Data for Investigating large scale metabolomics in mice serum lacking insulin receptors and IGF-1 receptors (Study ST000549)
(Analysis AN000839)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
---|---|---|---|---|---|---|---|---|
(-)-11-hydroxy-9,10-dihydrojasmonic acid | 1.1630 | 1.3076 | 0.9053 | 1.2768 | 0.6597 | 1.7441 | 0.8353 | 0.4736 |
1,2-Dioctanoyl-sn-glycerol | 0.9280 | 0.6833 | 1.3760 | 1.6076 | 0.4862 | 1.6731 | 1.1000 | 0.4203 |
13,14-dihydro Prostaglandin F1? | 0.8456 | 0.6917 | 1.2489 | 0.9177 | 1.0977 | 0.9000 | 1.1571 | 1.0007 |
1,4-Naphthoquinone | 1.4934 | 1.2535 | 1.4777 | 1.1999 | 0.3966 | 1.1058 | 0.6953 | 0.8617 |
1,5-Anhydrosorbitol | 1.1989 | 0.6943 | 1.0171 | 1.1238 | 1.1873 | 0.7426 | 1.0829 | 0.8844 |
18-hydroxy-9S,10R-epoxy-stearic acid | 1.1399 | 0.9185 | 1.0437 | 1.2038 | 0.8304 | 1.0246 | 0.9632 | 0.9623 |
1-Aminocyclohexanecarboxylic acid | 1.3796 | 2.2039 | 0.4093 | 1.8215 | 0.0797 | 1.7243 | 0.5036 | 0.7215 |
1-Ethyl-1,3-dimethyl-cyclohexane skeleton | 1.0614 | 1.0078 | 0.9852 | 1.0547 | 0.9645 | 1.0279 | 0.9064 | 1.0188 |
2,2-Dimethyl-3,4-bis(4-methoxyphenyl)-2H-1-benzopyran-7-ol acetate | 1.0125 | 1.0089 | 0.9497 | 1.1129 | 0.8524 | 1.0145 | 1.2329 | 0.8869 |
2,3-bis (4-Hydroxyphenyl) Propionitrile | 2.1038 | 0.4041 | 0.4856 | 2.2874 | 0.1425 | 0.2758 | 0.6787 | 1.7755 |
2(5H)-Furanone | 1.4663 | 0.8345 | 0.9162 | 1.3709 | 0.7524 | 0.7749 | 1.0390 | 0.9831 |
2-(6^-Methylthio)hexylmalic acid | 1.6766 | 1.8324 | 0.6030 | 0.8879 | 0.3874 | 1.7507 | 0.5886 | 0.8020 |
2-Amino-3-methyl-1-butanol | 1.3990 | 0.9202 | 0.9166 | 1.3148 | 0.8844 | 0.9310 | 0.8933 | 0.8817 |
2-Amino-3-methyl-1-butanol + 10.466517 | 2.3998 | 0.8025 | 1.4243 | 1.2921 | 0.0955 | 1.1936 | 1.0921 | 0.3543 |
2-Aminopropanol | 2.0047 | 2.3909 | 0.6309 | 1.0302 | 0.0963 | 2.0205 | 0.6247 | 0.2267 |
2-Methyleneglutarate | 1.7470 | 0.6834 | 0.7637 | 1.5242 | 0.6606 | 0.9397 | 0.9225 | 0.9227 |
3,6-dioxo-decanoic acid | 1.1200 | 1.0009 | 0.9434 | 1.6666 | 0.4786 | 1.3677 | 0.7805 | 0.9107 |
3-ketosphingosine | 2.1534 | 0.3055 | 0.5838 | 1.1226 | 0.9721 | 0.6727 | 0.8489 | 1.2006 |
4-heptynoic acid | 1.5806 | 0.7808 | 0.8378 | 1.6183 | 0.8705 | 0.6867 | 0.7723 | 0.9988 |
4-Hydroxy-2-butynal | 0.9552 | 1.2369 | 0.9927 | 0.7717 | 1.0411 | 1.1105 | 1.0509 | 0.8928 |
4-Oxoproline | 1.5039 | 1.5860 | 0.8982 | 2.4491 | 0.3839 | 1.1269 | 0.8194 | 0.1337 |
6-Methoxyquinoline | 1.6945 | 0.9234 | 0.6264 | 1.0341 | 0.5253 | 1.1380 | 0.8305 | 1.3026 |
7(Z),11(Z)-Heptacosadiene | 7.5344 | 0.0013 | 0.0013 | 0.9011 | 0.0013 | 0.0013 | 0.0013 | 0.5378 |
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid | 0.8480 | 0.7392 | 1.0725 | 0.9374 | 1.1638 | 0.8897 | 1.1362 | 1.0398 |
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid + 10.442588 | 0.5853 | 0.9402 | 1.2858 | 0.7622 | 1.5277 | 0.7555 | 0.8638 | 1.0639 |
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid + 10.527603 | 0.7712 | 0.7358 | 1.2685 | 0.9009 | 1.2358 | 0.7937 | 1.0932 | 1.0301 |
Acetoacetic acid | 1.4822 | 1.1151 | 1.0435 | 1.1746 | 0.6210 | 0.9256 | 1.0204 | 0.8995 |
Acetone cyanohydrin | 2.0774 | 1.6748 | 0.1835 | 1.2771 | 0.5530 | 1.3200 | 0.7733 | 0.6732 |
ADMA | 0.9852 | 1.2698 | 0.7004 | 1.4540 | 0.7645 | 1.1460 | 0.7958 | 1.0560 |
Alanine | 1.0519 | 0.9615 | 0.8116 | 0.8996 | 0.9108 | 1.0294 | 1.1227 | 1.1396 |
alpha-Hydroxytamoxifen | 1.8302 | 1.1305 | 0.4580 | 0.8369 | 0.7310 | 1.3761 | 0.8770 | 0.9094 |
Amitrole | 1.2554 | 1.1725 | 0.6615 | 1.5236 | 1.1024 | 1.0856 | 0.5668 | 0.8074 |
Avizafone | 1.1876 | 1.1809 | 1.5558 | 0.8494 | 0.4627 | 0.7732 | 1.3806 | 0.9235 |
Barbital | 1.0397 | 1.0813 | 0.8809 | 1.7851 | 0.6301 | 1.4247 | 0.9336 | 0.5602 |
Benzaldehyde | 1.0361 | 1.5668 | 0.9090 | 1.3957 | 0.7180 | 1.4243 | 0.9984 | 0.4192 |
Buprenorphine | 1.4796 | 0.7433 | 1.3393 | 1.5030 | 0.4162 | 0.9964 | 1.2233 | 0.6477 |
C12 | 0.1883 | 0.9955 | 0.4410 | 0.6113 | 1.4848 | 0.6637 | 0.5234 | 2.3678 |
Caproic acid | 0.8349 | 1.5053 | 1.1510 | 1.3119 | 0.3376 | 1.0944 | 1.1631 | 0.9966 |
CB3717 | 2.4354 | 1.0436 | 0.9367 | 0.2048 | 0.2239 | 1.3227 | 1.4299 | 0.7425 |
Corticosterone | 0.6047 | 1.9240 | 0.5679 | 1.2471 | 0.4878 | 1.3878 | 1.0620 | 1.0622 |
Creatinine | 1.1359 | 1.3943 | 1.0555 | 1.4631 | 0.7513 | 1.3115 | 1.0652 | 0.3014 |
DL-pipecolic acid | 0.9990 | 1.4735 | 0.8105 | 1.3725 | 0.7899 | 1.0401 | 0.8613 | 0.9342 |
endo-1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-N-oxide | 3.0143 | 0.3251 | 0.7683 | 1.3379 | 0.9883 | 0.6405 | 0.6072 | 0.5624 |
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate | 1.3890 | 1.3498 | 1.1592 | 1.4356 | 0.6320 | 1.0344 | 0.9298 | 0.5671 |
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate + 10.542064 | 1.2369 | 0.4526 | 1.6147 | 1.1477 | 0.4342 | 1.3669 | 1.2252 | 0.6799 |
Fexofenadine | 2.6736 | 0.4534 | 0.5265 | 1.5881 | 0.6842 | 0.6101 | 0.8640 | 0.8352 |
Gymnodimine | 1.5687 | 0.6607 | 1.0843 | 1.4014 | 0.4397 | 1.1960 | 1.3529 | 0.5696 |
Heptanoic acid, 2-amino-, (R)-; (R)-2-Aminoheptanoic acid | 1.0763 | 1.2817 | 0.8312 | 1.5030 | 0.6789 | 1.4864 | 0.7916 | 0.6748 |
Hydroxyibuprofen | 0.9996 | 1.0152 | 0.9057 | 1.1522 | 0.9843 | 1.0517 | 0.8400 | 1.0599 |
Ile Pro | 0.8876 | 2.2103 | 0.4375 | 0.3500 | 0.6985 | 2.1765 | 1.5658 | 0.1277 |
Indoleacrylic acid | 0.8223 | 1.8063 | 0.6831 | 1.1631 | 0.6882 | 1.5056 | 0.6358 | 1.0118 |
Isowillardiine | 2.2842 | 1.1338 | 1.2097 | 1.6875 | 0.0836 | 0.6913 | 1.2507 | 0.4436 |
L-alpha-glutamyl-L-hydroxyproline | 0.9945 | 1.0982 | 1.2636 | 0.8401 | 1.0434 | 0.7465 | 1.0982 | 0.9715 |
L-Glutamic acid dibutyl ester | 1.7595 | 0.0492 | 0.6466 | 2.1485 | 0.8829 | 0.2615 | 0.3654 | 1.7003 |
L-Glutamic acid n-butyl ester | 1.5542 | 0.7680 | 0.9656 | 1.4903 | 0.7059 | 0.7709 | 0.8529 | 1.0503 |
L-Glutamic acid n-butyl ester + 1.51668 | 1.3020 | 0.8523 | 1.0815 | 1.2948 | 0.7759 | 1.0258 | 0.8288 | 0.9670 |
L-Isoleucine | 0.8854 | 1.2599 | 0.6705 | 1.7065 | 0.9248 | 1.1235 | 0.7342 | 0.8890 |
L-Leucine | 1.0154 | 0.3374 | 0.8826 | 1.6431 | 0.9570 | 1.5236 | 0.7682 | 0.7705 |
L-Pipecolic acid | 1.7540 | 1.5864 | 1.3071 | 1.4261 | 0.7985 | 1.1505 | 0.7494 | 0.0002 |
L-Tryptophan | 0.5703 | 2.8487 | 0.4067 | 2.0608 | 0.1213 | 2.5472 | 0.5669 | 0.0008 |
L-Valine | 0.7171 | 0.7329 | 0.8742 | 1.3155 | 1.0884 | 1.0737 | 0.9188 | 1.1135 |
L-Valine + 1.2355758 | 0.8902 | 1.4865 | 1.0175 | 1.2810 | 0.7775 | 1.0919 | 0.9666 | 0.8047 |
Lys Lys Lys | 0.6114 | 0.2008 | 1.4505 | 1.0753 | 1.7111 | 0.5972 | 1.0107 | 0.9239 |
Lys Lys Lys + 10.543157 | 0.6781 | 0.2013 | 1.3959 | 0.6719 | 1.5807 | 0.6378 | 1.0705 | 1.2311 |
LysoPE(0:0/18:2(9Z,12Z)) | 2.3562 | 0.7034 | 0.7701 | 0.9560 | 0.8246 | 0.9597 | 1.0759 | 0.5724 |
LysoPE(0:0/22:0) | 1.7982 | 0.3314 | 1.6795 | 0.9290 | 0.4240 | 1.2811 | 1.3861 | 0.4165 |
Methdilazine | 0.1163 | 2.1910 | 1.5158 | 0.6017 | 0.0004 | 2.4432 | 1.8543 | 0.0004 |
MS-275 | 6.2357 | 0.0006 | 0.0006 | 1.1506 | 0.1391 | 0.0006 | 0.0006 | 1.1015 |
N4-Acetylaminobutanal | 1.0470 | 1.3544 | 1.0741 | 1.1082 | 0.7222 | 1.1465 | 1.0205 | 0.8085 |
N(alpha)-t-Butoxycarbonyl-L-leucine | 0.7628 | 2.3006 | 0.6952 | 1.1165 | 0.3896 | 2.4375 | 0.5372 | 0.4315 |
N(alpha)-t-Butoxycarbonyl-L-leucine + 3.9469597 | 1.4121 | 0.8910 | 0.7942 | 1.6142 | 0.5939 | 1.4220 | 0.6194 | 0.8791 |
Naphthalic anhydride | 2.6840 | 0.7253 | 1.0038 | 1.3535 | 0.8113 | 0.9342 | 0.8676 | 0.1303 |
Niacin (Nicotinic acid) | 1.5900 | 0.4389 | 0.5797 | 2.8183 | 0.4606 | 0.8606 | 0.7923 | 0.7839 |
Nitrapyrin | 1.1764 | 1.7890 | 1.3756 | 0.5442 | 0.4778 | 1.2112 | 1.5209 | 0.4535 |
N-Methyl-2-pyrrolidinone | 0.2307 | 1.5101 | 0.9618 | 0.9519 | 0.9206 | 1.4694 | 0.9944 | 1.0082 |
N-n-Hexanoylglycine methyl ester | 1.6833 | 0.6715 | 0.4550 | 1.1196 | 2.1842 | 0.3251 | 0.6625 | 0.6518 |
Oxindole | 0.4768 | 3.2762 | 1.4710 | 1.2629 | 0.0003 | 1.9382 | 0.9267 | 0.0003 |
Oxyquinoline | 0.6258 | 2.5798 | 0.8550 | 1.0497 | 0.3375 | 2.1767 | 0.8782 | 0.3065 |
p-Aminobenzoic acid | 1.4002 | 1.4900 | 1.4116 | 1.7294 | 0.5532 | 1.2181 | 0.7815 | 0.1746 |
Pantoic acid | 0.8740 | 1.0298 | 1.2474 | 0.9425 | 1.0061 | 0.8797 | 1.0476 | 0.9970 |
PE(18:0/0:0) | 1.3163 | 0.8206 | 1.2549 | 1.1996 | 0.3448 | 1.2565 | 1.4362 | 0.6538 |
PE(19:1(9Z)/0:0) | 1.1267 | 0.6724 | 1.3359 | 1.1963 | 0.3706 | 1.4096 | 1.5384 | 0.5640 |
PE(19:1(9Z)/0:0) + 10.729481 | 1.7695 | 0.4329 | 1.3308 | 1.3039 | 0.3322 | 0.9406 | 1.6453 | 0.5269 |
PE(19:1(9Z)/0:0) + 10.803823 | 1.6780 | 0.3865 | 1.0205 | 1.3840 | 0.3769 | 0.9647 | 1.6694 | 0.6798 |
Phe His Phe | 0.1830 | 1.3686 | 1.0376 | 1.1017 | 0.6253 | 1.7104 | 1.3763 | 0.7365 |
Phenacylamine | 0.6642 | 1.6315 | 0.7021 | 1.6823 | 0.8949 | 1.3534 | 0.8315 | 0.6028 |
Phenylpyruvic acid | 0.6932 | 1.8352 | 0.4863 | 2.0889 | 0.8282 | 1.1274 | 0.7712 | 0.6597 |
Piperideine | 0.9352 | 1.2073 | 0.7643 | 1.2591 | 0.9349 | 1.3041 | 0.8359 | 0.8723 |
Piperideine + 1.3051474 | 1.0962 | 1.4455 | 1.0447 | 1.1133 | 0.7709 | 1.2412 | 1.0266 | 0.6137 |
Prometon | 1.3587 | 0.5831 | 0.5833 | 2.3935 | 0.6984 | 0.6958 | 0.4577 | 1.3252 |
Prometon + 1.7550333 | 1.1003 | 0.2029 | 0.7409 | 2.0243 | 0.7694 | 0.2658 | 0.6321 | 1.9706 |
Prostaglandin D1 Alcohol | 0.7137 | 0.5264 | 1.0100 | 1.0118 | 1.4157 | 0.8389 | 1.0161 | 1.1182 |
Rebaudioside C | 1.5347 | 0.9726 | 1.0288 | 0.6839 | 0.6240 | 1.4718 | 1.0331 | 0.8040 |
Sarcoaldesterol A | 2.8377 | 1.3900 | 0.7225 | 0.0005 | 0.3085 | 0.9531 | 1.5264 | 0.7232 |
(S)-ATPA | 1.1570 | 1.2756 | 0.0004 | 3.0515 | 0.0787 | 1.3508 | 0.3435 | 1.2322 |
Taurine | 1.6792 | 0.9043 | 0.6542 | 1.3827 | 0.6645 | 0.9808 | 0.7869 | 1.0996 |
(+)-Tephrorin A | 2.7853 | 0.4082 | 0.7400 | 0.2499 | 0.0006 | 1.4229 | 1.7868 | 0.7704 |
Tetrahydrofuran | 1.1964 | 0.9781 | 1.4707 | 0.7560 | 0.8782 | 0.6589 | 1.4677 | 0.7452 |
Thr Ser Ser | 0.9128 | 1.5869 | 1.3688 | 0.9225 | 0.7610 | 1.2374 | 1.3513 | 0.3189 |
Tranexamic acid | 1.3825 | 1.9812 | 0.5101 | 1.6935 | 0.0341 | 1.9763 | 0.7638 | 0.4677 |
Traumatic Acid | 1.0751 | 1.3308 | 0.9551 | 1.9043 | 0.5307 | 1.2067 | 0.7129 | 0.7480 |
Trp Tyr Tyr | 3.3716 | 0.0007 | 0.0007 | 2.3898 | 0.2806 | 0.0007 | 0.0007 | 2.0430 |
Tubastatin A | 3.1058 | 0.2248 | 0.2252 | 1.0540 | 0.1048 | 1.0365 | 0.1997 | 1.9960 |
Tyr Thr Gln | 3.1066 | 0.0398 | 0.0257 | 2.1115 | 0.4618 | 0.1287 | 0.1246 | 1.9780 |
Urea | 1.0397 | 1.4681 | 1.3586 | 0.8804 | 0.9519 | 1.1982 | 1.0325 | 0.4360 |
Uric acid | 2.8511 | 0.3719 | 0.2856 | 1.4047 | 0.8365 | 1.3138 | 0.4548 | 0.6427 |
Val Gly | 1.1062 | 2.2675 | 0.8993 | 1.0427 | 0.1690 | 1.3654 | 1.1643 | 0.7238 |
Factors:
F1 | Group:CD | Genotype:Irlox |
F2 | Group:Control | Genotype:IGFR lox |
F3 | Group:Control | Genotype:Irlox |
F4 | Group:Control | Genotype:IRlox IGFR lox |
F5 | Group:HFD | Genotype:Irlox |
F6 | Group:IGFRKO | Genotype:IGFR -/- |
F7 | Group:IRKO | Genotype:IR -/- |
F8 | Group:MIGIRKO | Genotype:IR -/- IGFR -/- |