Data for Targeting CRBN to alter CD8 T cell metabolism (Study ST000307)
(Analysis AN000487)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 |
---|---|---|---|---|---|---|
2^,4^-DIHYDROXYACETOPHENONE | 1.4069 | 0.6538 | 1.5395 | 0.6686 | 0.6241 | 1.1070 |
2-HYDROXYPHENYLACETIC ACID | 0.9452 | 0.4553 | 1.1470 | 0.3614 | 0.2299 | 2.8613 |
3-(2-HYDROXYPHENYL)PROPANOATE | 4.9285 | 0.3382 | 0.2541 | 0.0806 | 0.2975 | 0.1010 |
3-HYDROXYPHENYLACETATE | 2.2184 | 1.0474 | 1.4474 | 0.5010 | 0.3677 | 0.4180 |
3-METHYL-2-OXOVALERIC ACID | 4.1264 | 0.3525 | 0.4584 | 0.2153 | 0.3794 | 0.4680 |
3-SULFINO-L-ALANINE | 0.0338 | 3.4235 | 0.2654 | 1.1554 | 0.4208 | 0.7012 |
4-COUMARATE | 1.8283 | 0.7093 | 0.7906 | 0.7294 | 0.7009 | 1.2415 |
4-GUANIDINOBUTANOATE | 1.4636 | 1.4237 | 1.4403 | 0.7691 | 0.3832 | 0.5202 |
4-METHYL-2-OXO-PENTANOIC ACID | 4.1251 | 0.3282 | 0.3498 | 0.3650 | 0.3585 | 0.4734 |
4-PYRIDOXATE | 2.5004 | 0.4912 | 2.0007 | 0.3637 | 0.2740 | 0.3701 |
ADENINE | 0.9552 | 0.7365 | 0.9375 | 0.6246 | 0.8692 | 1.8770 |
ALDOPENTOSE | 0.1355 | 1.3259 | 0.0560 | 0.9491 | 0.1233 | 3.4101 |
ALLANTOIN | 0.3687 | 2.2177 | 0.6067 | 1.3934 | 0.4743 | 0.7499 |
ALPHA-HYDROXYISOBUTYRIC ACID | 3.3551 | 0.4663 | 0.5314 | 0.4865 | 0.5437 | 0.6170 |
AZELAIC ACID | 1.8350 | 0.9329 | 1.6885 | 0.4812 | 0.5486 | 0.5138 |
C12H22O11-DISACCHARIDE-(6C/6C; GLC-GLC/GLC-FRC/GAL-GLC) | 0.0262 | 1.9552 | 1.1616 | 0.7113 | 0.2242 | 1.9215 |
C6H12O6-HEXOSE/KETOSE/INOSITOL | 0.0483 | 0.9454 | 0.0861 | 0.9330 | 0.0694 | 3.9179 |
CITRAMALATE | 2.3570 | 1.4142 | 0.2071 | 0.5956 | 0.4051 | 1.0210 |
CREATINE | 0.0151 | 2.4688 | 0.2883 | 1.2124 | 1.1900 | 0.8254 |
CYTIDINE | 2.4703 | 0.6394 | 0.2050 | 0.2782 | 0.4419 | 1.9652 |
Disaccharide (6C/6C) | 0.1610 | 2.2900 | 1.1236 | 0.9573 | 0.3368 | 1.1314 |
ETHYLMALONIC ACID | 1.6454 | 1.0969 | 0.4735 | 0.7152 | 0.5446 | 1.5244 |
GLUCONIC ACID | 0.3043 | 1.9187 | 0.0841 | 0.9577 | 0.2532 | 2.4820 |
GLUTARATE | 1.0915 | 1.4861 | 0.5206 | 0.7188 | 0.6737 | 1.5094 |
GLYCERALDEHYDE/LACTATE | 0.8674 | 0.9552 | 0.9930 | 0.7916 | 0.8575 | 1.5354 |
GLYCOLATE | 0.5744 | 0.7389 | 1.5933 | 0.8231 | 0.5246 | 1.7456 |
GUANINE | 0.1761 | 2.5931 | 0.3286 | 0.9148 | 0.9166 | 1.0709 |
GUANOSINE 5^-MONOPHOSPHATE | 0.5533 | 1.4173 | NA | 0.1043 | 0.3078 | 1.9817 |
hexose alcohol | 0.1995 | 2.6345 | 0.5957 | 1.3965 | 0.3055 | 0.8683 |
HOMOVANILLATE | 4.5201 | 0.7054 | 0.3214 | 0.1703 | 0.2069 | 0.0759 |
HYPOXANTHINE | 0.1490 | 1.5613 | 0.2653 | 1.0273 | 0.7369 | 2.2602 |
ISOCITRIC ACID | 1.0243 | 2.2008 | 0.3173 | 2.1336 | 0.1802 | 0.1438 |
L-GLUTAMINE | 0.5803 | 1.6147 | 0.6452 | 0.7410 | 0.5700 | 1.8487 |
L-METHIONINE | 0.5994 | 0.6600 | 0.1685 | 0.0940 | 0.2549 | 4.2231 |
L-PHENYLALANINE | 0.7743 | 1.0677 | 0.2844 | 0.3265 | 0.2483 | 3.2987 |
L-TYROSINE | 1.4289 | 1.6444 | 0.4290 | 0.6501 | 0.3699 | 1.4777 |
MALONIC ACID | 0.2257 | 2.5460 | 0.5589 | 1.1500 | 0.3739 | 1.1456 |
MEVALOLACTONE | 3.7923 | 0.6285 | 0.8467 | 0.2698 | 0.1839 | 0.2788 |
N-ACETYL-DL-GLUTAMIC ACID | 3.9151 | 0.6088 | 0.2928 | 0.2838 | 0.2369 | 0.6627 |
N-ACETYL-DL-SERINE | 1.2290 | 1.7635 | 0.7755 | 0.8343 | 0.6612 | 0.7365 |
N-ACETYLGLYCINE | 1.7136 | 0.9973 | 0.4643 | 0.7391 | 1.3643 | 0.7215 |
N-ACETYL-L-ASPARTIC ACID | 1.1867 | 2.8533 | 0.1862 | 0.9338 | 0.3836 | 0.4563 |
N-ACETYL-L-LEUCINE | 4.4487 | 0.3314 | 0.2999 | 0.2658 | 0.2989 | 0.3553 |
NICOTINATE | 4.2821 | 0.2919 | 0.1345 | 0.2502 | 0.0756 | 0.9657 |
N-METHYL-D-ASPARTIC ACID | 0.4707 | 0.6953 | 0.2249 | 0.6245 | 0.2862 | 3.6983 |
O-ACETYL-L-SERINE | 1.1682 | 0.6732 | 0.2657 | 0.3640 | 0.3028 | 3.2262 |
(R)-MALATE | 1.6440 | 1.8768 | 0.1303 | 1.0562 | 0.3649 | 0.9278 |
Salicylic Acid-d4 | 0.9870 | 0.9742 | 0.9018 | 0.9766 | 1.0344 | 1.1259 |
SUCCINATE | 3.1801 | 0.9522 | 0.2817 | 0.5150 | 0.4249 | 0.6461 |
Succinic Acid-d4 | 0.8859 | 1.0344 | 0.9700 | 1.0791 | 0.9915 | 1.0391 |
THREONINE/HOMOSERINE | 0.4796 | 0.9555 | 0.5011 | 0.6160 | 0.3833 | 3.0646 |
THYMIDINE 5^-MONOPHOSPHATE | 0.0226 | 0.2333 | 0.0002 | 0.0014 | 0.0951 | 3.3099 |
URACIL | 2.8052 | 0.3958 | 0.3066 | 0.2086 | 0.4546 | 1.8291 |
URATE | 0.7567 | 2.0073 | 0.6887 | 0.9199 | 0.6726 | 0.9549 |
URIDINE | 2.5718 | 0.9950 | 0.2394 | 0.3133 | 0.4704 | 1.4101 |
UROCANATE | 1.3817 | 1.7653 | 0.7861 | 0.7302 | 0.7409 | 0.5958 |
XANTHINE | 0.6044 | 1.0749 | 0.2826 | 0.5895 | 0.4922 | 2.9564 |
Factors:
F1 | Strain:CRBN -/- | Treatment:anti-CD3 & anti-CD28 stimulation |
F2 | Strain:CRBN +/+ | Treatment:anti-CD3 & anti-CD28 stimulation |
F3 | Strain:CRBN -/- | Treatment:anti-CD3 stimulation |
F4 | Strain:CRBN +/+ | Treatment:anti-CD3 stimulation |
F5 | Strain:CRBN -/- | Treatment:unstimulated |
F6 | Strain:CRBN +/+ | Treatment:unstimulated |