Data for MuRF1-Related Metabolic Alterations in HL-1 Cardiomyocyte Induced by Cyclic Stretch (Study ST000924)
(Analysis AN001517)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|
| 2-Deoxyglucose | 0.9899 | 1.0166 | 1.0059 | 1.0047 | 0.9937 | 0.9949 | 0.9856 | 1.0087 |
| 2-Ethylhexanoic acid | 0.9743 | 1.0091 | 0.9873 | NA | 1.0260 | 1.0030 | 0.9654 | NA |
| 2-Hydroxybutyric acid | 0.9976 | 1.0214 | 1.0060 | 1.0239 | 1.0266 | 1.0030 | 0.9965 | 0.9146 |
| 2-Hydroxypyridine | 0.9989 | 1.0054 | 0.9956 | 0.9989 | 1.0106 | 1.0052 | 0.9961 | 0.9893 |
| 2-Hydroxyvaleric acid | 0.9893 | 0.9950 | 1.0093 | 1.0355 | 0.9937 | 0.9849 | 0.9898 | 1.0038 |
| 2-Ketoleucine/ketoisoleucine | 1.0030 | 1.0154 | 1.0062 | 0.9870 | 1.0113 | 1.0033 | 0.9891 | 0.9846 |
| 2-Ketovaline | 1.0014 | 1.0130 | 1.0132 | 0.9926 | 1.0142 | 1.0007 | 0.9858 | 0.9792 |
| 3-Indolelactic acid/tryptophan | 1.0082 | 1.0140 | 1.0185 | 1.0378 | 0.9861 | 0.9367 | 0.9767 | 0.9795 |
| 3-Phenyllactic acid | 0.9935 | 0.9781 | 1.0400 | 1.0663 | 0.9543 | 0.9851 | 0.9540 | 1.0578 |
| 4-Hydroxyphenylpyruvic acid | 0.9604 | 1.0346 | 0.9221 | 1.0193 | 1.0491 | 0.9840 | 1.0187 | 0.9660 |
| 5-(Hydroxymethyl)furfural | NA | 1.0111 | 0.9865 | 0.9981 | 1.0012 | 0.9767 | NA | 1.0422 |
| 5-Hydroxytryptophan | NA | NA | 0.9611 | NA | 1.0129 | NA | 1.0260 | NA |
| 6-Aminohexanoic acid/delta-Aminolevulinic acid | 0.9656 | 0.9864 | 1.0270 | NA | 1.0007 | 0.9944 | 1.0481 | 0.9495 |
| Alanine | 1.0006 | 1.0034 | 0.9957 | 1.0032 | 1.0004 | 0.9991 | 0.9991 | 0.9986 |
| Aldopentoses | 1.0101 | 1.0103 | 0.9683 | 1.0149 | 0.9860 | 1.0253 | 1.0019 | 0.9980 |
| Allantoin | 1.0012 | 0.9984 | 0.9920 | 1.0005 | 0.9984 | 1.0042 | 1.0092 | 0.9962 |
| alpha Ketoglutaric acid | 0.9978 | 1.0076 | 0.9937 | 0.9987 | 1.0079 | 0.9992 | 0.9949 | 1.0002 |
| alpha-Monopalmitin | 0.9873 | 1.0103 | 1.0041 | 1.0004 | 1.0152 | 1.0009 | 0.9950 | 0.9869 |
| alpha-Monostearin | 0.9930 | 1.0075 | 1.0009 | 0.9988 | 1.0083 | 1.0049 | 0.9956 | 0.9910 |
| Aminomalonic acid | 0.9880 | 1.0245 | 0.9768 | 0.9833 | 1.0203 | 1.0204 | 0.9933 | 0.9933 |
| Arginine | 1.0067 | 1.0514 | 0.9867 | 1.0064 | 0.9920 | 1.0073 | 0.9840 | 0.9655 |
| Asparagine | 0.9967 | 1.0114 | 0.9774 | 0.9884 | 1.0157 | 1.0105 | 1.0003 | 0.9996 |
| Aspartic Acid | 1.0001 | 1.0172 | 0.9888 | 0.9976 | 1.0147 | 1.0022 | 0.9934 | 0.9861 |
| Benzoic acid | 0.9920 | 1.0294 | 1.0087 | 0.9667 | 1.0236 | 1.0158 | 0.9686 | 0.9951 |
| beta-Alanine | 0.9686 | 1.0395 | 1.0233 | 0.9672 | 1.0190 | 1.0152 | 0.9913 | 0.9759 |
| beta-Monopalmitin | 0.9828 | 1.0329 | NA | 1.0259 | 0.9934 | 0.9715 | NA | NA |
| beta-Monostearin | 0.9891 | 1.0142 | 0.9994 | 0.9953 | 1.0173 | 1.0106 | 0.9895 | 0.9845 |
| Cholesterol | 0.9822 | 0.9894 | 0.9900 | 1.0125 | 1.0094 | 1.0190 | 0.9846 | 1.0192 |
| Citric acid/isocitric acid | 1.0087 | 0.9998 | 1.0053 | 1.0022 | 1.0127 | 0.9885 | 0.9976 | 0.9852 |
| Cysteine/Creatinine (co-elution) | 0.9971 | 1.0109 | 1.0048 | 0.9926 | 1.0060 | 0.9952 | 0.9997 | 0.9936 |
| Cysteinesulfinic acid | NA | NA | 1.1294 | NA | NA | 1.0251 | NA | 0.9228 |
| Cystine | 1.0015 | 1.0065 | 0.9909 | 0.9981 | 1.0147 | 1.0058 | 0.9921 | 0.9904 |
| Erythronic acid/Threonic acid | 0.9982 | 1.0149 | 0.9974 | 0.9996 | 1.0043 | 1.0005 | 0.9929 | 0.9922 |
| Ethanolamine | 0.9967 | 0.9962 | 0.9970 | 0.9861 | 1.0046 | 1.0177 | 1.0034 | 0.9947 |
| Fructose or similar ketohexose | 1.0004 | 1.0061 | 0.9978 | 0.9992 | 1.0061 | 0.9994 | 0.9949 | 0.9961 |
| Fumaric acid | 0.9931 | 1.0049 | 1.0028 | 1.0015 | 1.0132 | 0.9990 | 0.9876 | 0.9979 |
| gamma-Aminobutyric acid | 0.9956 | 1.0108 | 1.0026 | 1.0009 | 1.0344 | 1.0020 | 0.9651 | 0.9886 |
| Gluconic acid or similar sugar acid | 0.9973 | 1.0087 | 0.9982 | 1.0032 | 1.0059 | 1.0019 | 0.9927 | 0.9921 |
| Glucose and other aldohexoses | 0.9919 | 0.9994 | 1.0102 | 0.9911 | 1.0022 | 1.0034 | 1.0009 | 1.0010 |
| Glutamic acid | 0.9997 | 1.0139 | 1.0001 | 0.9937 | 1.0076 | 1.0027 | 0.9917 | 0.9907 |
| Glutamine | 1.0047 | 1.0400 | 0.9966 | 0.9677 | 1.0165 | 1.0137 | 0.9889 | 0.9719 |
| Glyceric acid | 0.9859 | 1.0271 | 1.0115 | 1.0004 | 0.9995 | 0.9917 | 0.9876 | 0.9963 |
| Glycerol | 1.0053 | 1.0078 | 0.9950 | 1.0038 | 1.0241 | 0.9992 | 0.9672 | 0.9976 |
| Glycerol 1-phosphate | 1.0004 | 1.0270 | 1.0040 | 0.9332 | 1.0309 | 1.0181 | 0.9970 | 0.9893 |
| Glycine | 0.9962 | 1.0078 | 0.9995 | 1.0005 | 1.0048 | 0.9996 | 0.9933 | 0.9983 |
| Glycolic acid | 0.9926 | 1.0046 | 1.0013 | 1.0384 | 1.0210 | 1.0045 | 0.9757 | 0.9894 |
| Hexitols | 1.0006 | 1.0075 | 0.9996 | 1.0018 | 1.0061 | 0.9992 | 0.9907 | 0.9944 |
| Hexuronic acid | NA | NA | 0.9758 | NA | NA | 1.0233 | 1.0279 | 0.9973 |
| Histidine | 1.0019 | 0.9997 | 0.9970 | 0.9788 | 1.0082 | 1.0075 | 1.0027 | 1.0042 |
| Hydroxyprolines | 1.0079 | NA | 0.9985 | 0.9964 | 0.9900 | 1.0126 | 1.0018 | 0.9948 |
| Isoleucine | 1.0017 | 1.0073 | 1.0013 | 0.9930 | 1.0074 | 1.0052 | 0.9898 | 0.9942 |
| Isomaltose or similar disaccharide | 0.9983 | 0.9950 | 0.9969 | 0.9932 | 1.0213 | 1.0104 | 0.9932 | 0.9917 |
| Ketopentoses | 1.0408 | 1.0746 | 1.0130 | 0.9923 | 1.0108 | 1.0224 | 0.9374 | 0.9770 |
| Lactic acid | 1.0009 | 1.0019 | 1.0016 | 1.0019 | 1.0044 | 0.9964 | 0.9951 | 0.9978 |
| Leucine | 1.0022 | 1.0092 | 0.9903 | 0.9838 | 1.0081 | 1.0086 | 0.9951 | 1.0027 |
| Lysine | 1.0025 | 1.0045 | 0.9969 | 1.0005 | 1.0047 | 1.0009 | 0.9943 | 0.9958 |
| Malic acid | 0.9950 | 1.0075 | 0.9957 | 1.0045 | 1.0101 | 0.9982 | 0.9890 | 1.0000 |
| Maltose or similar disaccharide | 0.9643 | 0.9737 | 1.0108 | 1.0003 | 1.0260 | 1.0191 | 1.0002 | 1.0088 |
| Methionine | 1.0051 | 1.0134 | 0.9959 | 0.9928 | 1.0051 | 1.0028 | 0.9945 | 0.9904 |
| Methionine sulfoxide | 0.9685 | 1.0177 | 1.0101 | 1.0348 | 1.0156 | 0.9622 | 0.9627 | 1.0335 |
| Methylglutamic acid | 1.0020 | 1.0391 | 0.9995 | 0.8870 | 1.0398 | 0.9677 | 1.0066 | 0.9763 |
| Myoinositol | 0.9977 | 1.0034 | 0.9953 | 0.9985 | 1.0098 | 1.0028 | 0.9954 | 0.9971 |
| Myristic acid or Pentadecanol | 0.9939 | 1.0152 | 1.0103 | 1.0092 | 0.9922 | 0.9982 | 0.9933 | 0.9912 |
| Nicotinamide | 0.9972 | 1.0246 | 1.0059 | 1.0003 | 0.9569 | 1.0092 | 0.9732 | 1.0096 |
| N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine | 1.0167 | NA | NA | 1.0183 | 1.0000 | NA | 0.9916 | 0.9817 |
| Norepinephrine/Methyltryptamine | 1.0386 | 1.0160 | 0.9996 | 0.9847 | 0.9949 | 0.9847 | 0.9918 | NA |
| Ornithine | 1.0074 | 1.0124 | 0.9923 | 0.9931 | 1.0079 | 1.0027 | 0.9934 | 0.9908 |
| Palmitic acid | 0.9928 | 1.0000 | 1.0028 | 1.0017 | 1.0064 | 1.0062 | 0.9825 | 1.0076 |
| Pantothenic acid | 0.9988 | 1.0088 | 0.9979 | 1.0011 | 1.0132 | 1.0026 | 0.9846 | 0.9930 |
| Pentitols | 1.0028 | 1.0076 | 1.0012 | 1.0056 | 0.9955 | 0.9939 | 0.9984 | 0.9950 |
| Pentonic acids | 0.9996 | 0.9996 | 0.9803 | 0.9927 | 1.0202 | 1.0075 | NA | NA |
| Phenylalanine | 1.0002 | 1.0133 | 0.9974 | 0.9977 | 1.0043 | 1.0003 | 0.9924 | 0.9943 |
| Phosphoric acid | 0.9777 | 1.0081 | 0.9888 | 1.0311 | 1.0027 | 0.9859 | 0.9841 | 1.0217 |
| Proline | 1.0015 | 1.0012 | 0.9976 | 1.0041 | 1.0012 | 0.9970 | 0.9925 | 1.0048 |
| Pseudouridine | 0.9945 | 1.0126 | 1.0202 | 0.9851 | 1.0211 | 1.0043 | 0.9869 | 0.9627 |
| Putrescine | 0.9590 | 0.9895 | 1.0302 | NA | 1.0039 | 0.9975 | 1.0515 | 0.9525 |
| Pyridoxine | 1.0035 | 0.9965 | 0.9705 | 0.9839 | 1.0234 | 1.0160 | 0.9944 | 1.0107 |
| Pyruvic acid | 1.0006 | 1.0126 | 0.9998 | 0.9758 | 1.0190 | 1.0137 | 0.9962 | 0.9823 |
| Serine | 1.0028 | 1.0137 | 0.9963 | 0.9982 | 1.0055 | 0.9998 | 0.9926 | 0.9912 |
| Serotonin | 0.9506 | 1.0178 | NA | 1.0186 | 1.0227 | 0.9903 | NA | NA |
| Stearic acid | 0.9914 | 1.0054 | 1.0002 | 0.9996 | 1.0092 | 1.0070 | 0.9898 | 0.9974 |
| Succinic acid | 0.9956 | 1.0162 | 1.0021 | 0.9981 | 1.0107 | 1.0009 | 0.9842 | 0.9923 |
| Threitol/Erythritol | 0.9974 | 1.0116 | 1.0019 | 0.9991 | 1.0055 | 1.0006 | 0.9891 | 0.9948 |
| Threonine | 1.0011 | 1.0125 | 0.9964 | 1.0014 | 1.0014 | 0.9970 | 0.9935 | 0.9968 |
| Thymine | NA | 0.9922 | NA | 1.0413 | 1.0948 | 0.9358 | NA | NA |
| Tryptophan | 1.0018 | 1.0068 | 0.9937 | 0.9974 | 1.0106 | 1.0035 | 0.9931 | 0.9932 |
| Tyrosine | 1.0013 | 1.0050 | 0.9954 | 1.0006 | 1.0038 | 1.0011 | 0.9949 | 0.9980 |
| Uracil | 1.0256 | 1.0513 | 1.0214 | 0.8930 | 1.0311 | 1.0322 | 0.9865 | 0.9588 |
| Urea | 0.9977 | 1.0101 | 1.0022 | 0.9968 | 1.0070 | 1.0006 | 0.9910 | 0.9945 |
| Uric acid | 1.0040 | 1.0125 | 0.9972 | 0.9962 | 1.0135 | 1.0052 | 0.9950 | 0.9763 |
| Valine | 1.0033 | 1.0108 | 0.9905 | 0.9962 | 1.0059 | 1.0023 | 0.9931 | 0.9980 |
| Xanthine | 0.9970 | 1.0272 | 0.9892 | 0.9861 | 1.0266 | 1.0143 | 0.9953 | 0.9643 |
Factors:
| F1 | type:Ad.shMuRF1 | Stretch Cycle:15 min cyclic stretch |
| F2 | type:Ad.shMuRF1 | Stretch Cycle:30 min cyclic stretch |
| F3 | type:Ad.shMuRF1 | Stretch Cycle:60 min cyclic stretch |
| F4 | type:Ad.shMuRF1 | Stretch Cycle:No stretch |
| F5 | type:Ad.shRNA Scramble | Stretch Cycle:15 min cyclic stretch |
| F6 | type:Ad.shRNA Scramble | Stretch Cycle:30 min cyclic stretch |
| F7 | type:Ad.shRNA Scramble | Stretch Cycle:60 min cyclic stretch |
| F8 | type:Ad.shRNA Scramble | Stretch Cycle:No stretch |
