Data for (Study ST000876)

(Analysis AN001413)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
1-methylhistamine 0.9247 1.1483 1.1921 1.0475 1.1719 0.6557 0.9399 0.8339 1.0693 1.0609 1.0122 0.9718
2-Aminoisobutyric acid 1.2124 1.1159 0.8223 1.3319 1.1421 1.1695 1.2158 0.8414 0.7346 0.9838 0.7743 0.8280
2-deoxyuridine NA NA NA NA NA NA NA NA NA NA NA NA
3-Hydroxyanthranilic acid 1.0639 NA 0.8051 1.0946 1.2694 1.2031 1.0371 1.3261 0.4363 1.2974 0.8315 0.8177
3-OH-DL-KYNURENINE 0.8787 1.1440 1.1846 1.1121 1.0580 0.9349 1.0663 1.1135 0.8103 0.9920 1.0623 0.8217
4-Pyridoxic Acid 1.3418 1.4112 1.0697 0.4970 0.4952 0.4583 0.4050 0.3348 1.8181 1.4316 0.8876 1.4249
5-Deoxy-5Methylthio Adenosine NA NA NA NA NA NA NA NA NA NA NA NA
5-Hydroxyindole-3-acetic acid 1.1537 0.6454 1.5100 1.0843 0.8189 0.8684 0.6086 1.0861 1.2268 0.7661 0.8608 1.1855
Acetoacetic acid 1.5792 1.2704 0.9976 1.0255 1.0393 0.5929 1.1041 0.7509 1.3122 1.3061 0.5501 0.7358
Acetylcarnitine 1.2326 0.9992 1.0396 1.1215 0.8347 0.7122 1.0617 0.9747 0.9187 1.0987 0.8774 1.0644
Adenine 5.0440 0.6105 0.5960 0.4991 0.8431 0.9933 0.6347 0.4312 0.7462 0.4991 1.1338 0.4845
Adenosine 0.7534 1.2103 1.1891 1.8351 0.3767 0.9818 1.2012 1.1225 0.5567 0.7337 1.2284 0.9054
Alanine 0.9059 1.0099 0.9337 0.9459 1.0543 1.0286 0.8547 1.1315 0.9791 1.0588 1.0918 1.0028
Allantoin 1.8891 0.5817 0.7768 0.7346 0.5950 2.3562 0.5603 1.1191 0.2125 0.8791 1.0848 1.1055
Aminodipic Acid 1.0411 1.4783 1.5506 0.7212 1.0145 0.9779 0.9963 0.8110 0.9024 0.9352 0.9839 0.7937
AMP 2.2633 0.4737 0.8843 0.6535 0.5722 2.4630 0.3355 1.2397 0.8245 0.6059 1.6519 0.5163
Arachidyl Carnitine 1.1064 1.1427 0.9997 0.9235 0.9587 0.9435 1.2517 0.9364 0.9693 1.0478 0.9716 0.8743
Arginine 1.0537 1.0711 1.0005 0.8880 0.9430 0.9483 0.9710 0.9918 1.2373 1.0054 0.9760 0.9570
Asparagine 0.9927 0.9305 0.9276 1.0558 1.0575 1.1736 0.9656 1.1097 1.0130 1.0031 1.0185 0.8763
Aspartate 1.1619 0.7674 0.7789 0.9019 1.2770 1.3281 0.8042 1.1583 0.9614 0.8885 1.1347 0.9189
Asymmetric dimethylarginine 1.0200 1.1917 1.2219 0.8036 1.0393 1.0000 0.9390 0.8598 0.9338 1.2472 0.9063 0.9187
Betaine 0.9983 0.8061 1.2138 0.9620 1.1920 0.8701 1.0546 0.8439 1.0070 0.7598 1.1698 1.0613
cAMP 0.8204 1.5898 0.8906 0.5656 0.5520 0.1667 0.6306 0.4936 1.7727 2.4719 0.5185 1.2639
Carnitine 1.1382 0.8922 1.0249 0.8824 0.8664 1.0306 1.0063 1.1022 0.9922 1.0879 0.8353 1.0707
Carnosine 1.5024 1.1502 0.8483 0.9178 0.7411 0.9665 1.1376 0.8049 0.9245 0.9511 1.0988 0.9783
cGMP 0.4818 2.6646 0.4593 NA NA NA 0.6933 NA NA NA NA 0.8505
Chenodeoxycholic Acid 1.6913 1.6493 0.7477 0.8242 0.5451 1.1324 0.7723 0.9647 1.3326 0.7868 0.6315 0.9610
Cholic Acid 0.6892 0.7037 NA NA NA NA NA NA NA NA 1.6071 NA
Choline 1.0307 0.9344 1.0225 1.1195 1.0790 1.0237 1.1137 0.8909 0.9117 0.6870 1.1095 1.0386
Citrulline 0.9966 1.3501 1.0848 0.9239 0.8673 1.0491 0.8485 0.8720 0.9904 0.9470 1.1126 0.9788
Cotinine 1.7256 NA NA NA NA NA NA NA NA NA 0.2744 NA
Creatine 1.2915 1.0735 0.8537 1.0755 0.8065 1.4700 1.1453 1.0248 0.8253 0.9388 0.8310 0.8320
Creatinine 0.8759 0.9704 1.1153 0.9365 1.0081 0.7802 1.0428 1.1226 1.1030 1.0668 0.9548 1.0118
Cystathionine 0.8839 1.1914 0.7939 0.8570 1.4111 1.3227 1.6001 1.0586 0.6997 0.9111 0.7005 0.7850
Cysteine 1.1142 0.9984 1.0590 0.9680 0.9098 1.0526 0.9611 1.0158 0.9812 0.9869 0.9717 0.9906
Cytidine 1.1561 0.9508 0.9807 0.9499 0.8648 0.8637 1.1156 1.0428 0.9892 1.1682 0.7979 1.0602
Cytosine 1.0627 0.3167 2.9876 0.3611 0.2636 0.3766 0.2197 0.2414 0.5485 0.6219 1.1660 2.4172
Decanoylcarnitine 1.2871 1.1160 1.0396 0.9783 1.0097 0.6819 1.0496 0.9958 1.1808 1.2064 0.7042 0.8753
deoxycytidine 1.2011 1.2720 1.0251 0.9790 0.8086 0.9896 1.0299 1.0012 0.8337 1.0345 0.8268 0.9993
D-Glucuronic acid 1.2046 1.4886 1.1231 0.8683 0.9479 0.7931 0.6818 0.8139 0.7000 1.2173 0.8222 1.1696
DimethylGlycine 0.8975 0.7555 1.5172 0.9431 1.6797 0.6101 1.0885 0.5271 1.2945 0.7241 1.0508 0.9559
Dodecanoyl Carnitine 1.3253 1.4561 1.0575 1.3298 0.9829 0.5381 1.1385 0.9482 1.3358 1.1925 0.6998 0.4978
D-Ribose 5-phosphate 1.1997 0.7070 1.3212 2.0211 0.8275 0.8571 1.0986 0.9494 0.8130 0.5478 1.3081 0.6747
Folic Acid NA NA NA NA NA NA NA NA NA NA NA NA
GABA 0.9918 0.6969 0.8788 1.2267 0.9620 1.1575 0.6050 0.7031 0.8563 2.6831 0.7156 0.7616
Gamma-Glutamylcysteine 0.9585 1.1400 0.8618 0.8551 0.7884 1.2155 0.7741 0.9832 0.9751 0.9778 1.0908 1.1898
Glutamine 1.0451 1.0473 1.0915 0.9743 1.0755 0.8599 0.9339 1.0036 1.0746 1.0456 1.0348 0.9069
Glutathione 1.1740 0.5369 1.2927 0.6274 NA 1.5033 0.7882 NA 1.0775 NA NA NA
Glyceraldehyde 1.1416 1.0123 0.9275 0.9095 0.9715 1.4446 0.8607 0.9461 0.9095 0.8665 1.2331 0.8885
Glycine 0.8941 0.8611 0.9188 0.6898 1.3746 0.9671 0.9892 1.3036 1.2442 0.9874 1.0736 0.8482
Glycocholic Acid 1.2730 1.8310 0.7298 0.8549 0.5161 0.7439 1.0739 1.4089 0.8826 0.7113 0.7621 1.1063
Guanidinoacetic Acid 0.9792 0.9197 1.4679 0.7073 1.4381 0.6659 0.8473 1.2203 1.2631 0.8851 1.1621 0.7219
Guanosine 0.3344 2.8190 0.7753 0.4487 0.2951 0.4902 1.2002 0.3873 4.2725 0.6728 0.2847 0.5099
Hexanoylcarnitine 1.3426 1.1867 1.0189 1.0649 0.9166 0.6891 1.0242 0.9226 1.0165 1.2221 0.6987 0.9487
Hippuric acid 0.2027 0.3349 3.2131 1.7381 0.3250 0.2352 0.2148 1.7420 0.7509 0.3150 2.7387 0.5948
Histidine 1.1295 1.0684 1.0423 0.9326 0.9352 1.0619 0.9250 0.9330 1.0319 1.0208 1.1132 0.9031
Homocysteine 1.0000 NA NA NA NA NA NA NA NA NA NA NA
Homogentisic acid 2.1613 0.7265 0.9554 0.8912 1.4097 0.7245 0.6824 0.8532 1.2804 0.9896 0.4887 0.9186
Homoserine NA NA NA NA NA NA NA NA NA NA NA NA
Hydroxyproline 1.3413 1.3774 0.8814 0.8294 1.2920 0.8473 0.7426 0.9665 0.9591 0.9830 1.0989 0.8406
Hypoxanthine 1.0507 0.7470 1.0752 0.7887 1.0323 1.2884 0.9040 1.2752 0.8211 1.1908 1.0397 0.8934
IMP 1.8048 0.7589 1.1445 0.5133 0.7162 2.5765 0.4356 1.0670 0.9803 0.6793 1.4100 0.4568
Inosine 0.5892 1.6787 0.5487 0.4134 0.5303 1.0471 1.1747 1.1594 2.9397 1.2717 0.5670 0.5401
Isobutyrylcarnitine 1.0747 1.2162 1.0711 0.7311 0.7896 1.0365 0.9995 1.1869 0.9840 1.2320 0.8231 0.9276
Isoleucine 1.3136 1.1085 1.0310 1.1855 0.9312 0.9455 1.0779 0.9817 0.9646 0.9195 0.9754 0.7828
Isovalerylcarnitine 1.0190 1.5633 1.0941 0.9347 0.8263 0.8885 1.0675 1.0614 1.0108 1.1871 0.7867 0.7802
Kynurenic Acid 1.3863 0.9080 1.3075 1.2147 0.8701 0.8431 0.8311 0.7173 0.6265 0.9839 0.9706 1.1705
L-5-Hydroxytryptophan 1.1463 1.1472 0.9641 1.1656 0.9624 0.8758 1.2926 0.6643 0.9747 1.3564 0.6321 0.9093
Leucine 1.1012 1.1008 1.0616 0.9384 0.9845 1.1107 1.0137 1.0445 1.0176 1.0319 0.9107 0.8422
L-Glutamic Acid 0.8849 0.6771 0.8875 1.1093 1.0877 1.3468 1.0232 1.2100 0.7563 0.8793 1.3275 0.9052
L-Kynurenine 1.0982 1.1090 1.0463 1.0016 1.0405 1.0254 0.9683 0.8733 0.9935 0.9890 1.0125 0.9212
L-Methionine 1.2011 1.0084 1.1066 0.9652 1.1533 1.1431 0.8688 0.8786 0.9839 0.8826 1.0938 0.8572
Lysine 1.0498 1.0874 1.0102 1.0253 0.9569 1.1042 0.9707 1.0725 0.9803 1.0096 0.9483 0.8924
Myoinositol 0.9083 0.9251 0.9769 1.1454 0.9833 1.2613 0.8034 0.9057 0.7982 1.2439 1.1306 0.9590
Myristoyl Carnitine 0.5834 1.3273 1.0393 1.3888 1.2416 0.5783 1.2907 1.2269 1.1820 0.9817 1.0617 0.5491
NAD 3.6497 0.1344 0.5511 0.2563 0.4424 3.7010 0.2820 1.2995 0.3980 0.3983 1.1377 0.3749
Neopterin NA 0.7874 0.2333 1.0467 0.3747 1.3288 1.4989 0.8480 0.4354 1.4611 1.0779 1.4539
Niacinamide 0.9583 0.9086 1.1131 1.2081 0.9261 0.9341 1.3204 1.6662 0.6928 0.4563 1.2313 0.7923
Nicotinic Acid 1.0000 NA NA NA NA NA NA NA NA NA NA NA
Normetanephrine 1.0926 0.9659 1.0398 1.1137 0.7970 0.7495 1.0187 0.7178 1.0134 1.0873 1.0662 1.1691
Octanoylcarnitine 1.5615 1.2257 1.0276 1.0464 1.0109 0.5908 1.0205 0.8248 1.1384 1.2783 0.6073 0.8339
Ornithine 1.1761 1.2031 0.8678 1.0824 0.9956 1.0844 0.9347 0.9751 0.6724 0.9829 1.2938 0.8659
Orotic acid NA NA NA NA NA NA NA NA NA NA NA NA
Palmitoyl Carnitine 0.1246 0.9915 1.1932 1.3919 1.8195 0.1939 1.8092 1.5226 1.2536 0.4687 1.4286 0.4014
Pantothenic Acid 0.9489 0.9149 0.8034 0.9075 1.0664 1.0788 1.0185 1.0876 0.9324 0.9987 0.8154 1.2137
Phenylalanine 1.1519 1.0304 0.9650 0.9752 1.0406 1.1636 0.9252 0.9403 1.0281 0.9540 1.0132 0.9062
Phosphoethanolamine 0.9205 0.9304 1.3181 0.9767 1.0724 0.8868 0.9976 0.8284 1.0132 0.8094 1.1798 1.0333
Proline 0.9025 1.3578 1.3096 0.8036 0.8891 1.1463 0.7594 0.9190 0.9721 1.0047 1.0795 0.9282
Propionylcarnitine 1.1930 1.2650 1.0268 0.9138 0.7621 0.9900 1.0441 1.0976 0.8623 1.1179 0.7508 0.9883
Pyridoxine NA NA NA NA NA NA NA NA NA NA NA NA
S-5-Adenosyl-L-Methionine Chloride 0.5137 0.6142 1.4741 0.8706 0.4085 1.7671 0.3941 1.3734 1.3691 0.8933 1.9047 0.7086
S-Adenosyl-L-Homocysteine 0.9052 0.7051 1.0020 1.2341 0.8566 1.6267 0.9948 1.1294 0.8879 0.7976 1.3768 0.7419
Serine 0.8048 0.7381 0.7242 1.0168 1.6074 1.1111 1.3391 1.3340 1.4514 1.4060 0.6020 0.4327
Sorbitol 0.8666 0.5524 0.6584 0.9322 0.6604 1.1383 0.6399 0.6390 0.7382 0.6328 0.8408 2.3505
Spermidine 0.9950 0.7579 0.9048 1.4625 0.8704 1.8492 0.9557 1.1007 0.7058 1.0130 1.0107 0.6871
Stearoyl Carnitine 0.2692 0.8109 1.5173 1.0046 2.2341 0.1756 2.2255 1.1388 1.1678 0.3685 1.5219 0.2830
Succinate 1.0358 1.1115 1.0217 0.9444 1.0114 0.7928 0.8933 0.8740 0.9178 0.9020 1.0801 1.2077
Sucrose 0.8541 0.9621 1.0753 0.8228 0.7645 1.5701 0.6582 0.7425 1.2555 1.0184 1.2103 1.0329
Symmetric dimethylarginine 0.9244 0.8405 0.9069 0.9258 1.0932 1.0643 0.9989 1.1792 1.0861 1.1197 0.8714 0.9949
Taurine 1.1939 0.8218 1.0240 0.9435 1.0206 1.1796 0.8809 1.1265 0.6247 0.9345 1.1764 1.0369
Taurochenodeoxycholic Acid 1.7331 2.0436 0.4703 1.0036 0.4360 0.5311 1.0862 1.4931 0.9474 0.5438 1.0207 0.8455
Taurocholic Acid 1.4294 1.6763 0.4935 1.1243 0.5549 0.4230 1.0520 1.3390 1.1968 0.8443 0.8590 1.0037
Threonine 1.1596 1.0757 1.0666 1.0301 0.9698 0.9580 1.1079 0.9441 0.8390 0.9318 1.0778 0.9197
Trimethylamine-N-Oxide 0.8779 0.7825 1.1524 0.8915 1.9021 0.6390 0.9982 1.1535 0.9294 1.3908 0.5981 0.8424
Tryptophan 1.0714 1.0708 1.0173 0.9567 0.9997 1.0479 0.9891 0.9505 1.0100 0.9793 1.0909 0.9082
Tyrosine 0.9619 1.1533 0.9652 0.9612 0.9483 0.9264 0.9388 0.9639 1.0890 1.2100 1.0616 0.9102
UDP-Glucose 2.9629 0.2787 0.6195 0.3480 0.5760 3.0031 0.2554 1.3479 0.5145 NA 1.4456 0.3243
Uracil 1.2395 0.8046 1.2807 1.3389 1.3738 0.5522 0.7563 0.5784 1.6759 1.1016 0.4915 0.9033
Valine 1.0198 1.2638 1.1428 1.0821 0.9763 1.0665 0.9885 0.9090 0.9082 0.9054 1.0527 0.8424
Xanthine 1.0849 0.8245 1.0505 1.1384 0.9879 1.2209 0.9606 0.9559 0.7886 1.2671 1.0557 0.8325
Xanthosine 1.5230 0.8891 0.8697 0.9883 0.7495 1.4161 0.8245 1.0021 0.7432 1.0550 1.2053 0.8671
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1L-serine (mg/kg/day):100 | time point (weeks):6
F2L-serine (mg/kg/day):200 | time point (weeks):52
F3L-serine (mg/kg/day):200 | time point (weeks):9
F4L-serine (mg/kg/day):300 | time point (weeks):12
F5L-serine (mg/kg/day):400 | time point (weeks):15
F6L-serine (mg/kg/day):400 | time point (weeks):18
F7L-serine (mg/kg/day):400 | time point (weeks):21
F8L-serine (mg/kg/day):400 | time point (weeks):30
F9L-serine (mg/kg/day):400 | time point (weeks):38
F10L-serine (mg/kg/day):400 | time point (weeks):44
F11L-serine (mg/kg/day):50 | time point (weeks):3
F12L-serine (mg/kg/day):- | time point (weeks):-
  logo