Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [cecal] (Study ST000880)

(Analysis AN001433)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
1-Methylhistamine 1.3101 1.6416 2.0964 1.2712 1.0638 0.3358 1.4764 0.7112 0.4882 0.5370 0.6985 0.6437
1-methyl nicotinamide 0.0076 0.0720 0.0063 4.0453 1.9022 0.7837 1.2806 0.0124 0.0089 1.1883 2.0854 0.3587
2-Aminobenzoic acid 1.5926 3.9872 0.8857 0.5430 0.2507 0.4519 0.7691 0.5585 1.5698 0.1310 0.3354 0.1295
3^,5^ cyclic AMP NA NA NA NA NA NA NA NA 1.3586 0.8017 0.9198 NA
3-Dehydroxycarnitine 2.2597 1.1595 2.6298 0.3661 0.2801 0.0129 1.9673 2.0770 1.3631 0.0132 0.2667 0.0121
3-Hydroxyanthranilic acid 0.6482 0.6192 1.6669 1.1105 0.7664 0.2931 3.8101 1.0113 1.1921 0.0680 0.1361 0.2172
5-amino-levulinic acid 1.5412 1.3444 1.1223 0.7928 0.8440 0.4611 0.3536 0.3294 0.2932 1.8732 1.3296 1.7459
5-Hydroxy-L-tryptophan 0.8794 0.8214 1.4017 0.7032 0.2370 0.3009 1.6644 1.4406 1.8312 1.6331 0.2514 0.9360
5^-Methylthioadenosine 1.1989 0.6009 0.0598 0.2571 0.0639 0.5389 0.2694 0.1726 0.4960 5.2852 0.3719 2.4504
Acetylcholine 0.7486 0.7723 1.0918 0.3439 0.4161 0.6146 0.7871 0.9608 1.0925 1.7216 0.4611 3.0127
Adenosine 4.3753 0.9084 3.6520 0.1832 0.1012 0.2583 0.8223 0.8271 0.7492 0.1924 0.1920 0.4016
Alanine 1.1544 1.1843 1.4539 1.0087 0.3912 0.3284 1.5928 1.4836 1.7875 0.7766 0.4490 0.5031
Allantoin NA 0.0684 NA 2.0887 NA 0.5192 NA NA NA 0.9480 NA 0.6770
Aminoisobutyric acid 1.4537 1.1237 1.0975 NA 0.1752 NA 1.1546 0.6489 1.5312 NA 0.1115 0.0706
Anserine 0.9352 0.6506 2.9528 0.0616 0.0429 0.4491 0.8987 0.3612 4.0492 0.1711 0.1827 1.4985
Arginine 1.5253 0.7506 0.7788 0.4286 0.1863 0.5218 2.1071 1.9055 1.6047 0.4253 0.6585 1.0522
Asparagine 0.2023 0.9242 0.0259 1.3932 0.0094 0.8129 0.9051 1.0335 1.1962 2.9323 0.0090 2.3125
Aspartic acid 2.5329 2.0598 4.9234 0.1840 0.3443 0.0898 0.9640 0.6343 0.7214 0.1264 0.1670 0.2337
Beta-Alanine 1.2822 1.2569 1.9273 0.9346 0.3506 0.3289 2.0922 1.1324 1.3798 0.6273 0.4530 0.4666
Betaine 0.8779 0.7108 0.6406 1.4521 0.9076 1.1820 0.6163 0.5316 0.5412 1.5682 1.0917 1.7901
C3-DC-CH3 carnitine 0.9704 0.0743 0.1233 1.9211 1.0294 1.0799 1.8913 0.3558 0.7604 1.0121 1.0985 0.7945
C5-DC carnitine 0.9680 0.0534 0.0085 1.5888 1.0430 1.2981 1.5776 0.1949 1.4625 0.8337 1.2493 0.7420
CAR(10:0) 0.0131 0.0055 NA 2.0465 0.2756 2.1736 0.0027 NA 0.0168 1.9743 0.1870 1.8155
CAR(10:2) 0.0545 NA NA 2.0577 0.5862 0.8735 NA NA 0.0937 2.1230 0.6424 1.3327
CAR(12:0) 0.0293 0.0413 0.0108 1.8358 0.6111 1.7990 0.0689 NA 0.1001 2.0802 0.4826 2.7273
CAR(12:1) 0.0962 NA NA 1.5419 0.3758 1.4853 NA NA 0.0908 1.4268 0.2951 2.2348
CAR(14:0) 0.1198 0.0765 0.0894 1.3688 0.9003 1.8914 0.4652 0.0498 0.3776 2.9370 0.6420 2.8545
CAR(14:1) 0.1303 0.0452 0.0568 1.3440 0.5886 2.5789 0.1606 0.0017 0.3174 1.4465 0.5129 4.3316
CAR(14:2) 0.1772 0.0675 0.0044 1.8809 0.5399 1.9570 0.0331 NA 0.4962 1.3842 0.4535 2.8089
CAR(16:0) 0.1749 0.1327 0.1747 0.5702 0.6366 2.4758 0.5618 0.2666 1.1597 1.1106 0.6972 3.8329
CAR(16:0(OH)) 0.4598 0.1620 0.2695 0.7373 0.5097 1.9195 3.4795 0.1114 0.8036 1.0151 0.5074 1.8425
CAR(18:0) 0.1161 0.1588 0.1744 1.1771 0.8405 1.5696 1.3337 0.6704 1.4504 1.3859 0.7457 2.1712
CAR(18:1) 0.2408 0.2236 0.2721 0.3377 0.3805 2.9222 0.4854 0.2001 2.3615 0.3050 0.3814 3.7076
CAR(18:1(OH)) 3.2456 0.3460 0.6046 0.4985 0.3769 1.4801 1.2807 0.0413 1.1136 0.6649 0.6512 1.5978
CAR(18:2) 0.4465 0.2383 0.3022 0.4620 0.4566 3.2635 0.4315 0.0651 1.3209 0.4459 0.6369 3.7561
CAR(2:0) 2.0692 0.2404 0.5132 2.2912 0.0923 0.7815 1.0125 0.1042 0.2637 2.6766 0.1356 1.6980
CAR(20:0) 0.4195 0.8232 0.7062 0.5284 0.4178 0.8497 1.4370 2.1553 2.5906 0.2971 0.3792 1.0594
CAR(20:4) 0.2668 0.1794 0.2123 1.9693 0.4475 2.4451 0.4649 0.0513 1.8432 0.6498 0.6160 2.1830
CAR(26:0) NA NA NA NA NA NA NA 0.9758 1.1726 NA 0.8516 NA
CAR(3:0) 1.0561 0.1175 0.4463 3.3842 0.1891 1.4794 0.9611 0.0578 0.7370 1.5096 1.1213 0.4432
CAR(4:0) 4.9991 0.3251 0.7620 0.5341 0.0862 0.3787 2.7625 0.0995 0.9282 0.4659 0.0831 0.5163
CAR(4:0(OH)) 3.0962 0.4697 1.4422 0.9107 0.5254 0.3167 2.0040 0.2359 0.6742 1.1327 0.4674 0.8135
CAR(5:0) 0.2184 0.0272 0.0191 2.9440 1.5560 1.1237 0.2642 0.0184 0.2178 3.0725 1.0727 1.2207
CAR(5:1) 0.2644 NA 0.0859 2.1009 0.8597 0.7854 0.0566 0.0082 0.0283 2.5522 0.6340 1.3910
CAR(6:0) 0.3459 0.0584 0.0378 3.6579 0.3279 2.1459 0.0893 0.0306 0.0723 2.5966 0.2679 2.1290
CAR(7:0) 1.7222 NA NA 0.6689 0.1787 0.4895 NA NA 0.1518 1.7719 0.5410 2.1761
CAR(8:0) 0.0155 0.0061 NA 2.2161 0.1137 1.5194 NA 0.0032 0.0245 1.9557 0.0839 1.5913
CAR(9:0) NA NA NA 2.0374 0.3443 0.8779 NA NA NA 1.2718 0.3383 1.1304
CAR(DC3:0) 1.2479 0.2826 0.8026 1.8590 0.6877 0.4083 2.8846 0.6625 0.5769 1.0956 0.8761 0.5668
Carnitine 1.4421 0.2900 0.6909 1.9400 0.8918 1.3576 0.8876 0.3087 1.5845 1.2442 0.3751 0.9101
Choline 0.7387 0.5293 0.8828 0.2181 0.2455 0.3061 0.6271 0.3404 0.6496 2.7571 0.2744 4.4016
Choline phosphate 2.7855 2.1039 1.2487 0.0855 0.0355 0.0375 1.2074 0.3945 2.1849 0.3360 0.1262 0.3243
cis-3-hydroxyproline 2.6937 3.0810 5.4549 0.2773 0.2557 0.2107 0.1368 0.0829 0.1283 0.2501 0.1607 0.3815
Citrulline 1.9098 1.7357 3.4943 0.5001 0.2625 0.1924 1.3715 0.4632 2.1110 0.3687 0.0510 0.1634
Cotinine 0.8543 1.0731 1.4299 0.9120 1.0334 0.7151 1.2986 0.7634 0.9678 1.4277 0.7281 0.9042
Creatine 0.2699 0.0943 0.0962 2.1510 1.7488 1.4135 0.5924 0.2632 0.1741 1.7360 1.8202 1.4144
Creatinine 0.3405 0.3844 0.0259 2.1644 1.5254 0.7677 1.7223 0.3420 0.0380 1.4097 1.8927 1.1432
Cysteine NA 0.0620 NA 1.1500 0.9449 0.2974 NA 0.0410 0.0167 1.2796 1.3656 1.6826
Cytosine 0.4225 0.3800 1.0700 0.0366 0.0051 0.0860 1.1431 1.2166 0.5843 2.5933 0.2043 4.2757
Deoxyadenosine 2.3330 0.6874 6.5297 0.1273 0.0849 0.3732 0.7285 1.7578 0.3349 0.1314 0.1135 0.1809
Deoxycytidine 0.3561 0.3627 0.3155 0.0430 0.0123 0.0932 1.0977 1.2374 0.5532 2.8337 0.0108 4.4194
Dimethylarginine 1.5393 0.9481 2.3078 1.1795 0.4271 0.6756 0.4268 0.2096 0.7790 1.4139 0.5943 1.8260
Dimethylglycine 5.5170 0.7030 1.7116 0.6992 0.4531 0.3891 0.7643 0.1273 0.5410 0.4876 0.4448 0.3400
Gamma-Aminobutyric acid 0.6063 1.0584 0.6040 4.1532 0.7415 1.2328 1.0339 0.9620 1.0735 0.0411 0.2992 0.0950
Glutamic acid 2.5331 1.6565 2.7660 0.3360 0.3078 0.6999 1.1193 0.8166 0.9312 0.3795 0.2352 0.6602
Glutamine 1.2346 1.4055 0.7556 0.0754 0.0250 0.5204 1.3320 1.1349 1.2890 2.5013 0.0649 1.6003
Glycine 0.7285 0.6650 0.9103 2.1956 0.9775 0.6856 0.6853 0.9152 0.9112 1.4633 0.6332 1.2070
Guanine 0.6455 0.6396 0.8718 0.7459 0.0863 0.6486 0.8368 0.5853 0.5859 2.6703 0.2213 3.4306
Histamine 2.2590 4.0367 6.5561 0.0374 0.0373 0.0242 0.1674 0.0443 0.0610 0.0241 0.1138 0.0279
Histidine 1.1097 0.9105 1.1463 0.3074 0.1232 0.2753 1.1445 0.8162 1.8047 1.8301 0.3540 2.2147
Homocysteine 0.9769 1.7729 0.9341 0.8555 0.4803 NA 1.0342 0.9918 0.7979 0.8679 NA NA
Imidazoleacetic acid 0.5447 2.8895 0.5042 0.5049 0.0822 0.1069 5.1659 1.0730 0.1206 0.5461 0.0375 0.3005
Isoleucine 0.7271 0.9335 1.0222 1.6170 0.6835 0.4586 1.2785 1.4708 1.5353 0.9856 0.6389 0.6545
Kynurenic acid 0.3571 0.1752 0.6900 0.6931 0.7180 1.6655 0.7397 0.2114 0.9531 1.1785 0.7606 3.7803
Leucine 1.0065 1.0721 1.0232 1.1989 0.5153 0.3985 1.6746 1.5937 1.7761 0.6935 0.5630 0.4905
L-Histidinol 3.0227 1.1201 3.9563 0.2359 0.0408 0.1365 1.3793 1.2923 1.3471 0.0180 0.1698 0.0201
Lysine 1.0385 0.8973 1.2441 0.6018 0.3096 0.4431 1.3508 1.4719 2.3650 1.1385 0.2617 0.9387
Methionine 1.3827 1.1725 1.4352 0.6769 0.2780 0.2334 2.0850 1.5737 1.9418 0.4976 0.4363 0.3958
Methionine sulfoxide 1.4583 1.3768 2.1121 1.3965 0.3119 0.1871 1.7813 1.2675 0.9356 0.8569 0.3828 0.2111
methyl-hydroxyisobutyric acid 0.9727 1.2445 1.0912 1.0236 0.9482 0.6859 0.8405 0.9399 0.9552 0.9231 1.3720 1.0261
N-6-trimethyllysine 1.7235 1.0833 1.3123 1.6685 0.8439 0.7435 0.4868 0.3228 0.4869 1.1492 0.9357 1.3218
N-Acetylhistamine 1.8258 4.5420 6.8970 0.0092 0.0100 0.0059 0.0613 0.0278 0.0308 0.0019 0.0602 0.0025
Niacinamide 1.3167 0.3215 0.6381 0.2716 0.1933 0.2618 0.4266 0.3925 0.7137 0.2848 6.6439 0.4449
NMMA 1.3195 1.0416 1.1666 1.1495 0.4095 0.3253 0.5050 0.4359 0.6539 2.5818 0.3235 2.1296
Ornithine 0.2253 0.4281 0.3893 1.5686 0.2407 1.2152 0.2337 0.2154 0.6010 3.5364 0.1586 3.0351
Phenylalanine 1.2866 1.1421 1.2748 1.0975 0.4246 0.3231 1.9031 1.5449 1.6818 0.5751 0.4395 0.3758
phenylalanine-d8 (Internal Standard) 1.0732 1.0287 1.0878 1.0271 0.8790 0.8802 1.1491 1.0487 1.0907 0.9417 0.8962 0.9194
Pipecolic acid 3.5152 1.7475 2.9463 0.6372 1.0871 0.1092 0.8120 0.3694 0.7978 0.0935 0.2784 0.0930
Proline 0.5961 0.4822 0.5810 0.1819 0.1934 0.1205 0.7561 0.6046 0.6757 2.7098 2.5505 2.4434
Putrescine 0.2985 0.2464 0.4600 0.7954 3.8988 0.2136 0.1116 0.0749 0.0505 0.2765 4.9182 0.5206
Pyroglutamic acid NA NA 0.0736 1.3543 1.1142 1.5332 NA NA NA 0.4259 0.7710 1.0330
S-Adenosylmethionine 2.9967 0.5662 NA NA NA 0.6000 0.9318 0.4206 0.8480 0.4204 NA 0.8181
Sarcosine 1.2774 1.3896 1.2516 0.8050 0.3495 0.2847 1.5637 1.8048 1.7449 0.6741 0.4601 0.4575
Serine 0.9445 0.9978 0.8467 0.3519 0.2710 0.2762 1.0903 1.2418 1.4305 2.4967 0.4307 1.5836
Serotonin 1.0764 0.9040 1.1024 0.5482 0.4261 0.5780 3.0380 0.9616 1.5756 0.2370 0.5811 0.9973
sn-glycero-3-phosphocholine 2.6301 0.6329 0.4236 0.1366 0.1145 0.3743 0.2960 0.0495 0.1465 3.9263 0.1093 3.0162
Spermidine 0.2612 0.3009 0.6551 0.0382 0.0371 0.2526 0.8888 1.0422 7.7680 0.0637 0.1353 0.4707
Symmetric dimethyl-L-arginine 1.1719 1.3369 2.0409 1.0858 0.3151 0.6584 1.0302 0.2514 1.0635 1.1545 0.5715 1.5800
Taurine 1.7502 1.6117 0.7842 0.3649 0.3327 0.2168 1.8630 2.0187 2.4731 0.1786 0.1557 0.1966
Thiamine 0.7000 0.4800 2.0422 0.7387 0.4523 0.8356 1.9433 1.5331 1.5753 0.6004 0.4177 0.9420
Threonine 0.6377 0.7972 0.6162 0.2923 0.2106 0.1863 0.7635 0.9038 0.8926 3.7976 0.2782 2.5281
Thymidine 1.1951 0.8052 1.1226 NA NA NA 0.5129 0.4369 0.3788 1.1590 NA 2.4202
Trimethylamine N-oxide 0.9218 0.9984 0.9311 1.0369 1.0526 1.1026 1.0254 0.9750 1.0431 0.9322 1.0057 0.9579
Tryptophan 1.1025 0.8138 0.9769 0.5371 0.3120 0.3486 1.6321 1.3598 1.4522 1.9386 0.3816 1.1389
Tyrosine 1.2360 1.1178 1.3152 0.4235 0.3937 0.3232 1.9090 1.4357 1.6021 1.0842 0.5729 0.6656
Ureidopropionic acid 0.8656 0.8953 0.9397 1.2205 0.8253 3.0160 0.9434 0.3622 0.9575 0.3106 0.5126 1.1363
Urocanic acid 1.5875 1.3806 1.9888 0.0666 0.0221 0.0161 1.7708 0.6638 2.0103 0.5981 0.9863 1.1562
Valine 0.2531 0.3037 0.4205 3.0254 1.7035 1.9313 1.2931 1.4040 0.8115 0.3588 0.1607 0.1895
valine-d8 (Internal Standard) 0.9763 0.9860 0.9697 0.9276 0.9978 0.9644 0.9941 1.0242 1.0346 1.0633 1.0070 1.0475
Xanthosine 3.0007 0.7191 7.6495 0.1519 0.0922 0.1480 0.2778 0.1266 0.1782 0.4536 0.0809 0.7838
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Factors:

F1Diet:Chow | Treatment:none | Strain:129Jax
F2Diet:Chow | Treatment:none | Strain:129Tac
F3Diet:Chow | Treatment:none | Strain:B6Jax
F4Diet:HFD | Treatment:metronidazole | Strain:129Jax
F5Diet:HFD | Treatment:metronidazole | Strain:129Tac
F6Diet:HFD | Treatment:metronidazole | Strain:B6Jax
F7Diet:HFD | Treatment:placebo | Strain:129Jax
F8Diet:HFD | Treatment:placebo | Strain:129Tac
F9Diet:HFD | Treatment:placebo | Strain:B6Jax
F10Diet:HFD | Treatment:vancomycin | Strain:129Jax
F11Diet:HFD | Treatment:vancomycin | Strain:129Tac
F12Diet:HFD | Treatment:vancomycin | Strain:B6Jax
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