Data for Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine (Study ST000401)

(Analysis AN000640)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10
1,5-anhydroglucitol	0.7511	0.8676	0.9625	1.1867	1.1030	0.8397	0.8617	0.8135	1.4379	1.1762
1-monopalmitin	0.8464	2.0003	0.3980	0.4014	3.3773	0.6532	1.3594	0.4397	0.3465	0.1777
2,5-dihydroxypyrazine NIST	1.0209	0.3684	0.7004	1.4442	0.5376	0.6755	1.2699	1.0419	1.9396	1.0017
2-deoxytetronic acid NIST	0.8113	0.8770	1.1992	1.0373	0.9513	0.9007	0.7792	1.0373	1.2970	1.1098
2-hydroxybutanoic acid	0.6206	0.9440	0.7600	1.4153	1.1884	0.8406	0.9103	0.7032	1.1775	1.4404
2-hydroxyglutaric acid	0.7505	0.9301	1.3919	0.6671	1.4817	0.9622	0.6928	0.9365	0.9429	1.2444
2-ketoisocaproic acid	0.3974	5.0131	1.3518	0.3800	0.3679	0.3793	0.9369	0.3297	0.4752	0.3686
2-monopalmitin	1.0747	1.9982	0.6469	0.8703	3.3592	0.5416	0.7358	0.3258	0.3204	0.1272
3-hydroxybutyric acid	0.9140	1.1179	0.9313	1.2896	0.8736	0.8125	1.0619	0.7538	1.4011	0.8443
4-hydroxybutyric acid	1.1343	0.6942	0.7397	1.2459	1.0909	0.7707	0.8636	0.7872	1.3512	1.3223
5-aminovaleric acid	1.2546	1.2809	1.4503	0.8471	0.6661	0.7829	0.9023	1.0062	1.1205	0.6892
5-methoxytryptamine	0.5939	0.6742	1.1594	0.9071	0.8773	1.1581	1.1931	1.0132	1.2759	1.1478
6-deoxyglucose	0.4666	0.2835	0.2590	0.5692	1.8230	0.6902	0.6143	0.4164	2.1857	2.6922
adenosine	0.7910	0.8350	1.1426	0.9180	1.0986	1.2109	0.6592	0.8691	0.9033	1.5723
adenosine-5-monophosphate	0.7891	0.9339	1.1893	1.6946	1.0304	0.7891	0.8232	0.9339	0.9083	0.9083
alanine	0.9605	0.9701	0.9253	0.9961	0.8343	1.0650	0.9713	1.1337	1.0305	1.1133
alanine-alanine	1.2582	1.3443	2.2342	1.2938	0.9983	0.6335	0.5979	0.6446	0.4633	0.5319
allantoic acid	0.8604	0.6339	0.5080	0.6178	0.4943	1.1167	1.1876	1.4897	1.7094	1.3822
alpha-ketoglutarate	0.6218	0.9656	1.2058	1.1917	1.1776	0.9797	1.0457	0.8337	1.0740	0.9044
aminomalonate	0.8900	0.8402	1.1753	0.8479	1.3776	0.8956	0.8864	0.9340	1.0817	1.0712
arachidic acid	0.9962	1.3044	1.0027	0.9491	2.2621	0.7712	0.9729	0.5165	0.7337	0.4911
arachidonic acid	0.9000	0.9327	1.0200	1.1381	1.1322	1.2674	0.7245	0.8386	1.2426	0.8039
ascorbic acid	0.2221	2.2222	0.1406	2.9196	0.1255	1.0242	1.1336	0.7562	1.1483	0.3078
asparagine	1.1826	1.1963	1.1485	1.3260	0.8441	0.9351	0.7874	1.0103	0.8265	0.7432
aspartic acid	1.0245	0.8036	0.8784	0.9448	0.8257	0.9302	1.1330	1.1844	1.2114	1.0640
behenic acid	0.9535	1.0995	0.9501	1.1949	1.6587	0.9305	1.0010	0.5983	0.9937	0.6196
benzoic acid	0.9287	0.9001	1.0458	0.8849	1.0448	0.9957	1.0029	0.7776	1.0871	1.3325
beta-alanine	0.9810	0.8768	1.0644	1.2410	1.0902	0.7569	0.8819	0.8155	1.2973	0.9949
beta-glutamic acid	2.8901	0.2379	0.2897	0.2491	1.4628	1.3622	0.6974	1.6885	0.5906	0.5317
beta-glycerolphosphate	0.7830	0.9794	1.2991	1.1329	0.9743	1.1405	0.8510	0.8384	1.1934	0.8082
bisphosphoglycerol NIST	0.7250	0.6510	0.7404	2.1445	0.9216	0.9369	0.6102	0.5514	1.6722	1.0467
butyrolactam NIST	0.7640	1.3954	0.6332	0.7082	0.9123	0.6925	1.2768	0.9367	1.5768	1.1041
capric acid	0.7338	1.2666	0.2683	0.6402	2.9729	0.4282	2.0538	0.6384	0.6679	0.3300
cholestan-3-ol	0.7637	1.1111	0.9785	0.8724	1.0263	1.3286	0.8194	1.0634	1.0979	0.9387
cholesterol	0.7859	1.0457	0.9654	1.1613	1.1225	1.0130	0.9024	0.9705	1.1276	0.9058
cis-gondoic acid	0.8144	1.3151	0.4603	0.7081	3.1437	0.4460	1.8294	0.4527	0.5682	0.2622
citric acid	0.2525	0.5240	0.9866	0.3426	1.4295	0.7752	1.3584	1.1598	1.5417	1.6297
citrulline	1.4019	0.9960	1.1633	0.8993	0.7822	1.0412	0.9798	0.8012	0.8895	1.0455
conduritol-beta-epoxide	0.3458	0.3887	0.4221	0.4066	0.4149	0.6212	2.0830	1.0874	2.5885	1.6418
creatinine	1.0761	0.8929	0.8284	1.1905	1.0399	0.9709	0.8299	0.8096	1.2922	1.0696
cysteine	0.9972	1.2578	1.1641	1.1941	1.0324	0.9746	0.7504	0.9139	0.8698	0.8457
cysteine-glycine	1.8269	0.9338	1.1423	1.6276	1.0389	0.6643	0.9227	0.6034	0.8156	0.4244
cystine	1.0374	1.2524	1.5950	0.9977	1.3141	1.1647	0.4922	1.1242	0.4743	0.5479
cytidine	1.2936	1.6321	2.1589	1.8709	1.6713	0.2969	0.1832	0.2552	0.3108	0.3272
cytidine-5-monophosphate NIST	0.9315	1.3669	1.6807	1.4175	1.7955	0.5299	0.4489	0.5366	0.4826	0.8100
cytosin	1.0416	1.0183	1.9468	1.0150	1.6040	0.6522	0.4226	0.6955	0.5990	1.0050
dehydroascorbic acid	0.5321	1.0346	1.3296	1.0724	0.7852	1.1899	0.5566	1.5920	0.8746	1.0330
dihydroxyacetone	0.6710	1.0532	1.0283	2.6175	0.8684	0.9303	0.4051	0.8487	0.6804	0.8970
doconexent NIST	0.8285	0.9723	0.9955	1.0134	1.6072	0.9265	1.0727	0.7763	1.0924	0.7152
erythronic acid lactone	0.7937	0.7530	0.8018	0.9280	0.8059	1.1070	1.0256	1.0704	1.2007	1.5140
erythrose	0.6637	1.2844	1.4669	0.7839	1.0567	1.6173	0.5069	1.3746	0.4124	0.8333
ethanolamine	0.7844	0.9587	1.1886	1.1571	0.9538	1.2738	0.9060	0.8268	0.8347	1.1160
ethanol phosphate NIST	0.1698	0.2722	0.2557	0.8747	1.7970	0.7966	0.7820	0.7434	2.6632	1.6453
fructose	0.8507	0.7787	0.6184	0.9460	0.9523	1.1339	1.0640	0.9209	1.4204	1.3147
fructose-1-phosphate	0.2177	0.6553	0.7989	0.6243	0.9543	1.2031	1.8704	1.5762	1.7699	0.3301
fructose-6-phosphate	0.1398	0.5613	0.5258	0.4399	0.7252	0.8065	1.5431	1.6245	3.2444	0.3895
fucose	0.7741	0.8884	1.1992	1.1259	1.4777	0.8060	0.7741	0.8303	1.1554	0.9688
fumaric acid	0.8720	0.9048	1.1605	1.1968	0.9430	0.8480	0.8541	0.9577	1.2899	0.9733
gluconic acid	0.4138	1.1207	0.4862	1.5552	0.6483	0.8931	1.2138	0.9586	1.9103	0.8000
glucose	0.4927	0.7273	0.6637	0.7272	1.0823	0.9023	1.4634	0.9421	1.6057	1.3933
glucose-6-phosphate	0.0536	0.5537	0.3359	0.3549	0.6385	0.7817	1.6759	1.6970	3.6531	0.2558
glutamic acid	0.9865	0.8765	0.9754	0.9201	0.9745	1.0084	1.0252	1.0973	1.0667	1.0695
glutamine	1.1360	0.9665	0.8869	0.9598	0.6013	1.0328	0.9552	1.2404	1.0206	1.2006
glyceric acid	0.8911	0.7778	0.7666	1.0810	1.3129	0.6775	1.0874	0.7795	1.4383	1.1879
glycerol	1.0063	0.8317	0.9654	0.8196	0.9585	1.0865	0.9751	1.1261	0.9473	1.2835
glycerol-3-galactoside	0.5193	0.7332	1.0385	0.7205	1.1435	0.7711	1.5286	0.9422	1.4440	1.1591
glycerol-alpha-phosphate	1.0601	0.7532	1.3421	1.8297	1.2228	0.7701	0.5559	0.4734	1.6721	0.3205
glycine	0.8554	0.9395	0.9700	1.1635	0.9410	1.1408	0.8856	1.0562	0.9269	1.1212
glycolic acid	0.9502	0.6874	0.8033	0.8532	0.9210	0.9276	1.1837	1.0444	0.9973	1.6320
glycyl tyrosine	1.3328	1.6510	1.7339	1.8790	0.8158	0.6048	0.5170	0.5926	0.3756	0.4975
guanosine	0.7576	0.9586	1.4567	0.9000	3.1352	0.5693	0.5693	0.6195	0.4814	0.5525
heptadecanoic acid	0.9587	1.2177	0.6645	0.8209	2.2082	0.7528	1.5613	0.6086	0.7920	0.4154
hexadecylglycerol NIST	0.6590	0.5815	0.5093	0.7559	0.5850	1.1260	1.1101	1.7040	1.6952	1.2740
hexitol	0.7680	0.6858	1.0149	0.9465	0.7019	1.0330	0.9921	1.1678	1.7534	0.9366
hexonic acid	0.6468	0.8383	1.3830	1.2894	1.1915	0.6511	0.9362	1.2085	0.8128	1.0426
hexose-6-phosphate	0.2084	0.4749	0.4355	0.4130	0.5894	0.8241	1.6050	1.6351	3.3471	0.4674
hexuronic acid	1.1479	0.9409	0.8652	0.8935	0.8730	1.0662	1.1515	0.7435	0.9700	1.3484
hydroxycarbamate NIST	0.9085	0.6634	0.9454	0.8021	1.0448	1.0472	1.1697	0.8322	1.0703	1.5164
hydroxylamine	0.9923	0.7822	0.9699	0.8339	0.8101	1.0393	1.0787	0.9206	0.9441	1.6290
hypoxanthine	0.1888	0.4076	1.7802	1.4513	2.0311	0.5991	0.8417	0.7537	1.0141	0.9325
inosine	0.2310	0.3539	2.5852	1.0750	4.0964	0.3016	0.2645	0.2716	0.4641	0.3567
inositol-4-monophosphate	0.2696	0.5845	0.6148	0.3217	1.0338	1.4244	1.7511	1.2598	2.3079	0.4325
isoheptadecanoic acid NIST	1.1872	1.2526	0.8224	0.8922	2.1818	0.7726	1.3467	0.5113	0.6798	0.3535
isoleucine	1.1451	1.1472	0.9784	0.9420	0.6167	1.0034	1.0376	1.1945	0.9184	1.0167
isolinoleic acid NIST	1.3886	1.1339	1.3706	1.7719	0.8228	0.6560	0.7462	0.6357	0.6785	0.7958
isothreonic acid	0.9417	0.7292	0.6833	0.8500	0.8833	1.0625	0.9375	1.0750	1.3083	1.5292
lactic acid	0.6986	0.8361	0.7328	1.1706	1.0156	0.9362	0.8888	1.0801	1.1456	1.4955
lauric acid	0.7518	1.3399	0.3362	0.4616	2.8619	0.5434	1.9319	0.7699	0.6801	0.3234
leucine	1.1410	1.1708	0.9828	0.8582	0.7013	1.0005	1.0518	1.1989	0.9098	0.9848
lignoceric acid	0.6849	1.3636	0.7199	0.8124	2.4640	0.8803	1.0469	0.6047	0.8145	0.6088
lysine	1.6942	1.4627	1.7871	1.1249	0.5359	0.8864	0.6808	0.6937	0.5396	0.5947
lyxitol	0.6522	0.8209	1.0866	0.9685	1.3832	0.7042	0.8476	0.9924	1.1330	1.4113
malic acid	0.9240	0.8595	1.0918	0.9756	1.0166	0.8683	0.9430	0.9792	1.3295	1.0126
mannose	0.6410	0.6681	0.7123	0.6129	0.8455	1.1756	1.4220	1.2104	1.2944	1.4177
methanolphosphate	1.2476	0.3473	0.6789	0.6999	1.5089	1.0714	0.8510	0.8080	1.6338	1.1532
methionine	1.2047	1.2114	1.0462	1.2349	0.6463	0.9279	0.9448	1.1068	0.9366	0.7405
methionine sulfoxide	0.6663	0.4828	0.6241	0.5370	0.5016	1.1283	1.3670	1.3743	1.2576	2.0610
monomyristin	0.6993	2.3178	0.2656	0.3338	4.1185	0.3526	1.1695	0.3079	0.2280	0.2069
myo-inositol	0.8351	0.9376	0.9142	0.9139	1.0040	1.2052	1.0341	1.0634	0.9482	1.1443
myristic acid	0.9100	1.6352	0.5662	0.5427	2.5474	0.5736	1.8601	0.6096	0.4841	0.2709
N-acetylaspartic acid	0.6720	0.8920	0.9286	0.8536	1.5570	0.9618	0.8797	0.8291	1.1573	1.2690
n-acetyl-d-hexosamine	1.1995	0.9386	0.7941	1.0112	1.2326	0.7351	0.7045	0.6609	1.2207	1.5027
N-acetylgalactosamine	1.1346	1.1938	1.0551	1.3889	1.2718	0.9327	0.4398	0.5232	0.9088	1.1514
N-acetylglutamate	0.7006	0.8743	0.9265	0.9728	1.4592	0.9380	0.8801	0.8801	1.1697	1.1986
nicotinamide	0.9366	0.8635	1.0338	1.2269	1.0914	0.7795	0.7800	0.8416	1.3077	1.1391
nicotinic acid	0.3959	1.4511	0.4033	0.4867	0.8424	1.1386	1.9348	0.6534	0.4658	2.2280
N-methylalanine	0.8919	0.9909	1.1160	1.3055	1.7907	0.4459	0.7109	0.4746	0.7151	1.5584
nonadecanoic acid	0.9275	1.3484	0.7325	0.9355	2.2320	0.6853	1.4799	0.5550	0.6990	0.4048
octadecylglycerol	0.5450	0.4130	0.3918	0.5017	0.5418	1.6096	1.4375	1.5251	1.7343	1.3002
oleic acid	0.8575	1.5275	1.2886	0.5646	1.1848	0.7180	1.8349	1.0529	0.6750	0.2961
ornithine	1.8524	1.2000	1.3591	1.1149	0.8060	0.8823	0.7327	0.7615	0.5323	0.7588
orotic acid	1.2867	0.5983	0.8033	0.5762	0.7909	1.4765	1.1136	1.0429	0.8463	1.4654
oxalic acid	1.1443	0.5212	0.4991	0.6458	0.9424	1.0229	1.0567	0.7023	1.9783	1.4870
oxoproline	0.9503	0.9644	1.1802	0.9711	1.1714	0.8906	0.8895	0.8968	1.0311	1.0546
palmitoleic acid	1.5090	0.5689	1.2610	0.6857	1.0378	0.8404	2.4502	0.6612	0.6179	0.3678
pantothenic acid	1.0348	1.1746	1.2140	1.2643	1.0891	0.8446	0.6953	0.6790	0.9601	1.0443
parabanic acid NIST	1.2894	1.3688	1.1835	1.1936	0.8627	0.8355	0.9359	0.9896	0.7817	0.5591
p-cresol	0.9148	0.8201	0.9618	0.8839	0.9470	1.0584	1.0096	0.9919	0.9297	1.4829
pelargonic acid	1.0359	1.1985	0.9776	0.6875	1.4421	0.8269	0.9350	0.6846	1.2093	1.0025
pentadecanoic acid	0.9037	1.2045	0.6614	0.7379	2.1403	0.7743	1.5297	0.7954	0.8323	0.4204
pentonic acid	1.5764	0.6108	0.5862	0.7020	1.4335	0.8719	0.8399	0.5911	0.9384	1.8498
pentono-1,4-lactone	1.7284	1.4439	1.8430	1.5642	0.5672	0.5653	0.5080	0.3915	0.6226	0.7659
phenylalanine	1.3476	1.3753	1.1114	1.3234	0.7105	0.7543	0.8504	0.9670	0.8138	0.7462
phenylethylamine	0.8416	0.7255	0.6565	1.0461	1.0343	1.0681	1.0034	0.8305	1.5166	1.2776
phosphate	0.9970	0.8519	1.0975	1.0684	1.0337	0.8835	0.8601	0.8518	1.0876	1.2686
phosphoethanolamine	0.1891	0.4486	1.3441	0.4700	3.7293	0.3985	1.2446	0.6927	1.2798	0.2034
proline	0.8957	0.9469	0.8305	0.8442	0.7017	1.2044	1.0832	1.3863	1.0224	1.0847
propane-1,3-diol NIST	0.9077	0.8522	0.8855	0.8300	0.9743	1.1236	0.9299	1.0150	0.8905	1.5910
pseudo uridine	1.1861	1.0345	1.0152	1.1772	1.0672	0.8814	0.7982	0.6971	1.0746	1.0687
putrescine	1.7754	0.9902	0.9462	1.0189	0.7600	1.2952	0.7899	0.6710	0.8801	0.8731
pyrophosphate	0.6566	0.4718	1.5033	0.6888	0.9029	1.0871	1.4883	0.9522	1.2725	0.9764
ribitol	0.8111	0.8580	1.1162	1.3978	1.1235	0.7524	0.7436	0.7216	1.2438	1.2320
ribonic acid	1.4559	0.6284	0.5080	0.6520	1.5816	0.8641	0.5577	0.6520	0.8798	2.2205
ribose	1.2393	1.2381	1.1163	1.8338	1.1959	0.6719	0.3416	0.4882	0.7961	1.0788
salicylaldehyde	0.9569	0.9244	1.1195	0.8566	1.0382	0.5232	1.0111	0.9732	1.0274	1.5695
serine	1.0322	0.9852	0.9538	1.0201	0.7749	1.0008	0.9951	1.1519	1.0657	1.0203
shikimic acid	0.1602	0.6505	3.2233	1.1295	0.6816	0.7535	0.4299	0.6685	0.5884	1.7146
sorbitol	1.2186	1.0217	3.6690	0.1846	0.9504	0.3916	1.0716	0.9436	0.0829	0.4661
spermidine	1.2061	1.4624	1.3727	2.1605	1.0873	0.4961	0.6022	0.6211	0.6101	0.3813
squalene	0.5316	0.9388	1.0875	1.1412	1.5923	1.2509	0.8510	1.1509	0.9461	0.5096
stearic acid	1.0626	0.8621	1.0901	0.9063	1.3015	1.0369	1.0857	0.7920	1.1089	0.7539
succinate semialdehyde	1.1145	1.6684	1.2178	1.4534	0.6072	0.8035	0.8654	1.0098	0.7738	0.4863
sucrose	0.8645	0.9643	0.8645	1.0058	1.1554	0.9726	0.8313	0.8894	0.9061	1.5461
sulfuric acid	0.6041	0.7221	0.2042	0.1797	1.1858	2.1504	0.3190	0.3860	1.2666	2.9820
taurine	0.9690	0.5380	0.5226	0.8264	0.8005	1.0210	1.3141	1.2629	1.2190	1.5265
threonic acid	1.0097	0.4450	0.7690	1.2413	0.5315	0.7469	1.0650	1.1795	0.7469	2.2653
threonine	1.0333	0.9948	1.0199	0.9105	0.8047	1.0352	1.0292	1.1689	0.9498	1.0538
thymine	0.6623	1.0048	0.4473	0.7133	0.6569	1.7262	0.8893	1.3286	1.0330	1.5382
tocopherol alpha-	0.7071	1.1536	1.1421	1.0675	1.1834	0.9493	0.9481	1.0262	0.9102	0.9125
trans-4-hydroxyproline	0.9867	0.9200	1.2162	1.2569	1.2763	0.7602	0.7852	0.8158	1.0790	0.9037
tryptophan	1.6959	1.2716	1.6362	1.1242	0.5971	0.8397	0.6535	0.9635	0.7577	0.4605
tyrosine	0.7982	1.0268	1.0982	0.9696	1.1687	0.7588	1.1908	0.9396	0.9460	1.1033
UDP GlcNAc	0.6529	0.9485	1.3058	0.8316	1.3883	0.8866	0.9141	1.0790	1.0584	0.9347
UDP-glucuronic acid	0.6384	0.7902	0.3620	0.5021	0.7980	1.0354	1.8178	1.2768	1.0977	1.6816
uracil	1.1226	0.9729	0.9063	1.2526	1.0512	0.9102	0.7469	0.7593	1.0191	1.2590
urea	1.3485	0.9457	1.2494	1.3689	1.0566	0.8982	0.4985	0.4778	1.4326	0.7237
uric acid	1.0655	1.0335	0.8413	0.8349	0.8444	1.0811	1.0192	1.0600	0.8829	1.3371
uridine	0.5496	0.8322	1.4814	0.6320	2.0886	0.7382	0.6158	0.5491	1.8130	0.7002
valine	1.0832	1.0707	0.9504	0.9727	0.6645	1.0812	1.0264	1.1752	0.9155	1.0603
xanthine	0.6375	0.8613	1.5654	1.4445	0.9398	0.7675	0.7985	1.1596	0.8170	1.0088
xanthosine	0.7833	0.5382	0.5286	0.9995	0.6968	1.0476	1.1100	1.4320	1.3311	1.5329
xylitol	1.0805	1.1108	1.1579	1.2651	1.1411	0.7824	0.7191	0.7633	0.9002	1.0796
xylose	0.8402	0.8903	0.7401	0.8262	1.1045	0.9789	1.1212	1.0044	1.1879	1.3064

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1	Organ:Duodenum | Treatment:Aminoguanidine 10 mg/kg s.c.
F2	Organ:Duodenum | Treatment:Metformin 100mg/kg (oral administration)
F3	Organ:Duodenum | Treatment:Metformin 25mg/kg (oral administration)
F4	Organ:Duodenum | Treatment:Metformin 50mg/kg (oral administration)
F5	Organ:Duodenum | Treatment:Saline (oral administration)
F6	Organ:Ileum | Treatment:Aminoguanidine 10 mg/kg s.c.
F7	Organ:Ileum | Treatment:Metformin 100mg/kg (oral administration)
F8	Organ:Ileum | Treatment:Metformin 25mg/kg (oral administration)
F9	Organ:Ileum | Treatment:Metformin 50mg/kg (oral administration)
F10	Organ:Ileum | Treatment:Saline (oral administration)