Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [cecal] (Study ST000880)
(Analysis AN001435)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11-HETE | 0.4910 | 1.4595 | 0.7705 | NA | 0.4855 | 1.2430 | 0.5204 | 0.3976 | 3.5094 | 0.5438 | 0.7530 | 0.9880 |
| 12S-HETE | 1.4590 | 1.1208 | 1.0093 | 0.2544 | 0.5755 | 0.9242 | 0.8930 | 0.9450 | 2.4320 | 0.4192 | 1.2237 | 0.7462 |
| 15S-HETE | 1.4284 | 1.2290 | 0.8751 | 0.3273 | 0.6350 | 0.9390 | 0.7545 | 0.8981 | 2.2949 | 0.6030 | 0.9598 | 0.8566 |
| 5-HETE | 2.1001 | 1.6309 | 1.4775 | 0.2199 | 0.2636 | 0.4694 | 0.9736 | 1.0660 | 2.1679 | 0.2243 | 0.4784 | 0.8528 |
| 9-HETE | 1.6091 | 1.0374 | 0.9839 | 0.1123 | 0.3711 | 0.7533 | 0.6159 | 0.6173 | 2.7097 | 0.2045 | 0.5205 | 1.0063 |
| Adrenic Acid | 1.0304 | 1.0936 | 1.0866 | 0.3379 | 0.3890 | 1.2670 | 1.0522 | 0.8703 | 2.8841 | 0.2045 | 0.4522 | 1.3541 |
| Alpha-muricholic acid | 2.8199 | 0.7340 | 1.0266 | 0.0326 | 0.0266 | 0.0285 | 0.7909 | 1.2819 | 2.7654 | 0.0007 | NA | 0.0002 |
| Arachidonic acid | 0.8054 | 0.7038 | 0.6643 | 0.4680 | 0.6939 | 1.4739 | 0.9094 | 0.9825 | 2.5416 | 0.4088 | 0.7024 | 1.5620 |
| Beta-muricholic acid | 2.3097 | 1.3052 | 1.0754 | 0.0698 | 0.3598 | 0.0900 | 1.4380 | 2.0585 | 3.2616 | 0.0068 | 0.0162 | 0.0279 |
| Bishomo-gamma-linolenic acid | 1.1467 | 1.2520 | 0.8261 | 0.5805 | 0.4757 | 0.9732 | 1.4857 | 1.2076 | 2.1326 | 0.2839 | 0.5101 | 1.0824 |
| Chenodeoxycholic Acid | 0.8314 | 3.2142 | 0.4335 | 0.0113 | 0.0683 | 0.5648 | 1.2361 | 0.9873 | 2.3284 | 0.0072 | 0.0113 | NA |
| Cholic acid | 0.8709 | 2.2987 | 0.1073 | 0.3306 | 0.7726 | 0.5836 | 1.7014 | 2.2966 | 2.5553 | 0.0010 | 0.0084 | 0.0008 |
| Deoxycholic acid | 1.8050 | 1.6874 | 1.2156 | 0.0009 | 0.0009 | 0.0034 | 1.5474 | 2.8488 | 2.9414 | 0.0006 | 0.0014 | 0.0011 |
| DHA | 1.8534 | 2.6613 | 2.1658 | 0.2805 | 0.3589 | 0.9120 | 0.3824 | 0.5476 | 1.7312 | 0.1524 | 0.3715 | 0.8744 |
| DPA | 2.2059 | 3.0583 | 2.0910 | 0.1351 | 0.1773 | 0.5612 | 0.5616 | 0.4721 | 2.1042 | 0.0842 | 0.1695 | 0.6524 |
| Eicosapentaenoic acid | 3.2348 | 4.1210 | 2.7136 | 0.1260 | 0.1711 | 0.3270 | 0.2106 | 0.2213 | 0.6789 | 0.0954 | 0.1789 | 0.3497 |
| Gamma-linolenic acid | 2.2928 | 1.4364 | 1.0283 | 0.3439 | 0.2078 | 0.4657 | 2.1100 | 1.1842 | 1.7817 | 0.1609 | 0.3573 | 0.6380 |
| Glycocholic Acid | 0.2626 | 0.5507 | 0.0160 | 0.2863 | 0.2591 | 0.5326 | 0.7134 | 5.2717 | 2.5805 | 0.0361 | 0.2235 | 0.1609 |
| Glycodeoxycholic acid | 0.3937 | 0.1105 | 0.0968 | NA | NA | 0.0221 | 2.3271 | 2.1667 | 1.2532 | NA | 0.0207 | NA |
| Linoleic acid | 1.7698 | 1.0996 | 0.9460 | 0.4849 | 0.4216 | 0.6538 | 2.0339 | 1.2792 | 1.6446 | 0.3221 | 0.5385 | 0.7926 |
| Lipoxin A4 | 2.1013 | 0.9861 | 1.5232 | 1.4467 | 0.4294 | 0.3276 | 0.5165 | 0.8599 | 1.8313 | NA | 0.2927 | 0.2649 |
| Lithocholic acid | 1.2646 | 1.2372 | 1.5988 | NA | NA | 0.0003 | 0.3598 | 0.5810 | 1.6082 | NA | NA | 0.0004 |
| LTB4 | 1.0897 | NA | 0.8206 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Myristic acid | 2.0198 | 0.9238 | 0.9596 | 0.5503 | 0.4258 | 0.5826 | 2.1572 | 1.2264 | 1.5775 | 0.3498 | 0.5225 | 0.6948 |
| Myristoleic acid | 2.8582 | 0.5884 | 0.6542 | 0.3632 | 0.1308 | 0.3505 | 3.2002 | 1.3267 | 1.5374 | 0.1158 | 0.3463 | 0.4418 |
| Oleic acid | 1.4334 | 0.8495 | 0.8916 | 0.6599 | 0.5573 | 0.8395 | 1.8800 | 1.1881 | 1.6568 | 0.4469 | 0.6305 | 0.9394 |
| Palmitic acid | 1.4687 | 0.8696 | 0.9420 | 0.7577 | 0.7443 | 0.7848 | 1.6882 | 1.0931 | 1.5326 | 0.5771 | 0.7099 | 0.8175 |
| Palmitoleic acid | 1.9699 | 0.5015 | 0.6245 | 0.5877 | 0.1986 | 0.5311 | 2.8700 | 1.6493 | 1.6611 | 0.2029 | 0.5340 | 0.5756 |
| PGD2 | NA | 1.1458 | 2.6862 | 0.4381 | 0.4479 | 0.3003 | 0.2657 | 1.5859 | 1.8733 | NA | 0.7202 | 0.4807 |
| PGE1 | 0.4016 | 0.8727 | 0.1611 | 1.5527 | 0.5602 | 1.0686 | 1.9965 | 1.0072 | 1.1209 | NA | 0.0795 | NA |
| PGE2-d4 (Internal Standard) | 0.9232 | 0.9542 | 0.9930 | 1.0512 | 1.1288 | 1.0765 | 0.9222 | 0.9403 | 0.8298 | 1.0309 | 1.1071 | 1.0412 |
| Sphingosine-1-phosphate | NA | 0.3610 | 1.0405 | 0.4211 | NA | 0.8079 | NA | NA | 2.8688 | NA | 1.1982 | 0.7270 |
| Stearic acid | 0.6975 | 0.6658 | 0.8556 | 1.2230 | 1.3355 | 1.0366 | 1.1140 | 0.8334 | 1.0799 | 1.0766 | 1.0972 | 0.9487 |
| Tauro-beta-muricholic acid | 0.0927 | 0.0379 | 0.0025 | 1.7658 | 0.8785 | 1.9313 | 1.2567 | 0.4632 | 0.6792 | 1.0339 | 1.3432 | 2.2657 |
| Taurochenodeoxycholic acid | 0.3278 | 0.0617 | 0.0302 | 1.0393 | 0.6265 | 3.5900 | 1.0773 | 0.6882 | 0.5812 | 0.4427 | 0.9653 | 2.3274 |
| Taurocholic acid | 0.0960 | 0.0065 | 0.0023 | 2.1697 | 1.4324 | 1.0803 | 2.0795 | 0.4535 | 0.3815 | 0.9580 | 2.1563 | 0.9344 |
| Taurodeoxycholic acid | 0.4582 | 0.0110 | 0.0334 | 0.0007 | 0.0004 | 0.0009 | 1.7766 | 2.9370 | 4.2885 | 0.0002 | 0.0024 | 0.0002 |
| Taurohyodeoxycholate/Tauroursodeoxycholate | 0.4505 | 0.0981 | 0.0177 | 1.2831 | 0.8878 | 1.5552 | 2.1317 | 1.3357 | 1.1064 | 0.5264 | 1.1015 | 1.2602 |
| Taurolithocholic acid | 0.6366 | 0.0606 | 0.0584 | 0.0090 | 0.0034 | 0.0137 | 1.5820 | 1.9014 | 4.7143 | 0.0049 | 0.0682 | 0.0098 |
Factors:
| F1 | Diet:Chow | Treatment:none | Strain:129Jax |
| F2 | Diet:Chow | Treatment:none | Strain:129Tac |
| F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
| F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
| F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
| F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
| F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
| F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
| F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
| F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
| F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
| F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |
