Data for Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures (part II) (Study ST000380)
(Analysis AN000614)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5^-Methylthioadenosine | 1.0647 | 0.9726 | 1.6936 | 0.5202 | 0.9798 | 0.7997 | 1.4415 | 0.5357 | 1.1554 | 1.0454 | 1.7636 | 0.5234 | 0.5543 |
| Acylcarnitine C12:0 | 0.5225 | 0.2990 | 0.7093 | 0.4092 | 1.0808 | 0.8654 | 2.4869 | 0.9347 | 1.2575 | 0.8413 | 3.2847 | 0.5815 | 0.0969 |
| Acylcarnitine C14:0 | 0.5948 | 0.4204 | 0.5902 | 0.5696 | 1.0996 | 0.8732 | 1.7581 | 0.9276 | 1.6117 | 1.0956 | 2.8142 | 0.6627 | 0.2726 |
| Acylcarnitine C14:1 | 0.4182 | 0.2893 | 0.5766 | 0.3656 | 0.9393 | 0.9026 | 1.9487 | 0.8160 | 1.5040 | 1.1347 | 3.7679 | 0.5901 | 0.1777 |
| Acylcarnitine C16:0 | 0.8355 | 0.5381 | 0.5831 | 0.5989 | 1.1874 | 0.8524 | 1.5332 | 0.8439 | 1.5774 | 1.0452 | 2.5335 | 0.6206 | 0.4804 |
| Acylcarnitine C16:1 | 0.6876 | 0.5126 | 0.4605 | 0.6855 | 0.9807 | 0.9688 | 1.2648 | 1.0935 | 1.8828 | 1.4004 | 2.1609 | 0.7475 | 0.3635 |
| Acylcarnitine C18:0 | 0.5953 | 0.3555 | 0.8683 | 0.4877 | 0.9246 | 0.5514 | 2.2898 | 0.6713 | 1.3487 | 0.8092 | 3.6872 | 0.4987 | 0.3056 |
| Acylcarnitine C18:1 | 0.7709 | 0.5067 | 0.6403 | 0.6122 | 0.9925 | 0.8101 | 1.4537 | 0.9210 | 1.7575 | 1.2118 | 2.5461 | 0.6112 | 0.4106 |
| Acylcarnitine C2:0 | 1.4021 | 1.0074 | 0.8075 | 1.1105 | 1.1349 | 1.0189 | 1.0144 | 1.0251 | 1.0693 | 1.0097 | 0.9538 | 1.0741 | 0.3688 |
| Acylcarnitine C3:0 | 0.8729 | 1.1007 | 0.9958 | 0.8155 | 0.9816 | 1.3868 | 0.9660 | 0.8033 | 1.1006 | 1.1456 | 0.7477 | 0.7367 | 1.2719 |
| Acylcarnitine C4:0 | 0.8252 | 1.2300 | 0.5794 | 1.0215 | 0.8837 | 2.0925 | 0.6794 | 0.9662 | 0.8891 | 1.8367 | 0.3229 | 1.1477 | 0.4072 |
| Adenine | 1.0538 | 0.9831 | 1.5770 | 0.5642 | 0.9762 | 0.8243 | 1.4072 | 0.5347 | 1.2145 | 1.1192 | 1.5929 | 0.5659 | 0.6083 |
| Adenosine | 1.0701 | 0.7852 | 1.0562 | 1.2295 | 1.0877 | 1.2606 | 1.3531 | 1.3517 | 0.7462 | 0.6582 | 0.8753 | 0.8662 | 0.6977 |
| Betaine | 0.8708 | 0.8962 | 1.0442 | 0.9649 | 1.0155 | 1.1059 | 1.1259 | 0.9659 | 0.9754 | 1.0618 | 0.9962 | 1.0326 | 0.9385 |
| Carnitine | 0.7932 | 0.9780 | 1.0502 | 0.9962 | 0.9232 | 1.4490 | 1.1198 | 0.9075 | 1.0737 | 1.3798 | 0.6420 | 1.2360 | 0.3763 |
| Choline | 1.1360 | 1.0038 | 1.5285 | 1.0649 | 0.9217 | 1.0460 | 1.3147 | 0.9846 | 0.6169 | 0.5377 | 0.5172 | 0.8141 | 1.4308 |
| Creatine | 0.9159 | 0.7722 | 0.9042 | 1.0268 | 1.0687 | 1.1484 | 1.2942 | 1.1144 | 0.8861 | 0.8470 | 1.4982 | 1.0789 | 0.5472 |
| Creatinine | 1.0434 | 0.9414 | 0.9196 | 1.0720 | 0.9092 | 1.1003 | 0.8690 | 1.1678 | 1.0379 | 1.3659 | 0.6702 | 1.4888 | 0.3876 |
| Glutamine | 1.0517 | 1.4082 | 0.2727 | 1.3635 | 0.8250 | 1.7970 | 0.2333 | 1.1388 | 0.9546 | 1.5684 | 0.1094 | 1.3931 | 0.7588 |
| lysoPC 16:0 | 1.1212 | 1.2471 | 1.1651 | 1.0179 | 0.9154 | 1.1623 | 0.9558 | 0.7841 | 0.9619 | 1.0538 | 0.7887 | 0.8444 | 0.9111 |
| lysoPC 16:1 | 0.8544 | 1.0616 | 1.1290 | 0.9403 | 0.7666 | 1.1477 | 1.3195 | 0.9419 | 0.9286 | 1.1072 | 1.0926 | 0.9854 | 0.7310 |
| lysoPC 18:0 | 1.2365 | 1.3444 | 1.0504 | 1.1105 | 0.9202 | 1.1721 | 0.7003 | 0.7893 | 1.0371 | 1.1748 | 0.6540 | 0.8771 | 0.8405 |
| lysoPC 18:1 | 1.0266 | 1.1471 | 1.4117 | 1.0375 | 0.8202 | 1.0775 | 1.1392 | 0.8302 | 0.8798 | 0.9754 | 0.9638 | 0.8706 | 0.7862 |
| lysoPE 16:0 | 1.0181 | 0.9019 | 0.9431 | 0.7816 | 1.1300 | 1.1231 | 1.0956 | 0.7768 | 1.2022 | 1.1839 | 1.1801 | 0.7939 | 0.8626 |
| lysoPE 18:0 | 1.3503 | 1.0793 | 1.0062 | 0.9759 | 1.1608 | 1.1325 | 1.0623 | 0.8189 | 1.0019 | 0.9185 | 0.8188 | 0.7687 | 0.8455 |
| lysoPE 18:1 | 1.0420 | 0.9950 | 1.1835 | 0.8610 | 1.0673 | 1.0652 | 1.2856 | 0.8253 | 1.0153 | 1.0521 | 1.1702 | 0.7746 | 0.6620 |
| Pantothenic Acid | 0.9207 | 1.3260 | 0.4448 | 1.3530 | 0.8103 | 1.4459 | 0.4932 | 1.3423 | 0.8377 | 1.4731 | 0.2930 | 1.5570 | 0.6421 |
| PC 32:2 | 0.7609 | 0.8297 | 0.8690 | 1.0592 | 1.0015 | 1.0042 | 1.1316 | 1.1044 | 1.0273 | 1.0771 | 1.1820 | 1.1085 | 0.8924 |
| PC 34:1 | 1.0320 | 1.0336 | 0.9789 | 1.0413 | 0.9451 | 1.0240 | 0.9840 | 1.0547 | 0.9904 | 0.9883 | 0.9235 | 1.0462 | 0.9543 |
| PC 34:2 | 0.9723 | 0.9837 | 0.9451 | 1.1188 | 0.9265 | 1.0196 | 0.9522 | 1.0816 | 0.9775 | 1.0224 | 0.9103 | 1.1504 | 0.9384 |
| PC 34:4 | 0.9461 | 0.9931 | 0.9034 | 1.0934 | 0.9637 | 1.0867 | 1.0307 | 1.1132 | 1.0041 | 0.9153 | 0.9159 | 1.0801 | 0.9592 |
| PC 36:2 | 1.0704 | 1.0762 | 0.9877 | 1.1378 | 0.7972 | 1.1005 | 0.9304 | 1.0710 | 0.9677 | 1.0653 | 0.7893 | 1.2382 | 0.7451 |
| PC 36:3 | 0.9754 | 0.9773 | 0.9844 | 1.1115 | 0.7945 | 1.1186 | 0.9987 | 1.0652 | 0.9516 | 1.0845 | 0.8749 | 1.2796 | 0.7739 |
| PC 38:2 | 1.1621 | 1.2634 | 1.0541 | 1.1108 | 0.8252 | 1.1377 | 1.0348 | 1.2130 | 0.9986 | 0.8713 | 0.6962 | 1.0790 | 0.5385 |
| PC 38:3 | 1.1216 | 1.1497 | 0.9825 | 1.0228 | 0.8661 | 1.1672 | 1.0528 | 1.1538 | 1.0816 | 0.9077 | 0.7703 | 1.0220 | 0.6891 |
| PC 38:4 | 1.0644 | 1.0792 | 0.9468 | 1.0593 | 0.8169 | 1.0598 | 1.0619 | 1.1243 | 1.0909 | 0.9273 | 0.8324 | 1.1216 | 0.8079 |
| PC 38:5 | 1.0354 | 1.0389 | 0.9645 | 1.1030 | 0.9507 | 1.0670 | 0.9645 | 1.0767 | 0.9714 | 0.9645 | 0.8241 | 1.0932 | 0.9296 |
| PC 40:7 | 1.0599 | 1.0370 | 0.8962 | 1.0631 | 0.8405 | 1.0303 | 1.0704 | 1.2031 | 1.0983 | 0.9017 | 0.8633 | 1.1627 | 0.7845 |
| PE 32:1 | 0.7937 | 0.7911 | 0.6871 | 0.7770 | 0.8594 | 1.1147 | 1.1424 | 1.0431 | 1.1467 | 1.1587 | 1.2554 | 1.0901 | 1.1903 |
| PE 32:2 | 0.6785 | 0.7103 | 0.6641 | 0.7384 | 0.9239 | 1.0986 | 1.2834 | 1.0728 | 1.1803 | 1.1938 | 1.4184 | 1.0663 | 1.0531 |
| PE 34:1 | 0.8637 | 0.8926 | 0.7738 | 0.7595 | 0.8651 | 1.0996 | 1.0827 | 0.9810 | 1.1767 | 1.1332 | 1.3164 | 0.9923 | 1.1131 |
| PE 34:2 | 0.8844 | 0.9113 | 0.7098 | 0.8790 | 0.8567 | 1.1065 | 1.0401 | 1.1249 | 1.1166 | 1.0874 | 1.0623 | 1.1504 | 1.1017 |
| PE 34:3 | 0.8784 | 0.8767 | 0.6956 | 0.8838 | 0.9203 | 1.1159 | 1.1249 | 1.1574 | 1.0684 | 1.0706 | 1.0041 | 1.1739 | 1.0569 |
| PE 36:2 | 0.9430 | 0.9905 | 0.8322 | 0.8621 | 0.8856 | 1.1133 | 1.0792 | 1.0633 | 1.1133 | 1.0231 | 1.0673 | 1.0586 | 0.9902 |
| PE 36:3 | 0.8980 | 0.9668 | 0.7532 | 0.9122 | 0.8864 | 1.1581 | 1.1019 | 1.1960 | 1.0673 | 1.0221 | 0.9509 | 1.1697 | 0.9419 |
| PE 36:4 | 0.9329 | 0.9955 | 0.7811 | 0.9471 | 0.8423 | 1.1110 | 1.0436 | 1.1687 | 1.0594 | 1.0466 | 0.9551 | 1.1684 | 0.9688 |
| PE 38:6 | 0.9166 | 1.0107 | 0.7493 | 0.9949 | 0.8546 | 1.1338 | 1.0575 | 1.2545 | 1.0302 | 1.0186 | 0.8814 | 1.1909 | 0.9297 |
| Phenylalanine | 0.8936 | 1.0785 | 0.9942 | 1.0984 | 1.0696 | 1.3112 | 1.0730 | 1.1552 | 0.9841 | 0.9050 | 0.6507 | 1.0876 | 0.6665 |
| Proline | 0.8718 | 0.9067 | 1.3642 | 1.2106 | 0.8158 | 0.9726 | 1.2998 | 1.0907 | 0.7911 | 0.9439 | 0.7546 | 1.2623 | 0.6901 |
| SM 32:1 | 0.9330 | 0.8878 | 0.8554 | 0.9393 | 0.9932 | 1.1265 | 1.1723 | 1.0967 | 1.0185 | 1.0638 | 1.0472 | 1.1328 | 0.7574 |
| SM 34:1 | 1.0146 | 1.0319 | 0.8876 | 1.0005 | 0.9897 | 1.1363 | 0.9603 | 1.0327 | 0.9918 | 1.0805 | 0.9617 | 1.0318 | 0.8798 |
| Taurine | 0.9142 | 0.8675 | 0.9144 | 0.9382 | 1.0614 | 1.1343 | 1.2869 | 0.8443 | 1.2856 | 1.2342 | 1.4197 | 0.8788 | 0.2645 |
| Taurine Dimer | 0.8442 | 0.7641 | 0.8161 | 0.8384 | 1.0323 | 1.1556 | 1.4666 | 0.7684 | 1.4894 | 1.3364 | 1.6611 | 0.7880 | 0.1110 |
| Thiamine | 0.7933 | 1.1737 | 0.9812 | 0.9307 | 0.9573 | 1.2689 | 1.0386 | 0.9338 | 1.0645 | 1.0822 | 1.0727 | 0.9267 | 0.7775 |
Factors:
| F1 | Treatment:10.5mM Glu | Time:10min |
| F2 | Treatment:10.5mM Glu | Time:1hr |
| F3 | Treatment:10.5mM Glu | Time:24hr |
| F4 | Treatment:10.5mM Glu | Time:6hr |
| F5 | Treatment:5.5mM Glu 5mM Fru | Time:10min |
| F6 | Treatment:5.5mM Glu 5mM Fru | Time:1hr |
| F7 | Treatment:5.5mM Glu 5mM Fru | Time:24hr |
| F8 | Treatment:5.5mM Glu 5mM Fru | Time:6hr |
| F9 | Treatment:5.5mM Glu | Time:10min |
| F10 | Treatment:5.5mM Glu | Time:1hr |
| F11 | Treatment:5.5mM Glu | Time:24hr |
| F12 | Treatment:5.5mM Glu | Time:6hr |
| F13 | Treatment:Glucosamine | Time:10min |
