Data for (Study ST002237)
(Analysis AN003650)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1,3-bisphospho-D-glycerate | NA | NA | NA | NA |
| 1-methylnicotinamide+ | 1.0653 | 1.3340 | 0.6536 | 0.9471 |
| 2,3-bisphospho-D-glycerate | 1.0286 | 0.3885 | 1.3923 | 1.0578 |
| 2/3-phosphoglycerate | 1.1887 | 0.7273 | 0.9378 | 1.1463 |
| 2-aminobutanoate | 0.3531 | 1.9101 | 0.4287 | 1.3081 |
| 2-aminoisobutanoate | 0.9854 | 0.9068 | 1.2625 | 0.8454 |
| 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine | 0.8181 | 0.5995 | 1.3932 | 1.1529 |
| 2-HG | 1.0140 | 1.3237 | 0.7725 | 0.8899 |
| 2-hydroxybutanoic acid | 0.1568 | 2.5736 | 0.1511 | 1.1186 |
| 2-keto-isovaleric acid | 0.9348 | 1.0219 | 1.1933 | 0.8628 |
| 2-ketovaleric acid | 1.1615 | 1.2174 | 0.8159 | 0.8122 |
| 2-oxobutanoic acid | 0.9680 | 0.9748 | 0.8366 | 1.2206 |
| 3,4-dihydroxymandelic acid | NA | NA | NA | NA |
| 3,4-dihydroxyphenylpropanoate | 1.0344 | 1.0959 | 0.9049 | 0.9000 |
| 3- / 7-methylguanine | 0.8913 | 1.2655 | 0.8960 | 0.9472 |
| 3-aminoisobutanoate | 0.4910 | 1.8485 | 0.8015 | 0.8589 |
| 3-hydroxybutanoic acid | 0.3660 | 1.8733 | 0.3031 | 1.4576 |
| 3-hydroxyphenylacetic acid / vanillin | 0.8560 | 1.1786 | 1.0576 | 0.9078 |
| 3-hydroxypropanoic acid | 1.1330 | 0.8413 | 1.0347 | 0.9910 |
| 3-methoxytyramine | 0.4436 | 0.7706 | 1.6567 | 1.1292 |
| 3-phosphohydroxypyruvic acid | NA | NA | NA | NA |
| 3-phospho-serine | 0.9655 | 0.8777 | 1.1561 | 1.0006 |
| 3-ureidopropionic acid | 0.6115 | 0.9316 | 0.6591 | 1.4279 |
| 4-hydroxybutanoic acid | 0.6054 | 1.6080 | 0.6305 | 1.1561 |
| 4-hydroxyphenylacetic acid | 0.6360 | 2.0836 | 0.9121 | 0.7291 |
| 4-hydroxyphenylpyruvic acid - | 0.7983 | NA | 1.5112 | 0.9461 |
| 4-hydroxyproline | 1.1752 | 0.9469 | 0.8968 | 0.9811 |
| 4-phosphopantothenate | NA | NA | NA | NA |
| 5,6-dihydroxyindole | 0.6609 | 0.8717 | 0.7492 | 2.3482 |
| 5-aminolevulinate | 0.9456 | 0.9813 | 1.0628 | 1.0103 |
| 5-methylcytosine | 1.2037 | 0.8285 | 1.0462 | 0.9216 |
| 5-methyl-THF | 0.9082 | 1.1741 | 0.7394 | 1.2359 |
| 5^-methylthioadenosine | 1.0319 | 1.0379 | 0.9555 | 0.9747 |
| 6-aminocaproic acid | 1.2214 | 1.1884 | 0.8037 | 0.5815 |
| 6-O-methylguanine | NA | NA | NA | NA |
| 6-phosphogluconic acid | 1.2694 | 0.6213 | 1.1365 | 0.9728 |
| 6-phosphoglucono-D-lactone | 0.7517 | 1.1113 | 1.0375 | 1.0601 |
| acetoacetic acid | 0.9939 | 0.9456 | 1.3505 | 0.7704 |
| acetylcholine+ | 1.0605 | 1.0271 | 0.9675 | 0.9449 |
| aconitic acid | 0.2689 | 0.2996 | 2.8714 | 0.4870 |
| adenine | 0.9986 | 1.0860 | 0.9962 | 0.9192 |
| adenosine | 1.0692 | 1.1650 | 0.8686 | 0.8972 |
| adenylosuccinate | 1.0226 | 0.9830 | 0.9608 | 1.0336 |
| ADP | 1.0796 | 0.9389 | 0.9401 | 1.0414 |
| ADP-D-glucose | NA | NA | 0.8585 | 1.1415 |
| agmatine | 0.9210 | 0.8174 | 0.9719 | 1.2553 |
| AICA ribonucleotide | 1.3867 | 1.2264 | 0.6468 | 0.5455 |
| a-KG | 1.1616 | 0.9223 | 1.1314 | 0.7846 |
| alanine | 1.0542 | 1.0437 | 0.9518 | 0.9503 |
| allantoin | 0.9503 | 1.1976 | 0.7625 | 1.0897 |
| AMP / dGMP | 1.0244 | 1.0590 | 0.8823 | 1.0342 |
| anandamide | 0.4214 | 1.0265 | 1.8231 | 0.7654 |
| arginine | 1.0068 | 0.7516 | 1.1996 | 1.0420 |
| asparagine | 0.9375 | 0.7853 | 1.2262 | 1.0510 |
| aspartic acid | 1.0089 | 1.0382 | 0.9532 | 0.9997 |
| ATP / dGTP | 1.0652 | 0.9732 | 0.9779 | 0.9837 |
| b-alanine | 1.0771 | 1.1130 | 0.9675 | 0.8424 |
| betaine | 1.3362 | 1.2939 | 0.6450 | 0.7249 |
| carbamoyl phosphate | 1.0914 | 0.9701 | 0.9993 | 0.9247 |
| carnitine+ | 1.0560 | 0.9947 | 0.9849 | 0.9644 |
| CDP | 1.1265 | 0.9079 | 0.9142 | 1.0515 |
| CDP-choline | 1.0600 | 1.0412 | 0.9370 | 0.9617 |
| choline+ | 0.9830 | 0.9241 | 1.1935 | 0.8995 |
| citraconic acid | 1.1931 | 1.0210 | 0.7114 | 1.0744 |
| citramalic acid | 0.8162 | 0.8135 | 1.2286 | 1.1261 |
| citrate / citrate(iso) | 1.0619 | 1.0558 | 1.0237 | 0.8586 |
| citrulline | 1.2439 | 0.9293 | 1.1308 | 0.6960 |
| CMP | 1.0091 | 1.0980 | 0.8709 | 1.0219 |
| creatine | 1.0248 | 1.0425 | 0.9463 | 0.9864 |
| Creatinine | 0.9478 | 1.0618 | 0.9348 | 1.0556 |
| CTP | 1.0582 | 0.9025 | 1.0802 | 0.9174 |
| cystathionine | 1.0384 | 0.9301 | 0.8487 | 1.1828 |
| cysteine | 0.4857 | 0.6417 | 1.4845 | 1.3919 |
| cysteine-S-sulfate | NA | NA | NA | NA |
| cystine | NA | NA | 1.0000 | NA |
| cytidine | 1.0086 | 1.2661 | 0.8359 | 0.8894 |
| cytosine | 0.8198 | 1.0654 | 0.9096 | 1.2052 |
| dADP | 1.6659 | 0.9303 | 0.9049 | 0.9618 |
| dAMP | 0.8694 | 0.9023 | 1.3627 | 0.8402 |
| D-arabinono-1,4-lactone | 1.0606 | 1.0411 | 0.9105 | 0.9879 |
| dATP | NA | 1.0000 | NA | NA |
| dCDP | 1.2955 | 0.7045 | NA | NA |
| dCMP | 1.1543 | 1.1877 | 0.6401 | 1.0198 |
| dCTP | 0.8953 | 1.1047 | NA | NA |
| dehydroascorbic acid | 0.9596 | 0.9369 | 0.8782 | 1.2253 |
| deoxyguanosine | 1.1956 | 0.8377 | 1.6010 | 0.6336 |
| deoxyinosine | NA | 0.5262 | 2.4215 | NA |
| deoxyuridine | 0.6981 | 1.5916 | 0.7367 | 0.9736 |
| D-erythrose-4-phosphate | 1.2090 | 0.9472 | 0.9536 | 0.8730 |
| D-galactonic acid | 1.1486 | 1.1792 | 0.8424 | 0.8299 |
| D-galactosamine/glucosamine-1-phosphate | 1.3353 | 0.4432 | 1.2692 | 0.7853 |
| D-galactosamine/glucosamine-6-phosphate | 1.4302 | 0.5972 | 1.0573 | 0.9154 |
| dGDP | 0.3212 | NA | 0.9022 | 1.7765 |
| D-gluconic acid - | 0.9888 | 1.5981 | 0.7458 | 0.8225 |
| dihydroorotate | 1.0180 | 0.8666 | 1.0487 | NA |
| dimethylglycine | 1.0052 | 0.9795 | 1.1236 | 0.8917 |
| DL-DOPA | 0.7538 | 0.8243 | 1.5672 | 1.2713 |
| DOPAC | 1.2976 | 0.7942 | 1.1178 | 0.7968 |
| DOPAL | 0.8376 | 1.1785 | 0.9123 | 1.0716 |
| dopamine / octopamine | 0.7061 | 0.8190 | 1.5143 | 0.9035 |
| dopamine quinone | 0.9468 | 1.0819 | 0.8941 | 1.0718 |
| DOPEG | 1.1128 | 0.9307 | NA | 0.9218 |
| DOPET | 1.1247 | 0.9556 | 1.0850 | 0.8341 |
| D-ribose-1/5-phosphate / D-ribulose 5-phosphate | 1.0112 | 1.0385 | 1.0385 | 0.9118 |
| D-sedoheptulose-7-phosphate | 1.0727 | 1.0067 | 0.9945 | 0.9260 |
| dTMP | NA | NA | NA | NA |
| dTTP | NA | NA | NA | NA |
| dUMP | 0.9166 | 1.0106 | 1.1874 | NA |
| dUTP | NA | NA | NA | NA |
| epinephrine | 0.8759 | 0.6336 | 1.3893 | 1.0888 |
| F-1,6/2,6-DP | 1.0515 | 0.7652 | 1.0390 | 1.1443 |
| F1P | 1.0147 | 0.6440 | 1.3363 | 1.0050 |
| F6P / G1P | 1.2609 | 0.6648 | 1.0429 | 1.0314 |
| FAD | 0.8965 | 1.1117 | 0.9919 | NA |
| FMN | 1.2743 | 0.8517 | 0.5943 | 0.9103 |
| folic acid | NA | NA | NA | NA |
| fructose / mannose | 1.2911 | 0.5581 | 1.2928 | 0.8580 |
| fumaric acid | 1.0794 | 1.2976 | 0.7745 | 0.8486 |
| G6P | 1.0367 | 1.0344 | 0.8393 | 1.0896 |
| GABA | 1.0208 | 0.9513 | 1.1220 | 0.9059 |
| galactosamine / glucosamine | 1.8846 | 0.4556 | 1.1609 | 0.4607 |
| galactose / glucose | NA | 1.0000 | NA | NA |
| GalNAC/GlcNAC/ManNAC | 1.1802 | 1.1437 | 0.9771 | 0.6989 |
| GAP / DHAP | 1.1927 | 0.6157 | 0.9851 | 1.2066 |
| GDP | 1.0011 | 1.0052 | 0.9362 | 1.0576 |
| GDP-L-fucose | 0.9907 | 1.0124 | 0.9618 | 1.0351 |
| glucono-lactone | NA | NA | NA | 1.0000 |
| glutamine | 0.8639 | 0.5855 | 1.3445 | 1.2060 |
| glutaminic acid | 0.9779 | 0.9490 | 1.0303 | 1.0429 |
| glutathione | 0.8850 | 0.9196 | 1.0369 | 1.1585 |
| glutathione disulfide | 1.0855 | 1.0378 | 0.8935 | 0.9833 |
| glyceraldehyde | NA | NA | NA | NA |
| glyceric acid | 0.9793 | 1.0385 | 0.9517 | 1.0305 |
| glycerol 2/3-phosphate | 1.2126 | 1.0658 | 0.9327 | 0.7889 |
| glycine | 0.9659 | 1.3158 | 0.7953 | 0.9230 |
| glycylglycine | NA | 0.8816 | 1.1184 | NA |
| GMP | 1.0072 | 1.0569 | 0.9454 | 0.9904 |
| GTP | 0.8883 | 1.0735 | 0.9197 | 1.1185 |
| guanidine | 1.4879 | 1.0823 | 0.5252 | 0.9046 |
| guanidinoacetate | 1.2367 | 1.2065 | 0.7217 | 0.8352 |
| guanine | 0.9443 | 1.0381 | 1.2097 | 0.8078 |
| guanosine | 0.9427 | 1.0498 | 1.2199 | 0.7876 |
| gulonic-lactone | 1.0885 | 1.0027 | 0.9909 | 0.9050 |
| histamine | 0.8165 | 0.8700 | 0.7426 | 1.5709 |
| histidine | 0.9725 | 0.7488 | 1.2094 | 1.0693 |
| homocysteine | 0.8395 | 0.7922 | 1.2286 | 1.0055 |
| homoserine / theronine | 0.7506 | 0.8410 | 1.0512 | 1.3572 |
| homovanillic acid | 0.6464 | 0.8284 | 1.0986 | 1.4658 |
| hydroxyphenyllactic acid | 1.2807 | 0.6256 | 1.3176 | 0.7761 |
| hypoxanthine | 0.7281 | 0.7950 | 1.7157 | 0.7612 |
| IDA | 0.8684 | 1.2041 | 0.9593 | 0.9446 |
| IDP | 1.2036 | NA | 0.8079 | 0.7906 |
| imidazole-4-acetate | 1.2242 | 0.9374 | 0.9934 | 0.8450 |
| IMP | 0.8983 | 1.0741 | 0.9539 | 1.0738 |
| inosine | 0.7067 | 0.7742 | 1.7852 | 0.7339 |
| isonictinic acid | 0.6937 | 1.0739 | 1.2642 | 0.9681 |
| itaconic acid | 1.0557 | 0.9965 | 0.9254 | 1.0225 |
| kynurenine | 0.4892 | 1.1182 | 0.8790 | 1.5136 |
| lactic acid | 1.1829 | 0.8153 | 1.0388 | 0.9630 |
| L-arginino-succinate | 0.9611 | 0.7502 | 1.3206 | 0.9681 |
| L-cysteic acid | 1.1223 | NA | 0.9388 | NA |
| leucine / leucine(iso) | 0.7590 | 0.9732 | 1.0698 | 1.1981 |
| levulinic acid | 0.3894 | 1.1268 | 1.1628 | 1.1598 |
| L-NMMA | 1.1883 | 0.6403 | 1.3855 | 0.7859 |
| lysine | 1.1095 | 0.8556 | 1.1104 | 0.9245 |
| maleic acid | 1.0777 | 1.0230 | 0.9330 | 0.9663 |
| malic acid | 1.0695 | 1.0374 | 0.9295 | 0.9635 |
| mesaconic acid | 1.1179 | 1.0830 | 0.8782 | 0.9209 |
| methionine | 1.2499 | 0.5088 | 1.4391 | 0.8022 |
| methyl acetoacetate | NA | NA | NA | NA |
| methylglyoxal | NA | 1.0279 | 1.0375 | 0.9371 |
| methylmalonic acid | 0.7683 | 1.2532 | 0.9926 | 0.9344 |
| mevalonic acid | 1.0015 | 0.6270 | 1.6498 | 0.9569 |
| N1/N8-acetylspermidine | 1.2133 | 0.9387 | 1.0158 | 0.8322 |
| N-acetylaspartic acid | 0.9761 | 1.0433 | 0.9716 | 1.0090 |
| N-acetylaspartylglutamic acid | 1.0184 | 1.0360 | 0.8669 | 1.0787 |
| N-acetyl-b-alanine | 1.0441 | 0.6984 | 1.2379 | 1.0196 |
| N-acetyl-DL-alanine | 1.0935 | 1.1209 | 0.9545 | 0.8311 |
| N-acetyl-dopamine | 1.2171 | 1.1583 | 0.8664 | 0.7581 |
| N-acetylglucosamine 1/6-phosphate | 1.0678 | 0.9258 | 0.9784 | 0.9570 |
| N-acetyl-L-glutamic acid | 1.2189 | 1.1408 | 0.9763 | 0.6640 |
| NAD+ | 1.0917 | 1.0739 | 0.8740 | 0.9605 |
| NADH | 1.0526 | 1.0848 | 0.8455 | 0.9829 |
| NADP+ | 1.0418 | 0.9798 | 0.8764 | 1.1021 |
| NADPH | 0.9187 | 0.9377 | 1.0697 | 1.1011 |
| N-carbamoyl-L-aspartate | 1.5666 | 1.1177 | 0.6975 | 0.6299 |
| nicotinamide | 0.9046 | 0.8801 | 1.2831 | 0.9322 |
| nicotinamide riboside+ | 1.1572 | 1.2784 | 0.8045 | 0.7598 |
| nicotinic acid | 0.9315 | 0.8379 | 1.1621 | 1.0617 |
| N-methyltryptamine | NA | NA | NA | 1.0000 |
| NMN | 1.1911 | 1.1684 | 0.7951 | 0.8455 |
| N,N-dimethylaniline | 0.9984 | 0.9080 | 1.2104 | 0.8833 |
| norepinephrine | 0.8816 | 0.8900 | 1.1532 | 1.0752 |
| octopamine | 1.1358 | 0.8172 | 0.9787 | 1.0409 |
| ornithine | 1.0918 | 1.1691 | 0.9005 | 0.8387 |
| orotic acid | 0.8819 | 1.1848 | 0.9833 | 0.9500 |
| orotidylic acid | NA | 1.0257 | 0.9694 | 1.0025 |
| oxalacetic acid | NA | NA | 1.3381 | 0.6619 |
| pantothenic acid | 0.7271 | 1.0540 | 0.8088 | 1.4101 |
| phenethylamine | 1.0762 | 0.9207 | 0.9919 | 1.0103 |
| phenylalanine | 0.8941 | 0.7182 | 1.2687 | 1.1190 |
| phenylephrine / synephrine | 1.0871 | 1.2965 | 0.8414 | 0.7678 |
| phosphocreatine | 1.0908 | 1.1580 | 0.9486 | 0.8026 |
| phosphoenolpyruvate | 1.1242 | 0.4755 | 1.3093 | 1.0910 |
| phosphorylcholine+ | 1.1884 | 0.9502 | 0.9854 | 0.8759 |
| picolinic acid | 1.5060 | 0.8149 | 0.7187 | 0.9604 |
| proline | 1.0471 | 1.0782 | 0.9103 | 0.9643 |
| PRPP | 0.9431 | NA | NA | 1.0285 |
| pseudouridine | 0.9731 | 1.2253 | 0.8780 | 0.9237 |
| putrescine | 1.0693 | 0.9904 | 1.0663 | 0.8740 |
| pyridoxine | 1.1352 | 0.9627 | 1.0006 | 0.9166 |
| pyruvic acid | 1.2315 | 0.8573 | 0.9629 | 0.9484 |
| (S)-4-hydroxymandelonitrile + | NA | 0.5059 | 1.1481 | 1.3460 |
| S-adenosyl-L-homocysteine | 1.0164 | 0.8737 | 1.0207 | 1.0992 |
| S-adenosyl-L-methionine+ | 1.0443 | 1.1135 | 0.8584 | 0.9837 |
| S-adenosylmethioninamine+ | 1.0000 | NA | NA | NA |
| serine | 0.9884 | 0.8421 | 1.0405 | 1.1289 |
| serotonin | 0.9218 | 0.9637 | 0.9270 | 1.1874 |
| spermidine | 1.0294 | 1.0236 | 0.9329 | 1.0142 |
| spermine | 1.0223 | 1.0021 | 0.9798 | 0.9958 |
| succinic acid | 1.1301 | 1.0709 | 0.8668 | 0.9323 |
| succinic semialdehyde | NA | NA | NA | NA |
| taurine | 1.0868 | 1.0719 | 0.8839 | 0.9573 |
| thiamine+ | 1.0215 | 0.7854 | 1.2371 | 0.9560 |
| thymidine | 0.6510 | 1.5779 | 0.8040 | 0.9670 |
| thymine | 0.7548 | 1.2782 | 0.9966 | 0.9704 |
| tryptamine | NA | 0.9318 | 1.2175 | 0.4841 |
| tryptophan | 0.9011 | 0.8584 | 1.1692 | 1.0714 |
| tyramine | 0.9798 | 1.0363 | 0.9808 | 1.0032 |
| tyrosine | 1.2425 | 0.5035 | 1.4287 | 0.8253 |
| UDP | 1.0344 | 0.9144 | 0.9173 | 1.1339 |
| UDP-D-glucose | 1.0410 | 1.0622 | 0.9090 | 0.9878 |
| UDP-N-acetyl-galactosamine/UDP-N-acetyl-glucosamine | 1.0174 | 1.0905 | 0.8876 | 1.0045 |
| UMP | 0.9664 | 1.1128 | 0.8190 | 1.1017 |
| uracil | 0.8623 | 1.2476 | 1.0564 | 0.8337 |
| urea | 0.9094 | 1.2665 | 0.8156 | 1.0086 |
| uric acid | 0.9053 | 1.1400 | 0.8706 | 1.0841 |
| uridine | 1.0004 | 1.2008 | 0.8805 | 0.9184 |
| UTP | 0.6999 | 1.0814 | 0.9992 | 1.1920 |
| valine | 0.8050 | 1.0420 | 1.0072 | 1.1457 |
| xanthine | 0.7519 | 0.8818 | 1.5232 | 0.8431 |
| xanthosine | NA | NA | NA | NA |
| XMP | 0.6203 | 0.5644 | 2.3720 | 0.6147 |
| y-glutamylcysteine | 1.0835 | 0.7252 | 0.6446 | 1.2316 |
Factors:
| F1 | Genotype:Depdc5 KO | Treatment:Control |
| F2 | Genotype:Depdc5 KO | Treatment:Fasted |
| F3 | Genotype:Depdc5 WT | Treatment:Control |
| F4 | Genotype:Depdc5 WT | Treatment:Fasted |
