Data for Large Scale C18 Profiling of the Effects of Curcumin Supplementation of Older Adults: Relation to Vascular Function (Study ST000566)
(Analysis AN000869)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 11E-octadecen-9-ynoic acid | 1.2694 | 1.3699 | 0.3872 | 1.0538 | 0.7884 | NA |
| 11-methyl-tridecanoic acid | 1.0607 | 1.1352 | 0.8394 | 0.9866 | 0.9377 | NA |
| 12-oxo-14,18-dihydroxy-9Z,13E,15Z-octadecatrienoic acid | 1.0442 | 1.1028 | 0.6823 | 0.8192 | 1.2948 | NA |
| 13Z-octadecenoic acid | 1.1304 | 1.3915 | 0.5571 | 1.0996 | 0.7223 | NA |
| 17-?, 21-dihydroxy-11,20-dioxo-5-?-pregnan-3-?-yl-?-d-glucuronide | 0.9825 | 1.0519 | 1.1196 | 1.1997 | 0.6641 | NA |
| 2,4-Dichloro-3-oxoadipate | 1.0539 | 1.0123 | 1.0625 | 1.0489 | 0.8209 | NA |
| 2-Aminoadenosine | 0.7676 | 0.6837 | 0.9941 | 0.8516 | 1.7704 | NA |
| 2^-Deoxyuridine | 0.6906 | 1.2147 | 1.0514 | 1.2149 | 0.8610 | NA |
| 2-Hydroxy-3-(4-methoxyethylphenoxy)-propanoic acid | 0.8750 | 1.0098 | 1.3556 | 1.5146 | 0.3236 | NA |
| 2-Pyridylthioamide | 1.0410 | 1.0222 | 1.1893 | 0.9417 | 0.8061 | NA |
| 36:4(21Z,24Z,27Z,30Z) | 1.0529 | 1.3042 | 0.5587 | 1.1158 | 0.8942 | NA |
| 3b,16a-Dihydroxyandrostenone sulfate | 0.7442 | 0.7238 | 1.1710 | 1.3503 | 1.1240 | NA |
| 3-keto-n-caproic acid | 0.9057 | 0.9076 | 1.0576 | 1.0262 | 1.1355 | NA |
| 4-Hydroxybenzenesulfonic acid | 1.4098 | 0.9564 | 0.8676 | 0.9690 | 0.7332 | NA |
| 4-Hydroxylevamisole Glucuronide | 0.9622 | 0.9170 | 1.0567 | 1.1271 | 0.9674 | NA |
| 4-Methylumbelliferyl ?-D-glucuronide | 1.1961 | 1.5720 | 1.0736 | 0.5718 | 0.4515 | NA |
| 4-Sulfobenzyl alcohol | 0.9715 | 1.0297 | 1.1227 | 1.2099 | 0.6898 | NA |
| 5,7,4^-Trihydroxyflavanone 7-sulfate | 1.0273 | 1.0771 | 0.9519 | 1.0776 | 0.8533 | NA |
| 5,8-Dihydroxy-3,4-dihydrocarbostyril | 1.1606 | 0.9889 | 1.0290 | 1.1353 | 0.6766 | NA |
| 5?-Androstan-3?-ol-17-one sulfate | 0.5614 | 0.6150 | 0.9428 | 1.0811 | 1.9192 | NA |
| 5?-Androstan-3?-ol-17-one sulfate - 7.5459185 | 0.6772 | 0.8200 | 0.8386 | 1.0067 | 1.7183 | NA |
| 5?-Androstan-3?-ol-17-one sulfate - 7.7291727 | 0.6934 | 0.7153 | 0.7196 | 0.8467 | 2.0786 | NA |
| 5?-Androstan-3?-ol-17-one sulfate - 8.185043 | 0.4844 | 0.4463 | 0.6397 | 0.7612 | 2.7784 | NA |
| 5-Dehydro-4-deoxy-D-glucarate | 1.2064 | 1.1917 | 0.8897 | 1.0403 | 0.6100 | NA |
| 5-O-Feruloylquinic acid | 1.0258 | 1.2331 | 0.7855 | 1.0782 | 0.8306 | NA |
| 6-dehydrotestosterone 17-glucosiduronic acid | 0.8356 | 1.3234 | 1.6637 | 0.8116 | 0.3769 | NA |
| 6E,9E-octadecadienoic acid | 1.1865 | 1.4010 | 0.4313 | 0.9639 | 0.8902 | NA |
| 6-Gingerol | 1.1216 | 1.0459 | 0.8307 | 1.1002 | 0.8727 | NA |
| 6-Thioxanthine 5^-monophosphate | 1.0963 | 1.0508 | 0.9750 | 1.0554 | 0.8037 | NA |
| 7-Hydroxymethotrexate | 1.0356 | 1.1533 | 0.9454 | 1.0843 | 0.7565 | NA |
| AFMK | 1.0896 | 1.1606 | 1.0921 | 1.3382 | 0.3144 | NA |
| Allopregnanalone sulfate | 0.6731 | 0.6923 | 0.8313 | 0.9203 | 1.9558 | NA |
| AMCC | 0.1969 | 0.4913 | 0.3470 | 0.4631 | 3.6041 | NA |
| Carboxytolbutamide | 1.0645 | 1.0375 | 0.9838 | 1.0649 | 0.8382 | NA |
| Creatinine | 1.1016 | 0.9372 | 1.1383 | 1.0472 | 0.7834 | NA |
| Deoxycholic acid glycine conjugate | 0.8549 | 0.5802 | 0.7236 | 0.9787 | 1.9220 | NA |
| Distemonanthin | 1.0644 | 1.0353 | 0.9786 | 1.0772 | 0.8344 | NA |
| Distemonanthin - 0.9142415 | 1.0855 | 1.0192 | 0.9428 | 1.0894 | 0.8504 | NA |
| Dolichol-16 | 1.0158 | 1.0090 | 1.1199 | 1.1033 | 0.7644 | NA |
| edetate | 1.0530 | 1.1060 | 0.9440 | 1.0436 | 0.8298 | NA |
| Fagomine | 1.1064 | 0.8616 | 1.1690 | 1.2728 | 0.6263 | NA |
| floxuridine | 1.0617 | 1.0182 | 1.0047 | 1.1205 | 0.7924 | NA |
| Fluroxypyr | 1.0398 | 1.0208 | 1.0105 | 1.0501 | 0.8745 | NA |
| Gluconic acid | 1.1345 | 1.1813 | 0.9304 | 1.0236 | 0.6818 | NA |
| Glu Glu Met | 0.6490 | 0.6873 | 0.7724 | 0.9878 | 1.9812 | NA |
| Herbimycin | 1.0913 | 1.1053 | 0.8084 | 1.1230 | 0.8390 | NA |
| His Cys His | 0.5791 | 0.6354 | 0.7093 | 0.8185 | 2.3361 | NA |
| Hydroxyibuprofen | 1.0042 | 0.9655 | 0.9213 | 1.0199 | 1.0892 | NA |
| Lactacystin | 0.4973 | 0.5951 | 0.7309 | 0.9765 | 2.3089 | NA |
| Lys His Cys | 0.7155 | 0.6857 | 0.7539 | 1.0238 | 1.8907 | NA |
| Lys Met His | 0.6717 | 0.6779 | 0.8762 | 0.9680 | 1.8879 | NA |
| Mahuannin D | 1.0879 | 1.1502 | 0.9633 | 1.1009 | 0.6684 | NA |
| Marinobufagenin | 0.4575 | 0.8790 | 0.6179 | 1.2139 | 1.9145 | NA |
| Mesuagin | 0.1497 | 0.5071 | 0.2185 | 0.4493 | 3.7722 | NA |
| MID42238:(6R)-1?,25-dihydroxyvitamin D3 6,19-sulfur dioxide adduct / (6R)-1?,25-dihydroxycholecalcif | 1.0290 | 1.0828 | 1.0309 | 1.0886 | 0.7612 | NA |
| Millettosin | 1.1442 | 1.1635 | 0.8389 | 1.0883 | 0.7160 | NA |
| N(6)-Methyllysine | 1.1565 | 0.9849 | 1.0075 | 1.1878 | 0.6570 | NA |
| N-Methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenathridine-6-ethanoic acid | 0.2740 | 0.2093 | 0.4688 | 0.3389 | 3.8405 | NA |
| p-cresol | 1.0007 | 1.0672 | 1.1130 | 1.1983 | 0.6333 | NA |
| Phenol | 1.4609 | 0.8686 | 0.8284 | 1.0262 | 0.7584 | NA |
| Phenyl beta-D-glucopyranoside | 0.8962 | 1.0437 | 1.4317 | 1.5043 | 0.1996 | NA |
| Phosphonoacetate | 1.0152 | 0.9942 | 1.0152 | 1.0439 | 0.9344 | NA |
| Prasterone sulfate | 0.6254 | 0.6750 | 0.7815 | 0.9923 | 2.0096 | NA |
| Prasterone sulfate - 7.9986095 | 0.3890 | 0.1352 | 0.1087 | 0.3260 | 4.1402 | NA |
| pregnenolone sulfate | 0.4266 | 0.4530 | 0.5916 | 0.7948 | 2.8502 | NA |
| Proanthocyanidin A2 | 1.0811 | 1.1844 | 0.8913 | 1.1176 | 0.6883 | NA |
| Quinic acid | 1.2780 | 1.6111 | 0.7193 | 0.9502 | 0.2908 | NA |
| Quinol sulfate | 0.9387 | 0.7710 | 1.2143 | 1.0232 | 1.1113 | NA |
| Steryl sulfate | 0.2375 | 0.3476 | 0.7721 | 0.9642 | 2.8619 | NA |
| Sulfamethizole | 1.0302 | 1.0956 | 0.9431 | 1.0667 | 0.8471 | NA |
| Sulfinpyrazone sulfone | 1.0040 | 1.1377 | 0.9315 | 1.1294 | 0.7815 | NA |
| Tauroursodeoxycholic acid | 0.3489 | 0.1870 | 1.7090 | 1.5610 | 1.4940 | NA |
| TG(22:0/22:0/22:0) | 1.2433 | 0.9220 | 1.0071 | 1.0879 | 0.7229 | NA |
| Trilauroyl-glycerol | 1.2394 | 1.4207 | 0.3884 | 0.8700 | 0.9342 | NA |
| Tris(2-chloroethyl)phosphate | 1.0356 | 0.9243 | 0.9383 | 0.9940 | 1.1087 | NA |
| Trp His Glu | 0.9000 | 1.4738 | 1.7560 | 0.7773 | 0.0775 | NA |
| Tryptophan | 0.9637 | 0.9362 | 0.9682 | 1.0005 | 1.1435 | NA |
| UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine | 1.0961 | 1.1040 | 0.9435 | 1.0996 | 0.7314 | NA |
| Uric acid | 1.0171 | 1.0166 | 1.0351 | 1.0398 | 0.8919 | NA |
| Valdecoxib | 1.0450 | 1.0585 | 0.9763 | 1.0809 | 0.8286 | NA |
| Z-Arg-Arg-NHMec | 1.2166 | 1.0980 | 0.7223 | 1.1942 | 0.7180 | NA |
Factors:
| F1 | group:Old-Curcumin | Time point:Post |
| F2 | group:Old-Curcumin | Time point:Pre |
| F3 | group:Old-Placebo | Time point:Post |
| F4 | group:Old-Placebo | Time point:Pre |
| F5 | group:young | Time point:Baseline |
| F6 | group:young | Time point:Pre |
