Data for Maternal Hypoxemia and oxidative stress in the fetus, newborn, and adult. exercise training for peripheral artery disease (Study ST000872)
(Analysis AN001404)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11_12-DiHETrE | 0.6427 | 0.6723 | 3.3926 | 2.2328 | 1.7759 | 0.8131 | 2.6382 | 1.4116 | 1.6913 | 0.3511 | 0.3012 | 0.2903 | 0.2591 | 0.3259 | 0.2092 |
11(12)-EpETE | 0.6398 | 0.4550 | 1.3548 | 1.5772 | 0.5779 | 0.4147 | 5.2366 | 0.7226 | 1.4092 | 0.6192 | 0.6178 | 0.9777 | 0.7296 | 0.5522 | 0.8709 |
11(12)-EpETrE | 0.8524 | 0.7272 | 1.1406 | 1.2199 | 1.5682 | 0.6865 | 2.9781 | 1.4893 | 1.9260 | 0.7738 | 0.6049 | 0.7195 | 0.3369 | 0.2361 | 0.2935 |
11-HETE | 0.2768 | 0.2863 | 0.6764 | 0.7582 | 1.0925 | 0.4290 | 0.8862 | 0.8026 | 0.6655 | 1.4694 | 3.1546 | 1.3780 | 2.2085 | 0.1491 | 0.0990 |
12_13-DiHODE | 0.5713 | 0.9966 | 4.8615 | 2.7555 | 1.7812 | 0.9318 | 4.1124 | 0.7132 | 1.1830 | 0.0463 | 0.0659 | 0.0726 | 0.1709 | 0.0988 | 0.2102 |
12_13-DiHOME | 1.1030 | 1.8671 | 2.0054 | 1.1978 | 4.0107 | 2.3339 | 1.5494 | 1.0346 | 2.0630 | 0.0765 | 0.0905 | 0.1200 | 0.1165 | 0.1195 | 0.1283 |
12(13)-Ep-9-KODE | 0.6284 | 1.4662 | 3.5832 | 1.7786 | 1.5124 | 0.4893 | 4.8806 | 1.7046 | 0.9655 | 0.3341 | 0.2437 | 0.3657 | 0.4073 | 0.2883 | 0.2971 |
12(13)-EpODE | 0.6196 | 1.2700 | 2.5221 | 2.6448 | 0.8696 | 0.7120 | 4.2173 | 1.0631 | 1.2499 | 0.0454 | 0.0485 | 0.1488 | 0.1671 | 0.0725 | 0.1892 |
12(13)-EpOME | 2.8570 | 1.2958 | 0.8412 | 0.6418 | 1.4964 | 1.6363 | 1.0185 | 4.0352 | 1.2399 | 0.0420 | 0.0705 | 0.0438 | 0.0374 | 0.1367 | 0.1509 |
12-HEPE | 0.0873 | 0.0513 | 0.1416 | 7.8001 | 0.2142 | 0.0512 | 0.5338 | 0.5158 | 0.0839 | 0.0368 | 0.0083 | 0.2891 | 0.8203 | 0.0524 | 0.5421 |
12-HETE | 0.2701 | 0.1569 | 0.1154 | 5.2405 | 0.6663 | 0.1874 | 0.3910 | 1.7164 | 0.1914 | 0.2654 | 0.0879 | 0.6673 | 2.3081 | 0.5426 | 0.4540 |
13-HODE | 0.9402 | 1.6815 | 1.7038 | 2.1255 | 2.1759 | 1.8732 | 1.5712 | 0.6237 | 1.4397 | 0.2559 | 0.2530 | 0.3770 | 0.3936 | 0.2553 | 0.3273 |
13-HOTE | 0.6207 | 1.3800 | 4.0143 | 3.2834 | 1.6283 | 1.1302 | 2.7712 | 0.4572 | 1.1677 | 0.0200 | 0.0200 | 0.0389 | 0.0366 | 0.0876 | 0.2146 |
13-KODE | 0.9957 | 0.9267 | 2.2505 | 1.2095 | 2.6166 | 2.2340 | 2.6192 | 1.0587 | 1.5112 | 0.3305 | 0.5194 | 0.3441 | 0.5874 | 0.2803 | 0.4895 |
14_15-DiHETE | 0.2504 | 0.2638 | 5.0148 | 2.8686 | 0.7881 | 0.1639 | 8.5802 | 0.6277 | 0.7926 | 0.0757 | 0.0604 | 0.2847 | 0.0870 | 0.0905 | 0.2715 |
14_15-DiHETrE | 0.5521 | 0.5653 | 4.5194 | 2.2718 | 2.3590 | 0.8243 | 3.5520 | 1.2560 | 1.7069 | 0.1768 | 0.1665 | 0.1828 | 0.1428 | 0.2413 | 0.1863 |
14(15)-EpETrE | 0.9012 | 0.5640 | 1.5716 | 1.7297 | 4.2422 | 0.8088 | 2.5693 | 1.4463 | 1.7820 | 0.5066 | 0.2375 | 0.3945 | 0.2728 | 0.5759 | 0.4546 |
14-HDoHE | 0.1291 | 0.2749 | 0.5902 | 6.4537 | 0.1318 | 0.2165 | 1.0267 | 0.2540 | 0.5984 | 0.0699 | 0.0357 | 0.3350 | 0.5783 | 0.1430 | 0.2049 |
15_16-DiHODE | 0.9218 | 1.0756 | 4.6561 | 2.1689 | 2.7937 | 1.1600 | 3.6841 | 0.7237 | 1.3261 | 0.0566 | 0.0915 | 0.1462 | 0.1627 | 0.1304 | 0.2197 |
15(16)-EpODE | 0.5315 | 1.2100 | 3.6362 | 2.1811 | 2.4450 | 1.3029 | 5.4674 | 0.6611 | 1.3787 | 0.0412 | 0.0719 | 0.0871 | 0.1240 | 0.0842 | 0.2008 |
15-deoxy PGJ2 | 1.0621 | 0.7244 | 0.5547 | 1.1706 | 0.3885 | 0.8745 | 0.8239 | 0.7679 | 1.1942 | 1.0468 | 1.1776 | 1.4947 | 0.7126 | 0.5942 | 1.0676 |
15-HEPE | 0.4096 | 0.5872 | 1.4659 | 2.6146 | 0.5983 | 0.4639 | 2.8616 | 0.4994 | 0.6182 | 0.6453 | 0.3608 | 1.7254 | 1.1329 | 0.6842 | 1.2362 |
15-HETE | 0.4811 | 0.4755 | 0.5541 | 1.0029 | 1.1576 | 0.7092 | 1.4683 | 0.8521 | 0.8166 | 1.1362 | 2.4380 | 1.1472 | 1.5963 | 0.7341 | 0.4079 |
15-Keto PGE2 | 0.7587 | 1.1416 | 1.6142 | 1.1619 | 0.2266 | 1.5844 | 0.8400 | 0.7515 | 0.9191 | 0.8697 | 1.2232 | 0.6465 | 1.3472 | 0.8104 | 0.7970 |
17_18-DiHETE | 0.1669 | 0.2382 | 5.1028 | 3.3913 | 0.6587 | 0.2746 | 7.2223 | 0.7935 | 0.7073 | 0.0926 | 0.1060 | 0.3593 | 0.4290 | 0.0731 | 0.3316 |
17-HDoHE | 0.4864 | 0.5614 | 2.2555 | 3.5899 | 0.6779 | 0.5789 | 1.6700 | 0.2473 | 0.5869 | 0.5173 | 0.6268 | 0.8744 | 0.4633 | 0.5685 | 1.3701 |
19_20-DiHDoPE | 0.2420 | 0.3077 | 4.8153 | 3.3891 | 0.8360 | 0.2872 | 4.6820 | 0.7848 | 0.9148 | 0.2436 | 0.2966 | 0.4329 | 0.4469 | 0.1535 | 0.3415 |
19(20)-EpDPE | 0.2927 | 0.3014 | 4.0160 | 3.2544 | 1.2465 | 0.3108 | 4.3499 | 0.8070 | 0.9877 | 0.2430 | 0.5165 | 0.4471 | 0.7883 | 0.1103 | 0.1290 |
20-HETE | 0.3918 | 0.2818 | 2.1900 | 1.3176 | 2.0474 | 0.8643 | 5.5044 | 1.4082 | 1.2662 | 0.3889 | 1.1045 | 0.5594 | 0.8008 | 0.6948 | 0.5650 |
4-HDoHE | 0.5845 | 0.8453 | 0.5122 | 2.5625 | 3.2759 | 0.6889 | 1.5607 | 0.5413 | 0.8435 | 0.5219 | 0.5161 | 1.1381 | 0.8681 | 1.0670 | 0.9141 |
5_6-DiHETrE | 0.5585 | 0.4239 | 2.4333 | 2.5913 | 2.7492 | 0.7507 | 4.0275 | 1.4560 | 1.7087 | 0.0588 | 0.0546 | 0.0494 | 0.0708 | 0.2019 | 0.0739 |
5-HEPE | 0.3608 | 0.6344 | 1.2658 | 4.2635 | 1.1259 | 0.5697 | 3.0706 | 0.6182 | 0.9660 | 0.1210 | 0.1278 | 0.2520 | 0.2918 | 0.1403 | 0.5115 |
5-HETE | 0.7804 | 1.0185 | 1.2160 | 3.1299 | 3.6065 | 0.8495 | 1.5678 | 0.8266 | 1.2777 | 0.3005 | 0.0946 | 0.5637 | 0.5441 | 0.2872 | 0.2138 |
5-KETE | 0.9102 | 0.9304 | 0.2668 | 3.0580 | 1.7075 | 0.9249 | 0.7020 | 0.4629 | 1.0478 | 0.6447 | 0.3818 | 0.9771 | 0.3066 | 0.3451 | 0.9221 |
8_9-DiHETrE | 0.4216 | 0.3462 | 4.8488 | 3.2760 | 1.6723 | 0.4398 | 3.7851 | 0.9321 | 1.6048 | 0.0917 | 0.0823 | 0.1033 | 0.0961 | 0.0872 | 0.0651 |
8-HETE | 0.5019 | 0.4803 | 2.0331 | 1.9077 | 2.0791 | 0.8946 | 3.4753 | 1.3415 | 1.5884 | 0.5052 | 0.6077 | 0.4174 | 0.3538 | 0.2691 | 0.2476 |
9_10-DiHODE | 0.4000 | 0.7293 | 5.6089 | 2.8782 | 1.3186 | 0.6801 | 5.1631 | 0.9639 | 1.2014 | 0.0229 | 0.0379 | 0.0732 | 0.0981 | 0.0679 | 0.2387 |
9_10-DiHOME | 0.8917 | 1.4404 | 2.5798 | 1.4660 | 2.8392 | 1.5742 | 2.4205 | 1.4339 | 1.9137 | 0.1117 | 0.0894 | 0.1935 | 0.4981 | 0.1392 | 0.1615 |
9_10-e-DiHO | 1.1047 | 1.0498 | 1.9267 | 1.6448 | 1.4004 | 1.2536 | 1.5859 | 1.7157 | 1.3882 | 0.3805 | 0.3089 | 0.4187 | 1.0058 | 0.3464 | 0.4527 |
9(10)-EpO | 3.2218 | 0.2049 | 0.2447 | 1.0969 | 0.3026 | 0.3699 | 0.3064 | 8.4191 | 0.2983 | 0.1426 | 0.1630 | 0.1259 | 0.2330 | 0.1931 | 0.1579 |
9(10)-EpODE | 0.5933 | 1.3384 | 2.5972 | 2.6467 | 1.3047 | 0.8448 | 4.8885 | 0.9320 | 1.3282 | 0.0627 | 0.0836 | 0.1025 | 0.0984 | 0.1653 | 0.3922 |
9(10)-EpOME | 3.7305 | 0.5001 | 0.5391 | 0.5045 | 1.4846 | 0.6333 | 1.7404 | 6.1138 | 0.7065 | 0.0473 | 0.0807 | 0.0601 | 0.0578 | 0.0962 | 0.1092 |
9-HEPE | 0.3824 | 0.7055 | 2.5974 | 3.7945 | 1.2337 | 0.4640 | 2.3766 | 0.6031 | 0.8259 | 0.3107 | 0.2429 | 0.3732 | 0.7780 | 0.4274 | 0.7824 |
9-HETE | 0.9507 | 1.3426 | 1.0775 | 2.2129 | 3.2275 | 0.4278 | 2.7907 | 0.6494 | 0.4613 | 0.7915 | 0.3523 | 1.4796 | 0.8910 | 0.7191 | 0.2401 |
9-HODE | 0.9333 | 1.5773 | 1.5782 | 1.9494 | 2.1558 | 1.5777 | 1.9012 | 0.7996 | 1.4291 | 0.3149 | 0.3687 | 0.4875 | 0.5522 | 0.1823 | 0.2907 |
9-HOTE | 0.4510 | 1.0797 | 3.0806 | 3.4810 | 1.4118 | 1.0117 | 3.8529 | 0.5246 | 0.9917 | 0.0340 | 0.0296 | 0.0664 | 0.0920 | 0.1925 | 0.5535 |
9-KODE | 0.8145 | 1.6119 | 1.7485 | 2.1832 | 2.1194 | 1.6305 | 2.7202 | 1.2521 | 1.6565 | 0.1182 | 0.1460 | 0.1158 | 0.1726 | 0.1094 | 0.2416 |
PGE2 | 0.1269 | 0.2594 | 0.1845 | 0.2695 | 1.1729 | 1.2298 | 0.8287 | 1.2453 | 1.2800 | 0.7406 | 5.1319 | 0.5487 | 1.2265 | 0.2354 | 0.0262 |
PGF2a | 0.2886 | 0.4404 | 0.5700 | 0.3336 | 0.4781 | 0.8973 | 0.5167 | 1.0481 | 0.7230 | 1.1955 | 2.3179 | 1.2117 | 2.3058 | 0.6970 | 0.1306 |
SUM-TriHOME | 2.8615 | 0.6674 | 0.6780 | 1.3681 | 0.4603 | 1.0881 | 0.5876 | 3.4349 | 0.5647 | 0.3421 | 0.3831 | 0.3777 | 0.5008 | 0.5180 | 0.6384 |
TXB2 | 0.2618 | 0.2874 | 0.7947 | 3.6736 | 0.2805 | 0.1762 | 0.2666 | 0.4427 | 0.3230 | 0.8832 | 0.3957 | 1.1556 | 2.4567 | 1.4018 | 0.5298 |
Factors:
F1 | Life stage:Adult | Pregnancy status:Non-pregnant | Treatment group:Hypoxic | Sample origin:Arterial |
F2 | Life stage:Adult | Pregnancy status:Non-pregnant | Treatment group:Hypoxic | Sample origin:Venous |
F3 | Life stage:Adult | Pregnancy status:Non-pregnant | Treatment group:Normoxic | Sample origin:Arterial |
F4 | Life stage:Adult | Pregnancy status:Non-pregnant | Treatment group:Normoxic | Sample origin:Venous |
F5 | Life stage:Adult | Pregnancy status:Pregnant | Treatment group:Hypoxic | Sample origin:Arterial |
F6 | Life stage:Adult | Pregnancy status:Pregnant | Treatment group:Hypoxic | Sample origin:Venous |
F7 | Life stage:Adult | Pregnancy status:Pregnant | Treatment group:Normoxic | Sample origin:Venous |
F8 | Life stage:Adult | Pregnancy status:Unknown | Treatment group:Hypoxic | Sample origin:Arterial |
F9 | Life stage:Adult | Pregnancy status:Unknown | Treatment group:Hypoxic | Sample origin:Venous |
F10 | Life stage:Fetus | Pregnancy status:- | Treatment group:Hypoxic | Sample origin:Arterial |
F11 | Life stage:Fetus | Pregnancy status:- | Treatment group:Hypoxic | Sample origin:Venous |
F12 | Life stage:Fetus | Pregnancy status:- | Treatment group:Normoxic | Sample origin:Arterial |
F13 | Life stage:Fetus | Pregnancy status:- | Treatment group:Normoxic | Sample origin:Venous |
F14 | Life stage:Newborn | Pregnancy status:- | Treatment group:Hypoxic | Sample origin:Venous |
F15 | Life stage:Newborn | Pregnancy status:- | Treatment group:Normoxic | Sample origin:Venous |