Data for Metabolite-phenotype link in X-linked Adrenoleukodystrophy (part II) (Study ST000742)
(Analysis AN001157)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|
| 16:0-18:0 PC (M+CL)- | 0.8733 | 1.1084 | 0.4024 | 0.3060 | 1.5404 | 1.3899 | 1.2347 | NA |
| 16:0 LYSO PC (M+HCOO)- | 1.0226 | 0.8235 | 0.8164 | 0.7510 | 1.2801 | 1.8377 | 1.3555 | NA |
| 18:0 LYSO-PE (M-H)- | 0.7648 | 0.7504 | 0.8244 | 0.9923 | 0.3697 | 3.1303 | 1.0056 | NA |
| 2-AMINOETHYL DIHYDROGEN PHOSPHATE (M-H)- | 1.1265 | 1.3423 | 1.4385 | 1.0142 | 0.3549 | 0.2429 | 0.0829 | NA |
| 3-HYDROXY-3-METHYLGLUTARIC ACID (M-H)- | 1.7512 | 0.8428 | 1.3540 | 1.1361 | 0.1619 | 0.1647 | 0.1712 | NA |
| ARACHIDONIC ACID (M-H)- | 1.6167 | 0.8157 | 0.8110 | 0.8153 | 0.8552 | 1.1642 | 0.9039 | NA |
| BEHENIC ACID (M-H)- | 0.5258 | 0.9662 | 0.9126 | 0.9286 | 1.1715 | 2.1039 | 1.2991 | NA |
| BENZOIC ACID (M-H)- | 0.9715 | 0.7984 | 1.2858 | 0.9096 | 0.9816 | 0.9900 | 1.2287 | NA |
| BETA-ALANINE (M-H)- | 0.9128 | 1.1232 | 1.4176 | 0.8037 | 0.7331 | 1.3949 | 0.7227 | NA |
| BETA-ALANYL-N(PAI)-METHYL-L-HISTIDINE (M-H)- | 2.0286 | 1.3422 | 0.5105 | 0.6584 | 0.5179 | 0.5924 | 0.6949 | NA |
| CIS-11-EICOSENOIC ACID (M-H)- | 1.3706 | 0.8151 | 0.6482 | 0.6309 | 0.9426 | 1.4014 | 2.0338 | NA |
| CYTIDINE 5^-DIPHOSPHOCHOLINE (M+CL)- | 0.4693 | 0.9154 | 1.0417 | 1.3179 | 1.0054 | 0.8767 | 1.2439 | NA |
| DEHYDROASCORBIC ACID (M+CL)- | 0.3832 | 0.8918 | 1.5278 | 1.4861 | NA | NA | NA | NA |
| DOCOSAHEXAENOIC ACID (M-H)- | 1.1190 | 0.6161 | 0.8783 | 0.8792 | 1.1917 | 1.3800 | 1.6521 | NA |
| EPIBRASSINOLIDE [ISTD] (M+CL)- | 0.8479 | 0.8320 | 1.2455 | 1.1390 | 0.8121 | 0.9851 | 1.0420 | NA |
| EPIBRASSINOLIDE [ISTD] (M+HCOO)- | 0.8663 | 0.8574 | 1.2033 | 1.1324 | 0.8124 | 0.9917 | 1.0367 | NA |
| ETHANOLAMINE PHOSPHATE (M-H)- | 1.0170 | 1.5234 | 1.4764 | 0.9268 | 0.1352 | 0.2737 | 0.3958 | NA |
| GLUCOSE (M+CL)- | 0.8163 | 1.2208 | 1.3810 | 1.3938 | 0.4081 | 0.4191 | 0.3969 | NA |
| GLUCURONIC ACID (M-H)- | 0.1651 | 0.9728 | 1.2302 | 1.2078 | 0.2384 | NA | 0.1539 | NA |
| GLUTAMIC ACID (M-H)- | 1.3984 | 0.7842 | 0.7474 | 0.6678 | 1.4678 | 1.2822 | 1.3260 | NA |
| GUANOSINE 5^-PHOSPHATE (M-H)- | 0.8831 | 0.8228 | 0.3493 | 0.5060 | 1.9767 | 1.2389 | 1.5632 | NA |
| GUANOSINE (M-H)- | 1.0011 | 0.6845 | 0.8666 | 0.6671 | 1.4369 | 1.6083 | 1.9538 | NA |
| HYODEOXYCHOLIC ACID (M-H)- | 0.8130 | 1.1280 | 0.7445 | 0.9378 | 1.3830 | 1.2852 | 1.1672 | NA |
| HYPOXANTHINE (M-H)- | 0.9100 | 0.8274 | 1.6868 | 1.2675 | 0.3756 | 0.4955 | 0.5655 | NA |
| INOSINE (M-H)- | 0.6937 | 0.5464 | 1.0019 | 0.7645 | 1.5710 | 2.0817 | 1.8229 | NA |
| ISOCITRIC ACID (M-H)- | 0.8055 | 0.5727 | 1.0226 | 1.1599 | 1.5234 | 1.6734 | 0.7365 | NA |
| KYNURENIC ACID (M-H)- | NA | 0.8800 | 1.2092 | 1.0004 | NA | NA | NA | NA |
| LAURIC ACID (M-H)- | 0.9329 | 0.9455 | 1.1226 | 1.1988 | 0.7840 | 0.8084 | 0.8498 | NA |
| LEUCINE (M-H)- | 0.9061 | 1.0121 | 1.6753 | 1.4522 | 0.1165 | 0.2116 | 0.1557 | NA |
| LINOLEIC ACID (M-H)- | 0.5558 | 0.8323 | 1.5381 | 1.6249 | 0.4418 | 0.4926 | 0.5423 | NA |
| L-TRYPTOPHAN-15N2 [ISTD] (M-H)- | 0.8804 | 0.8679 | 1.2286 | 1.1483 | 0.7585 | 0.9211 | 1.0055 | NA |
| MANNITOL (M-H)- | 0.3208 | 1.3574 | 1.7800 | 1.3408 | 0.1000 | 0.1291 | 0.1225 | NA |
| N-ACETYL-ASPARTIC ACID (M-H)- | 1.8651 | 0.5816 | 0.5250 | 0.3407 | 1.5306 | 1.7113 | 1.6435 | NA |
| N-ACETYL-D-GLUCOSAMINE (M+CL)- | 0.4320 | 1.0474 | 1.9133 | 1.6742 | 0.1158 | 0.1589 | 0.0908 | NA |
| N-ACETYL-DL-METHIONINE (M-H)- | 0.9283 | 1.2221 | 1.3069 | 1.5706 | 0.0934 | 0.1166 | 0.1134 | NA |
| N-ACETYL-L-PHENYLALANINE (M-H)- | 0.6739 | 0.9220 | 1.2978 | 0.8753 | 1.1027 | 0.9094 | 1.3712 | NA |
| N-ACETYLNEURAMINIC ACID (M-H)- | 1.1996 | 0.8219 | 1.1708 | 0.3837 | 1.1106 | 1.3971 | 0.9174 | NA |
| OPHTHALMIC ACID (M-H)- | NA | 0.5359 | 0.9844 | 1.3427 | NA | NA | NA | NA |
| OXALOACETIC ACID (M-H)-[-H2O] | 0.9877 | 1.0862 | 1.0516 | 1.0569 | 0.8361 | 0.8631 | 0.8545 | NA |
| P-ACETAMIDOPHENYL BETA-D-GLUCURONIDE (M-H)- | NA | 0.7479 | 0.9347 | 1.2645 | NA | NA | NA | NA |
| PALMITIC ACID (M-H)- | 1.2043 | 0.7641 | 0.6815 | 0.7023 | 1.0924 | 1.9209 | 1.5905 | NA |
| PALMITOLEIC ACID (M-H)- | 0.6357 | 0.9640 | 1.3507 | 1.6793 | 0.2591 | 0.5125 | 0.4231 | NA |
| PANTOTHENIC ACID (M-H)- | 0.8552 | 0.5931 | 1.2153 | 0.8880 | 0.9515 | 1.5612 | 1.6800 | NA |
| RAFFINOSE (M+CL)- | 0.0917 | 1.2187 | 1.6695 | 0.9177 | 0.1196 | NA | 0.1635 | NA |
| RIBOFLAVIN (M+HCOO)- | 0.3091 | 0.8407 | 1.7457 | 1.0888 | 0.3941 | 0.5013 | 0.4240 | NA |
| RIBOSE (M+CL)- | 0.9980 | 0.8127 | 0.4682 | 0.5707 | 1.5150 | 1.2962 | 1.1201 | NA |
| SERINE (M-H)- | 1.1663 | 1.1815 | 0.9156 | 1.1381 | 0.7166 | 0.6403 | 0.5267 | NA |
| SN-GLYCERO-3-PHOSPHOCHOLINE (M+CL)- | 0.3708 | 0.8930 | 1.3397 | 1.2163 | NA | NA | 0.2811 | NA |
| SN-GLYCERO-3-PHOSPHOCHOLINE (M+HCOO)- | 0.4227 | 0.9768 | 1.6779 | 1.4160 | 0.2554 | 0.3462 | 0.4187 | NA |
| STEARIC ACID (M-H)- | 2.0971 | 0.6146 | 0.5162 | 0.4558 | 0.9117 | 1.8075 | 1.2200 | NA |
| SUCCINIC ACID (M-H)- | 0.9376 | 0.9671 | 1.6567 | 1.3120 | 0.0886 | 0.1704 | 0.1151 | NA |
| SUCROSE (M+CL)- | NA | 1.8398 | 0.5500 | 0.7782 | NA | NA | NA | NA |
| TAURINE (M-H)- | 0.5081 | 0.5229 | 0.6612 | 0.7208 | 2.2140 | 2.4117 | 2.1506 | NA |
| THYMIDINE (M-H)- | NA | NA | NA | NA | 1.0229 | 1.1035 | 0.8737 | NA |
| TRIACONTANOIC ACID (M-H)- | NA | 1.2584 | 0.9342 | 1.0439 | NA | 0.0847 | NA | NA |
| URIC ACID (M-H)- | 0.0718 | 0.8454 | 1.0747 | 1.6804 | 0.0263 | NA | 0.0418 | NA |
| URIDINE-5-MONOPHOSPHATE #2 (M-H)- | 0.9214 | 0.9487 | 0.6311 | 1.2258 | 1.5252 | 1.2077 | 0.8778 | NA |
| URIDINE-5-MONOPHOSPHATE (M-H)- | 0.7506 | 1.0407 | 0.5534 | 1.4420 | 1.7644 | 1.1953 | 0.6821 | NA |
| URIDINE (M-H)- | 1.0450 | 0.4144 | 0.8750 | 0.4848 | 1.9305 | 1.5961 | 2.5306 | NA |
| URIDINE (M+HCOO)- | 0.9385 | 0.3829 | 0.8729 | 0.4726 | 1.6102 | 1.8366 | 2.7973 | NA |
Factors:
| F1 | Species:Homo sapiens | TYPE:Healthy control |
| F2 | Species:Homo sapiens | TYPE:NLA |
| F3 | Species:Homo sapiens | TYPE:PL |
| F4 | Species:Homo sapiens | TYPE:PLS |
| F5 | Species:Mus musculus | TYPE:ALD-KO |
| F6 | Species:Mus musculus | TYPE:KO-M |
| F7 | Species:Mus musculus | TYPE:WT |
| F8 | Species:- | TYPE:- |
