Data for Cyclobutene- and cyclobutane-functionalized fatty acids as novel biochemical probes of structure and function in HepG2 cells (Study ST000241)
(Analysis AN000374)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
---|---|---|---|---|---|---|---|---|
12a-Hydroxy-3-oxocholadienic acid | NA | 0.1171 | 0.6084 | 1.1035 | 1.4901 | NA | NA | 1.0922 |
19-Hydroxy-PGE2 | 4.0763 | 0.2125 | 0.2211 | 0.5692 | 0.2204 | 1.2294 | 0.5075 | 0.1577 |
3a,16b-Dihydroxyandrostenone | NA | 1.3619 | 0.9622 | NA | NA | NA | NA | 0.0275 |
Azythromycin | 0.6528 | 0.5577 | 0.7224 | 1.4605 | 1.3315 | 1.8358 | 0.4505 | 0.9888 |
Canrenone | 3.6750 | 1.0135 | 0.1960 | 0.8957 | 0.4301 | 0.9045 | 0.3498 | 0.5353 |
DG(14:0/22:4(7Z,10Z,13Z,16Z)/0:0) | 0.0887 | NA | NA | 0.7627 | 0.5000 | 0.8049 | 0.0898 | 2.5395 |
DG(15:0/18:0/0:0) | 1.3916 | 1.0557 | 1.2572 | 0.5349 | 0.3191 | 0.3898 | 2.5922 | 0.4596 |
DG(15:0/20:0/0:0) | 0.9967 | 1.2912 | 1.3371 | 0.6803 | 0.7893 | 0.5435 | 1.9008 | 0.4612 |
DG(15:0/22:0/0:0) | 0.7918 | 1.6479 | 1.2122 | 0.8824 | 0.8964 | 0.4912 | 1.6913 | 0.3869 |
DG(16:0/22:5(4Z,7Z,10Z,13Z,16Z)/0:0) | 0.6370 | 0.1828 | 0.0751 | 1.4506 | 1.3068 | 1.2845 | 0.9494 | 2.1138 |
DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) | 0.1830 | NA | 0.1258 | 0.1610 | 0.1627 | 0.1336 | 4.9662 | 0.1262 |
DG(22:2(13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) | 0.0170 | 1.8265 | 1.1560 | NA | 0.0177 | NA | NA | NA |
Eicosadienoic acid | NA | 1.8227 | 1.1561 | NA | NA | 0.0213 | 0.0201 | 0.0221 |
Eicosapentaenoic acid | 0.3322 | 0.1622 | 1.4990 | 1.1399 | 1.8744 | 0.1357 | NA | 0.4992 |
Finasteride | 0.6011 | 0.2405 | 0.4911 | 0.5860 | 0.4136 | 0.5838 | 4.6835 | 0.1006 |
Gingerol | 2.5063 | 0.3201 | 0.5809 | 1.5493 | 0.4927 | 1.7217 | 0.6084 | 0.2206 |
Isoacitretin | 2.9137 | 0.8244 | 0.4736 | 1.0660 | 0.6636 | 0.8765 | 0.6610 | 0.5212 |
Lactosylceramide (d18:1/12:0) | 2.4478 | 0.1857 | 0.2253 | 1.8569 | 0.3189 | 0.5384 | 0.3216 | 0.5939 |
LysoPC(10:0) | 4.4371 | 0.0923 | 0.2271 | 0.4892 | 0.3362 | 1.1398 | 0.2706 | 0.4025 |
LysoPE(0:0/16:1(9Z)) | 0.5247 | 0.3322 | 0.2668 | 0.9346 | 0.3332 | 0.7943 | NA | 3.1032 |
Nonadecanoic acid | 1.1625 | 0.6745 | 0.8439 | 1.1371 | 1.3580 | 1.3629 | 0.7485 | 0.7126 |
Oleic acid | 0.4752 | 0.5498 | 1.5565 | 1.0502 | 1.3275 | 0.9952 | 0.8036 | 1.2420 |
PA(20:4(5Z,8Z,11Z,14Z)e/2:0) | 3.2950 | 0.3285 | NA | 0.3331 | NA | 0.3142 | 0.3478 | 0.2340 |
Palmitic acid | 1.3188 | 0.6993 | 1.4261 | 1.0241 | 1.2389 | 0.8885 | 0.3774 | 1.0269 |
PC(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 1.5288 | 0.7760 | 0.9293 | 1.0734 | 1.4696 | 1.8549 | 0.1020 | 0.2338 |
PC(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 1.3940 | 0.8588 | 0.8099 | 0.9163 | 0.9592 | 1.2222 | 1.0302 | 0.8082 |
PC(o-22:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 2.0565 | 0.7145 | 0.5361 | 0.8101 | 0.9151 | 1.3004 | 0.3863 | 1.2810 |
PE(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 0.9149 | 0.5293 | 0.5906 | 0.6243 | 0.5351 | 0.4018 | 0.3976 | 4.0063 |
PE(18:4(6Z,9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 2.4992 | 0.8768 | 0.9340 | 0.4467 | 0.3478 | 0.3022 | 0.7575 | 1.8358 |
PE(20:3(5Z,8Z,11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 1.1764 | 0.4170 | 1.4501 | 1.0978 | 0.6941 | 0.8036 | 1.4979 | 0.8632 |
PE(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 2.3146 | 1.0835 | 1.4827 | 0.3604 | 0.2971 | 0.2466 | 1.3123 | 0.9030 |
PE(20:5(5Z,8Z,11Z,14Z,17Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 3.2916 | 0.6144 | 0.7233 | 0.2565 | 0.2155 | 0.1831 | 1.9861 | 0.7296 |
PE(22:4(7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z)) | 1.5465 | 0.7724 | 1.1053 | 1.2254 | 0.6400 | 0.5636 | 1.4846 | 0.6622 |
PE(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 1.2998 | 1.2138 | 1.5259 | 0.7270 | 0.5771 | 0.6503 | 1.2563 | 0.7498 |
PE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 1.4805 | 0.9707 | 1.1201 | 0.9240 | 0.6411 | 0.7488 | 1.2733 | 0.8416 |
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z)) | NA | NA | NA | NA | 0.0282 | 1.3239 | NA | NA |
Retinoic acid | 0.3169 | 0.2828 | 3.9815 | 0.6221 | 1.5623 | 0.2312 | 0.0840 | 0.9191 |
SM(d18:0/14:1(9Z)(OH)) | 1.1259 | 0.4191 | 0.2674 | 0.7131 | 0.6108 | 1.6609 | 2.1026 | 1.1003 |
Stearic acid | 1.6558 | 0.8287 | 1.5152 | 0.9387 | 1.0755 | 0.7306 | 0.5855 | 0.6701 |
TG(16:0/16:1(9Z)/20:4(5Z,8Z,11Z,14Z))[iso6] | 0.1293 | 0.0457 | NA | 0.1707 | 0.0927 | 0.2930 | NA | 4.3967 |
TG(16:0/18:1(9Z)/20:4(5Z,8Z,11Z,14Z))[iso6] | 0.1127 | NA | NA | 0.2307 | 0.1268 | 0.1386 | NA | 3.8043 |
TG(16:0/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))[iso6] | 1.0359 | 0.1914 | 0.3223 | 0.5677 | 0.6246 | 0.8379 | 0.2589 | 4.1615 |
TG(16:0/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))[iso3] | 1.2462 | 0.5824 | 0.8163 | 0.2257 | 0.2980 | 0.3637 | 3.1281 | 1.3396 |
TG(16:1(9Z)/16:1(9Z)/20:4(5Z,8Z,11Z,14Z))[iso3] | 0.7242 | 0.1755 | 0.2270 | 0.3350 | 0.3836 | 0.3421 | 0.3516 | 5.4610 |
TG(16:1(9Z)/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))[iso6] | 1.1111 | 0.2932 | 0.3622 | 0.3294 | 0.3728 | 0.3877 | 1.6415 | 3.5022 |
TG(16:1(9Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))[iso3] | NA | 1.1449 | 1.0079 | NA | NA | NA | NA | 0.0832 |
TG(18:0/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))[iso6] | 1.4114 | 0.1085 | 0.1575 | 0.5590 | 0.6640 | 0.9032 | 0.7070 | 3.1922 |
TG(18:1(9Z)/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))[iso6] | 1.8255 | 0.3041 | 0.4442 | 0.5909 | 0.6409 | 0.6831 | 1.6478 | 1.8634 |
TG(18:1(9Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))[iso3] | 0.7190 | 1.3849 | 1.4452 | 0.2064 | 0.2316 | 0.3762 | 2.2951 | 0.5661 |
TG(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))[iso3] | 0.1630 | 2.9856 | 2.4768 | 0.1034 | NA | 0.1271 | 0.4737 | 0.3337 |
TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z))[iso3] | 0.7531 | 0.9659 | 0.6128 | 0.0720 | 0.1363 | 0.0680 | 1.1638 | 2.7093 |
TG(20:4(5Z,8Z,11Z,14Z)/14:0/18:3(9Z,12Z,15Z))[iso6] | 0.4101 | 0.0736 | 0.1677 | 0.0720 | 0.0728 | 0.0536 | 1.1981 | 4.3936 |
Trihexosylceramide (d18:1/18:0) | 1.5087 | 0.8676 | 0.9229 | 0.5940 | 0.6751 | 1.0970 | 1.3222 | 1.0125 |
Verapamil | 0.4406 | 0.3906 | 0.3361 | 1.5237 | 1.6238 | 2.1539 | 0.0816 | 1.4496 |
Factors:
F1 | Concentration (uM):0 | Treatment_compound:BSA |
F2 | Concentration (uM):500 | Treatment_compound:CB-cis |
F3 | Concentration (uM):500 | Treatment_compound:CB-trans |
F4 | Concentration (uM):500 | Treatment_compound:CK-cis |
F5 | Concentration (uM):500 | Treatment_compound:CK-trans |
F6 | Concentration (uM):500 | Treatment_compound:K-cis |
F7 | Concentration (uM):500 | Treatment_compound:Oleic acid |
F8 | Concentration (uM):500 | Treatment_compound:Palmitic acid |