Metabolite_name	RefMet_name	11	12	15	6	2	4B	5B	9	1	10	14	1B	3B	4	13	2B	3	5	8
Factors	-	sex:F | genetic status:KO	sex:F | genetic status:KO	sex:F | genetic status:KO	sex:F | genetic status:KO	sex:F | genetic status:WT	sex:F | genetic status:WT	sex:F | genetic status:WT	sex:F | genetic status:WT	sex:M | genetic status:KO	sex:M | genetic status:KO	sex:M | genetic status:KO	sex:M | genetic status:KO	sex:M | genetic status:KO	sex:M | genetic status:KO	sex:M | genetic status:WT	sex:M | genetic status:WT	sex:M | genetic status:WT	sex:M | genetic status:WT	sex:M | genetic status:WT
1-3-Bisphosphoglycerate	3-Phospho-D-glyceroyl dihydrogen phosphate	17610	6940	8979	3096	3982	13781	4089	16671	7640	9026	6630	4046	8392	4058	7479	2491	7431	3904	8296
2^_3^-Cyclic CMP	2',3' cyclic CMP	2900	12327	9204	5240	3753	12737	6897	5866	8135	7813	4107	5986	3145	7394	3351	10922	7289	4821	3564
2/3-Phospho-D-glycerate	2-Phosphoglyceric acid	56979	68236	114640	34368	44300	195552	44295	42779	73139	47877	50090	40450	42749	42992	21971	26330	31103	54950	18351
2-Hydroxyglutarate/Citramalate	2-Hydroxyglutaric acid	833410	903762	838069	589020	766636	877957	517767	776926	735390	847569	790506	626172	632629	838307	632432	509855	708757	711883	687974
2-Oxoglutaramate	2-Keto-glutaramic acid	13221	9273	9712	4374	13781	11589	8570	7762	3603	11480	14033	4842	9216	16301	12448	2240	9243	6181	13789
2-Oxoglutarate	2-Oxoglutaric acid	359162	470831	346524	256013	409667	509002	436414	371178	430935	432364	378102	396068	542461	303062	435540	499373	438916	447326	382146
3^_5^-Cyclic AMP	3',5' cyclic AMP	18359	17209	17828	11408	17714	29498	14978	13335	19596	20246	22424	15179	23659	18520	16982	14745	14684	24459	21268
3-Phosphonooxypyruvate	Phosphohydroxypyruvic acid	117038	64728	61388	77959	79876	77180	63023	82366	62991	72658	72868	59725	54092	74845	67313	61693	68475	92193	59043
4-Acetamidobutanoate	4-Acetamidobutanoic acid	7197	14608	11184	3697	9649	8446	3960	4357	3353	3344	6249	10958	18903	8313	2808	6509	4223	8586	7508
5-6-Dihydrothymine	Dihydrothymine	951298	1358746	1062685	1143042	1134018	1820636	2038532	1659118	1120711	1556641	861316	1680465	1493053	1127561	972275	1668446	1233315	1188775	1224503
5-Hydroxyindoleacetate	5-Hydroxyindoleacetic acid	48099	65461	72993	64013	96889	60351	105638	76479	75715	86730	88632	70010	111046	68968	108586	161579	96513	76509	96995
5-L-Glutamyl-taurine	5-L-Glutamyl-taurine	55988	65494	71360	44487	66171	52533	60157	61948	53568	65995	58441	50622	44399	62946	58104	46040	69389	78404	52047
(7Z-10Z-13Z-16Z-19Z)-Docosa-7-10-13-16-19-pentaenoic acid	DPA	69709	185984	149214	175141	145037	91791	166847	137362	140151	121289	132400	108785	155689	142616	176054	342372	134569	160946	192879
(8Z-11Z-14Z)-Icosatrienoic acid	Dihomo-gamma-linolenic acid	171219	253295	417423	260899	335456	123110	242920	285988	337073	267486	289650	237824	274912	314495	336083	480130	252426	333828	363290
Adenine	Adenine	23882	17963	13142	19274	24454	123822	24607	14707	23139	19909	19650	22471	27985	18554	23550	21226	17750	17138	20316
ADP	ADP	159564	247037	282931	172894	174204	403172	186356	96318	312636	266858	229014	170798	204358	176415	215276	194303	163436	276308	113801
alpha-D-Glucosamine 1-phosphate	Glucosamine 1-phosphate	53325	62578	39854	42073	51764	66659	67947	61179	44060	77576	62047	66730	46809	43058	85235	67177	45271	59689	62870
alpha-D-Ribose 1-phosphate	Ribose 1-phosphate	2270155	2250566	2027112	2806403	2809857	958296	2630469	2351740	2679889	3222369	3121066	2512350	2856184	1427182	3837386	2362576	1738346	2462984	2469375
Ascorbate	Vitamin C	2572418	4555144	5418976	9234214	13079530	5639372	7779614	2530170	5457002	5184746	7077418	9977248	4101078	7980398	6725586	6175896	3855263	11152060	2514904
ATP	ATP	5456	2767	2388	2872	4068	2429	1427	1056	1386	2138	1331	1697	1754	2464	2507	2779	996	4291	1216
Bis-gamma-glutamylcystine	Bis-gamma-glutamylcystine	66849	62573	73731	64999	50233	106319	25993	36905	28473	39809	57944	43361	36298	17938	20531	29616	37997	76540	46143
Butanoic acid	Butyric acid	59677	101494	98235	89040	54721	90195	90142	64520	115261	89797	83417	65573	108136	49225	123821	79251	75857	32952	131002
Carnosine	Carnosine	147058	166290	133708	123941	210705	283423	324927	156147	183293	155796	188568	287377	322957	105616	132282	232381	116550	185599	170439
CDP-choline	CDP-choline	7828	23862	8951	10219	10545	25611	20766	22131	13603	16563	8613	29440	16100	21537	3716	23028	13030	27001	9554
Citrate	Citric acid	1174778	2995822	3550006	2313846	2803388	2182521	3043761	2116640	2423268	3174525	2978397	2968153	3888857	3348617	2454023	3082795	2936611	3299230	1533486
CMP-N-acetylneuraminate	CMP-N-acetylneuraminic acid	100655	120045	124868	132829	113931	155622	123300	79967	104097	83555	107651	128472	127417	147562	111148	154877	118701	128403	101333
D-Arabitol	Arabitol	83281	105927	97010	84956	74719	112560	93768	91796	96347	108833	104998	102241	112166	94103	84682	104480	76568	92189	76855
dCMP	dCMP	21680	29338	33328	16929	21739	38770	28946	21667	27051	30491	25201	19950	27238	22871	23342	20753	31074	24562	25167
Dehydroascorbate	L-Dehydroascorbic acid	1905033	2267122	1770248	1469061	2324278	2705859	2204051	1824975	2378826	2337051	2036549	2262830	2757686	1684942	2355039	2754502	2514172	2435541	2079867
D-Erythrose 4-phosphate	Erythrose 4-phosphate	46738	38590	36926	72224	83414	37261	73980	45966	41246	51518	82023	70096	77116	38112	221285	67246	46514	72897	60609
D-Fructose 1-6-bisphosphate	Fructose 1,6-bisphosphate	15924	19332	6464	16652	31121	16365	20735	11243	13125	16317	15312	15278	30337	30700	122985	43232	14573	27113	14422
D-Glucose	Glucose	6326412	10622510	10192610	6555940	6369864	8062070	6349724	14164090	8031094	9410031	8279776	5208168	7092866	7653490	5731712	8413204	7073190	7493210	8872997
Diphosphate	Pyrophosphate	2545558	2313991	2417049	2333636	2782235	3026821	3185798	2322468	2246984	2166432	2742389	2848500	2485940	2622463	1677411	3938086	2676282	2816459	1328381
Docosahexaenoic acid	Docosahexaenoic acid	1633724	1756368	2143392	2387292	2253824	1076797	2737675	1735175	1513043	1508382	1998411	1948757	2360035	3159823	1926539	3257455	1927849	2340664	1805036
Dodecanoic acid	Lauric acid	146941	319266	248815	234557	330050	110296	180498	224575	234882	252630	213116	143197	147485	220460	444796	139529	161863	338308	266875
D-Rhamnose	Rhamnose	138837	160691	110641	61448	79499	136407	99298	135167	67074	99167	90309	99400	128730	47639	34234	104488	61789	50594	80978
D-Ribose	Ribose	43206	38772	37934	41067	50038	50286	43611	40187	38670	40390	49015	47276	67397	49447	52069	77459	36622	47914	31551
dTMP	dTMP	8919	13067	8566	11330	3976	12142	2803	5463	11662	3227	12220	4013	4389	3249	10569	5261	3568	11320	2978
Eicosapentaenoic acid	Eicosapentaenoic acid	30007	31593	31727	29102	31720	15459	32411	25354	17899	26785	23328	19940	29906	41253	30623	36783	20045	27170	26130
Eicosatetraenoic acid	Eicosatetraenoic acid	6649906	4538442	5501184	5843278	7818840	3727408	8778577	5817524	5660052	5413504	6311388	7448984	11026570	6366342	8408349	16867290	4927624	7814178	7077200
Ethanolamine phosphate	Phosphoethanolamine	5658118	7984820	9510389	7767922	8159838	7419518	6045440	7577644	8091726	8253578	8669698	6135156	6139928	7159932	8330810	6864282	7903518	7954510	7471246
Fumarate	Fumaric acid	617010	734220	878895	702226	1066418	955627	1168586	814567	733482	928517	1128853	1051066	1333552	1145712	1030934	1264691	1100628	834770	641027
gamma-L-Glutamyl-D-alanine	gamma-L-Glutamyl-D-alanine	7981	13681	18138	11502	31400	24199	39612	27983	16154	18192	20651	27072	33825	17629	6490	38595	23117	21530	6213
Glycerol 3-phosphate	sn-Glycero-3-phosphate	235350	319005	728553	164302	151745	130794	340027	307608	213699	304032	251564	213692	185400	178735	192643	187431	187562	153859	202394
Hexadecanoic acid	Palmitic acid	6743124	7176504	7964956	6230430	8432108	5366705	11295570	9399421	11940610	8041390	7960582	8662827	8283690	7538520	15415560	9200345	7323042	5710924	11934330
Hexanoic acid (caproate)	Caproic acid	340937	262716	310409	240528	196264	231344	228034	325061	330734	306259	245263	240753	348030	216418	501912	329315	197487	192211	421160
Homocarnosine	Homocarnosine	105679	91278	89832	97489	130822	429534	444561	60520	183239	98819	121579	428252	380756	91857	71396	347727	79389	146952	103981
Lactate	Lactic acid	41268480	54316350	72730740	60395190	74025780	44633340	71539750	59464400	61509420	61307820	63361280	75425370	70620610	60112810	50847200	85472360	70940740	65937840	63116520
Linoleate	Linoleic acid	344461	798284	870816	667024	1009445	457027	650882	762524	717038	780930	744925	638757	711324	601433	949693	1480590	636097	885412	891145
Malate	Malic acid	4315850	6075402	8339410	7025006	9060457	10078550	9595483	6461508	6720500	7847980	7971806	8917365	9871153	9279680	8511321	10066440	8795489	5880798	5055006
Maltose	Maltose	5112	11277	14563	9385	16271	7905	25615	20268	28667	16915	9791	17416	18847	12946	23386	19525	11110	11251	34715
Mannitol	Mannitol	169392	219145	194984	192191	192627	269635	210884	207802	267147	250142	223368	230467	252863	217237	185958	313102	194773	180967	182464
N-Acetylneuraminate	N-Acetylneuraminic acid	1509302	1603202	1312844	1390564	1664129	2019253	1793048	1571337	1648077	1799026	1670683	1555132	1641787	1560220	1654627	1717922	1677837	1674758	1780650
N-Acetylornithine	N-Acetylornithine	65087	13635	15008	9372	12531	26024	31017	26939	10784	18434	12864	23398	24221	25587	10825	30873	25962	18068	14711
N-Methylethanolamine phosphate	N-Methylethanolamine phosphate	8742	28806	16787	10955	7748	11042	795	13595	23330	10152	16139	8883	9519	11375	8421	6001	25060	11735	7382
Octadecanoic acid	Stearic acid	3240471	2976108	2428889	3332683	3661498	2273320	3691680	2803624	5052164	2706390	2222747	2505899	4375918	2641468	5243246	2851051	2895140	3894447	3423839
Octadecatrienoic acid	Octadecatrienoic acid	46433	61735	64775	63660	70711	34847	62517	50411	37571	50365	51577	47501	53820	81538	64819	65898	51430	58828	52044
Octadecenoic acid	Octadecenoic acid	3284460	3781596	4319114	5291938	4916312	3167321	5654198	3769320	4064665	4187412	4353150	5879838	5798886	5389770	5514896	8542063	5300146	4982924	5088892
Pantetheine	Pantetheine	2992	3614	7199	11502	8059	3760	13145	7178	6630	4101	8873	5769	6746	9505	9078	12018	9861	8241	6797
Pantothenol	Pantothenol	1567777	1779488	1626899	1573365	1314271	1724657	1169147	1714307	1922743	2058599	1468397	1326152	1467918	1741758	1822408	1667125	1298854	1499832	1813038
Pyridoxamine 5^-phosphate	Pyridoxamine 5'-phosphate	5487	10554	3775	5842	5325	7095	16320	15397	5639	12619	7395	14753	6905	15664	12321	14612	8658	8063	16982
Pyruvate	Pyruvic acid	835259	851445	761529	761349	789865	1918596	718970	867858	683058	1024821	878040	1169054	828945	1284593	592786	637054	894181	835335	658627
quinolinic acid	Quinolinic acid	309466	401051	406741	351245	354253	331004	242563	409269	315719	389797	294309	302372	285473	416915	430830	290800	343538	355040	273490
(S)(+)-Allantoin	Allantoin	408020	456428	504900	400672	392036	333683	222222	474487	318524	412001	487039	251168	331801	464562	296109	277814	394179	399987	378164
S-Glutathionyl-L-cysteine	S-Glutathionyl-cysteine	62201	65141	164250	111190	117036	40698	154861	92554	60494	64763	84749	137725	192128	75972	100899	284346	87258	105609	80124
Sphingosine 1-phosphate	Sphingosine 1-phosphate	10674	10363	14811	23434	23038	9725	21090	13137	17449	14418	17892	24045	20143	21271	21156	20547	17506	19078	20295
Succinate	Succinic acid	2844581	2688528	1921556	626957	667462	4872072	670575	860569	1777237	1993547	770871	808324	640419	595362	626123	557418	755393	721522	894370
Taurine	Taurine	147424700	170790500	150563200	164685500	159710000	149463900	167316100	182132100	164659800	187246700	147557100	158604500	162767600	186842500	163937100	171443900	185897900	165561300	165926300
Tetradecanoic acid	Myristic acid	804657	771784	829414	636246	763444	499705	745208	806536	881928	670882	751467	658972	715395	680385	1280626	1035345	693430	849393	957210
Tetradecenoic acid	Tetradecenoic acid	40627	44869	42792	42212	50603	31899	51203	41076	43358	34931	39698	34473	41966	47309	50133	32927	33756	54865	40243
Thymidine	Thymidine	57219	76814	78830	35852	31475	62567	44443	61772	68848	81239	46984	23834	27501	32711	40667	50625	55077	46768	62248
trans-4-Hydroxy-L-proline	trans-4-Hydroxyproline	3287842	3879434	3785388	4073681	4147197	5329945	4802766	3336089	3778387	3699713	3658208	4498072	4005296	4095633	3369591	4577290	3798711	3973180	3155142
UDP	UDP	71144	312444	334756	119940	87272	222751	172818	202098	249883	325420	208373	155779	425101	89707	265055	221572	217664	140218	298987
UDP-glucose	UDP-glucose	906755	1094009	1201408	890863	973649	1197260	888261	747962	797648	1043961	1013957	984135	885720	1009760	1092949	828834	913850	1206025	863360
UDP-N-acetyl-D-glucosamine	UDP-N-acetylglucosamine	884453	958555	1017610	876626	1006344	1050004	880268	698975	757862	912785	924552	914199	821253	1141298	944465	877373	853318	1028126	806126
UMP	UMP	2418894	2692203	1901694	2006782	1630021	2679521	1485859	1801532	2031066	2276923	2240977	1422959	1443761	1140998	2336480	1117313	1721796	1674128	1730714
Urate	Uric acid	19441	19183	32213	36261	92860	27475	37166	27280	26896	33700	24903	28109	34499	39054	33799	34669	18226	37755	18778
Xanthine	Xanthine	281537	298608	538716	392454	662415	419440	1070410	487166	386886	359160	510091	695741	839987	795738	641669	1708243	567921	585349	453784