Data for Statin Immuno-Metabolomics in Asthma (part I) (Study ST000843)
(Analysis AN001364)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11_12-DiHETrE | 1.2648 | 0.6771 | 1.0409 | 2.4512 | 0.5708 | 0.3805 | 2.6023 | 0.7051 | 1.6117 | 3.2794 | 0.4141 | 0.6380 | 0.3917 | 0.7387 | 0.2518 | 0.0672 | 0.2574 | 0.2350 |
| 11(12)-EpETE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 11(12)-EpETrE | 1.3465 | 0.9265 | 0.6487 | 1.8942 | 0.6889 | 0.7403 | 2.0377 | 0.6969 | 2.2577 | 3.8989 | 1.0245 | 0.5347 | 0.5139 | 0.2377 | 0.1991 | 0.3597 | 0.2505 | 0.2184 |
| 11-HETE | 0.7629 | 0.6109 | 0.9019 | 3.3861 | 1.1783 | 0.4470 | 1.2386 | 0.5558 | 1.6601 | 3.7556 | 0.5950 | 1.0731 | 0.2612 | 0.2220 | 0.2046 | 0.1828 | 0.2177 | 0.2003 |
| 12_13-DiHODE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 12_13-DiHOME | 1.3869 | 1.0421 | 0.7696 | 1.9823 | 1.1670 | 0.5910 | 1.5927 | 1.0674 | 0.4802 | 3.0651 | 1.1426 | 0.4116 | 0.4933 | 0.4153 | 0.4388 | 0.6737 | 0.4905 | 0.4379 |
| 12(13)-Ep-9-KODE | 0.1845 | 0.2432 | 0.1825 | 7.7156 | 1.2496 | 0.3525 | 0.1291 | 0.2540 | 1.8620 | 1.9422 | 0.3220 | 0.2342 | 0.0704 | 0.0818 | 0.0608 | 0.1371 | 0.1308 | 0.0690 |
| 12(13)-EpODE | 1.0635 | 0.5815 | 0.9692 | 2.5308 | 1.1397 | 0.7808 | 0.9423 | 2.1179 | 0.7000 | 2.5128 | 0.7000 | NA | 0.1615 | 0.4487 | 0.2154 | 0.2692 | 0.3410 | 0.1974 |
| 12(13)-EpOME | 1.3613 | 0.8839 | 0.8996 | 1.6149 | 0.9688 | 0.7275 | 0.7822 | 0.3039 | 0.6514 | 1.6916 | 0.3482 | 0.4372 | 1.3064 | 0.8801 | 0.9954 | 1.5955 | 1.0850 | 1.1967 |
| 12-HEPE | 1.5905 | 0.7042 | 0.5180 | 2.2488 | 1.5608 | 0.2078 | 1.7443 | 0.1282 | 1.1278 | 1.6593 | 0.3454 | 0.4148 | NA | NA | NA | NA | NA | NA |
| 12-HETE | 1.2633 | 0.9763 | 0.8392 | 2.0967 | 1.8191 | 0.1768 | 1.7864 | 0.1450 | 2.3819 | 2.5920 | 0.7045 | 0.5396 | 0.3278 | 0.3266 | 0.3498 | 0.5377 | 0.2505 | 0.3652 |
| 13-HODE | 0.7298 | 0.5739 | 1.2854 | 3.6154 | 1.1604 | 0.4342 | 1.0531 | 0.3689 | 1.7170 | 2.9572 | 0.5193 | 0.5471 | 0.3138 | 0.2816 | 0.2711 | 0.3875 | 0.2536 | 0.2898 |
| 13-HOTE | 0.4595 | 0.3614 | 3.7967 | 3.4311 | 1.2683 | 0.6312 | 0.7629 | 0.3718 | 1.0869 | 1.0430 | 0.4363 | 0.2130 | 0.4453 | 0.0968 | 0.0361 | 0.2672 | 0.0349 | 0.0155 |
| 13-KODE | 0.2655 | 0.1448 | 0.1723 | 6.5878 | 0.8830 | 0.2458 | 0.1527 | 0.0786 | 1.1607 | 6.0865 | 0.1239 | 0.1420 | 0.0894 | 0.0325 | 0.0604 | 0.1048 | 0.0725 | 0.1021 |
| 14_15-DiHETE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 14_15-DiHETrE | 1.0500 | 0.9286 | 1.5286 | 1.6929 | 1.1714 | 0.1714 | 1.0286 | 1.3286 | 0.8714 | 2.0000 | 1.0714 | 0.9000 | 0.7429 | 0.6000 | 0.3857 | 0.6143 | 0.6286 | 0.3857 |
| 14(15)-EpETE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 14(15)-EpETrE | 1.4709 | 0.7442 | 0.8624 | 1.9858 | 0.7695 | 0.7526 | 2.0915 | 0.3353 | 1.6211 | 3.9224 | 0.5162 | 0.6767 | 0.6923 | 0.3594 | 0.2822 | 0.4728 | 0.3980 | 0.3594 |
| 14-HDoHE | 1.7874 | 1.0287 | 0.8355 | 2.4892 | 1.3215 | 0.1963 | 2.6460 | 0.1113 | 1.9521 | 2.1903 | 0.5493 | 0.5846 | 0.4780 | 0.3345 | 0.2456 | 0.5779 | 0.1380 | 0.3067 |
| 15_16-DiHODE | 1.4113 | 0.6312 | 1.0193 | 2.0385 | 0.7514 | 0.9997 | 1.1957 | 0.5684 | 0.5423 | 3.7373 | 0.6762 | 0.4802 | 0.6076 | 0.0980 | 0.1307 | 0.4051 | 0.6860 | 0.2548 |
| 15(16)-EpODE | 0.6417 | 0.3614 | 0.9585 | 0.8204 | 0.6701 | 0.8204 | 0.6051 | 0.4873 | 0.5077 | 3.8257 | 0.2559 | NA | NA | NA | NA | NA | NA | NA |
| 15-deoxy PGJ2 | 1.1027 | 0.8427 | 1.1117 | 1.1296 | 1.0623 | 1.2103 | 0.6656 | 0.9144 | 0.9906 | 1.1430 | 0.8382 | 0.8674 | NA | NA | NA | NA | NA | NA |
| 15-HEPE | 0.8616 | 0.3998 | 0.8250 | 2.2272 | 1.0249 | 0.2872 | 1.3346 | 0.2661 | 1.3093 | 2.1061 | 0.5702 | 0.1985 | NA | NA | NA | NA | NA | NA |
| 15-HETE | 1.4874 | 0.4957 | 0.6229 | 4.4285 | 1.1049 | 0.5902 | 1.2781 | 0.2161 | 1.8914 | 5.0172 | 0.3222 | 0.4813 | 0.2218 | 0.1937 | 0.1202 | 0.2026 | 0.0984 | 0.0952 |
| 15-KETE | 0.6675 | 0.1370 | 0.3195 | 1.2613 | 0.4761 | 0.2799 | 0.1655 | 0.0304 | 0.5198 | 6.9450 | 0.0672 | 0.1466 | NA | NA | NA | NA | NA | NA |
| 15-Keto PGE2 | 1.1732 | 0.4791 | 0.3572 | 1.6991 | 1.2714 | 0.3882 | 1.0521 | 0.6896 | 0.1196 | 3.6781 | 0.8058 | 0.0423 | NA | NA | NA | NA | NA | NA |
| 16(17)-EpDPE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 17_18-DiHETE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 17(18)-EpETE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 17-HDoHE | 0.6768 | 0.9462 | 0.2972 | 3.3036 | 1.0775 | 0.5726 | 1.0822 | 0.1789 | 0.7532 | 0.9436 | 0.4555 | 0.5392 | NA | NA | NA | NA | NA | NA |
| 19_20-DiHDoPA | 1.1522 | 0.7155 | 0.7113 | 1.3732 | 1.7818 | 0.6208 | 1.2311 | 1.1084 | 1.4311 | 2.7289 | 1.4241 | 0.3999 | 0.5823 | 0.1368 | 0.3016 | 0.4630 | 0.3472 | 0.2631 |
| 19(20)-EpDPE | 1.4745 | 0.7919 | 0.7056 | 1.6233 | 0.7334 | 1.9906 | 0.4252 | 1.0970 | 1.2449 | 3.0136 | 1.0045 | 0.4992 | 0.5916 | 0.2280 | 0.0370 | 0.3328 | NA | 0.0462 |
| 20-HETE | 3.2333 | 0.2536 | 0.7467 | 0.5283 | 0.6199 | 1.0566 | NA | NA | NA | NA | NA | NA | 1.0073 | 1.2891 | 0.3593 | 2.4021 | 0.4015 | 0.7608 |
| 4-HDoHE | 1.2301 | 0.4365 | 1.4705 | 2.7110 | 1.3614 | 1.0254 | 0.8008 | 0.2904 | 2.1212 | 2.5631 | 0.6511 | 0.2354 | 0.1082 | 0.0812 | 0.0379 | 0.0460 | 0.1380 | 0.0054 |
| 5_15-DiHETE | 0.0409 | 0.9632 | 1.8198 | 0.1612 | 1.4275 | 1.1012 | 0.0673 | 1.3259 | 1.4718 | 0.0204 | 0.9581 | 1.5487 | NA | NA | NA | NA | NA | NA |
| 5_6-DiHETrE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 5-HEPE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 5-HETE | 0.7144 | 0.4762 | 2.8764 | 1.2820 | 0.4093 | 1.0272 | 3.2195 | 0.2221 | 2.0680 | 2.6770 | 0.7808 | 0.4908 | 0.3674 | 0.1531 | 0.1636 | 0.1288 | 0.4584 | 0.1732 |
| 5-KETE | 0.2969 | 0.2232 | 0.5244 | 1.9043 | 0.8007 | 0.5091 | 0.5526 | 0.1734 | 1.8197 | 11.1687 | 0.2514 | 0.3522 | 0.0846 | 0.0631 | 0.0639 | 0.0614 | 0.2149 | 0.1444 |
| 6-keto PGF1a | 0.6708 | 0.6642 | 0.4878 | 4.3876 | 2.6619 | 0.5164 | 0.3280 | 0.1828 | 0.8092 | 1.4663 | 0.8467 | 0.3987 | 0.2237 | 0.2041 | 0.3578 | 0.1099 | 0.3701 | 0.4105 |
| 6-trans-LTB4 | 0.6548 | 0.3390 | 3.7135 | 1.3622 | 0.3297 | 1.0619 | 1.7553 | 0.1641 | 1.0696 | 1.1470 | 0.3932 | 0.2229 | NA | NA | NA | NA | 0.3390 | NA |
| 8_15-DiHETE | 0.9182 | 0.7940 | 0.6787 | 2.3186 | 0.9060 | 1.2746 | 0.4019 | 1.1869 | 0.9174 | 1.1414 | 0.5910 | 1.0472 | NA | NA | NA | NA | NA | NA |
| 8_9-DiHETrE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 8(9)-EpETrE | 1.2582 | 0.5722 | 0.4902 | 2.1789 | 0.8052 | 1.0508 | 1.5983 | 0.2268 | 2.7773 | 5.2501 | 0.5871 | 0.1631 | 0.3138 | 0.1491 | 0.1553 | 0.2268 | 0.1864 | 0.2516 |
| 8-HETE | 0.5293 | 0.2203 | 0.8919 | 4.7876 | 1.0670 | 1.1013 | 1.1883 | 0.2583 | 1.8980 | 2.7355 | 0.3100 | 0.2746 | 0.1414 | 0.1414 | 0.0272 | 0.1088 | 0.0489 | 0.0272 |
| 9_10-DiHODE | 1.5080 | 0.6724 | 0.9889 | 2.6370 | 1.4009 | 0.7087 | 1.1619 | 0.7087 | 0.2143 | 2.5216 | 0.7417 | 0.0989 | 0.1483 | 0.0494 | NA | 0.0989 | 0.0494 | NA |
| 9_10-DiHOME | 1.3879 | 1.0275 | 0.8498 | 1.9481 | 1.0603 | 0.5956 | 1.4330 | 1.0099 | 0.5474 | 2.8268 | 1.0380 | 0.4043 | 0.5976 | 0.5033 | 0.5364 | 0.8236 | 0.5204 | 0.5413 |
| 9_10-e-DiHO | 1.0533 | 1.0149 | 1.3858 | 1.4113 | 0.9018 | 0.9565 | 0.8605 | 0.9828 | 0.6160 | 1.3500 | 0.6364 | 0.7027 | NA | NA | NA | NA | NA | NA |
| 9_10-EpO | 1.1790 | 1.1684 | 1.3390 | 1.1218 | 0.8636 | 1.1329 | 0.8439 | 1.0885 | 0.6685 | 1.1500 | 0.4957 | 0.9343 | NA | NA | NA | NA | NA | NA |
| 9(10)-EpODE | 0.7451 | 0.4221 | 0.5295 | 3.7359 | 0.8183 | 0.3184 | 0.6850 | 0.6356 | 0.9133 | 5.9920 | 0.6294 | 0.5184 | 0.3147 | 0.0679 | 0.1296 | 0.1851 | 0.1728 | 0.1851 |
| 9(10)-EpOME | 1.3847 | 0.7576 | 0.8474 | 1.9127 | 1.0230 | 0.7145 | 0.7751 | 0.2528 | 0.6886 | 1.9359 | 0.3687 | 0.3789 | 1.2620 | 0.8097 | 0.9361 | 1.3912 | 1.0454 | 1.1547 |
| 9-HEPE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 9-HETE | 0.6644 | 0.4639 | 1.2657 | 2.9856 | 0.9004 | 0.7129 | 0.3370 | 0.2635 | 0.9230 | 1.9608 | 0.5722 | 0.4267 | NA | NA | NA | NA | NA | NA |
| 9-HODE | 0.7611 | 0.5200 | 0.9863 | 4.1722 | 1.1496 | 0.4672 | 0.8717 | 0.4671 | 1.5510 | 3.1094 | 0.5756 | 0.5705 | 0.2584 | 0.1937 | 0.2272 | 0.3071 | 0.2426 | 0.2252 |
| 9-HOTE | 0.5956 | 0.4947 | 1.5556 | 3.7817 | 0.8787 | 0.5272 | 0.3417 | 0.4361 | 0.9243 | 1.2888 | 0.2213 | 0.4003 | NA | NA | NA | NA | NA | NA |
| 9-KODE | 0.2968 | 0.1784 | 0.2453 | 6.6462 | 0.8936 | 0.2423 | 0.2328 | 0.1281 | 1.1911 | 5.2026 | 0.1927 | 0.1491 | 0.1337 | 0.0814 | 0.1101 | 0.1569 | 0.1425 | 0.1474 |
| Lipoxin A4 | 0.6713 | 1.0779 | 0.9442 | 0.7163 | 0.9551 | 1.0070 | NA | NA | NA | NA | NA | NA | 0.9688 | 1.1161 | 0.8105 | 1.2580 | 0.9879 | 1.2826 |
| LTB4 | 1.1348 | 0.3075 | 2.3817 | 1.3426 | 0.2085 | 1.3075 | 5.7538 | 0.4079 | 0.8940 | 2.0072 | 0.7266 | 0.5860 | 0.3602 | 0.1654 | 0.1857 | 0.1390 | 0.7459 | 0.3136 |
| LTB5 | 1.3167 | 0.4938 | 1.7007 | 1.0698 | 0.4663 | 1.2344 | 2.9626 | 0.6584 | 0.4389 | 1.1247 | 0.6309 | 0.4938 | NA | NA | NA | NA | NA | NA |
| PGD2 | 0.4269 | 0.6346 | 0.8542 | 0.6216 | 0.3856 | 0.2457 | 1.0951 | 1.9433 | 1.7389 | 1.3718 | 3.2628 | 1.7634 | 0.8306 | 1.2198 | 1.5541 | 0.5076 | 1.3694 | 0.7840 |
| PGE1 | 0.7006 | 1.4573 | 1.1179 | 0.4598 | 1.5093 | 0.5733 | 0.6240 | 1.3574 | 1.8664 | 0.5336 | 1.6310 | 5.1394 | 0.2572 | 0.5145 | 0.5254 | 0.2244 | 0.2737 | 0.1916 |
| PGE2 | 0.9012 | 1.2552 | 1.3537 | 0.7136 | 1.6177 | 0.5524 | 1.2466 | 0.7593 | 1.4385 | 1.4923 | 1.2389 | 2.9449 | 0.4524 | 0.6625 | 0.6053 | 0.3237 | 0.3825 | 0.2345 |
| PGF2a | 0.9811 | 1.0187 | 2.1368 | 1.4658 | 0.8358 | 0.9894 | 1.5442 | 0.2467 | 0.8459 | 2.3869 | 0.5106 | 1.1144 | 0.5367 | 0.4505 | 0.6277 | 0.4928 | 0.3909 | 0.3599 |
| Resolvin D1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| SUM-TriHOME | 0.9937 | 1.0155 | 1.3713 | 1.9270 | 1.1129 | 0.8048 | 1.6451 | 1.2935 | 1.5750 | 2.2446 | 1.1773 | 0.9550 | 0.2054 | 0.1972 | 0.1692 | 0.2299 | 0.1746 | 0.1876 |
| TXB2 | 1.1137 | 0.8056 | 1.1170 | 1.2912 | 2.5863 | 0.6784 | 1.3122 | 0.4531 | 1.4406 | 1.2922 | 0.7929 | 0.5162 | 0.5793 | 0.2940 | 0.7577 | 0.3109 | 0.8285 | 0.3538 |
Factors:
| F1 | Treatment:Control | Lung:Left Lung | Time point (day):- |
| F2 | Treatment:Control | Lung:Left Lung | Time point (day):12 |
| F3 | Treatment:Control | Lung:Left Lung | Time point (day):8 |
| F4 | Treatment:Control | Lung:Right Lung | Time point (day):- |
| F5 | Treatment:Control | Lung:Right Lung | Time point (day):12 |
| F6 | Treatment:Control | Lung:Right Lung | Time point (day):8 |
| F7 | Treatment:Pravastatin | Lung:Left Lung | Time point (day):- |
| F8 | Treatment:Pravastatin | Lung:Left Lung | Time point (day):12 |
| F9 | Treatment:Pravastatin | Lung:Left Lung | Time point (day):8 |
| F10 | Treatment:Pravastatin | Lung:Right Lung | Time point (day):- |
| F11 | Treatment:Pravastatin | Lung:Right Lung | Time point (day):12 |
| F12 | Treatment:Pravastatin | Lung:Right Lung | Time point (day):8 |
| F13 | Treatment:Simvastatin | Lung:Left Lung | Time point (day):- |
| F14 | Treatment:Simvastatin | Lung:Left Lung | Time point (day):12 |
| F15 | Treatment:Simvastatin | Lung:Left Lung | Time point (day):8 |
| F16 | Treatment:Simvastatin | Lung:Right Lung | Time point (day):- |
| F17 | Treatment:Simvastatin | Lung:Right Lung | Time point (day):12 |
| F18 | Treatment:Simvastatin | Lung:Right Lung | Time point (day):8 |
