Data for Uniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response (Study ST000465)
(Analysis AN000726)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
11,12-DiHETrE | 0.9185 | 1.0587 | 0.9379 | 1.0849 |
11(R)-HETE | 0.7495 | 0.7336 | 1.1591 | 1.3579 |
12-HETE | NA | NA | NA | NA |
13,14-Dihydro-15-keto PGF2a | NA | NA | NA | NA |
13S-hydroxyoctadecadienoic acid | 1.3155 | 0.6850 | 1.6620 | 0.3375 |
14,15-DHET | NA | NA | NA | NA |
15(S)-HETE | NA | NA | NA | NA |
20-Hydroxyeicosatetraenoic acid | NA | NA | NA | NA |
2-Aminoisobutyric acid | 1.0105 | 0.6505 | 1.7775 | 0.5615 |
2-deoxyglucose-6-phosphate | 1.1760 | 0.7592 | 1.0249 | 1.0400 |
2-Deoxyinosine triphosphate | NA | NA | NA | NA |
2-Hydroxy-3-methylbutyric acid | NA | NA | NA | NA |
2-Hydroxyglutarate | 1.1605 | 0.9228 | 0.9871 | 0.9296 |
2-Isopropylmalic acid | 0.8490 | 0.6948 | 1.4275 | 1.0287 |
2-Ketohexanoic acid | NA | NA | NA | NA |
2-Keto-L-gluconate | 1.2691 | 0.9052 | 1.1400 | 0.6857 |
2-Methylcitric acid | 0.9980 | 0.8762 | 1.1939 | 0.9320 |
2-Oxo-4-methylthiobutanoic acid | NA | NA | NA | NA |
2-Pyrocatechuic acid | NA | NA | NA | NA |
3-methylphenylacetic acid | NA | NA | NA | NA |
3-Methylthiopropionic acid | NA | NA | NA | NA |
3-Phosphoglyceric acid | NA | NA | NA | NA |
4-Hydroxybenzoic acid | 1.0983 | 0.9106 | 1.0983 | 0.8928 |
4-Hydroxynonenal | NA | NA | NA | NA |
4-Hydroxyphenyllactic acid | 0.8483 | 1.1002 | 1.5487 | 0.5028 |
4-Hydroxyphenylpyruvic acid | 1.2675 | 0.8311 | 1.1788 | 0.7225 |
4-Pyridoxic acid | 1.2323 | 0.9870 | 1.0122 | 0.7685 |
5,6-DHET | 0.8454 | 0.8601 | 1.2813 | 1.0132 |
5-HETE | 1.2163 | 0.6813 | 0.6059 | 1.4965 |
5-Hydroxyindoleacetic acid | NA | NA | NA | NA |
5-Hydroxy-L-tryptophan | NA | NA | NA | NA |
6-Phosphogluconic acid | 0.7598 | 0.5079 | 1.4101 | 1.3221 |
8,9-DiHETrE | NA | NA | NA | NA |
8-HETE | NA | NA | NA | NA |
8-Hydroxy-deoxyguanosine | NA | NA | NA | NA |
8-hydroxyguanosine | 1.1939 | 0.7542 | 1.0271 | 1.0248 |
9-HETE | 1.0641 | 0.7201 | 1.6217 | 0.5941 |
Acetic acid | 1.2601 | 0.7324 | 1.2098 | 0.7977 |
Adenosine diphosphate | NA | NA | NA | NA |
Adenylsuccinic acid | 1.3382 | 0.8954 | 0.8811 | 0.8853 |
Adipic acid | 0.7465 | 0.8788 | 1.2449 | 1.1299 |
AICAR | 0.4612 | 1.8956 | 1.2865 | 0.3567 |
Allantoic acid | 1.6329 | 0.7107 | 1.0003 | 0.6561 |
Allantoin | NA | NA | 1.0805 | 0.9195 |
Alpha-ketoisocaproic acid | 0.9362 | 0.6311 | 1.0748 | 1.3579 |
Alpha-ketoisovaleric acid | 0.9099 | 0.7821 | 1.3930 | 0.9149 |
Aminoadipic acid | 1.4958 | 0.9188 | 0.8776 | 0.7078 |
Arachidonic Acid | 0.3845 | 0.8338 | 1.5714 | 1.2103 |
Arginine | 1.1909 | 0.7896 | 1.1310 | 0.8885 |
Azelaic acid | 0.8365 | 0.7860 | 1.3864 | 0.9911 |
Behenic acid | 1.0428 | 0.7131 | 1.3972 | 0.8469 |
Benzoic acid | 0.9263 | 0.9072 | 1.2278 | 0.9387 |
Carbamoylphosphate | 0.7436 | 0.8044 | 1.9867 | 0.4653 |
Chenodeoxyglycocholic acid | 1.1548 | 0.7796 | 1.1187 | 0.9469 |
Cholesteryl sulfate | 1.4627 | 0.6408 | 1.1534 | 0.7432 |
Cholic acid | 0.7756 | 0.5727 | 1.3716 | 1.2802 |
cis-aconitic acid | 1.1909 | 1.0779 | 0.8047 | 0.9265 |
Citraconic acid | 1.1644 | 0.9670 | 0.8955 | 0.9732 |
Citramalic acid | 1.1026 | 0.8743 | 1.0563 | 0.9668 |
Citric acid | 1.1277 | 0.9213 | 0.9147 | 1.0362 |
Citrulline | 1.1865 | 0.7701 | 1.1659 | 0.8774 |
CL(14:1/14:1/14:1/15:1) | NA | NA | NA | NA |
CL(15:0/15:0/15:0/16:1) | NA | NA | NA | NA |
CL(18:2/18:1/18:1/20:4) | 1.7012 | 0.5098 | 0.9723 | 0.8167 |
CL(18:2/18:2/16:1/16:1) | NA | NA | NA | NA |
CL(18:2/18:2/18:1/18:1) | 1.3733 | 0.8125 | 1.0435 | 0.7707 |
CL(18:2/18:2/18:2/16:1) | NA | NA | NA | NA |
CL(18:2/18:2/18:2/18:1) | NA | NA | NA | NA |
CL(18:2/18:2/18:2/18:2) | NA | NA | NA | NA |
CL(18:2/18:2/18:2/20:4) | 1.3404 | 0.5984 | 1.0155 | 1.0457 |
CL(18:2/18:2/18:2/22:6) | 1.0060 | 0.5501 | 1.6831 | 0.7607 |
CL(22:1/22:1/22:1/14:1) | NA | NA | NA | NA |
CL(24:1/24:1/24:1/14:1) | NA | NA | NA | NA |
Coenzyme A | NA | NA | NA | NA |
Cyclic adenosine monophosphate | 1.6623 | 1.2068 | 0.5655 | 0.5655 |
Cytidine diphosphate | 0.6784 | 0.8230 | 1.1892 | 1.3093 |
Cytidine diphosphate ethanolamine | NA | NA | NA | NA |
Cytidine triphosphate | 0.9034 | 0.9377 | 1.5444 | 0.6145 |
Dehydroascorbic acid | 1.1812 | 1.0328 | 0.9903 | 0.7957 |
Dehydroisoandrosterone 3-sulfate | 0.8170 | 0.7132 | 1.5837 | 0.8862 |
Deoxyadenosine diphosphate | 0.8771 | 0.6252 | 1.2494 | 1.2482 |
Deoxyadenosine triphosphate | NA | NA | NA | NA |
Deoxycholic acid | NA | NA | NA | NA |
Deoxycytidine triphosphate | NA | NA | NA | NA |
Deoxyguanosine diphosphate | 0.8258 | 0.7557 | 0.9462 | 1.4724 |
Deoxyguanosine triphosphate | NA | NA | NA | NA |
Deoxyinosine | NA | NA | NA | NA |
Deoxythymidine diphospahte | 0.6820 | 0.6474 | 1.2526 | 1.4179 |
D-Glyceraldehyde 3-phosphate | 1.0039 | 0.8499 | 1.1734 | 0.9728 |
Dihydroxyacetone phosphate | 1.2826 | 0.8812 | 0.5621 | 1.2741 |
DL-2-Aminooctanoic acid | 1.4922 | 0.7591 | 0.8074 | 0.9412 |
Docosahexaenoic acid | 0.9998 | 0.8688 | 1.4910 | 0.6405 |
Eicosapentaenoic acid | NA | NA | NA | NA |
Erythrose-4-phosphate | 1.0519 | 1.0288 | 0.9920 | 0.9273 |
Farnesyl diphosphate | 0.9845 | 0.8466 | 1.0726 | 1.0964 |
Folic acid | 0.9958 | 0.6995 | 1.1524 | 1.1524 |
Fructose 1,6-bisphosphate | 1.1620 | 0.9070 | 0.8869 | 1.0441 |
Fumaric acid | 1.3657 | 0.8594 | 0.6809 | 1.0940 |
Gamma-Aminobutyric acid | 1.0520 | 0.8106 | 1.4443 | 0.6931 |
Geranyl-PP | 0.8234 | 0.9662 | 1.3031 | 0.9074 |
Glucaric acid | NA | NA | NA | NA |
Gluconic acid | 1.1386 | 0.9184 | 0.9294 | 1.0135 |
Glucosamine 6-phosphate | 1.3854 | 0.8009 | 0.6410 | 1.1727 |
Glutaconic acid | NA | NA | NA | NA |
Glutathione | 1.6056 | 0.8698 | 0.3128 | 1.2118 |
Glyceric acid | 1.0981 | 0.8805 | 1.4440 | 0.5774 |
Glyceric acid 1,3-biphosphate | NA | NA | NA | NA |
Glycerol | 0.6511 | 0.4169 | 1.5577 | 1.3742 |
Glycerol 3-phosphate | 0.8967 | 0.9647 | 1.2249 | 0.9138 |
Glycocholic acid | 1.1166 | 0.8221 | 1.2973 | 0.7641 |
Guanosine diphosphate | 0.7026 | 0.5302 | 1.3172 | 1.4501 |
Guanosine triphosphate | 0.9501 | 0.7166 | 1.1997 | 1.1336 |
Hexacosanoic acid | NA | NA | NA | NA |
Hexose Monophosphate Pool | 0.9860 | 0.9709 | 1.0609 | 0.9822 |
Hexose Pool | 1.2381 | 0.8436 | 1.1771 | 0.7412 |
Hippuric acid | 1.1617 | 0.8946 | 1.2714 | 0.6723 |
Homogentisic acid | NA | NA | NA | NA |
Homovanillic acid | NA | NA | NA | NA |
Hydroxyisocaproic acid | NA | NA | NA | NA |
Imidazoleacetic acid | NA | NA | NA | NA |
Indole-3-carboxylic acid | NA | NA | NA | NA |
Inosine | 0.5119 | 0.9081 | 1.5797 | 1.0004 |
Inosine diphosphate | 0.7910 | 0.6275 | 1.2971 | 1.2844 |
Inosine triphosphate | 0.7547 | 0.9403 | 1.1036 | 1.2013 |
IP4 | 1.0729 | 0.8850 | 1.1685 | 0.8735 |
Isocitric acid | 1.2173 | 0.8950 | 0.8928 | 0.9949 |
Kynurenic acid | 0.8231 | 0.8886 | 1.4490 | 0.8392 |
L-Ascorbic acid | 0.7705 | 0.7422 | 1.6368 | 0.8505 |
L-Aspartic acid | 1.1159 | 1.0158 | 1.0989 | 0.7693 |
L-Cystine | 0.8380 | 0.8064 | 1.9608 | 0.3948 |
L-Glutamic acid | 1.0644 | 0.8769 | 1.1824 | 0.8763 |
L-Homocysteic acid | NA | NA | NA | NA |
Lignoceric acid | NA | NA | NA | NA |
Linoleic acid | NA | NA | NA | NA |
Lipoic acid | NA | NA | NA | NA |
L-Lactic acid | 1.2519 | 0.8046 | 1.0771 | 0.8664 |
L-Threonine | 1.1228 | 0.8669 | 1.2248 | 0.7855 |
Maleic acid | 1.3481 | 0.8612 | 0.7015 | 1.0891 |
Malic acid | 1.3287 | 0.9084 | 0.6341 | 1.1289 |
Malondialdehyde | NA | NA | NA | NA |
Methylmalonic acid | 1.1655 | 0.9257 | 0.9832 | 0.9257 |
Mevalonic acid | 0.6738 | 0.5870 | 1.4726 | 1.2665 |
Myoinositol | 1.3426 | 0.7648 | 0.9699 | 0.9227 |
N-Acetylaspartylglutamic acid | 1.3980 | 0.7263 | 0.7357 | 1.1399 |
N-Acetyl-glucosamine 1-phosphate | NA | NA | NA | NA |
N-Acetyl-L-aspartic acid | 0.9873 | 0.8707 | 1.3011 | 0.8410 |
NAD+ | 1.6278 | 0.9747 | 0.4608 | 0.9367 |
NADH | 0.7722 | 1.0951 | 1.0265 | 1.1062 |
Nicotinic acid | 0.9527 | 0.8552 | 1.2444 | 0.9478 |
Octulose-1,8-bisphosphate | 0.8820 | 0.6716 | 1.1549 | 1.2916 |
Oleic acid | NA | NA | NA | NA |
Orotic acid | NA | NA | NA | NA |
Orotidine monophosphate | 1.1886 | 0.5302 | 1.4601 | 0.8212 |
Oxalic acid | NA | NA | NA | NA |
Oxaloacetic acid | 0.7338 | 0.7116 | 1.5138 | 1.0408 |
Oxidized glutathione | 1.4525 | 0.9753 | 0.8470 | 0.7252 |
Oxoglutaric acid | 1.3251 | 0.7111 | 0.7925 | 1.1713 |
p-Aminobenzoic acid | NA | NA | NA | NA |
Pantothenic acid | 0.8543 | 0.5575 | 0.9732 | 1.6150 |
p-Cresol | NA | NA | NA | NA |
PE(18:0/18:0) | NA | NA | NA | NA |
PE(28:0) | NA | NA | NA | NA |
PE(28:1) | NA | NA | NA | NA |
PE(30:0) | NA | NA | NA | NA |
PE(30:1) | NA | NA | NA | NA |
PE(30:2) | NA | NA | NA | NA |
PE(32:1) | NA | NA | NA | NA |
PE(32:2) | NA | NA | NA | NA |
PE(34:1) | 1.6558 | 0.6443 | 1.0775 | 0.6225 |
PE(34:2) | 1.9401 | 0.4537 | 0.8968 | 0.7094 |
PE(36:1) | NA | NA | NA | NA |
PE(36:2) | 1.9852 | 0.6267 | 0.8044 | 0.5837 |
PE(36:3) | NA | NA | NA | NA |
PE(38:4) | NA | NA | NA | NA |
PE(38:5) | NA | NA | NA | NA |
Phenyllactic acid | 1.1271 | 0.8953 | 1.2062 | 0.7713 |
Phenylpropiolic acid | 1.1163 | 0.8852 | 1.1237 | 0.8748 |
Phenylpyruvic acid | NA | NA | NA | NA |
Phosphoenolpyruvic acid | 0.5756 | 0.9695 | 1.2578 | 1.1972 |
p-Hydroxyphenylacetic acid | 0.7678 | 0.4762 | 1.4162 | 1.3397 |
PI(16:0/16:0) | NA | NA | NA | NA |
PI(26:0) | NA | NA | NA | NA |
PI(26:1) | NA | NA | NA | NA |
PI(28:0) | NA | NA | NA | NA |
PI(28:1) | NA | NA | NA | NA |
PI(30:0) | NA | NA | NA | NA |
PI(30:1) | NA | NA | NA | NA |
PI(30:2) | 1.4004 | 0.6323 | 1.0444 | 0.9228 |
PI(32:1) | NA | NA | NA | NA |
PI(32:2) | NA | NA | NA | NA |
PI(34:0) | NA | NA | NA | NA |
PI(34:1) | NA | NA | NA | NA |
PI(34:2) | 1.5039 | 0.6291 | 1.0135 | 0.8534 |
PI(36:0) | NA | NA | NA | NA |
PI(36:1) | 1.4659 | 0.5341 | NA | NA |
PI(36:2) | 1.5804 | 0.5534 | 1.0658 | 0.8004 |
PI(36:4) | NA | NA | NA | NA |
PI(38:3) | NA | NA | 1.3859 | 0.6141 |
PI(38:4) | 1.1538 | 0.4064 | 1.8180 | 0.6219 |
PI(38:5) | NA | NA | 1.5079 | 0.4921 |
PI(40:5) | NA | NA | NA | NA |
Pipecolic acid | 1.1134 | 0.8370 | 1.2144 | 0.8353 |
Plasmalogen(20:4/p18:1) | NA | NA | NA | NA |
Plasmalogen(p16:0/20:4) | NA | NA | NA | NA |
Plasmalogen(p18:0/20:4) | NA | NA | NA | NA |
Plasmalogen(p18:0/22:6) | NA | NA | NA | NA |
Prostaglandin D2 | NA | NA | NA | NA |
Prostaglandin E2 | NA | NA | NA | NA |
Prostaglandin J2 | NA | NA | NA | NA |
PS(18:0/18:1) | NA | NA | NA | NA |
PS(18:0/20:4) | 1.0417 | 0.4785 | 2.1755 | 0.3043 |
PS(32:0) | NA | NA | NA | NA |
PS(32:1) | NA | NA | NA | NA |
PS(32:2) | NA | NA | NA | NA |
PS(34:1) | NA | NA | NA | NA |
PS(34:2) | NA | NA | NA | NA |
PS(36:0) | NA | NA | NA | NA |
PS(36:2) | NA | NA | NA | NA |
Pyroglutamic acid | 0.8559 | 0.6770 | 1.4581 | 1.0089 |
Pyrophosphate | 0.9778 | 0.6712 | 1.0432 | 1.3077 |
Quinolinic Acid | 0.9147 | 0.8205 | 1.2687 | 0.9961 |
Resolvin D1 | NA | NA | NA | NA |
Riboflavin | 1.1300 | 0.8052 | 1.1405 | 0.9243 |
Salicyluric acid | 1.1517 | 0.8224 | 1.0132 | 1.0127 |
Sedoheptulose 1,7-bisphosphate | NA | NA | NA | NA |
Sedoheptulose monophosphate | 1.0950 | 0.8059 | 1.0503 | 1.0488 |
Shikimate-3-phosphate | 0.8279 | 0.6481 | 1.2776 | 1.2463 |
Shikimic acid | NA | NA | NA | NA |
SM(d18:1/12:0) | 1.5650 | 0.4992 | 1.1300 | 0.8057 |
SM(d18:1/16:0) | 1.9070 | 0.3940 | 1.0094 | 0.6896 |
SM(d18:1/16:0 OH) | 1.8986 | 0.3088 | 1.0576 | 0.7350 |
SM(d18:1/16:1) | 1.7924 | 0.4592 | 0.9419 | 0.8064 |
SM(d18:1/16:1 OH) | 1.8497 | 0.3713 | 1.1305 | 0.6485 |
SM(d18:1/16:2) | 1.5129 | 0.4829 | 1.1592 | 0.8450 |
SM(d18:1/16:2 OH) | 1.7822 | 0.4297 | 1.0184 | 0.7696 |
SM(d18:1/18:0) | NA | NA | NA | NA |
SM(d18:1/18:0 OH) | 1.6231 | 0.4830 | 1.0655 | 0.8283 |
SM(d18:1/18:1) | 1.6728 | 0.3729 | 1.2319 | 0.7224 |
SM(d18:1/18:1 OH) | 1.9274 | 0.3903 | 1.2025 | 0.4798 |
SM(d18:1/18:2) | 1.3875 | 0.4236 | 1.0458 | 1.1430 |
SM(d18:1/18:2 OH) | 1.7285 | 0.3713 | 1.1753 | 0.7249 |
SM(d18:1/20:0) | 1.5674 | 0.4807 | 1.0066 | 0.9453 |
SM(d18:1/20:0 OH) | NA | NA | NA | NA |
SM(d18:1/20:1) | 1.5530 | 0.4348 | 1.0490 | 0.9631 |
SM(d18:1/20:1 OH) | NA | NA | NA | NA |
SM(d18:1/20:2) | 1.6418 | 0.3954 | 0.9393 | 1.0234 |
SM(d18:1/20:2 OH) | NA | NA | NA | NA |
SM(d18:1/22:0) | NA | NA | NA | NA |
SM(d18:1/22:0 OH) | 1.6681 | 0.4296 | 1.2363 | 0.6660 |
SM(d18:1/22:1) | 1.4580 | 0.4057 | 1.2969 | 0.8393 |
SM(d18:1/22:2) | 1.3696 | 0.5433 | 1.2041 | 0.8830 |
SM(d18:1/22:2 OH) | 1.0646 | 0.3497 | 1.4450 | 1.1407 |
SM(d18:1/23:0) or SM(d18:1/22:1 OH) | 1.1171 | 0.4804 | 1.4765 | 0.9260 |
SM(d18:1/24:0) | 1.3962 | 0.6301 | 1.2337 | 0.7400 |
SM(d18:1/24:0 OH) | NA | NA | NA | NA |
SM(d18:1/24:1) | 1.5588 | 0.4174 | 1.2332 | 0.7906 |
SM(d18:1/24:2) | 0.9910 | 0.3713 | 1.5577 | 1.0799 |
SM(d18:1/24:2 OH) | NA | NA | NA | NA |
SM(d18:1/25:0) or SM(d18:1/24:1 OH) | 1.1335 | 0.5592 | 1.6385 | 0.6688 |
SM(d18:1/26:0) | 1.4928 | 0.5178 | 1.2827 | 0.7067 |
SM(d18:1/26:0 OH) | NA | NA | NA | NA |
SM(d18:1/26:1) | 1.1227 | 0.6197 | 1.5314 | 0.7263 |
SM(d18:1/26:1 OH) | NA | NA | NA | NA |
SM(d18:1/26:2) | 1.1626 | 0.6928 | 1.4488 | 0.6959 |
SM(d18:1/26:2 OH) | 1.3351 | 0.5936 | 1.2497 | 0.8216 |
Succinic acid | 1.1935 | 0.9004 | 0.9575 | 0.9487 |
Sucrose | NA | NA | NA | NA |
Taurine | 1.3433 | 0.7918 | 0.9896 | 0.8753 |
Taurochenodesoxycholic acid | NA | NA | NA | NA |
Taurocholic acid | 1.6494 | 0.5178 | 1.0667 | 0.7661 |
Taurodeoxycholic acid | 1.2628 | 0.7644 | 1.0428 | 0.9300 |
Tetranor-PGEM | NA | NA | NA | NA |
Tetranor-PGFM | NA | NA | NA | NA |
Thiamine pyrophosphate | NA | NA | NA | NA |
Thromboxane B2 | NA | NA | NA | NA |
Thymidine 5-triphosphate | NA | NA | NA | NA |
Uracil | 0.9768 | 0.7265 | 1.4396 | 0.8571 |
Ureidosuccinic acid | NA | NA | NA | NA |
Uric acid | 1.1130 | 0.7456 | 1.1567 | 0.9846 |
Uridine | 1.2410 | 0.8275 | 1.0672 | 0.8643 |
Uridine 5-diphosphate | 0.8741 | 0.7861 | 1.0353 | 1.3044 |
Uridine diphosphate glucose | 1.1665 | 1.1499 | 0.9684 | 0.7152 |
Uridine diphosphate-n-acetyl-D-glucosamine | NA | NA | NA | NA |
Uridine triphosphate | 0.8062 | 1.2059 | 0.9692 | 1.0186 |
Xanthine | 0.8359 | 1.0790 | 1.4005 | 0.6846 |
Xanthosine | 1.0865 | 0.9135 | NA | NA |
Xanthurenic acid | NA | NA | NA | NA |
Factors:
F1 | Time:24hr | Treatment:Control |
F2 | Time:24hr | Treatment:Englerin (100 nM) |
F3 | Time:48hr | Treatment:Control |
F4 | Time:48hr | Treatment:Englerin (100 nM) |