Metabolite_name RefMet_name 1 2 3 4 5 6 10 11 12 7 8 9 Factors - treatment:RT treatment:RT treatment:RT treatment:RT+aCD25 treatment:RT+aCD25 treatment:RT+aCD25 treatment:RT+aCD25+IL2v treatment:RT+aCD25+IL2v treatment:RT+aCD25+IL2v treatment:RT+IL2v treatment:RT+IL2v treatment:RT+IL2v 3-methyldioxyindole 3-Methyldioxyindole 170725.9000 11222.0200 41872.5800 65159.4600 126085.7000 210961.2000 61558.4100 139875.7000 115110.2000 189920.9000 162750 163128.4000 4-Pyridoxate 4-Pyridoxic acid 149427.7000 89438.6200 574328.7000 164666.3000 200599.9000 245014.6000 142744.6000 138671.9000 187581.2000 140709.2000 154018.7000 107323.8000 5-6-Dihydrouracil Dihydrouracil 458315.3000 253948.2000 581000.5000 653260.4000 714780.2000 457843.2000 1350784 674764.6000 890505.1000 1147595 671648.1000 1193862 5-Guanidino-2-oxopentanoate 2-Oxoarginine 37964.4800 33232.7100 62144.6700 195334.9000 105004.6000 85620.1500 85629.3200 83774.4400 93424.1200 88480.0600 79565.1200 196129.8000 5-Hydroxyisourate 5-Hydroxyisouric acid 319004.2000 467126.8000 517530.5000 388169.6000 324577.8000 273524.8000 528290.2000 335498.1000 314322 317033.5000 262931.4000 379580.2000 6-Hydroxykynurenic acid 6-Hydroxykynurenic acid 61795.7700 129628.5000 54327.0100 46153.9500 33671.4100 39655.6600 12464.0700 26603.7600 56088.3200 79077.7500 48695.9600 64190.9300 Acetylcholine Acetylcholine 4386157 7232706 2163192 3146376 3429789 4518818 3681014 3749314 5191534 5038862 5282486 4385476 acyl-C10:1 (O-Decenoyl-L-carnitine) CAR 10:1 453481.4000 303543.1000 335832.2000 175408.4000 172743.9000 207698.7000 320950.2000 343675.5000 221266.2000 216286.9000 323410 236142 acyl-C10 (O-Decanoyl-L-carnitine) CAR 10:0 184047 88265.4100 377057 154117.1000 230807.2000 125139.8000 295470.5000 279970.6000 135657.2000 169440.3000 187593.6000 217395.4000 acyl-C12:1 (O-dodecenoyl-carnitine) CAR 12:1 839396.9000 595160.1000 892244.8000 120063.8000 226155.4000 150442.8000 288045 308452.2000 223881.8000 206158.2000 312863.4000 194543.1000 acyl-C12 (O-dodecanoyl-carnitine) CAR 12:0 140810.7000 51844.1000 435012.1000 73451.9100 73240.3300 58058.5300 119048.6000 211748.5000 45129.3300 66554.9800 135130.1000 86994.6600 acyl-C14:1 (Tetradecenoyl Carnitine) CAR 14:1 206939.9000 175350.9000 2128636 76195.6200 148570.4000 111704.8000 401154.2000 278240.6000 97729.5900 127218.6000 205641.9000 105968.8000 acyl-C14 (O-tetradecanoyl-L-carnitine) CAR 14:0 107003.1000 39414.9700 1060657 74448.3800 63124.8100 58367.6000 108359.9000 94208.2700 46576.9800 57379.7400 83556.0300 66157.4800 acyl-C16:1 (Hexadecenoyl-carnitine) CAR 16:1 51337.9000 38701.8600 1001806 48493.9500 80479.7500 58782.7600 161094 103151.9000 42781.2300 46112.0200 58807.6400 55616.1200 acyl-C16 (L-Palmitoylcarnitine) CAR 16:0 151378.5000 100391.8000 2930927 117454.6000 194043 76933.0400 235761.1000 247862.7000 94972.6600 116359 108592.8000 123860.9000 acyl-C18:1 (O-octadecenoyl-L-carnitine) CAR 18:1 173818.2000 80951.9300 3989957 85410.0900 177644.7000 82063.1600 273821.3000 237437.2000 67836 73398.4600 129866 103560.1000 acyl-C18:2 (Linoleoyl-CoA) Linoleoyl-CoA 133144.8000 117681.4000 1912201 71691.7100 100192.4000 61798.0700 189335.9000 104179.8000 53712.0700 72174.2500 74470.2100 83964.5300 acyl-C18:2-OH CAR 18:2;OH 13203.1300 11676.3700 163528.9000 3154.8060 4730.7350 4306.4310 14226.2800 5713.8320 3647.0270 4789.0410 4577.1060 3300.2180 acyl-C18 (Octadecanoyl-L-carnitine) CAR 18:0 35318.0600 24783.7700 1285418 10982.2000 24011.3300 13811.7100 21184.7500 17511.1000 13932.4100 12670.8500 14154.9600 13630.9700 acyl-C20:4 CAR 20:4 61751.5900 43455.9000 947815.2000 28880.9700 39140.5700 20858.4900 58882.3500 45051.7800 19587.9400 36498.4200 27773.8800 28491.7900 acyl-C2 (acetyl-carnitine) CAR 2:0 95355430 100569100 99470900 87069950 98123750 100479900 152563300 147520600 110081800 107316700 149541400 121145500 acyl-C3 (propionyl-carnitine) CAR 3:0 6921592 6394694 3802878 5759650 4847701 6933650 3137358 3847261 6452078 7476658 9542933 6551590 acyl-C4 (butanoyl-l-carnitine) CAR 4:0 7133774 7255494 1162372 12980000 14641860 10667430 12046010 8125088 24071750 13871460 13418070 18751220 acyl-C4-OH (Hydroxybutyrylcarnitine) CAR 4:0;OH 115154.4000 65708.6200 134181 316834.5000 170344.8000 178892.9000 133287.4000 120217.8000 125488.2000 158254.9000 85533.2300 228801.8000 acyl-C5 (isovalerylcarnitine) CAR 4:0;3Me 3203706 3146460 1556592 1986285 1616397 2304764 1462040 1298938 2576178 3015563 3362582 2809728 acyl-C5-OH CAR 5:0;OH 168396.4000 60198.2500 111403.9000 339376.3000 178925.1000 220539.4000 211680.7000 232093.4000 171560.2000 255814 187150.5000 265451.6000 acyl-C6 (hexanoyl-l-carnitine) CAR 6:0 1606454 1208467 375387.3000 3515610 3749555 1201706 3537498 1715394 4039469 4811896 3233520 5645008 acyl-C8:1 (octenoyl-l-carnitine) CAR 8:1 221406.8000 254258.3000 69983.4200 91964.3500 112164.6000 75371.4800 160714.2000 141720.6000 90332.6600 98399.0300 146060 145170.5000 acyl-C8 (L-octanoylcarnitine CAR 8:0 275341.6000 214388.7000 218673.7000 525209.4000 624609.3000 241964 756496.5000 395742.1000 494477.7000 611547.1000 578005.2000 956629.8000 Adenosine Adenosine 5404.4710 1217.7920 2651.2640 3130.5530 1401.9590 3466.9220 1141.7160 2796.5090 1487.8720 2507.3320 3492.2000 4717.3860 Allantoate Allantoic acid 1450495 1586608 3184196 1027322 953027.6000 731706.5000 789785.8000 568984.4000 1030114 1193424 655928.4000 1147108 Anthranilate 2-Aminobenzoic acid 741427.9000 4052574 320458.8000 1255079 697157.2000 1121237 596178.4000 809811 1074667 1193697 1537376 1073914 Bilirubin Bilirubin 199630.4000 162555.9000 25322.8500 4718.4230 81167.0500 62406.4500 90250.3500 112983.9000 17627.4700 48879.7800 44930.8600 27826.6600 Biliverdin Biliverdin 9318.5400 13021.8100 106150.3000 9651.1950 7945.4960 7740.8540 1622.4640 1523.4780 6316.4880 6256.1140 2495.3750 4764.2250 Choline Choline 48795390 50019910 73107540 35133060 32071610 26661400 32782600 25569720 32883630 22480550 17893540 35258900 Creatinine Creatinine 1436770 3341532 2254314 1396172 1219089 1380517 1662436 1512549 1349851 1472554 1309160 1636442 Cytosine Cytosine 163622.5000 129270.4000 264669.6000 188648.1000 142906 126128.4000 220827 230447.1000 277055 213864.9000 237007.6000 264417.8000 dAMP dAMP 97352.0600 47291.8500 132928.1000 75801.2600 98182.4100 96857.7500 99980.7100 74255.1500 61913.1700 77077.8700 89315.7400 Dopamine Dopamine 169545.9000 146680.7000 578967.3000 115888.9000 156926.2000 307146.7000 115591.2000 173532.6000 257605 184791.6000 174822.9000 134962.3000 Ectoine Ectoine 27684.7600 55713.9300 273074.1000 102090.1000 56170.6400 50871.4100 14634.1400 34903.0900 57244.3200 52102.4300 51269.5000 49008.5000 gamma-Glutamyl-Se-methylselenocysteine gamma-Glutamyl-Se-methylselenocysteine 543703.6000 587287.9000 1449767 411644.9000 413860.4000 254874.5000 314326.4000 274138.3000 364233.8000 529601.1000 254202 468513.5000 gamma-L-Glutamyl-D-alanine gamma-L-Glutamyl-D-alanine 332354.9000 443817 263645.9000 182618.4000 201247.6000 281555.1000 178320 200629.6000 284367.5000 292966.3000 384674.2000 302831.4000 Glutathione Glutathione 56091.4600 84400.4300 20740.5100 91829.3800 104372.9000 65013.7100 96050.3400 69118.9300 67678.5900 92201.3200 120654.5000 g-Oxalo-crotonate 4-Oxalocrotonic acid 9906.2760 1805.8030 280147.4000 8317.3780 477509.6000 1761.7560 2826.3390 2211.3630 4230.6660 6061.4090 Guanine Guanine 309425.7000 299575.8000 188008.5000 329572.2000 185063.8000 371359.8000 163664.7000 202689.1000 380645.3000 290488.2000 369437.6000 248053.7000 Hypoxanthine Hypoxanthine 7492.1150 27802.7300 3180.5490 620432.2000 73982.6200 1610326 33723.4100 3852.2260 27556.0300 38293.9700 21440.1800 56764.9200 Indole Indole 317976.9000 762405.1000 442282.2000 1045774 735925.5000 471665 569273.7000 370244.4000 657745.2000 557853.1000 570600.3000 1088742 Indole-3-acetaldehyde Indoleacetaldehyde 559843.7000 771560.6000 1384869 3702147 4558138 9439970 3497950 3881744 1896672 3144985 3796877 3353858 Indole-3-acetate Indoleacetic acid 66177.8000 164498.9000 24432.2400 758360.4000 279088.5000 233309.4000 318066 216456.1000 273136.5000 439280.1000 241718.4000 416017 kynurenine Kynurenine 200534 133091.5000 522607.8000 208062.1000 146484.7000 149100.9000 130201.7000 240482.9000 165847.8000 178649.4000 113349.6000 211311.1000 L-alanine Alanine 15800180 17823870 10124510 9727420 7813568 9785114 6914096 6264812 14011350 10188390 9498863 10885160 L-arginine Arginine 10072410 7968570 83070.0900 10724460 11478290 16001950 9347515 11710710 13177410 7536732 11971180 8950375 L-Carnitine Carnitine 63273570 81049960 49178340 59571190 65939560 75111200 58971520 57684140 75863740 71475970 96323540 73198220 L-Citrulline Citrulline 1962625 3590712 2089418 1881596 1080799 2342799 1216216 1473773 2100686 1713092 1606462 2086814 L-leucine Leucine 60649590 50899730 97859380 54224510 38984760 62416210 39712310 43805630 65761870 57792040 55802820 48364020 L-lysine Lysine 15903560 13339560 8703347 8966953 7791226 8873349 8570831 10189960 9865579 8399610 7048130 8599469 L-methionine Methionine 8784535 11526430 6571202 8451901 4301808 10089530 4577828 5665624 10508000 9762827 9332828 9452227 L-phenylalanine Phenylalanine 9102805 10560420 10923730 5637410 4708020 6282900 5100652 4834254 6865010 6107718 5984282 5458164 L-proline Proline 33187710 39015810 21818180 19519960 15384850 26806980 13872200 13947240 29187940 31180950 26939960 26125820 L-serine Serine 675409.2000 988892.8000 843850.7000 631259.9000 447863.5000 741096.5000 492246.5000 533911.7000 829390.7000 689088.3000 645170.1000 695450.4000 L-tyrosine Tyrosine 7556930 7760706 9422472 9212229 5725142 11060480 5566007 6164634 10433180 8408149 10199670 8037282 N-Acetyl-L-citrulline N-Acetylcitrulline 23236.9500 30614.5300 48086.9300 85705.4600 46765.0700 40927.7800 35395.9400 37312.6500 41254.5400 38726.0900 36356.6800 85990.9300 N-Acetylornithine N-Acetylornithine 34393.9800 114804 189982 135282.2000 117230.9000 192592.9000 98598.6900 123074.7000 166199.9000 152911 168892 126331 N-formyl kynurenine N-Formyl-L-kynurenine 4038.5290 4954.5320 10519.5500 5668.6660 3093.2700 2703.9310 1445.9370 3662.7010 3306.9860 13855.1100 1813.1130 8408.3710 Nicotinamide Niacinamide 385321.8000 578533.7000 969605.2000 1088308 629711.2000 775183.9000 850044.8000 547503.4000 1112353 1042039 805212 1043478 N-Methylethanolamine phosphate N-Methylethanolamine phosphate 480895.9000 675759.6000 317641.2000 831558.5000 866384.2000 480081 892771.7000 565028.6000 1036315 859373.6000 853334.8000 1044117 Ornithine Ornithine 2102211 2121771 4665136 1524641 1247577 883961.8000 1204048 972127.2000 1279171 1706421 879524.5000 1729809 Pantetheine Pantetheine 73031.0900 203557.8000 33425.4300 67620.2700 36157.5300 46409.2100 29840.0200 19149.4400 94856.8200 74963.8500 54639.7900 70790.8200 Pantothenate Pantothenic acid 1529633 2954867 2698430 1047119 1193088 819113.8000 950983.8000 549223.6000 1088994 1025729 835644.1000 1245671 Phosphocreatine Phosphocreatine 75725.6200 85472.4400 580740.1000 76659.8500 72173.4600 66659.7900 111318.8000 94595.6200 77583.1000 66163.9100 79382.4800 67461.3400 Picolinic acid Picolinic acid 1819966 1382315 2220762 1786794 1056265 1001100 2225247 1750721 773898.4000 1689423 1245171 1133048 Putrescine Putrescine 101879.7000 94124.5000 147376.5000 55834.0300 53945 40963.1800 96408.8500 57566.1000 43507 41174.2900 52764.2400 79081.6600 Pyridoxal Pyridoxal 119841.3000 235678.7000 39321.2500 166709.4000 150732 235085.5000 134958.6000 126114.7000 168142.1000 113673 188137.8000 205073.5000 Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 678651.9000 423833.5000 446164.2000 706080.4000 1014012 1414514 732274.7000 1056494 1201684 922773.2000 1085519 966741.1000 Serotonin Serotonin 119632.7000 198431.8000 364958.6000 755204.7000 895619.8000 2011971 653385.7000 728284.3000 441343.2000 690961.2000 796913.4000 733384.7000 Spermidine Spermidine 98988.1600 109570.2000 275782.3000 349921.7000 99951.7100 63999.5900 113919.6000 71798.2300 84679.2000 124500 109125.9000 152701.3000 Sphingosine Sphingosine 50205.6800 48972.5400 95328.6000 96130.3400 34062.6800 50792.3000 47239.8800 18323.6800 36438.6700 55969.3800 36503.6800 44736.2400 Sphingosine 1-phosphate Sphingosine 1-phosphate 39871.0800 41913.1400 24401.7800 9655.7160 28006.8600 33446.4500 16758.5500 39476.7900 37653.3200 34830.9900 41823.2300 28532.4000 Thymine Thymine 142060.4000 127700.6000 113148.1000 136582.8000 128648.1000 85585.0500 78658.1200 86233.6800 95456.3200 92385.8400 84463.8400 99233.8400 Uracil Uracil 252328.2000 304603 282062.5000 502016 317565 156197.4000 396249.6000 231251.9000 302982.2000 379457.6000 313446.7000 467565.2000 Xanthine Xanthine 133303.9000 131521.4000 178725 2635677 83981.0700 919966.8000 153787.2000 152374.5000 71894.4700 116841.2000 87449.2700 83772.4800