Data for Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures (Study ST000379)

(Analysis AN000613)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12F13
1,2,4-benzenetriol 0.9321 1.1269 1.0480 0.7735 0.7526 1.1397 0.9369 0.8685 1.2194 1.2267 1.1526 0.9353 0.8878
1-monostearin 1.0570 0.7424 0.6453 0.8468 0.8468 0.8874 0.7534 0.8173 0.8604 2.8330 0.9501 0.9169 0.8432
2-aminoadipic acid 0.5174 0.8496 0.4176 1.3285 1.5622 1.1275 0.9452 1.6706 1.6790 1.2721 0.3326 0.9226 0.3751
2-hydroxyglutaric acid 0.4875 0.5740 0.9371 0.7416 1.3791 0.5728 1.6089 0.7916 1.6972 1.2287 1.5311 0.9507 0.4998
2-ketoisocaproic acid 0.9750 0.9981 0.9852 1.1176 1.0748 0.9845 1.0042 0.9581 0.8983 1.0382 1.1292 0.9255 0.9112
3-aminoisobutyric acid 1.0555 0.9248 1.0367 0.9295 1.2415 0.8430 1.0423 0.9211 0.8788 0.9530 1.3609 0.9333 0.8797
3-phosphoglycerate 0.8982 1.1967 1.3464 1.3670 0.8799 0.8071 0.7114 0.8205 0.9233 1.2784 1.3259 1.1937 0.2515
5^-deoxy-5^-methylthioadenosine 1.0715 0.8483 1.4562 0.5854 0.9440 0.7736 1.2594 0.4414 1.3988 1.0664 2.1099 0.4921 0.5531
6-deoxyglucitol NIST 1.0527 0.9057 0.8092 1.5246 0.8557 0.7366 0.9018 0.8653 1.0595 0.8282 1.2026 1.3002 0.9579
adenine 1.1727 0.7777 1.2410 0.6197 1.1390 0.8043 1.1748 0.5849 1.4270 1.0918 1.5537 0.4755 0.9379
adenosine 1.2835 1.1728 0.6507 1.0102 0.5843 1.2507 0.9997 0.6981 1.0195 0.7286 1.6814 0.9032 1.0173
alanine 0.5264 0.6932 1.7978 1.1275 0.5096 0.6827 1.9378 1.2373 0.4554 0.6784 1.5686 1.2649 0.5204
alpha ketoglutaric acid 0.8511 0.7418 1.3698 1.6239 0.7133 0.4711 1.1700 1.0573 0.5227 1.0034 1.1109 2.0634 0.3014
arachidic acid 0.6324 0.6233 0.9568 0.9936 1.0377 0.9406 1.1119 1.3513 1.2107 1.2896 0.8840 0.9438 1.0244
asparagine 1.3513 0.8565 0.6919 0.8336 0.7495 0.7057 0.9472 0.7368 0.8957 1.2621 1.7497 1.0163 1.2039
aspartic acid 0.7025 1.6255 0.3703 1.1378 0.6528 2.0327 0.3996 1.7308 0.4898 1.5613 0.3078 1.4167 0.5724
behenic acid 0.9984 0.5713 0.5638 0.8446 0.9775 0.7739 0.8789 1.1865 1.0741 0.8744 1.0102 0.8262 2.4201
benzoic acid 1.0575 1.0668 0.9755 1.1279 1.0371 1.0789 1.0008 0.8959 1.1402 1.0660 0.7850 0.8884 0.8802
beta-alanine 1.3305 1.3702 0.5398 0.8741 1.1765 1.4580 0.5120 0.7600 1.1523 1.4056 0.3167 0.8921 1.2122
beta-sitosterol 1.0091 1.0583 1.3453 0.8101 1.0376 0.9870 1.0335 1.0221 1.0420 0.8540 1.1916 0.8119 0.7975
butylamine NIST 1.0719 0.8765 0.8306 0.8692 1.0067 0.9623 1.1346 0.9649 1.1421 0.9165 1.3553 1.0206 0.8489
capric acid 1.0529 0.9676 0.9183 0.9382 1.0951 0.8937 1.0810 0.9036 1.1235 1.0463 1.1909 0.8901 0.8989
cholesterol 1.7240 3.7788 0.1213 3.6081 0.1106 0.0933 0.1083 0.0958 0.1149 0.0950 1.4817 1.5798 0.0885
citramalic acid 1.1802 0.9246 0.8799 1.0305 1.0250 0.9732 0.8603 0.8368 1.0995 0.8822 0.9481 0.9615 1.3983
creatinine 0.7645 0.8569 0.7098 1.0290 1.4570 1.1234 0.9901 1.1109 1.0369 1.1347 1.2899 1.1749 0.3221
cysteine 0.8554 0.5930 0.7995 0.8252 0.9325 0.7854 0.6169 0.7951 1.0947 0.9095 0.7871 0.7836 3.2221
cytidine-5-monophosphate NIST 1.3934 0.8824 0.6369 0.3670 1.3161 1.0410 0.7332 0.6976 1.3298 1.0901 1.5229 1.0849 0.9046
dehydroabietic acid 1.0407 0.8735 0.8349 1.0725 1.0448 0.9555 0.9416 0.8611 1.1070 0.9625 1.1743 0.8428 1.2887
dodecane 0.7993 1.0322 1.0565 0.9895 1.0366 0.9587 1.1338 0.7740 1.1491 0.9633 1.3853 0.8527 0.8690
dodecanol 1.0877 1.2369 1.0020 0.9197 0.9517 0.9035 0.8245 0.8977 1.0148 1.0125 0.9605 0.9038 1.2845
elaidic acid 0.3919 0.8010 0.8040 1.0946 0.6759 0.7179 1.0100 2.2824 1.0759 0.9083 1.5255 0.7179 0.9949
erythritol 1.1816 0.7437 0.8345 0.8842 1.2549 0.8800 0.9506 0.9987 1.0884 0.7059 0.8036 0.8494 1.8245
fructose 0.1548 0.1602 0.2015 0.0911 3.6493 2.7815 2.2146 2.6688 0.2430 0.1163 0.1018 0.1159 0.5013
fructose-6-phosphate 1.6560 0.8323 0.7822 0.9806 1.0698 1.0414 1.8962 1.0583 1.5273 0.4186 0.1997 0.4792 1.0583
fumaric acid 0.9125 1.4712 0.7053 1.6436 0.5923 1.1706 0.6536 1.4386 0.5364 1.1694 0.5875 1.7757 0.3433
galactose-6-phosphate 1.3118 0.7260 1.4673 1.0494 1.4897 1.0822 1.1936 0.8302 1.9553 0.5433 0.2893 0.4640 0.5978
gluconic acid 0.9843 0.9770 0.7508 1.0234 1.1335 0.8180 0.6114 1.3059 0.9501 1.1958 0.6432 1.1347 1.4722
gluconic acid lactone 0.3644 0.3323 0.4361 0.2832 1.0273 1.1515 0.6792 1.2346 0.4257 0.2738 0.2053 0.2955 6.2911
glucose 1.6637 1.2960 2.2905 0.7712 1.0544 0.5877 0.5487 0.5385 1.7938 0.4643 0.4727 0.4585 1.0599
glucose-6-phosphate 1.4642 0.9020 1.0948 1.0201 1.5455 1.2990 1.1063 1.2463 1.6326 0.5327 0.2077 0.5175 0.4312
glutamic acid 1.0160 1.2610 0.6415 1.0602 1.0915 1.2272 0.6520 0.9851 1.3196 1.4694 0.8025 0.9658 0.5081
glutamine 1.1878 1.3382 0.2690 0.9285 1.2087 1.4052 0.1672 1.1403 1.4718 1.2472 0.1785 1.0548 1.4026
glutathione 1.0052 0.9401 1.1047 1.1353 0.7182 0.9074 1.0444 0.8371 1.0612 1.3356 1.1366 0.9586 0.8156
glycerol-alpha-phosphate 1.7798 1.1210 1.0256 1.1732 1.2710 0.8972 0.8998 0.7945 0.9631 0.9161 0.3907 0.8780 0.8898
glycerol-beta-phosphate 1.4831 0.8486 1.0417 1.0483 1.2493 0.7948 0.9485 0.7882 1.1941 0.9655 0.8263 0.7396 1.0719
glycine 0.8253 0.9239 0.9724 1.0548 0.9487 0.9542 1.3169 1.1778 0.8005 0.9187 1.1959 1.0688 0.8421
glycolic acid 0.7245 0.6914 0.9312 0.8144 1.3911 0.6370 1.0596 1.0871 1.1146 1.0179 1.6480 1.1117 0.7715
hexuronic acid 1.0501 0.9254 0.9616 0.9297 0.9848 0.7919 0.8470 0.7325 1.0196 0.8427 0.9964 0.8746 2.0436
homoserine 1.0560 0.7783 1.0339 0.8340 1.0312 0.8816 1.1909 0.6817 1.3137 1.1077 1.3452 0.7508 0.9950
hydroxylamine 1.0934 0.9636 0.7363 0.9798 1.0867 1.0255 0.9521 0.9220 1.1845 1.0023 1.2003 0.8074 1.0462
idonic acid NIST 0.9617 0.9964 1.0019 0.9232 1.1286 0.9129 1.1184 0.8272 0.9185 1.3639 1.3482 0.9192 0.5800
inosine 0.9809 0.7972 0.9321 0.9123 0.9405 0.8518 0.8856 0.8981 0.8754 0.7533 0.9178 0.7992 2.4558
inositol-4-monophosphate 0.9046 0.9172 1.3344 0.8643 0.9063 0.8748 1.2146 0.8811 1.0199 0.8659 1.5632 0.7078 0.9458
inositol myo- 0.8553 0.8401 1.1448 0.7043 1.1144 1.0187 1.1440 0.8320 1.2938 1.1039 1.3722 0.7225 0.8540
isoleucine 1.0449 1.0448 0.8355 0.8796 1.2029 1.2025 0.8650 0.9232 1.1884 1.1699 0.9073 0.8769 0.8590
isothreonic acid 1.0617 0.9396 0.8281 0.9896 1.1393 0.9633 0.9694 0.8643 0.6406 0.7169 0.4358 1.0803 2.3711
lactic acid 0.9853 0.8735 1.7317 1.0636 0.7690 0.7444 1.2723 1.0642 0.8540 0.7844 1.2056 1.1043 0.5477
lathosterol NIST 1.0567 0.8636 1.3674 1.2689 0.8445 0.7564 0.9222 1.1038 1.1240 0.7581 1.0616 1.2110 0.6618
lauric acid 0.5850 0.5933 1.1121 1.3763 1.5328 1.0564 0.8808 1.0595 1.1080 1.3083 0.5123 0.9414 0.9338
leucine 1.0746 1.0189 0.7845 0.8991 1.2906 1.2386 0.7901 0.8619 1.2010 1.2642 0.7716 0.8798 0.9251
lysine 0.7602 1.0032 1.2207 0.6776 0.9686 0.8871 1.0339 1.2096 1.2850 0.7420 1.0009 0.7923 1.4188
malic acid 0.9076 1.4761 0.6529 1.6501 0.5329 1.1689 0.6158 1.4687 0.4783 1.2127 0.6052 1.9831 0.2477
mannitol 0.8154 0.6693 1.1417 0.6988 0.9503 1.3855 0.6516 0.4611 0.8822 0.7068 0.7528 0.7553 3.1293
mannose 1.0490 0.8632 1.5035 0.4003 1.5882 1.0843 1.2235 1.1218 1.6771 0.1703 0.2621 0.1690 1.8876
mannose-6-phosphate NIST 2.2567 1.4035 1.1850 2.0477 0.6894 0.9881 0.4019 0.9246 0.9998 0.4902 0.2794 0.5220 0.8117
methanolphosphate 1.2689 1.1535 0.5820 1.1109 1.2443 1.0236 0.5987 1.1495 1.2907 1.2736 0.5429 1.3283 0.4331
methionine 1.0552 1.0009 0.6763 0.9327 1.2484 1.3759 0.7499 0.8892 1.1634 1.3309 0.8159 0.8834 0.8780
methylhexadecanoic acid 1.1136 1.0859 0.7694 1.0934 1.2026 0.9059 0.8105 1.4057 0.8931 0.9720 1.0321 0.9331 0.7828
monopalmitin-1-glyceride 1.0502 1.0084 0.8720 1.0759 0.9945 1.0669 0.8623 1.2478 1.1497 1.0230 0.9604 1.0042 0.6848
myristic acid 0.9160 0.7564 0.9497 1.0495 1.1212 0.9852 0.9818 1.2322 1.1626 1.0703 1.0402 0.8544 0.8807
N-acetylaspartic acid 1.1375 0.9440 0.7319 1.0883 1.1177 0.9889 0.8840 0.7928 1.3611 1.2071 1.1902 1.0511 0.5054
N-acetyl-D-mannosamine 1.1721 0.7282 0.7313 0.8332 1.0946 0.8754 0.9099 0.9030 1.1698 0.7405 0.7489 0.7750 2.3181
N-methylalanine 1.0712 1.1726 0.7279 1.0739 1.0849 1.1303 0.9928 0.8048 1.1112 0.9594 1.1824 0.9075 0.7810
octadecanol 1.0469 0.7802 0.8495 0.8726 1.0021 0.9228 1.4194 0.9582 1.0254 1.0201 1.0741 0.9883 1.0405
oleic acid 0.8657 0.9100 0.8344 0.7248 0.9872 0.6592 1.0297 1.8988 1.2987 1.1262 0.9641 0.8710 0.8301
ornithine 0.6679 0.7402 1.3003 0.9594 1.1710 0.9482 1.1219 1.2763 0.9815 1.0024 0.9663 0.9404 0.9241
oxoproline 1.2639 1.1629 0.6775 1.0604 1.0393 1.0791 0.6404 0.9173 1.3070 1.2668 0.7820 0.9965 0.8070
palmitic acid 0.9691 1.0225 0.8381 0.8397 1.0480 1.1479 0.9831 1.0520 0.9722 1.0090 1.2636 0.9245 0.9302
pantothenic acid 1.0350 1.2207 0.3832 1.1696 0.9297 1.2782 0.4883 1.2519 0.9218 1.5422 0.3300 1.4468 1.0026
pelargonic acid 1.0013 1.2390 1.2581 0.8055 1.0538 0.6459 1.1341 0.8153 0.9967 0.9304 1.4505 0.9376 0.7317
phenylalanine 1.0448 1.0909 0.7694 0.9207 1.1711 1.2568 0.7799 0.9964 1.1841 1.2141 0.8373 0.9276 0.8067
phosphoethanolamine 0.8848 0.7827 0.9947 0.8487 1.0666 0.9959 0.6659 1.1717 0.8794 1.1258 1.2724 1.0502 1.2613
phosphogluconic acid 0.9170 1.1959 0.9463 1.4505 0.7238 1.0633 0.7201 1.2336 1.1222 0.8935 0.6471 1.4573 0.6294
phosphoric acid 0.9787 0.9483 1.0122 0.7894 1.1327 0.9606 1.0653 0.8216 0.9172 0.8810 1.5064 0.8064 1.1802
p-hydroquinone 1.1720 0.9872 0.8973 0.9553 0.9878 1.0103 0.9915 0.8398 1.1295 0.9922 1.2176 0.8667 0.9528
proline 1.0076 0.8704 1.1659 1.1102 0.9932 0.9205 1.0974 0.8781 0.8748 1.1048 0.9741 1.1119 0.8913
propane-1,3-diol NIST 0.9185 0.9947 0.9096 0.8924 1.1123 0.8759 0.9633 0.8713 1.2586 1.1142 1.0428 1.0321 1.0144
putrescine 0.3540 0.6414 0.0859 2.8420 0.2997 0.2921 0.0701 3.3814 0.3751 0.3871 0.1695 4.0058 0.0959
pyrazine 2,5-dihydroxy NIST 0.7571 0.9363 0.6946 1.3916 1.0253 0.9016 0.8037 1.1924 0.9873 1.2915 0.8330 1.5259 0.6596
pyrophosphate 1.0020 0.9963 0.8172 1.0026 0.9144 0.9247 0.9145 1.0578 0.8506 0.7725 0.6200 1.2085 1.9189
ribitol 0.7719 0.7071 0.7740 0.6599 0.7240 0.7529 0.6261 0.7155 0.5789 0.6705 0.5627 0.7902 4.6664
ribose 0.9203 0.9243 0.6415 1.1138 0.8688 1.5915 1.0867 1.1882 0.9324 0.8783 0.8945 0.8878 1.0718
ribose-5-phosphate 1.3477 0.9365 1.1383 1.1265 1.2333 0.8230 0.8677 0.8939 1.0607 0.7527 0.7178 1.0274 1.0746
ribulose-5-phosphate 0.9087 0.9022 0.8687 0.8817 0.9368 0.9769 0.6567 0.9866 0.8330 0.9001 0.6491 1.0255 2.4741
salicylaldehyde 1.0560 1.2167 0.9030 0.6256 1.3262 1.1948 1.2474 0.8153 0.8021 0.9921 1.3391 0.9005 0.5812
serine 0.9766 0.9365 0.5868 0.9707 1.0408 1.1675 1.1624 1.3153 0.9395 1.2035 0.8185 1.2178 0.6642
sorbitol 0.0699 0.0889 0.1060 0.0784 0.3079 0.2528 0.2836 0.2402 0.1094 0.1070 0.0661 0.0775 11.2121
stearic acid 0.9721 0.9993 0.9126 0.9242 1.0089 1.0942 1.0187 0.8399 1.0570 1.0250 1.3164 0.8573 0.9745
succinic acid 0.5171 0.9690 0.7723 1.4189 1.0645 1.0362 0.8618 1.5846 0.7319 0.9637 0.7626 1.8973 0.4202
sucrose 1.3917 1.2752 0.7400 0.8363 0.7387 0.9688 0.6798 0.9206 1.1856 0.8377 1.0571 1.4786 0.8899
tagatose 0.3748 0.3303 0.3400 0.3936 0.4214 0.3442 0.4311 0.3665 0.5201 0.3609 0.4221 0.3762 8.3187
talose 2.2254 0.9389 4.6528 1.0947 0.0787 0.9619 0.4404 0.8573 1.0218 0.3505 0.1043 0.2336 0.0397
taurine 0.6617 0.6182 0.8501 0.8183 0.8419 1.0679 1.9475 0.6735 1.1233 0.8442 2.1936 0.6087 0.7512
threonine 0.9653 1.0373 0.7460 1.0181 1.0579 1.1755 0.8769 1.1496 0.9389 1.1523 0.7815 1.0850 1.0157
trans-4-hydroxyproline 1.0214 0.9917 0.7451 1.0709 1.0890 1.0359 0.9139 1.0979 0.9805 1.0118 0.8117 1.2746 0.9555
triethanolamine 0.9333 0.8019 0.8234 0.8477 1.0036 0.8640 0.8103 2.1007 0.9961 0.9737 1.0855 0.8568 0.9032
tryptophan 0.9147 0.9554 0.9233 0.8982 1.0918 1.1037 0.9728 1.0147 1.0435 1.1155 1.0772 0.9391 0.9502
tyrosine 0.3346 1.4404 0.9905 0.6971 1.1982 1.3236 1.1656 1.5732 0.8004 1.1697 0.3897 0.6936 1.2236
UDP GlcNAc 0.4247 0.4073 0.6506 0.5580 0.6113 0.4733 0.7749 0.5549 0.4355 0.3884 0.2988 0.5021 6.9202
uracil 1.1174 0.8658 0.6403 0.9564 0.7374 0.8251 0.9172 0.5222 0.8314 0.6845 0.9669 0.7530 3.1822
urea 1.5055 0.8393 0.8400 0.5497 1.0659 0.9218 0.0439 2.1312 2.0665 1.0944 0.0498 1.4638 0.4283
valine 1.0176 0.8060 0.9269 0.9142 1.1291 1.1723 0.9447 0.9063 1.1751 1.1847 1.0069 0.9385 0.8777
zymosterol 1.3179 0.9852 0.8217 0.9753 1.0080 0.8804 1.0335 1.0608 1.1535 0.8938 1.0469 0.8575 0.9655
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Treatment:10.5mM Glu | Time:10min
F2Treatment:10.5mM Glu | Time:1hr
F3Treatment:10.5mM Glu | Time:24hr
F4Treatment:10.5mM Glu | Time:6hr
F5Treatment:5.5mM Glu 5mM Fru | Time:10min
F6Treatment:5.5mM Glu 5mM Fru | Time:1hr
F7Treatment:5.5mM Glu 5mM Fru | Time:24hr
F8Treatment:5.5mM Glu 5mM Fru | Time:6hr
F9Treatment:5.5mM Glu | Time:10min
F10Treatment:5.5mM Glu | Time:1hr
F11Treatment:5.5mM Glu | Time:24hr
F12Treatment:5.5mM Glu | Time:6hr
F13Treatment:Glucosamine | Time:10min
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