Data for Noxa regulation of malate aspartate shuttle (Study ST000146)

(Analysis AN000232)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
2 or 3-phosphoglycerate_13C_1 NA NA NA NA NA NA
2 or 3-phosphoglycerate_13C_2 NA 1.0000 NA NA NA NA
2 or 3-phosphoglycerate_13C_3 NA NA NA NA NA NA
2 or 3-phosphoglycerate_2PG/3PG 0.8006 0.0943 1.4422 0.1763 1.6465 0.0614
3-Glycerophosphate 1.0163 0.0072 0.7801 0.0099 4.1808 0.0057
3-Glycerophosphate_13C_1 1.3459 0.0050 0.6464 0.0041 3.9943 0.0043
3-Glycerophosphate_13C_2 1.3875 0.0014 0.2653 0.0047 3.0095 0.0027
3-Glycerophosphate_13C_3 NA NA NA NA 1.4153 0.1694
3-phosphoglyceraldehyde 0.7791 NA 0.6991 NA 1.5218 NA
3-phosphoglyceraldehyde_13C_1 0.8299 NA 0.5337 NA 1.6364 NA
3-phosphoglyceraldehyde_13C_2 NA NA NA NA NA NA
3-phosphoglyceraldehyde_13C_3 NA NA NA NA NA NA
6-Phosphogluconate 0.6640 0.1537 1.0187 NA 1.5994 NA
6-Phosphogluconate_13C_1 0.3583 NA 1.5165 NA 1.1252 NA
6-Phosphogluconate_13C_2 NA NA NA NA NA NA
6-Phosphogluconate_13C_3 NA 1.0000 NA NA NA NA
6-Phosphogluconate_13C_4 NA NA NA NA NA NA
6-Phosphogluconate_13C_5 NA NA NA NA NA NA
6-Phosphogluconate_13C_6 NA NA NA NA NA NA
Acetyl-CoA 0.6179 NA 0.9495 NA 1.4326 NA
Acetyl-CoA_13C_1 0.7289 NA 1.0185 NA 1.2526 NA
Acetyl-CoA_13C_2 NA NA NA NA NA NA
Adenosine diphosphate 1.4088 0.0384 1.1372 0.0214 2.7206 0.0268
Adenosine diphosphate_13C_1 1.1450 0.0103 0.9140 NA 1.6016 0.0080
Adenosine diphosphate_13C_2 0.8748 NA 0.0206 NA 1.3682 NA
Adenosine diphosphate_13C_3 NA NA NA NA 1.0000 NA
Adenosine diphosphate_13C_4 NA NA NA NA NA NA
Adenosine diphosphate_13C_5 NA NA NA NA NA NA
Adenosine monophosphate 1.0514 0.0415 1.3742 0.0743 2.1391 NA
Adenosine monophosphate_13C_1 0.8524 NA 1.1504 0.0130 1.3262 NA
Adenosine monophosphate_13C_2 NA NA NA NA 1.0000 NA
Adenosine monophosphate_13C_3 NA NA NA NA NA NA
Adenosine monophosphate_13C_4 NA NA NA NA NA NA
Adenosine monophosphate_13C_5 NA NA NA NA NA NA
Adenosine triphosphate 1.9492 0.0413 1.6400 0.0265 2.3002 0.0428
Adenosine triphosphate_13C_1 2.0117 0.0301 1.8151 0.0286 1.7529 0.0378
Adenosine triphosphate_13C_2 0.9947 NA 0.9061 NA 1.0992 NA
Adenosine triphosphate_13C_3 1.0751 NA 1.2050 NA 0.7849 NA
Adenosine triphosphate_13C_4 NA NA NA NA 1.0000 NA
Adenosine triphosphate_13C_5 NA NA NA NA NA NA
Aspartate 0.2870 1.6474 1.0028 1.1043 0.2827 1.6759
Aspartate_13C_1 1.0620 0.1164 3.5204 0.1373 0.1957 0.0421
Aspartate_13C_2 NA 1.2369 2.2284 0.8353 NA 0.2312
Aspartate_13C_3 NA NA NA 1.0000 NA NA
Aspartate_13C_4 NA NA NA NA NA NA
Citrate or Isocitrate 1.8271 0.3696 1.6122 0.5865 0.8167 0.7879
Citrate or Isocitrate_13C_1 2.4810 0.2390 1.8241 0.5855 0.2696 0.6007
Citrate or Isocitrate_13C_2 0.8041 1.0210 2.3732 0.6786 0.0842 0.3787
Citrate or Isocitrate_13C_3 1.2319 0.7008 0.4087 2.1014 0.7713 1.0284
Citrate or Isocitrate_13C_4 NA NA NA 1.0000 NA NA
Citrate or Isocitrate_13C_5 NA 1.6180 NA 0.3820 NA NA
Citrate or Isocitrate_13C_6 1.1058 0.8367 1.6874 0.8429 0.8526 0.9391
Erythrose 4-phosphate 0.4901 0.0166 0.9004 NA 1.9373 NA
Erythrose 4-phosphate_13C_1 NA NA 1.2218 NA 0.6673 NA
Erythrose 4-phosphate_13C_2 NA NA NA NA 1.0000 NA
Erythrose 4-phosphate_13C_3 NA NA NA NA NA NA
Erythrose 4-phosphate_13C_4 NA NA NA NA NA NA
Fructose 1,6-bisphosphate 1.2677 0.1318 0.5479 0.0626 3.8924 0.0975
Fructose 1,6-bisphosphate_13C_1 1.5211 0.1151 0.5728 0.0582 3.6529 0.0798
Fructose 1,6-bisphosphate_13C_2 1.0276 0.1266 0.5117 NA 1.7518 NA
Fructose 1,6-bisphosphate_13C_3 NA NA NA NA NA NA
Fructose 1,6-bisphosphate_13C_4 NA NA NA NA NA NA
Fructose 1,6-bisphosphate_13C_5 NA NA NA NA NA NA
Fructose 1,6-bisphosphate_13C_6 NA NA NA NA NA NA
Glucose 6-phosphate or fructose-6-phosphate 0.9856 0.0443 1.0924 0.1964 3.6330 0.0482
Glucose 6-phosphate or fructose-6-phosphate_13C_1 1.2228 0.0423 1.5630 0.0619 3.0551 0.0550
Glucose 6-phosphate or fructose-6-phosphate_13C_2 0.1228 NA NA NA 1.2924 NA
Glucose 6-phosphate or fructose-6-phosphate_13C_3 NA NA NA NA 1.0000 NA
Glucose 6-phosphate or fructose-6-phosphate_13C_4 NA 1.0000 NA NA NA NA
Glucose 6-phosphate or fructose-6-phosphate_13C_5 1.9513 0.0487 NA NA NA NA
Glucose 6-phosphate or fructose-6-phosphate_13C_6 0.5880 0.8678 1.7345 NA 0.8097 NA
Glutamate 1.6678 0.2263 2.0138 0.3130 1.4872 0.2919
Glutamate_13C_1 1.6470 0.5588 0.9747 0.3535 0.7409 NA
Glutamate_13C_2 2.4253 0.0758 1.8265 0.5697 NA 0.1027
Glutamate_13C_3 1.5240 NA 0.3398 NA 1.0681 NA
Glutamate_13C_4 NA NA NA NA NA NA
Glutamate_13C_5 NA NA NA NA NA NA
Lactate 0.6771 NA 1.1864 NA 1.1365 NA
Lactate_13C_1 0.4376 NA 0.8859 NA 1.6765 NA
Lactate_13C_2 NA NA NA NA NA NA
Lactate_13C_3 NA NA NA NA NA NA
Malate 2.1322 0.0478 2.4957 0.1192 1.1381 0.0670
Malate_13C_1 2.7055 0.0343 2.6158 0.0580 0.5333 0.0531
Malate_13C_2 2.8294 0.0924 2.4231 0.0657 0.2581 0.0288
Malate_13C_3 1.6752 NA 0.7894 NA 0.3032 NA
Malate_13C_4 0.8380 1.2932 0.3916 1.0553 NA 0.9267
Malonyl-CoA 0.3697 NA 1.2194 NA 1.4109 NA
Malonyl-CoA_13C_1 0.3184 NA 1.2489 NA 1.4327 NA
Malonyl-CoA_13C_2 NA NA 1.0000 NA NA NA
Malonyl-CoA_13C_3 NA NA 1.0000 NA NA NA
Nicotinamide Adenine Dinucleotide oxidized 0.9385 0.0268 1.4378 0.0767 3.1695 0.0428
Nicotinamide Adenine Dinucleotide oxidized_13C_1 0.5583 NA 0.8966 NA 1.5452 NA
Nicotinamide Adenine Dinucleotide oxidized_13C_2 0.7006 NA 1.1244 NA 1.5082 0.0003
Nicotinamide Adenine Dinucleotide oxidized_13C_3 0.5114 NA 0.9193 2.0992 1.1166 1.2588
Nicotinamide Adenine Dinucleotide oxidized_13C_4 NA NA 0.7045 NA 1.2955 NA
Nicotinamide Adenine Dinucleotide oxidized_13C_5 NA NA NA NA 1.0000 NA
Nicotinamide Adenine Dinucleotide reduced 0.5236 NA 0.3874 NA 2.0890 NA
Nicotinamide Adenine Dinucleotide reduced_13C_1 0.6085 NA 0.4511 NA 1.9404 NA
Nicotinamide Adenine Dinucleotide reduced_13C_2 0.6781 NA 0.4739 NA 1.8480 NA
Nicotinamide Adenine Dinucleotide reduced_13C_3 0.7279 NA 0.4906 NA 1.7815 NA
Nicotinamide Adenine Dinucleotide reduced_13C_4 0.6779 NA 0.1542 NA 1.4967 NA
Nicotinamide Adenine Dinucleotide reduced_13C_5 NA NA NA NA 1.0000 NA
Phosphoenolpyruvate NA NA NA NA NA NA
Phosphoenolpyruvate_13C_1 NA NA NA NA NA NA
Phosphoenolpyruvate_13C_2 NA NA NA NA NA NA
Phosphoenolpyruvate_13C_3 NA NA NA NA NA NA
Ribose-5-phosphate or xylulose 5-phosphate 0.7415 0.0731 0.4568 0.8319 3.4283 0.1034
Ribose-5-phosphate or xylulose 5-phosphate_13C_1 0.7528 NA 0.3054 0.1677 1.9053 NA
Ribose-5-phosphate or xylulose 5-phosphate_13C_2 1.0688 NA 0.3338 NA 1.6204 NA
Ribose-5-phosphate or xylulose 5-phosphate_13C_3 NA 0.0014 NA NA 1.9986 NA
Ribose-5-phosphate or xylulose 5-phosphate_13C_4 NA 1.0000 NA NA NA NA
Ribose-5-phosphate or xylulose 5-phosphate_13C_5 NA 1.0000 NA NA NA NA
Sedoheptulose 7-phosphate 0.7258 NA 0.2490 0.0753 2.6417 NA
Sedoheptulose 7-phosphate_13C_1 0.5277 NA 0.2207 NA 2.2516 NA
Sedoheptulose 7-phosphate_13C_2 0.0820 NA NA NA 1.3060 NA
Sedoheptulose 7-phosphate_13C_3 NA NA NA NA 1.0000 NA
Sedoheptulose 7-phosphate_13C_4 1.4738 NA 0.5262 NA NA NA
Sedoheptulose 7-phosphate_13C_5 0.0726 NA 0.0595 NA 1.9317 NA
Sedoheptulose 7-phosphate_13C_6 NA 0.2170 NA NA 1.6830 0.3669
Sedoheptulose 7-phosphate_13C_7 NA 2.1604 NA NA 0.6132 NA
Sucrose 1.0590 0.4002 2.2179 0.3797 1.3470 0.5961
Sucrose_13C_1 0.1459 NA 2.1729 0.2104 0.7659 NA
Sucrose_13C_2 NA NA NA NA NA NA
Sucrose_13C_3 NA NA NA NA NA NA
Sucrose_13C_4 NA NA NA NA NA NA
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Factors:

F1genotype:Noxa knockdown line
F2genotype:Noxa knockdown line medium
F3genotype:Noxa overexpressing line
F4genotype:Noxa overexpressing line medium
F5genotype:Parental line
F6genotype:Parental line medium
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