Data for (Study ST001507)
(Analysis AN002498)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|
| 2-Hydroxyglutarate | 0.9958 | 0.6002 | 1.2055 | 0.7438 | 1.1514 | 0.7868 | 1.5748 | 0.9519 |
| 2-hydroxy isocapric acid | 0.8211 | 0.9301 | 1.0318 | 1.0272 | 1.0044 | 1.1350 | 1.0499 | 1.0008 |
| 3-hydroxybutyric acid | 1.6205 | 0.4718 | 1.5360 | 0.3953 | 1.5097 | 0.6106 | 1.3025 | 0.5875 |
| 3-hydroxybutyric acid+1 | 1.3897 | 0.6386 | 1.3108 | 0.4627 | 1.2653 | 1.0468 | 1.0059 | 0.8980 |
| 3-hydroxybutyric acid+2 | NA | 0.8926 | NA | 0.8217 | NA | 1.2979 | NA | 0.9877 |
| 3-hydroxybutyric acid+3 | NA | 1.1964 | NA | 0.8416 | NA | 1.1701 | NA | 0.6658 |
| 3-hydroxybutyric acid+4 | NA | 1.3141 | NA | 0.3168 | NA | 1.3409 | NA | 1.0321 |
| 5-Oxoproline (pyroglutamic Acid) | 0.6152 | 0.6403 | 0.6368 | 0.5365 | 1.7408 | 1.1423 | 1.7578 | 0.9797 |
| 5-Oxoproline (pyroglutamic Acid) +1 | 0.3114 | 0.8903 | 0.3316 | 0.6354 | 1.1716 | 1.8015 | 1.1777 | 1.6919 |
| 5-Oxoproline (pyroglutamic Acid) +2 | 0.2915 | 0.8051 | 0.3065 | 0.6198 | NA | 1.4834 | NA | 1.3721 |
| 5-Oxoproline (pyroglutamic Acid) +3 | NA | 0.6787 | NA | 0.3878 | NA | 1.5315 | NA | 1.4021 |
| 5-Oxoproline (pyroglutamic Acid) +4 | NA | 1.0393 | 0.0415 | 0.3256 | NA | 1.7029 | 0.0536 | 1.0411 |
| 5-Oxoproline (pyroglutamic Acid) +5 | NA | NA | NA | NA | NA | NA | NA | NA |
| acetyl-aspartate (N) | 0.7807 | 1.5325 | 0.6279 | 1.0799 | 0.6825 | 1.3812 | 0.6593 | 1.2349 |
| acetyl-carnitine | 1.0141 | 0.9545 | 1.1480 | 0.9049 | 1.0106 | 1.1930 | 0.8996 | 0.8760 |
| acetyl-choline | 1.0000 | NA | NA | NA | NA | NA | NA | NA |
| Acetyl CoA | 1.0695 | 0.8064 | 1.0323 | 0.6914 | 1.0233 | 1.3885 | 1.3138 | 0.6761 |
| Acetyl CoA+1 | 1.0516 | 0.8074 | 1.0190 | 0.6990 | 0.9945 | 1.4703 | 1.3154 | 0.6426 |
| Acetyl CoA+2 | 0.3160 | 1.3286 | 0.3494 | 1.2496 | 0.4176 | 2.8850 | 0.5952 | 0.8093 |
| acetyl-cysteine | 1.7963 | 0.4293 | 1.4206 | 0.4237 | 0.9806 | 0.7501 | 1.3613 | 0.5844 |
| acetyl-glutamine | 1.0834 | 0.7988 | 0.8946 | 0.8303 | 1.7045 | 0.8402 | 0.8545 | 1.1520 |
| acetyl-lysine | 0.8299 | 0.8065 | 0.9439 | 0.9440 | 1.0968 | 1.2054 | 1.0736 | 1.1063 |
| Adenine | 0.5600 | 0.8987 | 0.6857 | 0.9586 | 1.0987 | 1.4593 | 1.1348 | 1.2108 |
| Adenosine | 0.8861 | 0.6424 | 0.8706 | 0.8594 | 1.3456 | 1.2129 | 1.0432 | 1.1628 |
| Adenosine + 1 | 0.8884 | 0.6445 | 0.8762 | 0.8631 | 1.3339 | 1.2159 | 1.0351 | 1.1652 |
| Adenosine + 2 | 0.8631 | 0.6457 | 0.8519 | 0.8705 | 1.3231 | 1.2453 | 1.0190 | 1.2029 |
| Adenosine + 3 | 0.4566 | 0.7191 | 0.4253 | 1.0200 | 0.9131 | 1.7716 | 0.6117 | 2.0769 |
| Adenosine + 4 | NA | 0.1776 | NA | 0.1843 | NA | 0.5053 | NA | 1.5475 |
| Adenosine + 5 | NA | NA | NA | NA | NA | 0.7043 | NA | 1.1479 |
| ADP | 0.8789 | 1.0457 | 0.8641 | 0.8519 | 0.9107 | 1.4955 | 0.9977 | 0.9495 |
| aKG | 1.1125 | 0.8254 | 0.8991 | 0.5710 | 1.4062 | 1.0874 | 0.9435 | 1.1819 |
| aKG +1 | 0.4270 | 1.4640 | 0.2472 | 0.5705 | 0.5882 | 1.9063 | 0.2811 | 2.4381 |
| aKG +2 | 0.0094 | 0.9778 | 0.0205 | 0.4714 | NA | 1.2919 | 0.0085 | 1.4563 |
| aKG +3 | NA | 0.9398 | NA | 0.2627 | NA | 1.2297 | NA | 1.5186 |
| aKG +4 | NA | 0.6741 | NA | 0.1779 | NA | 2.0573 | NA | 0.7124 |
| aKG +5 | 0.4947 | 1.1202 | 0.6723 | 0.4794 | 0.4920 | 1.4631 | 1.0178 | 0.8434 |
| Alanine | 0.9762 | 1.1367 | 0.9020 | 0.9081 | 1.1354 | 0.9779 | 1.1214 | 0.8513 |
| Alanine+1 | 0.5503 | 1.5744 | 0.5169 | 1.1869 | 0.6216 | 1.4534 | 0.6203 | 1.4510 |
| Alanine+2 | NA | 1.0815 | NA | 0.7745 | NA | 1.0443 | NA | 1.0997 |
| Alanine+3 | NA | 1.1064 | NA | 0.9390 | NA | 0.9650 | NA | 0.9896 |
| Allantoin | 0.7556 | 0.8518 | 0.9014 | 0.9741 | 1.0319 | 1.3458 | 1.0810 | 1.0606 |
| aminoadipate | 0.8603 | 0.9418 | 1.2353 | 0.8032 | 0.6845 | 0.8970 | 1.3222 | 1.2346 |
| AMP | 0.8470 | 0.8345 | 0.8949 | 0.8253 | 0.9996 | 1.2937 | 1.0307 | 1.2742 |
| Arachidonic acid | 0.8169 | 0.7808 | 0.9850 | 0.8158 | 1.1277 | 1.2940 | 1.0149 | 1.1734 |
| Arginine | 0.7482 | 0.7174 | 0.9280 | 1.1889 | 0.8230 | 0.6955 | 2.0044 | 0.8827 |
| Argininosuccinate | 1.1554 | 0.7817 | 1.1380 | 0.8411 | 1.1255 | 0.8259 | 1.5087 | 0.6320 |
| Argininosuccinate +1 | 0.4693 | 1.8799 | 0.4223 | 1.6276 | 0.4520 | 1.4408 | 0.6412 | 1.0303 |
| Argininosuccinate +10 | NA | NA | NA | NA | NA | 1.0253 | NA | 0.9747 |
| Argininosuccinate +2 | 0.0354 | 1.7615 | 0.0259 | 1.4251 | 0.0351 | 1.1932 | 0.0615 | 1.0278 |
| Argininosuccinate +3 | NA | 1.4165 | NA | 1.0374 | NA | 0.8103 | 0.0310 | 0.8004 |
| Argininosuccinate +4 | NA | 1.9016 | NA | 0.8652 | NA | 0.4515 | NA | 0.7340 |
| Argininosuccinate +5 | NA | 0.8859 | 1.0760 | 0.8311 | NA | 1.2257 | NA | 1.0477 |
| Argininosuccinate +6 | 1.0000 | NA | NA | NA | NA | NA | NA | NA |
| Argininosuccinate +7 | NA | NA | NA | NA | NA | NA | NA | NA |
| Argininosuccinate +8 | NA | NA | NA | NA | NA | NA | NA | NA |
| Argininosuccinate +9 | NA | NA | NA | NA | NA | NA | NA | 1.0000 |
| Ascorbic Acid | 1.5831 | 0.7765 | 1.2682 | 0.5921 | 0.9964 | 1.1264 | 0.7773 | 0.8525 |
| Asparagine | 0.6735 | 1.1704 | 0.7307 | 1.2294 | 0.7326 | 1.2992 | 0.8369 | 1.3095 |
| Asparagine+1 | 0.1853 | 1.8906 | 0.1946 | 1.7544 | 0.2025 | 1.9430 | 0.2425 | 1.5340 |
| Asparagine+2 | NA | 1.1300 | NA | 0.9511 | NA | 1.1323 | NA | 0.7865 |
| Asparagine+3 | NA | 1.4970 | NA | 0.9166 | NA | 0.4164 | 0.4553 | 0.7242 |
| Asparagine+4 | NA | NA | NA | NA | NA | NA | NA | NA |
| Aspartate | 1.1894 | 0.5216 | 1.1907 | 0.8781 | 1.0963 | 0.7547 | 1.3452 | 1.0304 |
| Aspartate + 1 | 0.4037 | 1.2143 | 0.3964 | 1.2058 | 0.3694 | 1.5932 | 0.4528 | 2.3224 |
| Aspartate + 2 | NA | 0.7753 | NA | 0.7541 | NA | 0.9835 | NA | 1.4871 |
| Aspartate + 3 | NA | 0.8142 | NA | 0.6973 | NA | 0.9977 | NA | 1.4907 |
| Aspartate + 4 | NA | 0.8674 | NA | 0.7262 | NA | 0.9720 | NA | 1.4344 |
| ATP | 0.9316 | 1.1971 | 0.9643 | 1.0025 | 0.8004 | 1.4880 | 0.8956 | 0.7071 |
| beta Alanine | 0.8837 | 0.8610 | 1.1458 | 1.2162 | 0.8619 | 0.8822 | 1.1829 | 0.9571 |
| Beta-hydroxyvaleric Acid | 0.8069 | 0.7966 | 1.0796 | 1.0828 | 1.0001 | 1.1362 | 1.1263 | 0.9715 |
| betaine | 1.0063 | 1.0710 | 1.3395 | 0.9097 | 1.0645 | 0.9761 | 0.7154 | 0.9218 |
| Butyric acid | 0.9245 | 0.8185 | 0.9595 | 0.8437 | 1.2380 | 1.0064 | 1.1625 | 1.0627 |
| Butyryl-carnitine | 0.9507 | 0.9183 | 1.3031 | 0.9693 | 1.0123 | 1.0093 | 0.9108 | 0.9270 |
| cAMP | 0.6065 | 0.6081 | 1.2212 | 1.0717 | 0.7367 | 1.0687 | 1.5232 | 1.1464 |
| carnitine | 0.8212 | 1.1698 | 0.8063 | 1.0190 | 0.8947 | 1.4478 | 0.7293 | 1.1050 |
| CDP | 0.4682 | 0.9662 | 0.3946 | 1.1037 | 0.6056 | 1.9103 | 0.7845 | 0.9450 |
| cGMP | NA | NA | NA | NA | NA | NA | NA | NA |
| Choline | NA | NA | NA | 0.8091 | NA | NA | NA | 1.1909 |
| cis-aconitate | 1.3368 | 0.6846 | 0.8446 | 0.8594 | 1.1665 | 1.0009 | 1.2720 | 0.8463 |
| cis-aconitate + 1 | 0.2533 | 1.0608 | 0.1745 | 0.9803 | 0.2037 | 1.4766 | 0.1770 | 1.2854 |
| cis-aconitate + 2 | NA | 0.9444 | NA | 0.7458 | NA | 1.1477 | NA | 1.1037 |
| cis-aconitate + 3 | NA | 1.0319 | NA | 0.5908 | NA | 1.0990 | NA | 1.2127 |
| cis-aconitate + 4 | NA | NA | NA | NA | NA | NA | NA | 1.0000 |
| cis-aconitate + 5 | NA | NA | 1.0000 | NA | NA | NA | NA | NA |
| cis-aconitate + 6 | NA | NA | NA | NA | NA | NA | NA | NA |
| Citrate | 1.2732 | 0.7754 | 0.8485 | 0.8906 | 0.9575 | 1.1414 | 1.1650 | 0.9456 |
| citrate +1 | 0.4017 | 1.4959 | 0.2394 | 1.2776 | 0.2988 | 2.1438 | 0.3761 | 1.7200 |
| citrate +2 | 0.0246 | 1.6147 | 0.0190 | 1.4276 | 0.0152 | 2.4481 | 0.0270 | 1.9001 |
| citrate +3 | 0.0025 | 0.9594 | 0.0031 | 0.6632 | 0.0030 | 1.5786 | 0.0053 | 1.1976 |
| citrate +4 | NA | 0.8551 | NA | 0.5040 | NA | 1.6295 | NA | 1.0114 |
| citrate +5 | NA | 0.8789 | NA | 0.3927 | NA | 1.8825 | NA | 0.7781 |
| citrate +6 | NA | 0.7441 | NA | 0.8169 | NA | 1.1647 | NA | 0.9812 |
| Citrulline | 0.9508 | 0.9612 | 1.0426 | 1.0263 | 1.0163 | 0.8511 | 1.3701 | 0.7828 |
| citrulline +1 | 0.3678 | 1.8137 | 0.4019 | 1.6383 | 0.3940 | 1.4852 | 0.5317 | 1.3270 |
| citrulline +2 | 0.1428 | 1.9273 | 0.1855 | 2.0834 | 0.2119 | 1.4801 | 0.3521 | 1.5643 |
| citrulline +3 | NA | 0.9877 | NA | 1.5380 | NA | 0.3913 | NA | 0.9008 |
| citrulline +4 | NA | 0.6609 | NA | 1.4806 | NA | 0.5048 | NA | 0.6013 |
| citrulline +5 | NA | 0.9673 | NA | 1.0728 | NA | 1.0220 | NA | 0.9304 |
| citrulline +6 | NA | NA | NA | NA | NA | NA | NA | NA |
| CMP | 0.8157 | 0.8898 | 0.8011 | 0.8474 | 1.0346 | 1.3066 | 1.1287 | 1.1784 |
| Creatine | 0.7899 | 0.9232 | 0.8434 | 1.2457 | 0.8910 | 1.0401 | 1.1608 | 1.0986 |
| Creatinine | 0.6372 | 0.8065 | 0.6428 | 0.9225 | 0.9728 | 1.6610 | 1.0699 | 1.2856 |
| CTP | NA | 0.8484 | 1.1790 | 1.0468 | NA | 0.9739 | 0.9781 | NA |
| Cystathionine | 0.5237 | 1.2230 | 0.6222 | 1.4675 | 0.4741 | 1.3224 | 0.9269 | 1.4051 |
| Cysteine | 2.9208 | 1.1528 | 2.4105 | 0.6384 | 0.1583 | 0.0762 | 0.2240 | 0.1836 |
| Cystine | 1.6277 | 0.8654 | 0.9797 | 0.4872 | NA | NA | 0.2432 | 0.2908 |
| Cytidine | 0.8535 | 0.6896 | 1.1729 | 0.9454 | 0.8798 | 1.1659 | 1.0487 | 1.2362 |
| Decanoic acid | 1.1015 | 0.4691 | 0.9843 | 0.3781 | 1.5202 | 1.3239 | 1.1001 | 1.1575 |
| dihydroxyacetone phosphate (DHAP) | 1.1688 | 1.0749 | 1.2134 | 1.0627 | 0.7190 | 1.0388 | 1.1315 | 0.5722 |
| Docosahexaenoic acid | 0.9308 | 0.7986 | 1.0151 | 0.6428 | 1.1112 | 1.3988 | 0.9246 | 1.1856 |
| Dodecanoic acid/Lauric acid | 1.0147 | 0.9543 | 1.0189 | 0.7783 | 1.0965 | 1.0238 | 1.0709 | 1.0490 |
| Eicosapentaenoic acid | 0.6992 | 0.6999 | 0.7141 | 0.4251 | 1.7455 | 1.3055 | 1.2792 | 1.1812 |
| Ethanolamine phosphate | 0.7731 | 0.6663 | 1.0178 | 1.5661 | 0.7363 | 0.9157 | 1.0497 | 1.2573 |
| FAD | 0.9176 | 1.0419 | 0.8123 | 0.7903 | 1.0584 | 1.3734 | 0.9470 | 1.0630 |
| Fructose | 1.1647 | 0.8765 | 1.3475 | 0.8271 | 1.1319 | 0.9633 | 1.0057 | 0.6921 |
| Fructose +1 | 0.9623 | 0.7730 | 0.8145 | 0.7315 | 1.2645 | 1.1054 | 1.2183 | 1.1481 |
| Fructose +2 | 0.6741 | 0.5518 | 0.6521 | 0.3546 | 1.5099 | 0.8094 | 1.2460 | 1.4030 |
| Fructose-6-phosphate | 1.1281 | 1.0384 | 1.4786 | 0.8862 | 1.0393 | 0.8353 | 1.1297 | 0.4671 |
| Fructose-6-phosphate + 1 | 0.9379 | 1.2678 | 1.4342 | 0.9924 | 0.8997 | 0.9438 | 0.9987 | 0.4843 |
| Fructose-6-phosphate + 2 | 0.4348 | 2.1139 | 0.9196 | 1.7348 | 0.3559 | 1.1625 | 0.4299 | 0.5277 |
| Fructose-6-phosphate + 3 | NA | 1.5648 | NA | 0.8469 | NA | 1.1284 | NA | 0.3415 |
| Fructose-6-phosphate + 4 | NA | 1.4741 | NA | NA | NA | 0.8455 | NA | 0.6804 |
| Fructose-6-phosphate + 5 | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose-6-phosphate + 6 | NA | NA | NA | NA | NA | NA | NA | NA |
| G6P | 1.1663 | 1.0989 | 1.6085 | 0.9183 | 0.9272 | 0.7593 | 1.0792 | 0.4376 |
| G6P + 1 | 1.0515 | 1.2379 | 1.5136 | 1.0166 | 0.8392 | 0.8799 | 0.9951 | 0.4554 |
| G6P + 2 | 0.7010 | 1.7034 | 1.2145 | 1.2537 | 0.5519 | 1.2473 | 0.7095 | 0.5890 |
| G6P + 3 | NA | 1.4108 | 0.0468 | 1.0176 | NA | 1.1949 | 0.0374 | 0.4702 |
| G6P + 4 | NA | 1.6657 | NA | 0.5889 | NA | 0.5235 | NA | NA |
| G6P + 5 | NA | 1.4516 | NA | 0.3735 | NA | NA | NA | 0.4466 |
| G6P + 6 | NA | 1.0000 | NA | NA | NA | NA | NA | NA |
| GABA | 0.9774 | 0.9872 | 0.9330 | 1.0621 | 0.9080 | 1.0556 | 0.9799 | 1.0908 |
| gama-Glutamylcysteine | 0.9799 | 0.6315 | 0.8057 | 0.5664 | 1.2054 | 1.0628 | 1.4622 | 1.2997 |
| gama-Glutamylcysteine +1 | 0.4811 | 0.6049 | 0.3006 | 0.4390 | 0.7371 | 1.4870 | 0.9925 | 2.7376 |
| gama-Glutamylcysteine +2 | NA | 0.4047 | NA | 0.2294 | NA | 1.0617 | NA | 2.0987 |
| gama-Glutamylcysteine +3 | NA | 0.2487 | NA | 0.1894 | NA | 0.7551 | NA | 2.2202 |
| gama-Glutamylcysteine +4 | NA | NA | 0.2929 | 0.4080 | NA | 0.3766 | NA | 2.2643 |
| gama-Glutamylcysteine +5 | NA | NA | NA | NA | NA | NA | NA | NA |
| gama-Glutamylcysteine +6 | NA | NA | NA | NA | NA | NA | NA | NA |
| gama-Glutamylcysteine +7 | NA | NA | NA | 1.0000 | NA | NA | NA | NA |
| gama-Glutamylcysteine +8 | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose | 1.0861 | 0.8544 | 0.9517 | 0.5857 | 1.4743 | 1.1449 | 1.2497 | 0.6848 |
| Glucose +1 | 0.8313 | 1.0478 | 0.7290 | 0.7163 | 1.1316 | 1.5203 | 0.9592 | 1.0732 |
| Glucose +2 | 0.2517 | 1.4446 | 0.2381 | 0.9838 | 0.3485 | 2.3659 | 0.3243 | 1.9996 |
| Glucose +3 | NA | 0.9543 | 0.0007 | 0.6384 | 0.0010 | 1.6680 | 0.0008 | 1.4721 |
| Glucose +4 | NA | 0.7451 | NA | 0.4705 | NA | 1.3886 | NA | 1.3958 |
| Glucose +5 | NA | 0.6958 | NA | 0.3986 | NA | 1.4289 | NA | 1.4767 |
| Glucose +6 | NA | 0.5446 | NA | 0.2149 | NA | 1.5147 | NA | 1.7259 |
| Glutamate | 1.2669 | 0.6490 | 1.3968 | 0.9504 | 0.9757 | 0.7053 | 1.1336 | 0.9206 |
| Glutamate +1 | 0.7203 | 1.1487 | 0.8081 | 1.2487 | 0.5617 | 1.1595 | 0.6427 | 1.6810 |
| Glutamate +2 | 0.0045 | 1.7039 | 0.0061 | 1.8822 | 0.0085 | 1.7820 | 0.0083 | 2.5384 |
| Glutamate +3 | NA | 0.9306 | NA | 0.8447 | NA | 0.9050 | NA | 1.3197 |
| Glutamate +4 | NA | 0.9678 | NA | 1.0373 | NA | 0.9622 | NA | 1.0327 |
| Glutamate +5 | NA | 1.0281 | NA | 0.9915 | NA | 0.9728 | NA | 1.0077 |
| Glutamine | 1.3455 | 0.6428 | 1.3891 | 0.6304 | 1.3428 | 0.6655 | 1.4262 | 0.5806 |
| Glutamine +1 | 0.8268 | 1.1526 | 0.8463 | 1.0257 | 0.8237 | 1.2447 | 0.8783 | 1.1902 |
| Glutamine +2 | NA | 1.0069 | NA | 0.8969 | NA | 1.0639 | NA | 1.0323 |
| glutamine +3 | NA | 1.0233 | NA | 0.8441 | NA | 1.0998 | NA | 1.0327 |
| Glutamine +4 | NA | 1.0839 | NA | 0.9634 | NA | 1.1140 | NA | 0.8386 |
| Glutamine +5 | 0.0003 | 1.1762 | 0.0002 | 0.9369 | NA | 1.1842 | NA | 0.8360 |
| Glyceraldehyde 3-phosphate | NA | NA | NA | NA | NA | NA | 1.0000 | NA |
| Glyceraldehyde 3-phosphate +1 | NA | 1.0206 | 0.8150 | 1.5594 | 0.7625 | 1.0186 | 1.1802 | NA |
| Glyceraldehyde 3-phosphate +2 | NA | NA | 0.9435 | NA | 0.9651 | NA | 1.0914 | NA |
| Glyceraldehyde 3-phosphate +3 | NA | NA | 1.0000 | NA | NA | NA | NA | NA |
| Glycerate | 0.3986 | 0.9399 | 0.4629 | 0.9832 | 1.0064 | 1.7165 | 1.1179 | 1.3751 |
| Glycerol | 0.8514 | 0.8922 | 0.8759 | 0.6742 | 1.4713 | 1.1868 | 1.1181 | 0.9616 |
| Glycerol 3-phosphate | 0.7250 | 0.9363 | 0.5661 | 1.1004 | 0.7997 | 1.2979 | 1.2363 | 1.3249 |
| Glycine | 0.9361 | 1.0010 | 0.9931 | 0.9011 | 1.0120 | 1.0880 | 1.0731 | 0.9963 |
| Glycine+1 | 0.8347 | 1.0944 | 0.8946 | 0.9408 | 0.9306 | 1.2037 | 0.9896 | 1.1069 |
| Glycine+2 | 0.6017 | 0.9452 | NA | NA | NA | 1.7064 | NA | 0.9915 |
| GMP | 0.8490 | 0.8777 | 0.8496 | 0.7852 | 1.0274 | 1.3540 | 1.0906 | 1.1683 |
| GSH | 1.0652 | 0.9924 | 1.0169 | 0.9069 | 0.9890 | 1.0598 | 1.0284 | 0.9407 |
| GSH +1 | 1.0262 | 1.0129 | 0.9822 | 0.9117 | 0.9569 | 1.1085 | 0.9915 | 1.0071 |
| GSH +10 | NA | NA | NA | NA | NA | NA | 1.0000 | NA |
| GSH +2 | 0.0005 | 0.8971 | 0.0004 | 0.7018 | 0.0007 | 1.4535 | 0.0007 | 1.6605 |
| GSH +3 | 0.0006 | 0.7892 | 0.0004 | 0.5204 | NA | 1.3150 | NA | 1.5086 |
| GSH +4 | NA | 0.7159 | NA | 0.5933 | NA | 1.2109 | NA | 1.4257 |
| GSH +5 | NA | 0.7504 | NA | 0.5249 | NA | 1.2038 | NA | 1.4576 |
| GSH +6 | NA | NA | NA | NA | NA | 0.6878 | NA | 1.1561 |
| GSH +7 | NA | NA | NA | NA | NA | NA | NA | NA |
| GSH +8 | 0.7118 | NA | 0.8386 | 1.4337 | 0.6890 | NA | 0.7372 | NA |
| GSH +9 | NA | 0.5728 | NA | 0.7689 | 1.6583 | NA | NA | NA |
| GSSG | 0.8051 | 0.6910 | 0.7161 | 0.7769 | 1.0734 | 1.6297 | 1.1746 | 1.1381 |
| GSSG +1 | 0.7333 | 0.6476 | 0.6571 | 0.7746 | 0.9729 | 1.5850 | 1.0572 | 1.1318 |
| GSSG +2 | 0.0305 | 0.8992 | 0.0407 | 0.8705 | 0.0436 | 3.3135 | 0.0519 | 2.5585 |
| GSSG +3 | 0.0275 | 0.6648 | 0.0228 | 0.5898 | 0.0229 | 2.5347 | 0.0280 | 2.0673 |
| GSSG +4 | NA | 0.2017 | 0.0153 | 0.2145 | NA | 1.8197 | NA | 1.6203 |
| GSSG +5 | NA | 0.1207 | NA | 0.1383 | NA | 1.7092 | NA | 1.5688 |
| GSSG +6 | NA | NA | NA | NA | NA | 1.3882 | NA | 0.6506 |
| GSSG +7 | NA | 1.2825 | NA | NA | NA | 0.9849 | NA | 0.8738 |
| GSSG +8 | 0.5759 | 0.6369 | 0.5779 | 2.2354 | 0.4933 | 0.5741 | 0.6822 | 0.8696 |
| Guanine | 0.9771 | 1.1877 | 0.8991 | 0.9448 | 0.7696 | 1.3302 | 1.0261 | 0.8500 |
| Guanosine | 1.0604 | 0.7675 | 0.8409 | 0.8214 | 1.4616 | 1.0725 | 1.2148 | 0.7917 |
| Guanosine + 1 | 1.1072 | 0.7205 | 0.8144 | 0.7925 | 1.5438 | 1.0784 | 1.2582 | 0.7211 |
| Hexanoic acid | 0.7346 | 0.6865 | 0.7311 | 0.5787 | 1.4039 | 1.3147 | 1.2759 | 1.2839 |
| Homocysteine | 1.3637 | 0.6051 | 1.5735 | 0.8786 | 1.0843 | 0.4944 | 1.2854 | 0.7206 |
| Hydroxyproline | 0.5012 | 0.8975 | 0.6424 | 0.9403 | 0.7457 | 1.7398 | 0.7770 | 1.7392 |
| Hydroxyproline + 1 | 0.3394 | 0.9399 | 0.5546 | 0.9818 | 0.6698 | 1.8191 | 0.6630 | 2.0103 |
| Hydroxyproline + 2 | 1.1808 | 0.6906 | 1.3381 | 0.9630 | 0.4967 | 1.6227 | 1.4991 | 0.5619 |
| Hydroxyproline + 3 | NA | NA | NA | 0.4065 | 1.1406 | 1.4529 | NA | NA |
| hypoxanthine | 1.2622 | 0.5924 | 1.0884 | 0.7594 | 1.2382 | 0.9605 | 1.2069 | 0.9078 |
| IMP | 1.3143 | 0.4451 | 0.9826 | 0.4278 | 1.8945 | 0.7170 | 1.6482 | 0.6301 |
| IsoLeucine | 0.8624 | 0.9048 | 0.7931 | 0.8719 | 1.0246 | 1.2402 | 1.1367 | 1.1679 |
| Lactate | 0.6777 | 1.1156 | 0.6916 | 1.0171 | 1.1721 | 1.3508 | 1.1089 | 0.8777 |
| Lactate+1 | 0.4268 | 1.4271 | 0.4352 | 1.2366 | 0.6710 | 1.7926 | 0.6267 | 1.3620 |
| Lactate+2 | NA | 0.9442 | NA | 0.8020 | NA | 1.2610 | NA | 0.9928 |
| Lactate+3 | NA | 0.9394 | NA | 0.9081 | NA | 1.2840 | NA | 0.8686 |
| Leucine | 0.9032 | 0.8151 | 0.8446 | 0.8402 | 1.0928 | 1.1483 | 1.1845 | 1.1774 |
| Linoleic acid | 0.9231 | 0.7144 | 1.0080 | 0.5647 | 1.4774 | 1.2563 | 0.9804 | 1.1075 |
| Linolenic acid | 0.7432 | 0.6162 | 0.8548 | 0.4110 | 1.6656 | 1.3885 | 1.1642 | 1.2009 |
| Lysine | 0.9073 | 0.8512 | 0.9719 | 0.8977 | 1.0456 | 1.1248 | 1.1074 | 1.0972 |
| Malate | 1.4408 | 0.7002 | 1.1644 | 0.6587 | 1.2185 | 0.7678 | 1.2386 | 0.8255 |
| malate +1 | 0.3470 | 1.6922 | 0.2837 | 1.2599 | 0.2949 | 1.7703 | 0.2995 | 2.0055 |
| malate +2 | NA | 1.0243 | NA | 0.7336 | NA | 1.0427 | NA | 1.1994 |
| malate +3 | NA | 1.0800 | NA | 0.7319 | NA | 1.0248 | NA | 1.1633 |
| malate +4 | NA | 1.1737 | NA | 0.7383 | NA | 0.9931 | NA | 1.0949 |
| Methionine | 0.8171 | 0.7325 | 0.7970 | 0.7861 | 1.1857 | 1.1664 | 1.1449 | 1.3828 |
| methyl-lysine (N) | 0.8372 | 0.7339 | 0.9263 | 0.7486 | 1.0319 | 1.5272 | 1.0235 | 1.1736 |
| Myristic acid | 0.9917 | 0.7752 | 1.1238 | 0.7538 | 1.0544 | 1.2308 | 1.0108 | 1.0632 |
| Myristoyl-carnitine | 1.0751 | 0.7752 | 1.7851 | 0.8413 | 0.9637 | 0.9058 | 0.6979 | 0.9534 |
| NAD+ | 0.9706 | 1.1572 | 0.7350 | 0.7970 | 1.0261 | 1.4330 | 0.9575 | 0.9253 |
| NADH | 0.8606 | 1.2602 | 1.0847 | 0.5323 | 0.6069 | 0.9140 | 1.2127 | 0.5100 |
| NADP+ | 0.6975 | 0.8858 | 0.6717 | 0.6982 | 1.0289 | 1.6849 | 1.0954 | 1.2395 |
| NADPH | 1.1802 | 1.5153 | 0.8047 | 0.9872 | 0.4579 | 1.4357 | 0.7338 | 0.8491 |
| nicotinamide | 0.9477 | 0.8955 | 0.8798 | 0.8319 | 1.1956 | 1.1363 | 1.0627 | 1.0635 |
| nicotinamide N-oxide | 0.7207 | 1.2097 | 0.6589 | 0.8376 | 0.7785 | 1.5157 | 0.9786 | 1.2856 |
| Octanoic acid | 1.0627 | 0.4465 | 0.9941 | 0.4339 | 1.4218 | 1.4952 | 0.9901 | 1.1837 |
| Oleic acid | 0.9317 | 0.7078 | 1.0627 | 0.6618 | 1.3773 | 1.1505 | 1.1099 | 1.0235 |
| Oleic acid + 1 | 0.9185 | 0.6944 | 1.0665 | 0.6597 | 1.3984 | 1.1539 | 1.1117 | 1.0236 |
| Ornithine | 0.8198 | 0.8009 | 1.2249 | 0.8967 | 0.8830 | 1.1180 | 1.2414 | 1.0074 |
| ornithine +1 | 0.7962 | 0.8136 | 1.2366 | 0.9138 | 0.8602 | 1.1262 | 1.2291 | 1.0149 |
| Oxypurinol | 0.6378 | 0.9201 | 0.6247 | 0.8059 | 1.4009 | 1.4051 | 1.2933 | 0.9389 |
| Palmitic acid | 0.9369 | 0.6762 | 1.0075 | 0.6049 | 1.2939 | 1.2563 | 1.1183 | 1.1256 |
| Palmitic acid+1 | 0.9440 | 0.6931 | 0.9996 | 0.6160 | 1.2820 | 1.2472 | 1.1152 | 1.1217 |
| Palmitic acid+2 | 0.9089 | 0.6544 | 0.9781 | 0.6119 | 1.2743 | 1.3193 | 1.1061 | 1.1654 |
| Palmitic acid+3 | 0.5175 | 0.6031 | 0.4841 | 0.7368 | 1.1047 | 2.0961 | 0.7685 | 1.2482 |
| Palmitic acid+4 | NA | 0.4767 | NA | 0.2172 | NA | 2.6648 | NA | 0.4473 |
| Palmitic acid+5 | NA | NA | NA | NA | NA | 1.0000 | NA | NA |
| Palmitic acid+6 | NA | 0.9151 | NA | 0.3620 | NA | 1.4039 | NA | NA |
| Palmitic acid+8 | NA | NA | NA | NA | NA | NA | NA | NA |
| Palmitoleic acid | 0.8059 | 0.5871 | 1.0020 | 0.5405 | 1.4348 | 1.2713 | 1.3108 | 1.0766 |
| Palmitoyl-carnitine | 0.8421 | 0.9464 | 1.4898 | 1.2760 | 0.7810 | 0.9057 | 0.6634 | 1.0810 |
| PEP | 0.6191 | 1.2125 | 0.7728 | 0.9342 | 0.7242 | 1.5591 | 0.9520 | 1.2077 |
| PEP+1 | NA | 0.4004 | NA | 0.4560 | NA | 1.0046 | NA | 1.3329 |
| PEP+2 | NA | NA | NA | NA | NA | NA | NA | NA |
| PEP+3 | NA | 0.6219 | NA | NA | NA | NA | NA | 1.0756 |
| Phenylalanine | 0.9242 | 0.8597 | 0.9307 | 0.9181 | 1.0464 | 1.1373 | 1.0815 | 1.1053 |
| Phosphocreatine | 0.7325 | 0.8912 | 0.6830 | 1.0122 | 0.8465 | 1.5165 | 1.2037 | 1.1041 |
| Proline | 0.6799 | 1.1347 | 0.7423 | 1.1967 | 0.8348 | 1.2444 | 0.8760 | 1.2802 |
| Proline +1 | 0.6511 | 1.1716 | 0.7024 | 1.2140 | 0.8000 | 1.2792 | 0.8486 | 1.3198 |
| Proline +2 | NA | 1.1073 | NA | 1.0384 | NA | 0.8243 | NA | 1.0300 |
| Proline +3 | NA | 1.1000 | NA | 0.9311 | NA | 0.8632 | NA | 1.1057 |
| Proline +4 | NA | 1.0934 | NA | 0.9512 | NA | 0.8834 | NA | 1.0720 |
| Proline +5 | NA | 1.0488 | NA | 0.8706 | NA | 0.8851 | NA | 1.1869 |
| Propionyl-carnitine | 0.8444 | 0.7368 | 1.2627 | 0.9310 | 0.8680 | 1.1230 | 0.8569 | 1.3685 |
| Pyridoxal | 0.4157 | 0.3107 | 0.5616 | 0.6158 | 1.7366 | 1.5543 | 1.5821 | 1.2264 |
| Pyroglutamate | 1.2387 | 0.6755 | 1.3987 | 0.8624 | 1.0922 | 0.6869 | 1.2457 | 0.8061 |
| Pyruvate | 0.6398 | 0.7403 | 0.5305 | 0.5315 | 1.7838 | 1.3986 | 1.2347 | 1.1931 |
| Pyruvate+1 | 0.1914 | 0.9042 | 0.1081 | 0.4467 | 0.7523 | 2.5736 | 0.4218 | 2.4180 |
| Pyruvate+2 | 0.0775 | 0.5384 | 0.0709 | 0.2056 | 0.1387 | 1.9361 | 0.0469 | 1.9342 |
| Pyruvate+3 | NA | 0.7921 | NA | 0.4820 | NA | 1.5153 | NA | 1.2106 |
| Ribose | 1.1283 | 0.9069 | 0.9953 | 0.6079 | 1.4053 | 1.1272 | 1.2038 | 0.6524 |
| Ribose phosphate | 1.1507 | 0.7411 | 1.1177 | 0.6447 | 1.3788 | 0.9270 | 1.2725 | 0.7927 |
| S-Adenosyl-L-Homocysteine | 0.9305 | 0.8699 | 0.9624 | 0.6839 | 1.1432 | 1.2167 | 0.9677 | 1.2352 |
| S-Adenosyl-L-methionine | 1.2679 | 1.0389 | 1.2663 | 1.0876 | 0.9069 | 0.7157 | 0.9648 | 0.7456 |
| Sedoheptulose-7-phosphate (D) | 1.1434 | 0.8956 | 1.3018 | 0.7425 | 1.2410 | 0.8860 | 1.3231 | 0.4826 |
| Sedoheptulose-7-phosphate (D) + 1 | 0.7810 | 1.3885 | 0.9234 | 1.0348 | 0.8802 | 1.3475 | 0.9800 | 0.6566 |
| Sedoheptulose-7-phosphate (D) + 2 | 0.1941 | 2.0896 | 0.4007 | 1.4003 | 0.2669 | 2.1657 | 0.4440 | 0.9361 |
| Sedoheptulose-7-phosphate (D) + 3 | NA | 1.1819 | NA | 0.8191 | 0.0632 | 1.3584 | NA | 0.5621 |
| Sedoheptulose-7-phosphate (D) + 4 | NA | 1.2541 | NA | 1.0070 | NA | 0.8283 | NA | NA |
| Sedoheptulose-7-phosphate (D) + 5 | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose-7-phosphate (D) + 6 | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose-7-phosphate (D) + 7 | NA | NA | NA | NA | NA | NA | NA | NA |
| Serine | 1.0273 | 0.8981 | 0.7410 | 0.9215 | 1.0550 | 1.0134 | 1.2246 | 1.1228 |
| Serine+1 | 0.9511 | 0.9863 | 0.5364 | 0.9300 | 0.9786 | 1.1315 | 1.1808 | 1.3039 |
| Serine+2 | 1.0092 | 1.2414 | 1.0097 | NA | NA | NA | NA | 0.7397 |
| Serine+3 | NA | NA | NA | NA | NA | 1.0000 | NA | NA |
| Serotonin (nv) | 1.2816 | 0.9906 | 1.4162 | 1.3949 | 0.6564 | 0.6694 | 0.8738 | 0.6942 |
| Stearic acid | 1.1590 | 0.6413 | 1.2034 | 0.6801 | 0.9899 | 1.1573 | 1.0859 | 1.0824 |
| Succinic Acid | 1.0671 | 0.7638 | 0.9975 | 0.6278 | 1.4051 | 0.9528 | 1.3398 | 0.8731 |
| Succinic Acid + 1 | 0.2847 | 1.5833 | 0.2686 | 1.1741 | 0.3750 | 1.9943 | 0.3592 | 1.9191 |
| Succinic Acid + 2 | NA | 0.9466 | NA | 0.7195 | NA | 1.1891 | NA | 1.1448 |
| Succinic Acid + 3 | NA | 0.9991 | NA | 0.6373 | NA | 1.1945 | NA | 1.1691 |
| Succinic Acid + 4 | NA | 1.0653 | NA | 0.6755 | NA | 1.2176 | NA | 1.0417 |
| Succinyladenosine | 0.8657 | 0.7642 | 0.8901 | 0.7055 | 1.3017 | 1.3643 | 1.0839 | 1.0446 |
| SuccinylCys | 0.4369 | 0.4416 | 0.6682 | 0.9868 | 1.1985 | 1.3333 | 1.2395 | 1.5380 |
| SuccinylGSH | 0.4568 | 1.1902 | 0.4784 | 2.3958 | 0.6441 | 0.7845 | 0.7345 | 0.8670 |
| Taurine | 0.8391 | 0.9892 | 1.0682 | 1.0304 | 1.0750 | 1.0980 | 0.9090 | 0.9961 |
| Taurine + 1 | 0.8648 | 0.9774 | 1.0601 | 1.0176 | 1.0846 | 1.1053 | 0.9215 | 0.9744 |
| Taurine + 2 | NA | NA | NA | NA | NA | NA | NA | NA |
| Threonine | 0.9220 | 0.7956 | 0.8274 | 0.9878 | 1.0092 | 1.0723 | 1.1692 | 1.2172 |
| Thymidine | 0.5704 | 0.4687 | 1.2103 | 2.0356 | 0.4156 | 0.4202 | 1.3302 | 0.9875 |
| Trehalose | 1.1135 | 0.8843 | 0.8334 | 0.5574 | 1.2564 | 1.2672 | 1.2015 | 0.9034 |
| Tryptophan | 0.8608 | 0.9032 | 0.8325 | 0.8715 | 1.0147 | 1.2097 | 1.1332 | 1.1755 |
| Tyrosine | 0.9294 | 0.8481 | 0.8237 | 0.7499 | 1.1804 | 1.1274 | 1.1822 | 1.1710 |
| UDP | 0.7749 | 0.9501 | 0.8235 | 1.0037 | 0.9868 | 1.5325 | 0.9561 | 0.9715 |
| UDP-GlcNAc | 0.9218 | 0.9255 | 0.9876 | 0.7626 | 1.0498 | 1.1476 | 1.1766 | 1.0318 |
| UMP | 0.8339 | 0.9316 | 0.8393 | 0.8158 | 1.0501 | 1.3315 | 0.9908 | 1.2103 |
| Urate | 1.3586 | 0.7502 | 1.1828 | 0.9510 | 0.9884 | 0.5925 | 1.4548 | 0.7208 |
| Uridine | 1.0724 | 0.5676 | 1.2410 | 0.7227 | 1.4634 | 0.8428 | 1.1708 | 0.9502 |
| Valine | 0.8118 | 0.9387 | 0.7690 | 0.8765 | 1.0299 | 1.3277 | 1.0255 | 1.2228 |
| Xanthine | 1.1100 | 0.6559 | 1.0237 | 0.6406 | 1.3310 | 1.0006 | 1.2988 | 0.9615 |
Factors:
| F1 | Age:Old | Genotype:SIRT6-tg | Treatment:N/A |
| F2 | Age:Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| F3 | Age:Old | Genotype:Wild-type | Treatment:N/A |
| F4 | Age:Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| F5 | Age:Young | Genotype:SIRT6-tg | Treatment:N/A |
| F6 | Age:Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| F7 | Age:Young | Genotype:Wild-type | Treatment:N/A |
| F8 | Age:Young | Genotype:Wild-type | Treatment:[U-13C]Lactate |
