Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma] (Study ST000879)

(Analysis AN001429)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
1-Methylhistamine 0.9095 0.2570 0.3999 0.9867 0.5489 2.3192 2.9802 0.4279 0.9149 1.0281 0.3057 0.6593
1-methyl nicotinamide 1.1113 1.1182 1.0048 1.4372 0.8952 1.5027 1.3068 0.4430 0.6653 1.3809 0.4405 0.6690
2-Aminobenzoic acid 0.9558 0.6490 0.5560 1.5763 1.1743 1.0265 1.4484 1.2151 0.8178 1.2494 0.9687 0.2951
3-Hydroxyanthranilic acid NA 1.1292 0.3748 NA 1.7855 0.3780 1.3387 0.8214 1.1031 1.3725 1.9264 0.2373
5-amino-levulinic acid 0.9855 1.4550 1.5510 0.5132 1.0861 1.0568 0.5474 0.6083 1.1893 0.4588 0.8297 1.8779
5-Hydroxy-L-tryptophan 1.7590 0.0979 0.3644 1.0778 0.0490 3.6897 0.9390 0.4496 0.9482 1.1247 0.3996 0.7044
Acetylcholine 1.9685 1.7846 1.4423 0.8923 0.8253 0.6717 0.9384 0.8430 0.6548 0.6875 0.7441 0.6144
Adenosine 1.5442 0.3004 0.7410 1.2524 0.4090 2.2511 0.9830 1.1894 0.5670 0.6173 0.7575 1.1753
Alanine 0.8853 0.9730 0.6974 1.0853 1.5006 0.8907 1.0258 1.0026 1.0398 0.8816 1.3686 0.6988
Allantoin 1.0056 1.1599 1.2049 0.7715 1.4596 0.8509 0.9205 0.8102 1.2792 0.8420 0.8276 1.0343
Aminoisobutyric acid 0.0215 0.8033 1.2426 0.8699 1.4544 2.0649 1.2118 1.0989 1.3552 0.5404 0.3907 1.1207
Anserine 0.8546 0.4192 1.0607 1.0003 1.8563 1.6765 1.2700 0.4060 1.2999 0.6804 0.6230 1.0822
Arginine 0.5949 1.5096 1.4574 0.9775 1.6742 0.6497 0.7569 0.6618 0.9043 0.5392 1.6506 0.9068
Asparagine 0.7006 0.8871 0.6775 1.0291 1.4305 0.9392 0.8985 1.0589 0.9570 0.8221 1.5618 1.0648
Betaine 1.1496 1.5202 1.4044 0.9961 0.9546 0.9491 0.8910 0.8106 0.9249 0.8164 0.7388 0.9338
C3-DC-CH3 carnitine 1.8493 0.3508 0.3095 1.6187 0.4896 0.7886 2.6955 0.5724 0.3810 1.5968 0.7881 0.2595
CAR(10:0) 1.4125 0.9596 1.7617 1.3139 0.6250 0.9387 0.7814 0.7147 1.1580 0.8871 0.5586 0.9855
CAR(10:2) 1.3125 1.0671 1.2439 1.2274 0.9597 0.6946 0.9129 1.1249 0.8486 0.9906 0.8715 0.7971
CAR(12:0) 1.4425 0.8800 1.4435 1.4415 0.7377 0.6767 0.9614 0.7951 0.9288 1.1907 0.6122 0.9353
CAR(12:1) 1.5878 0.7983 1.6296 1.5163 0.6514 0.7388 0.7918 0.7024 1.0817 1.0074 0.4937 1.0709
CAR(14:0) 1.3180 0.8595 1.3162 1.3344 0.6992 0.7934 1.0296 0.6954 1.0215 1.2512 0.5882 1.0974
CAR(14:1) 1.2605 0.8549 1.3937 1.3874 0.8115 0.7364 0.9241 0.8540 1.0257 1.1358 0.6298 1.0375
CAR(14:2) 1.2034 0.7788 1.4405 1.4284 0.8065 0.7802 0.8151 0.7916 1.1284 1.0429 0.6519 1.1942
CAR(16:0) 1.0368 0.6635 1.3146 1.1007 0.6466 1.1377 0.9791 0.6633 1.3055 1.0444 0.5831 1.5150
CAR(16:0(OH)) 1.3814 0.5490 1.0309 1.4429 0.4835 0.9582 1.3718 0.6256 1.2038 1.3790 0.4502 1.0022
CAR(18:0) 0.6655 0.4979 0.7375 1.3568 1.0579 0.9535 1.1846 1.0289 1.1175 1.2543 1.0657 1.0288
CAR(18:1) 0.8097 0.5030 1.2310 1.3755 0.7730 1.0296 1.0756 0.7566 1.2456 1.1462 0.6618 1.3934
CAR(18:1(OH)) 0.9840 0.4806 1.0593 1.5184 0.6528 0.8963 1.4747 0.7334 1.2289 1.3139 0.5278 1.0579
CAR(18:2) 0.9607 0.5186 1.2938 1.4387 0.7533 1.0200 0.9635 0.6404 1.2953 1.1501 0.5713 1.4063
CAR(2:0) 1.4817 1.6754 1.5646 0.9009 0.8091 0.6967 1.0301 0.8799 0.7071 0.8490 0.8064 0.6926
CAR(20:4) 1.7743 0.1470 0.2244 0.7409 0.0691 1.8643 2.7237 0.9948 0.1022 3.2080 0.5252 0.1387
CAR(3:0) 1.3092 2.0573 1.0632 1.0182 1.2229 0.6923 0.6936 1.1626 0.4550 0.8176 1.2285 0.3512
CAR(4:0) 1.6217 3.0406 2.0889 0.6788 0.7076 0.6780 0.5628 0.5945 0.5740 0.4620 0.7501 0.4401
CAR(4:0(OH)) 1.4879 0.8401 1.3730 1.4753 0.6403 0.8385 1.5761 0.6221 0.6627 1.2351 0.6956 0.5566
CAR(5:0) 1.3971 2.2335 0.6616 0.9149 1.6108 0.3929 0.8382 1.1207 0.2818 0.8814 1.5297 0.2055
CAR(5:1) 1.5143 1.2598 0.7379 0.9804 1.5012 0.4667 1.2066 0.9401 0.6517 1.0942 1.2697 0.4373
CAR(6:0) 1.6519 3.0664 2.5502 0.5510 0.4692 0.7532 0.5399 0.4335 0.7092 0.4537 0.4872 0.5894
CAR(7:0) 1.5813 3.4496 2.5397 0.5096 0.4135 0.7011 0.2347 0.3073 0.5135 0.0957 0.7219 0.2776
CAR(9:0) 2.3460 2.9856 2.7655 0.6440 0.2549 0.9021 0.4790 0.2687 0.7495 0.2741 0.3589 0.2268
CAR(DC3:0) 2.0021 0.6818 0.7385 1.3525 0.9133 0.8137 2.0213 0.6855 0.5420 1.0452 0.6799 0.4372
Carnitine 1.3816 1.7000 1.2368 0.8893 0.9165 0.8051 0.9084 1.0561 0.7038 0.7619 1.0326 0.6462
Carnosine 0.5973 0.4415 1.2865 0.8811 2.2084 1.9090 0.8681 0.3800 1.3857 0.5119 0.6035 1.3006
Choline 0.9850 0.8396 0.9825 1.5021 0.8141 1.0452 1.1781 1.1098 0.8125 1.0147 0.8620 0.8035
Choline phosphate 1.1675 0.3211 0.5306 1.1916 0.6261 1.4432 2.0713 1.2140 0.6652 1.2091 0.7412 0.6082
cis-3-hydroxyproline 0.9856 1.4551 1.5506 0.5133 1.0862 1.0569 0.5473 0.6083 1.1894 0.4588 0.8297 1.8780
Citrulline 0.6633 1.1903 1.0710 0.8653 1.5565 1.0874 0.8559 0.8571 1.0238 0.7155 1.3405 0.9303
Cotinine 1.9479 1.4301 0.6819 0.8361 0.7762 0.6468 0.8615 0.7970 0.8799 1.0589 1.3466 0.6014
Creatine 1.1481 0.8381 0.9193 0.9864 1.1374 1.1607 1.2899 0.7863 0.9925 0.8365 1.1743 0.7447
Creatinine 1.3214 1.1224 1.1026 1.0952 1.0941 0.9499 1.1720 0.6961 1.0139 0.8657 0.7392 0.8768
Cytosine 0.9459 0.6364 0.7650 1.1842 1.1882 0.8470 1.6891 0.9918 0.8599 0.9305 0.9462 1.0042
Deoxycytidine 0.8770 0.5878 0.7000 1.2744 1.2799 0.8244 1.7720 1.0014 0.8747 0.9061 0.9243 0.9728
Dimethylarginine 1.0094 1.0214 0.9714 1.0445 1.2587 0.9287 0.9624 0.9248 1.0037 0.9018 1.0770 0.9538
Dimethylglycine 1.1506 1.9092 1.0381 0.9464 1.3588 0.6973 0.8634 0.9976 0.6245 0.8189 1.1195 0.5748
Gamma-Aminobutyric acid 1.2257 1.1299 0.5243 1.1387 1.1742 1.2145 1.3177 1.1003 0.3815 1.1778 1.1970 0.3428
Glucose 0.7442 1.0694 1.1032 0.7260 0.9700 1.1960 1.0095 1.1380 1.2133 0.6030 1.3068 0.9388
Glutamic acid 1.3344 0.6775 0.5981 1.2411 0.7435 1.0363 1.6999 1.0605 0.5230 1.3830 1.0947 0.4434
Glutamine 0.9113 0.9315 1.4001 0.9592 0.9314 1.1186 0.8449 0.8257 0.9723 0.8346 0.9816 1.3718
Glycine 0.9627 1.2540 1.0767 1.0373 0.9038 1.0501 0.9857 0.8671 0.9169 0.7756 0.9847 1.1803
Histamine 2.0712 0.1994 0.8277 1.9205 0.0847 0.9827 2.2802 0.8815 0.7106 0.8720 0.3579 0.5397
Histidine 0.8009 0.9963 1.0180 1.1450 1.0939 0.9146 0.9218 1.0623 0.9209 0.9520 1.2980 0.9043
Isoleucine 0.7475 0.8117 0.8189 1.1304 1.3460 0.9629 0.9853 1.0405 0.8777 1.1896 1.3737 0.7570
Kynurenic acid 1.2115 1.0650 0.7639 0.9391 2.3668 0.7728 0.7010 0.8403 0.8961 0.8088 1.2584 0.6590
Leucine 0.8355 0.9233 0.7243 1.1929 1.4001 0.8805 1.0093 1.0776 0.7623 1.2150 1.3767 0.6336
Lysine 0.5185 0.7571 0.6609 0.9702 1.6285 0.9575 0.8571 1.2294 0.9004 0.8769 1.9474 0.7685
Methionine 0.9447 1.6739 0.7850 0.8584 1.4889 0.8084 0.7851 1.1004 0.8702 0.8399 1.3113 0.6023
Methionine sulfoxide 1.2873 1.6089 0.6410 1.2449 1.2421 0.7475 1.0357 0.6776 0.6977 0.9673 1.3654 0.4555
N-acetylglycine 0.5096 0.6609 1.4690 0.5744 0.4125 1.4652 0.6018 0.5004 1.8808 0.4454 0.4167 2.8024
Niacinamide 1.1852 0.6815 0.4928 1.4422 0.5953 1.1131 2.4639 0.9466 0.5130 1.4422 0.5116 0.3847
NMMA 1.1415 1.8432 1.2828 0.7840 1.1525 0.8275 0.7490 0.9015 0.8137 0.7205 1.0268 0.8657
Ornithine 0.9745 1.0508 0.8228 1.0631 0.8230 0.9460 1.0107 1.3946 0.6331 1.1440 1.3606 0.6882
Phenylalanine 0.9597 1.0184 1.0106 1.1308 1.1200 1.1047 0.8832 0.9638 1.0161 0.9597 1.0121 0.8535
phenylalanine-d8 1.0155 1.0232 1.0046 0.9739 1.0223 1.0256 1.0299 0.9813 1.0509 0.9423 0.9334 1.0039
Phosphoethanolamine 1.1269 0.3795 0.4818 1.6927 0.6427 1.4532 2.0570 0.8520 0.5512 1.2297 0.7028 0.6117
Pipecolic acid 1.0276 1.0367 1.1349 1.0211 1.3436 0.6505 1.0689 1.0707 0.7468 0.9179 1.1742 0.9267
Proline 0.6412 0.8735 0.8092 0.8840 1.6265 1.0132 0.8803 1.0455 1.1093 0.7862 1.6634 0.7765
Putrescine 0.8645 0.6838 0.9564 1.0788 1.1824 1.2174 1.1206 0.7812 1.0235 1.0785 0.9545 1.0932
Pyroglutamic acid 0.9074 0.9355 1.4663 0.9260 0.9226 1.1269 0.8319 0.8183 0.9836 0.7954 0.9825 1.4010
S-Adenosylhomocysteine 0.8061 2.2330 0.9685 1.4468 1.3138 0.4475 0.3159 0.9114 0.4739 0.4073 1.8235 0.4345
Sarcosine 1.1231 0.8427 0.9772 0.9610 1.1333 1.1506 1.2600 0.7844 1.0220 0.7896 1.1886 0.7952
Serine 0.7264 1.1933 0.8237 0.9481 1.4205 0.9376 0.8856 1.0640 0.9359 0.7559 1.4353 0.9348
Serotonin 1.7270 0.1560 0.4468 1.0621 0.1298 3.2979 0.8881 0.5297 0.9923 1.0982 0.4698 0.8465
sn-glycero-3-phosphocholine 0.9172 0.5279 0.3808 1.5553 0.5226 1.0587 2.4594 1.2289 0.5067 1.5114 0.7110 0.3458
Symmetric dimethyl-L-arginine 1.0592 0.9283 0.9545 1.2218 1.2456 0.9287 1.0928 0.9262 0.8881 0.9583 0.9649 0.8817
Taurine 1.0258 0.6846 0.6790 1.2823 1.1309 0.9926 1.7028 0.9555 0.6470 1.2164 0.9224 0.7133
Thiamine 1.1328 1.3018 1.4499 1.0842 1.1016 1.2863 0.6816 0.8117 0.9677 0.6648 0.7884 0.8669
Threonine 0.6525 0.9993 0.6002 0.8725 1.7611 0.7783 0.9327 1.2163 0.9322 1.0011 1.7041 0.6402
Thymidine 0.5121 0.6089 1.9854 0.5124 0.8218 1.5727 0.5855 0.5635 1.9430 0.4917 0.5661 2.0388
Thyroxine 1.4844 1.6404 1.2112 0.9396 1.0002 0.8559 0.7525 0.7854 1.0962 0.4934 0.9431 0.8506
Trimethylamine N-oxide 1.5366 2.8821 3.5624 0.3225 0.8288 0.6602 0.3737 0.4612 1.4672 0.0989 0.3077 0.0966
Tryptophan 0.9355 1.0797 0.8861 0.9891 1.2654 0.9300 0.8313 1.1945 0.9010 1.0136 1.2318 0.7799
Tyrosine 0.6536 0.8593 0.7423 1.0193 1.8593 0.9045 0.8416 1.1651 0.9146 1.0219 1.4507 0.7182
Ureidopropionic acid 0.4748 0.5532 1.0785 1.2178 1.1635 1.5844 0.7800 0.9018 1.4601 0.7414 0.9137 1.1913
Valine 0.6970 0.8381 0.7212 1.0356 1.5510 0.8858 0.9587 1.1156 0.8455 1.1714 1.5617 0.6865
valine-d8 0.9603 1.0316 0.9623 1.0248 1.0620 0.9815 1.0248 1.0183 0.9684 0.9946 1.0147 0.9628
Xanthosine 1.3004 1.0628 1.3492 2.2902 0.3841 1.7104 0.6115 1.0434 0.3661 0.6740 0.5666 0.5744
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Factors:

F1Diet:Chow | Treatment:none | Strain:129Jax
F2Diet:Chow | Treatment:none | Strain:129Tac
F3Diet:Chow | Treatment:none | Strain:B6Jax
F4Diet:HFD | Treatment:metronidazole | Strain:129Jax
F5Diet:HFD | Treatment:metronidazole | Strain:129Tac
F6Diet:HFD | Treatment:metronidazole | Strain:B6Jax
F7Diet:HFD | Treatment:placebo | Strain:129Jax
F8Diet:HFD | Treatment:placebo | Strain:129Tac
F9Diet:HFD | Treatment:placebo | Strain:B6Jax
F10Diet:HFD | Treatment:vancomycin | Strain:129Jax
F11Diet:HFD | Treatment:vancomycin | Strain:129Tac
F12Diet:HFD | Treatment:vancomycin | Strain:B6Jax
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