030 | 0.0045 | 0.0029 | 0.0010 | 0.0010 | 0.0018 | 0.0018 | 0.0016 | 0.0013 | 0.0013 | 0.0148 | 0.0099 | 0.0152 | 0.0134 | 0.0022 | 0.0024 | 0.0020 | 0.0022 |
| Testosterone | 2.8994 | 2.7621 | 2.1942 | 1.7869 | NA | NA | NA | NA | 0.9572 | 0.7175 | 0.3389 | 0.2570 | 2.2838 | 0.2292 | 0.0860 | 0.2092 | 1.6441 | 1.3843 | 1.2020 | 1.1117 | 0.3830 | 0.2350 | 0.3650 | 0.3319 | 0.4587 | 0.3522 | 0.2497 | 0.1780 | 0.6983 | 0.5053 | 0.6555 | 0.5006 | 1.9671 | 1.4372 | 1.5038 | 0.9497 |
Factors:
| F1 | Tissue/Fluid:Adrenal gland | Treatment:Control |
| F2 | Tissue/Fluid:Adrenal gland | Treatment:Control + DEHP |
| F3 | Tissue/Fluid:Adrenal gland | Treatment:Marginal Zinc deficient |
| F4 | Tissue/Fluid:Adrenal gland | Treatment:Marginal Zinc deficient + DEHP |
| F5 | Tissue/Fluid:Amniotic fluid | Treatment:Control |
| F6 | Tissue/Fluid:Amniotic fluid | Treatment:Control + DEHP |
| F7 | Tissue/Fluid:Amniotic fluid | Treatment:Marginal Zinc deficient |
| F8 | Tissue/Fluid:Amniotic fluid | Treatment:Marginal Zinc deficient + DEHP |
| F9 | Tissue/Fluid:Fetal Female brain | Treatment:Control |
| F10 | Tissue/Fluid:Fetal Female brain | Treatment:Control + DEHP |
| F11 | Tissue/Fluid:Fetal Female brain | Treatment:Marginal Zinc deficient |
| F12 | Tissue/Fluid:Fetal Female brain | Treatment:Marginal Zinc deficient + DEHP |
| F13 | Tissue/Fluid:Fetal Female Liver | Treatment:Control |
| F14 | Tissue/Fluid:Fetal Female Liver | Treatment:Control + DEHP |
| F15 | Tissue/Fluid:Fetal Female Liver | Treatment:Marginal Zinc deficient |
| F16 | Tissue/Fluid:Fetal Female Liver | Treatment:Marginal Zinc deficient + DEHP |
| F17 | Tissue/Fluid:Fetal Male brain | Treatment:Control |
| F18 | Tissue/Fluid:Fetal Male brain | Treatment:Control + DEHP |
| F19 | Tissue/Fluid:Fetal Male brain | Treatment:Marginal Zinc deficient |
| F20 | Tissue/Fluid:Fetal Male brain | Treatment:Marginal Zinc deficient + DEHP |
| F21 | Tissue/Fluid:Fetal Male Liver | Treatment:Control |
| F22 | Tissue/Fluid:Fetal Male Liver | Treatment:Control + DEHP |
| F23 | Tissue/Fluid:Fetal Male Liver | Treatment:Marginal Zinc deficient |
| F24 | Tissue/Fluid:Fetal Male Liver | Treatment:Marginal Zinc deficient + DEHP |
| F25 | Tissue/Fluid:Maternal Liver | Treatment:Control |
| F26 | Tissue/Fluid:Maternal Liver | Treatment:Control + DEHP |
| F27 | Tissue/Fluid:Maternal Liver | Treatment:Marginal Zinc deficient |
| F28 | Tissue/Fluid:Maternal Liver | Treatment:Marginal Zinc deficient + DEHP |
| F29 | Tissue/Fluid:Maternal plasma | Treatment:Control |
| F30 | Tissue/Fluid:Maternal plasma | Treatment:Control + DEHP |
| F31 | Tissue/Fluid:Maternal plasma | Treatment:Marginal Zinc deficient |
| F32 | Tissue/Fluid:Maternal plasma | Treatment:Marginal Zinc deficient + DEHP |
| F33 | Tissue/Fluid:Placenta | Treatment:Control |
| F34 | Tissue/Fluid:Placenta | Treatment:Control + DEHP |
| F35 | Tissue/Fluid:Placenta | Treatment:Marginal Zinc deficient |
| F36 | Tissue/Fluid:Placenta | Treatment:Marginal Zinc deficient + DEHP |
