Data for (Study ST001856)

(Analysis AN003008)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
12-Keto-tetrahydro-leukotriene B4 1.0218 1.7317 0.2465
1-Aminocyclopropanecarboxylic acid 1.2499 0.8157 0.9344
1-Methylhistamine 2.1542 0.1168 0.7291
1-Methylhistidine 2.3974 0.2708 0.3318
1-Pyrroline-2-carboxylic acid 1.9819 0.5256 0.4925
1-Pyrroline-4-hydroxy-2-carboxylate 0.7707 1.2824 0.9469
2-Aminophenol 0.3759 1.2947 1.3294
2-Dehydropantoate 1.3144 0.7244 0.9613
2-Ketobutyric acid 1.6700 0.6210 0.7089
2-Naphthol 1.0000 1.0000 1.0000
2-Phenylacetamide 1.8681 0.5534 0.5784
3-Dehydrosphinganine 0.2090 1.3126 1.4785
3-Sulfinylpyruvic acid 0.3349 0.4066 2.2585
4,5-Dihydroorotic acid 3.0000 0.0000 0.0000
5-(2-Hydroxyethyl)-4-methylthiazole 2.5028 0.2434 0.2538
5,6-Dihydro-5-fluorouracil 1.3745 0.6633 0.9622
5-Hydroxylysine 2.6684 0.1643 0.1674
5-Methylthioadenosine 1.5276 0.6752 0.7972
5-phosphonooxy-L-lysine 2.6737 0.2272 0.0991
6-Amino-6-deoxyfutalosine 1.8255 0.8689 0.3056
Acetylcholine 0.5039 1.0346 1.4615
Acetylphosphate 1.6366 0.5192 0.8443
Allocholic acid 0.9250 0.9813 1.0937
alpha-Tocopherol 0.4757 2.0332 0.4911
Aminoadipic acid 1.2738 0.8584 0.8677
AMP 0.0539 1.1681 1.7780
Antibiotic JI-20A 2.7256 0.2651 0.0093
Argininosuccinic acid 1.7573 0.4498 0.7928
Aspartame 0.9396 0.9025 1.1579
Betaine 1.2640 0.7472 0.9889
Betaine aldehyde 1.6637 0.6036 0.7327
Carnosine 2.3724 0.3022 0.3255
Choline 1.5204 1.2690 0.2105
cis-4-Hydroxy-D-proline 0.7878 1.0742 1.1380
Citicoline 2.7409 0.0463 0.2129
CMP 1.4696 0.6326 0.8978
Corticosterone 1.7829 0.6656 0.5515
Cortisol 2.2011 0.0062 0.7927
Creatine 0.9897 0.8956 1.1147
Creatinine 2.0775 0.4901 0.4324
Cyclic GMP 1.2803 1.3136 0.4061
Cytosine 0.3375 1.4005 1.2620
D-4-Phosphopantothenate 1.1185 1.1108 0.7707
Dehypoxanthine futalosine 1.4125 0.5620 1.0255
Deoxycholic acid 0.1764 0.8874 1.9362
Deoxycytidine 2.4141 0.4950 0.0909
Deoxyuridine 0.8679 0.3705 1.7616
D-Fructose 1.2457 1.4657 0.2886
D-Glucose 1-phosphate 1.2216 0.9282 0.8502
Dodecanoic acid 0.8276 1.0311 1.1413
D-Ribose 1.4776 0.8237 0.6987
Ergocalciferol 1.0591 0.4195 1.5214
Ergothioneine 1.8045 0.4261 0.7694
Erucic acid 1.0000 1.0000 1.0000
gamma-Aminobutyric acid 1.0000 1.0000 1.0000
gamma-Glutamylcysteine 2.9627 0.0198 0.0175
gamma-L-Glutamyl-L-2-aminobutyrate 2.7106 0.1441 0.1453
Gentamicin C1a 1.4894 0.5569 0.9537
Gentisic acid 2.5887 0.4113 0.0000
GMP 1.8462 0.2899 0.8640
Guanine 2.1562 0.4099 0.4339
Guanosine 2.1070 0.4143 0.4787
Hippuric acid 2.7647 0.1377 0.0976
Hydrogen phosphate 1.1250 0.9219 0.9531
IMP 2.5652 0.0973 0.3375
Indole 2.2261 0.3932 0.3808
Indoleglycerol phosphate 1.0571 1.0533 0.8895
Isocitric acid 2.3994 0.3396 0.2610
Kynurenic acid 2.7811 0.1263 0.0926
L-2,4-diaminobutyric acid 1.6519 0.7735 0.5746
L-Arginine 1.6933 0.4121 0.8945
L-Asparagine 0.8143 1.1475 1.0382
L-Carnitine 1.1137 0.8100 1.0763
L-Cystine 1.9935 0.4861 0.5203
L-Glutamine 1.2721 0.7558 0.9721
L-Histidine 1.5719 0.6897 0.7384
Linoleic acid 1.3993 0.7750 0.8257
L-Isoleucine 0.5238 0.3800 2.0962
L-Leucine 0.2069 1.1121 1.6810
L-Lysine 1.5562 0.7503 0.6935
L-Methionine 2.1868 0.4032 0.4100
L-Phenylalanine 1.2255 0.7839 0.9906
L-Proline 1.2499 0.7303 1.0198
L-Rhamnofuranose 2.3057 0.4825 0.2118
L-Serine 1.2850 0.7419 0.9731
L-Threonine 1.3086 0.7949 0.8965
L-Tryptophan 1.2366 0.7729 0.9905
L-Tyrosine 2.4081 0.5919 0.0000
L-Valine 1.7403 0.7128 0.5469
Methyl beta-D-galactoside 3.0000 0.0000 0.0000
myo-Inositol 0.9240 0.4262 1.6498
N6-Acetyl-L-lysine 2.1933 0.3467 0.4600
N-Acetyl-alpha-D-glucosamine 1-phosphate 0.9074 0.8685 1.2241
Niacinamide 1.8956 0.5558 0.5485
Norepinephrine 1.0669 0.7171 1.2160
Oleic acid 2.8648 0.0000 0.1352
O-Phosphoethanolamine 0.6638 1.1807 1.1555
Ornithine 1.0069 1.1776 0.8155
Palmitic acid 0.9727 1.1919 0.8354
Palmitoleic acid 1.0626 0.6579 1.2796
Palmitoyl-L-carnitine 0.5534 1.4466 1.0000
p-Aminobenzoic acid 0.9507 1.0179 1.0314
Pantothenic acid 1.9113 0.4326 0.6561
Phenylacetylglycine 2.5207 0.3161 0.1632
Phosphorylcholine 0.6704 0.9756 1.3539
Phytosphingosine 0.2213 1.1614 1.6172
Pipecolic acid 1.1860 0.7270 1.0870
Prostaglandin F2a 0.2820 1.8883 0.8297
Protoporphyrinogen IX 2.4441 0.3063 0.2497
Pyridoxamine 5-phosphate 2.9606 0.0238 0.0156
Pyrimidodiazepine 2.2573 0.4469 0.2958
Pyroglutamic acid 0.8115 0.6887 1.4997
Pyrrolidonecarboxylic acid 0.0000 0.0000 3.0000
(R)-5,6-Dihydrothymine 0.2783 0.7965 1.9253
Retinoyl b-glucuronide 2.4436 0.3664 0.1901
Riboflavin 1.9788 0.4404 0.5808
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate 0.3080 1.4929 1.1992
Saccharopine 0.9667 1.4221 0.6113
S-Adenosylhomocysteine 2.8976 0.1024 0.0000
S-Adenosylmethionine 0.9876 0.8630 1.1494
Se-Methylselenocysteine 0.5810 0.6087 1.8103
Sorbitol 0.6868 1.4511 0.8621
Spermidine 0.5389 0.8952 1.5658
Sphinganine 0.6590 1.1195 1.2215
Sphingosine 0.4558 1.5065 1.0377
Sucrose 1.1904 0.8934 0.9162
Taurine 2.8190 0.1810 0.0000
Thiamine 2.1613 0.3608 0.4779
Thiamine aldehyde 1.7674 0.6282 0.6044
Thiamine monophosphate 2.0751 0.4414 0.4835
Thymine 0.1665 0.4599 2.3735
UMP 1.8204 0.4329 0.7467
Uracil 1.2512 0.7195 1.0293
Uric acid 0.2197 1.4075 1.3728
Uridine 2.0188 0.5697 0.4116
Vanillylmandelic acid 0.8865 0.8814 1.2321
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Factors:

F1surgery:sham | FG-4592(10 mg/kg):-
F2surgery:UIR | FG-4592(10 mg/kg):-
F3surgery:UIR | FG-4592(10 mg/kg):10
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