Data for Investigating large scale metabolomics in mice serum lacking insulin receptors and IGF-1 receptors (Study ST000549)

(Analysis AN000839)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8
(-)-11-hydroxy-9,10-dihydrojasmonic acid 1.1630 1.3076 0.9053 1.2768 0.6597 1.7441 0.8353 0.4736
1,2-Dioctanoyl-sn-glycerol 0.9280 0.6833 1.3760 1.6076 0.4862 1.6731 1.1000 0.4203
13,14-dihydro Prostaglandin F1? 0.8456 0.6917 1.2489 0.9177 1.0977 0.9000 1.1571 1.0007
1,4-Naphthoquinone 1.4934 1.2535 1.4777 1.1999 0.3966 1.1058 0.6953 0.8617
1,5-Anhydrosorbitol 1.1989 0.6943 1.0171 1.1238 1.1873 0.7426 1.0829 0.8844
18-hydroxy-9S,10R-epoxy-stearic acid 1.1399 0.9185 1.0437 1.2038 0.8304 1.0246 0.9632 0.9623
1-Aminocyclohexanecarboxylic acid 1.3796 2.2039 0.4093 1.8215 0.0797 1.7243 0.5036 0.7215
1-Ethyl-1,3-dimethyl-cyclohexane skeleton 1.0614 1.0078 0.9852 1.0547 0.9645 1.0279 0.9064 1.0188
2,2-Dimethyl-3,4-bis(4-methoxyphenyl)-2H-1-benzopyran-7-ol acetate 1.0125 1.0089 0.9497 1.1129 0.8524 1.0145 1.2329 0.8869
2,3-bis (4-Hydroxyphenyl) Propionitrile 2.1038 0.4041 0.4856 2.2874 0.1425 0.2758 0.6787 1.7755
2(5H)-Furanone 1.4663 0.8345 0.9162 1.3709 0.7524 0.7749 1.0390 0.9831
2-(6^-Methylthio)hexylmalic acid 1.6766 1.8324 0.6030 0.8879 0.3874 1.7507 0.5886 0.8020
2-Amino-3-methyl-1-butanol 1.3990 0.9202 0.9166 1.3148 0.8844 0.9310 0.8933 0.8817
2-Amino-3-methyl-1-butanol + 10.466517 2.3998 0.8025 1.4243 1.2921 0.0955 1.1936 1.0921 0.3543
2-Aminopropanol 2.0047 2.3909 0.6309 1.0302 0.0963 2.0205 0.6247 0.2267
2-Methyleneglutarate 1.7470 0.6834 0.7637 1.5242 0.6606 0.9397 0.9225 0.9227
3,6-dioxo-decanoic acid 1.1200 1.0009 0.9434 1.6666 0.4786 1.3677 0.7805 0.9107
3-ketosphingosine 2.1534 0.3055 0.5838 1.1226 0.9721 0.6727 0.8489 1.2006
4-heptynoic acid 1.5806 0.7808 0.8378 1.6183 0.8705 0.6867 0.7723 0.9988
4-Hydroxy-2-butynal 0.9552 1.2369 0.9927 0.7717 1.0411 1.1105 1.0509 0.8928
4-Oxoproline 1.5039 1.5860 0.8982 2.4491 0.3839 1.1269 0.8194 0.1337
6-Methoxyquinoline 1.6945 0.9234 0.6264 1.0341 0.5253 1.1380 0.8305 1.3026
7(Z),11(Z)-Heptacosadiene 7.5344 0.0013 0.0013 0.9011 0.0013 0.0013 0.0013 0.5378
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid 0.8480 0.7392 1.0725 0.9374 1.1638 0.8897 1.1362 1.0398
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid + 10.442588 0.5853 0.9402 1.2858 0.7622 1.5277 0.7555 0.8638 1.0639
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid + 10.527603 0.7712 0.7358 1.2685 0.9009 1.2358 0.7937 1.0932 1.0301
Acetoacetic acid 1.4822 1.1151 1.0435 1.1746 0.6210 0.9256 1.0204 0.8995
Acetone cyanohydrin 2.0774 1.6748 0.1835 1.2771 0.5530 1.3200 0.7733 0.6732
ADMA 0.9852 1.2698 0.7004 1.4540 0.7645 1.1460 0.7958 1.0560
Alanine 1.0519 0.9615 0.8116 0.8996 0.9108 1.0294 1.1227 1.1396
alpha-Hydroxytamoxifen 1.8302 1.1305 0.4580 0.8369 0.7310 1.3761 0.8770 0.9094
Amitrole 1.2554 1.1725 0.6615 1.5236 1.1024 1.0856 0.5668 0.8074
Avizafone 1.1876 1.1809 1.5558 0.8494 0.4627 0.7732 1.3806 0.9235
Barbital 1.0397 1.0813 0.8809 1.7851 0.6301 1.4247 0.9336 0.5602
Benzaldehyde 1.0361 1.5668 0.9090 1.3957 0.7180 1.4243 0.9984 0.4192
Buprenorphine 1.4796 0.7433 1.3393 1.5030 0.4162 0.9964 1.2233 0.6477
C12 0.1883 0.9955 0.4410 0.6113 1.4848 0.6637 0.5234 2.3678
Caproic acid 0.8349 1.5053 1.1510 1.3119 0.3376 1.0944 1.1631 0.9966
CB3717 2.4354 1.0436 0.9367 0.2048 0.2239 1.3227 1.4299 0.7425
Corticosterone 0.6047 1.9240 0.5679 1.2471 0.4878 1.3878 1.0620 1.0622
Creatinine 1.1359 1.3943 1.0555 1.4631 0.7513 1.3115 1.0652 0.3014
DL-pipecolic acid 0.9990 1.4735 0.8105 1.3725 0.7899 1.0401 0.8613 0.9342
endo-1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-N-oxide 3.0143 0.3251 0.7683 1.3379 0.9883 0.6405 0.6072 0.5624
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate 1.3890 1.3498 1.1592 1.4356 0.6320 1.0344 0.9298 0.5671
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate + 10.542064 1.2369 0.4526 1.6147 1.1477 0.4342 1.3669 1.2252 0.6799
Fexofenadine 2.6736 0.4534 0.5265 1.5881 0.6842 0.6101 0.8640 0.8352
Gymnodimine 1.5687 0.6607 1.0843 1.4014 0.4397 1.1960 1.3529 0.5696
Heptanoic acid, 2-amino-, (R)-; (R)-2-Aminoheptanoic acid 1.0763 1.2817 0.8312 1.5030 0.6789 1.4864 0.7916 0.6748
Hydroxyibuprofen 0.9996 1.0152 0.9057 1.1522 0.9843 1.0517 0.8400 1.0599
Ile Pro 0.8876 2.2103 0.4375 0.3500 0.6985 2.1765 1.5658 0.1277
Indoleacrylic acid 0.8223 1.8063 0.6831 1.1631 0.6882 1.5056 0.6358 1.0118
Isowillardiine 2.2842 1.1338 1.2097 1.6875 0.0836 0.6913 1.2507 0.4436
L-alpha-glutamyl-L-hydroxyproline 0.9945 1.0982 1.2636 0.8401 1.0434 0.7465 1.0982 0.9715
L-Glutamic acid dibutyl ester 1.7595 0.0492 0.6466 2.1485 0.8829 0.2615 0.3654 1.7003
L-Glutamic acid n-butyl ester 1.5542 0.7680 0.9656 1.4903 0.7059 0.7709 0.8529 1.0503
L-Glutamic acid n-butyl ester + 1.51668 1.3020 0.8523 1.0815 1.2948 0.7759 1.0258 0.8288 0.9670
L-Isoleucine 0.8854 1.2599 0.6705 1.7065 0.9248 1.1235 0.7342 0.8890
L-Leucine 1.0154 0.3374 0.8826 1.6431 0.9570 1.5236 0.7682 0.7705
L-Pipecolic acid 1.7540 1.5864 1.3071 1.4261 0.7985 1.1505 0.7494 0.0002
L-Tryptophan 0.5703 2.8487 0.4067 2.0608 0.1213 2.5472 0.5669 0.0008
L-Valine 0.7171 0.7329 0.8742 1.3155 1.0884 1.0737 0.9188 1.1135
L-Valine + 1.2355758 0.8902 1.4865 1.0175 1.2810 0.7775 1.0919 0.9666 0.8047
Lys Lys Lys 0.6114 0.2008 1.4505 1.0753 1.7111 0.5972 1.0107 0.9239
Lys Lys Lys + 10.543157 0.6781 0.2013 1.3959 0.6719 1.5807 0.6378 1.0705 1.2311
LysoPE(0:0/18:2(9Z,12Z)) 2.3562 0.7034 0.7701 0.9560 0.8246 0.9597 1.0759 0.5724
LysoPE(0:0/22:0) 1.7982 0.3314 1.6795 0.9290 0.4240 1.2811 1.3861 0.4165
Methdilazine 0.1163 2.1910 1.5158 0.6017 0.0004 2.4432 1.8543 0.0004
MS-275 6.2357 0.0006 0.0006 1.1506 0.1391 0.0006 0.0006 1.1015
N4-Acetylaminobutanal 1.0470 1.3544 1.0741 1.1082 0.7222 1.1465 1.0205 0.8085
N(alpha)-t-Butoxycarbonyl-L-leucine 0.7628 2.3006 0.6952 1.1165 0.3896 2.4375 0.5372 0.4315
N(alpha)-t-Butoxycarbonyl-L-leucine + 3.9469597 1.4121 0.8910 0.7942 1.6142 0.5939 1.4220 0.6194 0.8791
Naphthalic anhydride 2.6840 0.7253 1.0038 1.3535 0.8113 0.9342 0.8676 0.1303
Niacin (Nicotinic acid) 1.5900 0.4389 0.5797 2.8183 0.4606 0.8606 0.7923 0.7839
Nitrapyrin 1.1764 1.7890 1.3756 0.5442 0.4778 1.2112 1.5209 0.4535
N-Methyl-2-pyrrolidinone 0.2307 1.5101 0.9618 0.9519 0.9206 1.4694 0.9944 1.0082
N-n-Hexanoylglycine methyl ester 1.6833 0.6715 0.4550 1.1196 2.1842 0.3251 0.6625 0.6518
Oxindole 0.4768 3.2762 1.4710 1.2629 0.0003 1.9382 0.9267 0.0003
Oxyquinoline 0.6258 2.5798 0.8550 1.0497 0.3375 2.1767 0.8782 0.3065
p-Aminobenzoic acid 1.4002 1.4900 1.4116 1.7294 0.5532 1.2181 0.7815 0.1746
Pantoic acid 0.8740 1.0298 1.2474 0.9425 1.0061 0.8797 1.0476 0.9970
PE(18:0/0:0) 1.3163 0.8206 1.2549 1.1996 0.3448 1.2565 1.4362 0.6538
PE(19:1(9Z)/0:0) 1.1267 0.6724 1.3359 1.1963 0.3706 1.4096 1.5384 0.5640
PE(19:1(9Z)/0:0) + 10.729481 1.7695 0.4329 1.3308 1.3039 0.3322 0.9406 1.6453 0.5269
PE(19:1(9Z)/0:0) + 10.803823 1.6780 0.3865 1.0205 1.3840 0.3769 0.9647 1.6694 0.6798
Phe His Phe 0.1830 1.3686 1.0376 1.1017 0.6253 1.7104 1.3763 0.7365
Phenacylamine 0.6642 1.6315 0.7021 1.6823 0.8949 1.3534 0.8315 0.6028
Phenylpyruvic acid 0.6932 1.8352 0.4863 2.0889 0.8282 1.1274 0.7712 0.6597
Piperideine 0.9352 1.2073 0.7643 1.2591 0.9349 1.3041 0.8359 0.8723
Piperideine + 1.3051474 1.0962 1.4455 1.0447 1.1133 0.7709 1.2412 1.0266 0.6137
Prometon 1.3587 0.5831 0.5833 2.3935 0.6984 0.6958 0.4577 1.3252
Prometon + 1.7550333 1.1003 0.2029 0.7409 2.0243 0.7694 0.2658 0.6321 1.9706
Prostaglandin D1 Alcohol 0.7137 0.5264 1.0100 1.0118 1.4157 0.8389 1.0161 1.1182
Rebaudioside C 1.5347 0.9726 1.0288 0.6839 0.6240 1.4718 1.0331 0.8040
Sarcoaldesterol A 2.8377 1.3900 0.7225 0.0005 0.3085 0.9531 1.5264 0.7232
(S)-ATPA 1.1570 1.2756 0.0004 3.0515 0.0787 1.3508 0.3435 1.2322
Taurine 1.6792 0.9043 0.6542 1.3827 0.6645 0.9808 0.7869 1.0996
(+)-Tephrorin A 2.7853 0.4082 0.7400 0.2499 0.0006 1.4229 1.7868 0.7704
Tetrahydrofuran 1.1964 0.9781 1.4707 0.7560 0.8782 0.6589 1.4677 0.7452
Thr Ser Ser 0.9128 1.5869 1.3688 0.9225 0.7610 1.2374 1.3513 0.3189
Tranexamic acid 1.3825 1.9812 0.5101 1.6935 0.0341 1.9763 0.7638 0.4677
Traumatic Acid 1.0751 1.3308 0.9551 1.9043 0.5307 1.2067 0.7129 0.7480
Trp Tyr Tyr 3.3716 0.0007 0.0007 2.3898 0.2806 0.0007 0.0007 2.0430
Tubastatin A 3.1058 0.2248 0.2252 1.0540 0.1048 1.0365 0.1997 1.9960
Tyr Thr Gln 3.1066 0.0398 0.0257 2.1115 0.4618 0.1287 0.1246 1.9780
Urea 1.0397 1.4681 1.3586 0.8804 0.9519 1.1982 1.0325 0.4360
Uric acid 2.8511 0.3719 0.2856 1.4047 0.8365 1.3138 0.4548 0.6427
Val Gly 1.1062 2.2675 0.8993 1.0427 0.1690 1.3654 1.1643 0.7238
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Factors:

F1Group:CD | Genotype:Irlox
F2Group:Control | Genotype:IGFR lox
F3Group:Control | Genotype:Irlox
F4Group:Control | Genotype:IRlox IGFR lox
F5Group:HFD | Genotype:Irlox
F6Group:IGFRKO | Genotype:IGFR -/-
F7Group:IRKO | Genotype:IR -/-
F8Group:MIGIRKO | Genotype:IR -/- IGFR -/-
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