Data for Large Scale HILIC Profiling of the Effects of Curcumin Supplementation of Older Adults: Relation to Vascular Function (Study ST000567)
(Analysis AN000871)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 |
---|---|---|---|---|---|---|
1?,25-dihydroxy-11?-(2-hydroxyethyl)vitamin D3 / 1?,25-dihydroxy-11?-(2-hydroxyethyl)cholecalciferol | 1.0904 | 1.1901 | 0.8964 | 0.9068 | 0.8621 | NA |
12-hydroxy-10-octadecynoic acid | 0.8132 | 0.7697 | 0.6297 | 0.9391 | 1.8771 | NA |
13Z-hexadecenoic acid | 1.0139 | 1.0877 | 0.8211 | 1.5310 | 0.5569 | NA |
13Z-octadecenoic acid | 1.1144 | 1.2536 | 0.9507 | 1.0025 | 0.6229 | NA |
15-hydroxy-pentacosanoic acid | 0.8916 | 0.9901 | 1.2593 | 1.3948 | 0.5278 | NA |
16,16-dimethyl-PGA1 | 1.0187 | 0.9783 | 0.8182 | 0.8848 | 1.2792 | NA |
16-Feruloyloxypalmitate | 0.8596 | 0.8106 | 0.5013 | 0.5408 | 2.2663 | NA |
17-oxo-20Z-hexacosenoic acid | 1.0955 | 1.2318 | 0.9211 | 0.9191 | 0.7744 | NA |
1,9-dideoxyforskolin | 1.4060 | 1.4371 | 0.6259 | 1.1186 | 0.2738 | NA |
19-Hydroxy-8-O-methyltetrangulol | 1.1503 | 1.0339 | 1.1866 | 1.0632 | 0.5576 | NA |
1-Deacetoxy-1-Oxo-3,7-Dideacetylkhivorin | 1.0309 | 0.8890 | 1.1036 | 1.1213 | 0.8828 | NA |
1?-hydroxy-23,24,25,26,27-pentanorvitamin D3 / 1?-hydroxy-23,24,25,26,27-pentanorcholecalciferol | 1.0461 | 1.1914 | 0.9199 | 1.0171 | 0.7870 | NA |
(23S)-23,24,25-trihydroxyvitamin D3 / (23S)-23,24,25-trihydroxycholecalciferol | 0.8750 | 0.8673 | 1.0294 | 0.9203 | 1.3413 | NA |
(23S)-23,24,25-trihydroxyvitamin D3 / (23S)-23,24,25-trihydroxycholecalciferol - 1.2433269 | 0.8063 | 0.8367 | 1.1461 | 1.0871 | 1.1915 | NA |
2,4,5-Trichlorophenoxyacetic Acid, Isooctyl Ester | 1.0623 | 1.0627 | 0.9978 | 1.0127 | 0.8474 | NA |
2,4.6-Trichloroanisole | 1.0166 | 1.0320 | 1.0617 | 1.1548 | 0.7434 | NA |
2,4-dimethyl-tetradecanoic acid | 1.0770 | 1.1920 | 0.9218 | 0.9837 | 0.7804 | NA |
26,27-diethyl-1?,25-dihydroxy-23-oxavitamin D3 / 26,27-diethyl-1?,25-dihydroxy-23-oxacholecalciferol | 0.9956 | 1.1074 | 0.8637 | 0.8369 | 1.1603 | NA |
26-hydroxy-hexacosanoic acid | 0.8849 | 0.9931 | 1.2480 | 1.3702 | 0.5654 | NA |
2beta,7alpha,12alpha-Trihydroxy-3-oxo-5beta-cholan-24-oic Acid | 2.1778 | 1.2735 | 0.3101 | 0.2902 | 0.6411 | NA |
2-Butanone, 4-[6-(sulfooxy)-2-naphthalenyl]- | 1.0101 | 0.9096 | 0.9599 | 0.9363 | 1.1882 | NA |
2-Carboxy-2-hydroxy-8-carboxychromene | 0.6214 | 0.7720 | 1.0436 | 0.6067 | 2.0179 | NA |
2-Hydroxy-3-(4-methoxyethylphenoxy)-propanoic acid | 0.9377 | 1.0345 | 1.3286 | 1.4386 | 0.3194 | NA |
2-Hydroxyethanesulfonate | 1.0422 | 0.9907 | 1.1479 | 1.2202 | 0.6207 | NA |
2Z,13E-Octadecadienyl acetate | 1.0073 | 1.2640 | 0.8992 | 0.9424 | 0.8370 | NA |
2Z-dodecenoic acid | 1.3357 | 1.2741 | 0.7388 | 0.7528 | 0.7752 | NA |
3?,7?,12?-Trihydroxy-24-methyl-5?-cholest-23-en-26-oic acid | 1.1550 | 1.1464 | 0.6612 | 1.8239 | 0.2051 | NA |
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid | 1.1056 | 0.9957 | 0.8583 | 0.9444 | 1.0675 | NA |
3b,16a-Dihydroxyandrostenone sulfate | 0.8154 | 0.7874 | 1.1742 | 1.3144 | 1.0002 | NA |
3b,16a-Dihydroxyandrostenone sulfate - 1.2323091 | 1.3670 | 1.2971 | 1.0837 | 1.1027 | 0.0680 | NA |
3-keto valeric acid | 0.9693 | 1.1786 | 1.2870 | 0.7409 | 0.8050 | NA |
3-Methylxanthine | 1.2100 | 1.3861 | 0.8602 | 0.9897 | 0.4581 | NA |
3-O-Demethylamorphigenin | 4.4990 | 0.0003 | 0.0003 | 0.0003 | 0.0003 | NA |
3-oxohexacosanoic acid | 1.0417 | 1.1194 | 0.9830 | 1.0518 | 0.7836 | NA |
4-Ketonostoxanthin 3-sulfate | 0.6383 | 0.7717 | 0.7957 | 0.9443 | 1.9157 | NA |
4-Sulfobenzyl alcohol | 0.8615 | 1.0790 | 1.2247 | 1.3064 | 0.5748 | NA |
5,11,14-Eicosatrienoic acid, 8,9-dihydroxy-; 8,9-Dihydroxy-5,11,14-eicosatrienoic acid | 0.9345 | 0.8540 | 0.9778 | 0.8650 | 1.3876 | NA |
5,6-Dihydrouridine | 1.0847 | 1.0398 | 1.0415 | 1.0164 | 0.8040 | NA |
5-Acetylamino-6-amino-3-methyluracil | 1.1747 | 1.3266 | 1.1336 | 0.9992 | 0.3038 | NA |
5-Acetylamino-6-formylamino-3-methyluracil | 0.8738 | 1.1859 | 1.1525 | 1.0833 | 0.7127 | NA |
5?-Androstan-3?-ol-17-one sulfate | 0.6977 | 0.7766 | 0.8227 | 0.9209 | 1.8388 | NA |
5?-Cholestane-3?,7?,12?,24,26-pentol | 0.8550 | 1.1115 | 1.1479 | 1.2354 | 0.6823 | NA |
5-?-Hydroxybutyl Hydantoin | 0.9333 | 0.9590 | 0.9747 | 0.9115 | 1.2288 | NA |
6-dehydrotestosterone 17-glucosiduronic acid | 0.8559 | 1.2422 | 1.8142 | 0.7720 | 0.3435 | NA |
6-dehydrotestosterone 17-glucosiduronic acid - 3.373496 | 0.7882 | 1.3533 | 1.8136 | 0.7335 | 0.3303 | NA |
6-deoxoteasterone | 1.0587 | 1.1495 | 1.0880 | 1.0952 | 0.5920 | NA |
6E,9E-octadecadienoic acid | 1.0952 | 1.2442 | 0.8710 | 0.9621 | 0.7670 | NA |
7,11,14-Eicosatrienoic acid | 1.0607 | 1.1504 | 0.9144 | 1.0007 | 0.8376 | NA |
7?,12?-Dihydroxy-5?-cholan-24-oic Acid | 1.2362 | 1.1191 | 0.7363 | 0.6676 | 1.1474 | NA |
7-keto-stearic acid | 1.0397 | 1.1823 | 0.9456 | 1.0955 | 0.7081 | NA |
8,11,14-Docosatriynoic acid | 1.0142 | 1.0578 | 0.9616 | 1.1181 | 0.8438 | NA |
8,12,16,19-docosatetraenoic acid | 1.0555 | 1.2231 | 0.9331 | 0.9961 | 0.7474 | NA |
8-Prenylafzelechin 5-methyl ether | 1.0415 | 1.1816 | 0.9305 | 1.0372 | 0.7751 | NA |
9E,12Z,15Z-octadecatrienoic acid | 1.1851 | 1.2032 | 0.7878 | 0.8133 | 0.9266 | NA |
9-Hydroxyphenanthrene | 0.9863 | 0.9783 | 1.0257 | 0.9805 | 1.0348 | NA |
AFMK | 1.0700 | 1.2167 | 1.0919 | 1.3829 | 0.2315 | NA |
AMCC | 0.6061 | 0.8213 | 0.6693 | 0.8374 | 2.1125 | NA |
AMCC - 3.3688588 | 0.3437 | 0.6027 | 0.5551 | 0.8827 | 2.7261 | NA |
Arg Arg Lys | 1.1481 | 0.9551 | 0.9662 | 0.7623 | 1.1342 | NA |
Arg Arg Phe | 0.9802 | 0.8855 | 0.9271 | 0.9517 | 1.2660 | NA |
Arg Leu Tyr | 0.5097 | 0.4739 | 0.6233 | 0.6964 | 2.7933 | NA |
Ascorbate 2-sulfate | 0.9031 | 0.9681 | 1.3372 | 1.3941 | 0.4681 | NA |
Asp Asn | 0.6564 | 0.6615 | 0.9471 | 1.0866 | 1.7483 | NA |
Asp Asn - 1.0590627 | 0.4818 | 0.5128 | 1.1205 | 0.5599 | 2.4458 | NA |
Asp Glu His | 1.1826 | 1.2201 | 0.7588 | 1.0426 | 0.7242 | NA |
C16-OH Sulfatide | 0.6896 | 0.9879 | 1.0006 | 0.6935 | 1.6525 | NA |
Coformycin | 1.0459 | 1.6054 | 0.9200 | 0.8532 | 0.4661 | NA |
Creatinine | 1.0191 | 1.0142 | 1.0718 | 1.0876 | 0.8140 | NA |
cyclo-Dopa-glucuronylglucoside | 0.6888 | 0.7881 | 0.8534 | 1.0180 | 1.7173 | NA |
Dehydro-L-(+)-ascorbic acid dimer | 0.9313 | 0.9099 | 1.0028 | 1.0090 | 1.1705 | NA |
Deoxycholic acid glycine conjugate | 0.8821 | 0.5904 | 0.7571 | 0.8656 | 1.9532 | NA |
Deoxyribose 5-phosphate | 0.9758 | 1.0399 | 1.1378 | 1.0321 | 0.8243 | NA |
DG(22:5(4Z,7Z,10Z,13Z,16Z)/22:1(13Z)/0:0) | 0.9848 | 1.0854 | 0.9445 | 0.8825 | 1.0804 | NA |
Diphenylmethylphosphine | 1.0241 | 1.0119 | 0.8624 | 1.0337 | 1.0554 | NA |
Eicosanedioic acid | 0.9405 | 1.1131 | 1.0110 | 1.3023 | 0.6479 | NA |
Epicatechin 3-O-beta-D-glucopyranoside | 0.4781 | 0.4227 | 0.7463 | 0.9576 | 2.5312 | NA |
Epoxomicin | 0.9415 | 0.9122 | 0.9732 | 0.9298 | 1.2572 | NA |
Euparin | 1.2697 | 1.5418 | 0.8980 | 0.9515 | 0.2124 | NA |
Fagomine | 1.1808 | 0.9593 | 1.1653 | 1.0498 | 0.6401 | NA |
Furmecyclox | 1.0184 | 1.1539 | 0.8930 | 0.7968 | 1.0911 | NA |
Glutaconic acid | 1.1261 | 1.3429 | 1.1709 | 1.0024 | 0.3031 | NA |
Hippuric acid | 1.1478 | 0.9631 | 1.0152 | 1.1792 | 0.6927 | NA |
His His Cys | 0.9005 | 0.9411 | 0.9597 | 1.0349 | 1.1862 | NA |
Hydroquinone | 0.9191 | 0.8258 | 1.2549 | 1.0137 | 1.0422 | NA |
Hydroxyibuprofen | 1.0118 | 1.0209 | 1.0397 | 1.0618 | 0.8684 | NA |
Indole | 0.9880 | 1.0118 | 1.0092 | 0.9498 | 1.0383 | NA |
Lactic acid | 1.2379 | 1.5669 | 1.0331 | 0.5333 | 0.4828 | NA |
Laurencione diacetate | 0.1448 | 0.3823 | 0.7632 | 0.7453 | 3.1396 | NA |
Lys Met His | 0.8099 | 0.7783 | 1.0070 | 0.7814 | 1.6672 | NA |
Marinobufagenin | 0.6766 | 0.7226 | 0.8306 | 0.9445 | 1.8954 | NA |
Mestanolone | 1.0727 | 1.1772 | 0.8994 | 0.9746 | 0.8313 | NA |
Methionine | 1.0677 | 1.1776 | 1.5902 | 1.1847 | 0.0001 | NA |
Met His Asn | 1.4912 | 1.5061 | 0.9759 | 0.7413 | 0.1228 | NA |
Methyl oleate | 1.0225 | 1.0150 | 1.3699 | 0.7964 | 0.8027 | NA |
Methylprednisone | 0.8917 | 0.8436 | 0.6863 | 0.8363 | 1.7458 | NA |
Met Trp Met | 1.2608 | 1.2162 | 1.0419 | 0.8882 | 0.5198 | NA |
MG(0:0/22:1(13Z)/0:0) | 1.0170 | 1.1463 | 1.0175 | 1.0499 | 0.7508 | NA |
MG(0:0/24:0/0:0) | 0.8355 | 0.9945 | 1.3172 | 1.4284 | 0.5019 | NA |
MG(24:1(15Z)/0:0/0:0) | 0.8767 | 0.8819 | 1.2812 | 1.2664 | 0.7673 | NA |
MID42238:(6R)-1?,25-dihydroxyvitamin D3 6,19-sulfur dioxide adduct / (6R)-1?,25-dihydroxycholecalcif | 0.9660 | 1.0433 | 1.1188 | 1.1318 | 0.7567 | NA |
MID42262:(24R)-25-fluoro-1?,24-dihydroxy-24-methylvitamin D3 / (24R)-25-fluoro-1?,24-dihydroxy-24-me | 1.0530 | 1.2235 | 0.7004 | 0.7196 | 1.2225 | NA |
MID42315:1?,25-dihydroxy-26,27-dimethyl-22-oxavitamin D3 / 1?,25-dihydroxy-26,27-dimethyl-22-oxachol | 0.9667 | 1.0156 | 0.9185 | 0.9111 | 1.1785 | NA |
MID42391:26,27-diethyl-1?,25-dihydroxy-20,21-didehydro-23-oxavitamin D3 / 26,27-diethyl-1?,25-dihydr | 0.8825 | 1.1171 | 0.5679 | 0.7704 | 1.6148 | NA |
N-acetyl-LTE4 | 0.5513 | 0.8135 | 0.6855 | 0.9411 | 2.0728 | NA |
Neoabietic acid | 0.9592 | 1.0568 | 1.0478 | 1.2088 | 0.7434 | NA |
Norbixin | 0.3129 | 0.2665 | 0.9915 | 0.9600 | 2.6686 | NA |
NVP-BEZ235 | 1.0408 | 1.1856 | 1.0907 | 1.1208 | 0.5449 | NA |
Paraxanthine | 1.0528 | 1.2649 | 1.0844 | 1.3246 | 0.2571 | NA |
p-cresol | 0.8899 | 1.0634 | 1.1924 | 1.3046 | 0.5919 | NA |
PE(18:3(9Z,12Z,15Z)/20:3(8Z,11Z,14Z)) | 1.0414 | 1.1219 | 1.0455 | 0.9716 | 0.7976 | NA |
PE(22:5(7Z,10Z,13Z,16Z,19Z)/P-18:1(11Z)) | 1.0205 | 1.0158 | 1.1596 | 1.0607 | 0.7540 | NA |
PE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/P-18:1(9Z)) | 1.0520 | 1.0794 | 1.0791 | 1.0599 | 0.7207 | NA |
PE(P-16:0/20:5(5Z,8Z,11Z,14Z,17Z)) | 0.7298 | 0.6493 | 1.8393 | 1.3956 | 0.5629 | NA |
Phenyl beta-D-glucopyranoside | 0.9969 | 1.0683 | 1.3602 | 1.3760 | 0.2419 | NA |
PI(18:1(9Z)/18:2(9Z,12Z)) | 0.9928 | 1.0112 | 0.8712 | 0.8135 | 1.2881 | NA |
PI(20:2(11Z,14Z)/18:2(9Z,12Z)) | 1.0755 | 1.1725 | 0.9746 | 0.8887 | 0.8434 | NA |
PI(22:4(7Z,10Z,13Z,16Z)/18:3(6Z,9Z,12Z)) | 1.0800 | 1.1870 | 0.9376 | 0.9043 | 0.8416 | NA |
Prasterone sulfate | 0.6179 | 0.6747 | 0.8164 | 0.9919 | 1.9864 | NA |
Pregnanolone sulfate | 0.6802 | 0.7880 | 0.8916 | 0.9650 | 1.7410 | NA |
pregnenolone sulfate | 0.6767 | 0.6618 | 0.7242 | 0.8509 | 2.1506 | NA |
Proscillaridin A | 1.0056 | 1.2371 | 0.8963 | 1.0127 | 0.8072 | NA |
PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/19:0) | 1.0309 | 1.0750 | 1.2336 | 1.1218 | 0.5490 | NA |
PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/19:1(9Z)) | 0.9056 | 0.8266 | 1.9455 | 1.1445 | 0.2939 | NA |
PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/21:0) | 1.1965 | 1.2953 | 0.7903 | 0.7544 | 0.8607 | NA |
(S)-3-Hydroxybutyric acid | 1.3064 | 1.4947 | 0.8401 | 0.9785 | 0.2528 | NA |
SC-514 | 0.9142 | 0.8401 | 0.6341 | 0.9481 | 1.6688 | NA |
Scandoside methyl ester | 0.5950 | 0.6676 | 0.7762 | 1.1879 | 1.8761 | NA |
Scillaren A | 0.4860 | 0.5501 | 0.6437 | 0.7479 | 2.6665 | NA |
Sophoracoumestan A | 1.1658 | 1.0099 | 1.3193 | 1.0842 | 0.4246 | NA |
Stearic acid | 1.0662 | 1.1703 | 0.9253 | 0.9595 | 0.8367 | NA |
Tauropine | 1.1461 | 1.0360 | 1.0686 | 1.0857 | 0.6486 | NA |
Tauroursodeoxycholic acid | 0.4489 | 0.3039 | 1.7443 | 1.3753 | 1.3857 | NA |
Trp His Glu | 0.8835 | 1.4742 | 1.9592 | 0.5688 | 0.1010 | NA |
Tryptophan | 0.9891 | 0.9786 | 0.9764 | 0.9756 | 1.0815 | NA |
Tyr Met Val | 0.9586 | 1.4828 | 0.6274 | 0.9810 | 0.8590 | NA |
Uridine | 1.0610 | 1.0443 | 1.0728 | 1.0531 | 0.7628 | NA |
YM-201636 | 1.2277 | 1.4349 | 0.7104 | 0.8158 | 0.6827 | NA |
Factors:
F1 | groups:Old-Curcumin | Time point:Post |
F2 | groups:Old-Curcumin | Time point:Pre |
F3 | groups:Old-Placebo | Time point:Post |
F4 | groups:Old-Placebo | Time point:Pre |
F5 | groups:young | Time point:Baseline |
F6 | groups:young | Time point:Pre |