Data for Pharmacometabolomic analysis of rat hippocampus and plasma in response to chronic stress and albiflorin treament (Study ST000903)
(Analysis AN001469)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 12-HETE | 0.4336 | 1.0990 | 1.3869 | 1.0322 |
| 14,15-Epoxy-5,8,11-eicosatrienoic acid | 0.9690 | 1.1975 | 0.8397 | 1.0138 |
| 1-Pyrroline-5-carboxylic acid | 0.8673 | 0.9573 | 0.9750 | 1.2035 |
| 20-HETE | 0.6041 | 1.1809 | 1.1607 | 1.0342 |
| 2,3-Diphosphoglyceric acid | 0.9599 | 0.9230 | 0.8504 | 1.2854 |
| 2-Pyrocatechuic acid | 0.8748 | 1.1739 | 1.0334 | 0.9138 |
| 4-Pyridoxic acid | 1.0483 | 1.1607 | 0.8610 | 0.9474 |
| 5-HETE | 1.0331 | 1.2311 | 0.7774 | 0.9862 |
| Adipic acid | 0.7083 | 0.9517 | 1.0513 | 1.2823 |
| Allantoic acid | 1.0213 | 1.1583 | 0.9057 | 0.9265 |
| Allantoin | 0.9897 | 0.9731 | 0.8630 | 1.1913 |
| Anandamide | 1.2125 | 0.9315 | 0.9541 | 0.9078 |
| Arachidonic acid | 0.7332 | 0.9194 | 1.3292 | 0.9770 |
| Arginine | 1.0987 | 0.8892 | 1.0060 | 1.0053 |
| Ascorbic acid | 1.2989 | 1.0757 | 0.7047 | 0.9577 |
| Azelaic acid | 1.0065 | 1.0463 | 0.9899 | 0.9585 |
| Benzoic acid | 0.5839 | 1.1322 | 1.1432 | 1.1228 |
| Camp | 0.8930 | 1.0565 | 1.0134 | 1.0354 |
| Chenodeoxycholic acid | 0.7250 | 0.7623 | 0.8956 | 1.6301 |
| cis-aconitic acid | 1.1550 | 1.0343 | 1.0330 | 0.7735 |
| Citric acid | 1.1337 | 1.0217 | 0.9989 | 0.8459 |
| Citrulline | 1.0294 | 1.0112 | 1.0561 | 0.8963 |
| CL(18:2/18:2/16:1/16:1) | 0.9079 | 0.9608 | 1.2173 | 0.8868 |
| CL(18:2/18:2/18:1/18:1) | 1.0307 | 0.9444 | 1.0056 | 1.0187 |
| CL(18:2/18:2/18:2/16:1) | 0.9226 | 0.9122 | 1.0993 | 1.0534 |
| CL(18:2/18:2/18:2/18:1) | 1.0089 | 0.8580 | 1.2174 | 0.8885 |
| CL(18:2/18:2/18:2/18:2) | 0.9262 | 0.8842 | 1.0897 | 1.0887 |
| CoA | 1.3826 | 1.1704 | 0.9500 | 0.5033 |
| Cortisone | 1.0863 | 0.9147 | 0.8425 | 1.1761 |
| Creatinine | 1.0662 | 1.0082 | 0.9126 | 1.0239 |
| Deoxycholic acid | 0.7426 | 0.9899 | 0.8627 | 1.4220 |
| Dimethyl-L-arginine | 0.8418 | 0.9910 | 1.1189 | 1.0335 |
| Docosahexaenoic acid | 1.2259 | 0.9364 | 0.8884 | 0.9632 |
| Eicosapentaenoic acid | 0.3881 | 2.3632 | 0.7829 | 0.4929 |
| Fructose 6-phosphate | 0.6484 | 1.0992 | 1.1682 | 1.0631 |
| Gamma-glutamyl-Alanine | 1.0449 | 1.1038 | 0.8860 | 0.9795 |
| Glucose | 1.0072 | 1.0796 | 0.8750 | 1.0539 |
| Glutathione | 0.9257 | 1.0703 | 0.9093 | 1.1060 |
| Glyceraldehyde 3-phosphate | 1.2255 | 1.1576 | 0.8513 | 0.7842 |
| Glycerol | 1.1391 | 1.1284 | 0.9034 | 0.8411 |
| Glycerol 3-phosphate | 1.4323 | 0.7877 | 1.0258 | 0.7510 |
| Glycocholic acid | 1.5632 | 0.5231 | 0.9225 | 1.0008 |
| Guanosine | 0.8556 | 0.9864 | 1.3494 | 0.7650 |
| Hippuric acid | 0.9159 | 1.1572 | 1.0282 | 0.8951 |
| Homovanillic acid | 0.8461 | 1.0934 | 1.1536 | 0.8877 |
| Hydroxyisocaproic acid | 1.0186 | 1.1183 | 0.9339 | 0.9376 |
| Hydroxyproline | 0.8027 | 0.9449 | 0.9678 | 1.2885 |
| Hypoxanthine | 0.5987 | 1.0095 | 1.4285 | 0.9098 |
| Indoxyl sulfate | 0.8974 | 1.1007 | 0.8086 | 1.2172 |
| Inosine | 0.5991 | 1.0187 | 1.3428 | 0.9965 |
| Isovalerylglycine | 1.0664 | 0.9984 | 0.9242 | 1.0204 |
| Kynurenic acid | 1.0590 | 1.0085 | 0.9802 | 0.9548 |
| L-Aspartic acid | 0.8195 | 1.0485 | 1.0575 | 1.0673 |
| L-Cystine | 0.7669 | 0.9187 | 1.1846 | 1.1067 |
| Linoleic acid | 1.2768 | 1.0283 | 0.8721 | 0.8386 |
| L-Lactic acid | 0.8881 | 1.1285 | 1.0905 | 0.8816 |
| L-Proline | 0.8856 | 1.0360 | 1.0465 | 1.0260 |
| L-Threonine | 1.0111 | 0.9847 | 0.9955 | 1.0092 |
| Malic acid | 0.9072 | 1.2126 | 1.0337 | 0.8423 |
| Methylsuccinic acid | 0.9331 | 1.0605 | 0.9031 | 1.1155 |
| Myoinositol | 1.0417 | 1.1460 | 0.9193 | 0.9031 |
| N-acetyl-L-aspartic acid | 0.7808 | 1.4474 | 0.8619 | 0.9271 |
| NAD | 1.0968 | 0.8796 | 1.0097 | 1.0127 |
| NADP | 1.0146 | 0.9679 | 1.0094 | 1.0069 |
| Nicotinic acid | 0.7024 | 1.0520 | 1.0627 | 1.1752 |
| Oleic acid | 1.0796 | 1.1294 | 0.8369 | 0.9745 |
| Orotic acid | 0.8907 | 0.9039 | 1.1784 | 1.0047 |
| Oxaloacetic acid | 0.7876 | 0.6249 | 1.6383 | 0.8693 |
| PA(16:0/16:0) | 1.0005 | 0.9212 | 0.9898 | 1.0897 |
| PA(16:0/16:1) | 1.0865 | 1.0932 | 1.1638 | 0.6360 |
| PA(16:1/18:1) | 1.3040 | 1.1045 | 1.0132 | 0.5767 |
| PA(18:1/18:1) | 1.2879 | 1.0018 | 0.9904 | 0.7211 |
| p-Aminobenzoic acid | 0.5713 | 1.3644 | 0.6256 | 1.4856 |
| Pantothenic acid | 0.9548 | 0.8458 | 0.9627 | 1.2413 |
| PE(20:4/18:1) | 1.0962 | 1.0852 | 0.9026 | 0.9282 |
| PE(20:4/p18:0) | 1.0601 | 1.0336 | 1.0048 | 0.9008 |
| PE(22:6/p16:0) | 0.8631 | 1.0224 | 1.0436 | 1.0654 |
| PE(34:2) | 1.1383 | 1.0954 | 1.0481 | 0.7122 |
| PE(36:2) | 1.2285 | 1.0681 | 1.1068 | 0.5833 |
| PE(36:4) | 1.1313 | 1.0692 | 0.9754 | 0.8272 |
| PE(p16:0/20:4) | 0.8453 | 0.9281 | 0.9745 | 1.2553 |
| PE(p18:0/22:6) | 1.1265 | 1.1556 | 1.0645 | 0.6453 |
| PGF2alpha | 0.7823 | 1.1680 | 1.0594 | 0.9829 |
| Phenylacetylglutamine | 0.7666 | 1.1377 | 0.8262 | 1.2913 |
| PI(16:0/16:0) | 0.6873 | 1.1594 | 1.4869 | 0.6055 |
| PI(36:1) | 0.6324 | 1.2144 | 1.3366 | 0.7745 |
| PI(36:4) | 0.8650 | 1.1328 | 1.2437 | 0.7281 |
| PI(38:5) | 0.7159 | 1.1408 | 1.1709 | 0.9511 |
| PI(40:5) | 0.7328 | 1.0677 | 1.4394 | 0.7052 |
| PS(18:0/18:1) | 0.7928 | 1.0762 | 0.9975 | 1.1339 |
| Pseudouridine | 0.9392 | 1.1331 | 0.8944 | 1.0465 |
| Pyroglutamic acid | 0.8026 | 1.2806 | 1.0215 | 0.8926 |
| Pyrophosphate | 1.9763 | 0.7885 | 0.6130 | 0.6705 |
| Quinolinic acid | 0.3855 | 1.1859 | 1.3051 | 1.0854 |
| S-Adenosylhomocysteine | 0.9027 | 1.1388 | 0.9293 | 1.0380 |
| SM(d18:1/16:0) | 0.7926 | 1.0040 | 1.1245 | 1.0634 |
| SM(d18:1/16:1) | 0.9573 | 1.0795 | 1.0439 | 0.9138 |
| SM(d18:1/16:1 OH) | 0.8610 | 1.1404 | 1.0236 | 0.9720 |
| SM(d18:1/16:2 OH) | 0.9159 | 1.0082 | 1.1166 | 0.9447 |
| SM(d18:1/18:0) | 0.8607 | 0.9592 | 1.1509 | 1.0103 |
| SM(d18:1/18:0 OH) | 0.9556 | 1.0377 | 1.1020 | 0.8919 |
| SM(d18:1/18:1) | 1.0910 | 1.0095 | 0.9453 | 0.9610 |
| SM(d18:1/18:1 OH) | 1.0996 | 0.9620 | 1.0566 | 0.8747 |
| SM(d18:1/18:2 OH) | 0.9662 | 1.0633 | 0.9688 | 1.0056 |
| SM(d18:1/20:0) | 1.1934 | 1.2293 | 1.0108 | 0.5651 |
| SM(d18:1/20:0 OH) | 1.1103 | 0.9825 | 1.1048 | 0.7892 |
| SM(d18:1/20:1 OH) | 0.9656 | 1.1307 | 1.0072 | 0.8956 |
| SM(d18:1/20:2 OH) | 1.0431 | 1.0327 | 1.1121 | 0.7980 |
| SM(d18:1/22:1) | 1.2120 | 1.1422 | 0.9865 | 0.6610 |
| Suberic acid | 0.8473 | 1.1084 | 1.1310 | 0.8969 |
| Succinic acid | 0.6526 | 1.3894 | 1.2088 | 0.7231 |
| Taurine | 0.9408 | 0.9267 | 0.9220 | 1.2203 |
| Taurodeoxycholic acid | 0.6841 | 1.1036 | 1.5046 | 0.6447 |
| Uracil | 0.7164 | 1.5279 | 0.8321 | 0.9446 |
| Uric acid | 0.9089 | 1.1048 | 0.9279 | 1.0675 |
| Uridine | 1.0347 | 1.1132 | 0.8955 | 0.9697 |
| Xanthosine | 1.1923 | 1.1175 | 0.7812 | 0.9363 |
Factors:
| F1 | Genotype:CUMS model | Treatment:Albiflorin |
| F2 | Genotype:CUMS model | Treatment:Fluoxetine |
| F3 | Genotype:CUMS model | Treatment:Saline |
| F4 | Genotype:Wild-type | Treatment:Saline |
