Metabolite_name RefMet_name 11 12 15 6 2 4B 5B 9 1 10 14 1B 3B 4 13 2B 3 5 8 Factors - sex:F | genetic status:KO sex:F | genetic status:KO sex:F | genetic status:KO sex:F | genetic status:KO sex:F | genetic status:WT sex:F | genetic status:WT sex:F | genetic status:WT sex:F | genetic status:WT sex:M | genetic status:KO sex:M | genetic status:KO sex:M | genetic status:KO sex:M | genetic status:KO sex:M | genetic status:KO sex:M | genetic status:KO sex:M | genetic status:WT sex:M | genetic status:WT sex:M | genetic status:WT sex:M | genetic status:WT sex:M | genetic status:WT 1-3-Bisphosphoglycerate 3-Phospho-D-glyceroyl dihydrogen phosphate 17610 6940 8979 3096 3982 13781 4089 16671 7640 9026 6630 4046 8392 4058 7479 2491 7431 3904 8296 2^_3^-Cyclic CMP 2',3' cyclic CMP 2900 12327 9204 5240 3753 12737 6897 5866 8135 7813 4107 5986 3145 7394 3351 10922 7289 4821 3564 2/3-Phospho-D-glycerate 2-Phosphoglyceric acid 56979 68236 114640 34368 44300 195552 44295 42779 73139 47877 50090 40450 42749 42992 21971 26330 31103 54950 18351 2-Hydroxyglutarate/Citramalate 2-Hydroxyglutaric acid 833410 903762 838069 589020 766636 877957 517767 776926 735390 847569 790506 626172 632629 838307 632432 509855 708757 711883 687974 2-Oxoglutaramate 2-Keto-glutaramic acid 13221 9273 9712 4374 13781 11589 8570 7762 3603 11480 14033 4842 9216 16301 12448 2240 9243 6181 13789 2-Oxoglutarate 2-Oxoglutaric acid 359162 470831 346524 256013 409667 509002 436414 371178 430935 432364 378102 396068 542461 303062 435540 499373 438916 447326 382146 3^_5^-Cyclic AMP 3',5' cyclic AMP 18359 17209 17828 11408 17714 29498 14978 13335 19596 20246 22424 15179 23659 18520 16982 14745 14684 24459 21268 3-Phosphonooxypyruvate Phosphohydroxypyruvic acid 117038 64728 61388 77959 79876 77180 63023 82366 62991 72658 72868 59725 54092 74845 67313 61693 68475 92193 59043 4-Acetamidobutanoate 4-Acetamidobutanoic acid 7197 14608 11184 3697 9649 8446 3960 4357 3353 3344 6249 10958 18903 8313 2808 6509 4223 8586 7508 5-6-Dihydrothymine Dihydrothymine 951298 1358746 1062685 1143042 1134018 1820636 2038532 1659118 1120711 1556641 861316 1680465 1493053 1127561 972275 1668446 1233315 1188775 1224503 5-Hydroxyindoleacetate 5-Hydroxyindoleacetic acid 48099 65461 72993 64013 96889 60351 105638 76479 75715 86730 88632 70010 111046 68968 108586 161579 96513 76509 96995 5-L-Glutamyl-taurine 5-L-Glutamyl-taurine 55988 65494 71360 44487 66171 52533 60157 61948 53568 65995 58441 50622 44399 62946 58104 46040 69389 78404 52047 (7Z-10Z-13Z-16Z-19Z)-Docosa-7-10-13-16-19-pentaenoic acid DPA 69709 185984 149214 175141 145037 91791 166847 137362 140151 121289 132400 108785 155689 142616 176054 342372 134569 160946 192879 (8Z-11Z-14Z)-Icosatrienoic acid Dihomo-gamma-linolenic acid 171219 253295 417423 260899 335456 123110 242920 285988 337073 267486 289650 237824 274912 314495 336083 480130 252426 333828 363290 Adenine Adenine 23882 17963 13142 19274 24454 123822 24607 14707 23139 19909 19650 22471 27985 18554 23550 21226 17750 17138 20316 ADP ADP 159564 247037 282931 172894 174204 403172 186356 96318 312636 266858 229014 170798 204358 176415 215276 194303 163436 276308 113801 alpha-D-Glucosamine 1-phosphate Glucosamine 1-phosphate 53325 62578 39854 42073 51764 66659 67947 61179 44060 77576 62047 66730 46809 43058 85235 67177 45271 59689 62870 alpha-D-Ribose 1-phosphate Ribose 1-phosphate 2270155 2250566 2027112 2806403 2809857 958296 2630469 2351740 2679889 3222369 3121066 2512350 2856184 1427182 3837386 2362576 1738346 2462984 2469375 Ascorbate Vitamin C 2572418 4555144 5418976 9234214 13079530 5639372 7779614 2530170 5457002 5184746 7077418 9977248 4101078 7980398 6725586 6175896 3855263 11152060 2514904 ATP ATP 5456 2767 2388 2872 4068 2429 1427 1056 1386 2138 1331 1697 1754 2464 2507 2779 996 4291 1216 Bis-gamma-glutamylcystine Bis-gamma-glutamylcystine 66849 62573 73731 64999 50233 106319 25993 36905 28473 39809 57944 43361 36298 17938 20531 29616 37997 76540 46143 Butanoic acid Butyric acid 59677 101494 98235 89040 54721 90195 90142 64520 115261 89797 83417 65573 108136 49225 123821 79251 75857 32952 131002 Carnosine Carnosine 147058 166290 133708 123941 210705 283423 324927 156147 183293 155796 188568 287377 322957 105616 132282 232381 116550 185599 170439 CDP-choline CDP-choline 7828 23862 8951 10219 10545 25611 20766 22131 13603 16563 8613 29440 16100 21537 3716 23028 13030 27001 9554 Citrate Citric acid 1174778 2995822 3550006 2313846 2803388 2182521 3043761 2116640 2423268 3174525 2978397 2968153 3888857 3348617 2454023 3082795 2936611 3299230 1533486 CMP-N-acetylneuraminate CMP-N-acetylneuraminic acid 100655 120045 124868 132829 113931 155622 123300 79967 104097 83555 107651 128472 127417 147562 111148 154877 118701 128403 101333 D-Arabitol Arabitol 83281 105927 97010 84956 74719 112560 93768 91796 96347 108833 104998 102241 112166 94103 84682 104480 76568 92189 76855 dCMP dCMP 21680 29338 33328 16929 21739 38770 28946 21667 27051 30491 25201 19950 27238 22871 23342 20753 31074 24562 25167 Dehydroascorbate L-Dehydroascorbic acid 1905033 2267122 1770248 1469061 2324278 2705859 2204051 1824975 2378826 2337051 2036549 2262830 2757686 1684942 2355039 2754502 2514172 2435541 2079867 D-Erythrose 4-phosphate Erythrose 4-phosphate 46738 38590 36926 72224 83414 37261 73980 45966 41246 51518 82023 70096 77116 38112 221285 67246 46514 72897 60609 D-Fructose 1-6-bisphosphate Fructose 1,6-bisphosphate 15924 19332 6464 16652 31121 16365 20735 11243 13125 16317 15312 15278 30337 30700 122985 43232 14573 27113 14422 D-Glucose Glucose 6326412 10622510 10192610 6555940 6369864 8062070 6349724 14164090 8031094 9410031 8279776 5208168 7092866 7653490 5731712 8413204 7073190 7493210 8872997 Diphosphate Pyrophosphate 2545558 2313991 2417049 2333636 2782235 3026821 3185798 2322468 2246984 2166432 2742389 2848500 2485940 2622463 1677411 3938086 2676282 2816459 1328381 Docosahexaenoic acid Docosahexaenoic acid 1633724 1756368 2143392 2387292 2253824 1076797 2737675 1735175 1513043 1508382 1998411 1948757 2360035 3159823 1926539 3257455 1927849 2340664 1805036 Dodecanoic acid Lauric acid 146941 319266 248815 234557 330050 110296 180498 224575 234882 252630 213116 143197 147485 220460 444796 139529 161863 338308 266875 D-Rhamnose Rhamnose 138837 160691 110641 61448 79499 136407 99298 135167 67074 99167 90309 99400 128730 47639 34234 104488 61789 50594 80978 D-Ribose Ribose 43206 38772 37934 41067 50038 50286 43611 40187 38670 40390 49015 47276 67397 49447 52069 77459 36622 47914 31551 dTMP dTMP 8919 13067 8566 11330 3976 12142 2803 5463 11662 3227 12220 4013 4389 3249 10569 5261 3568 11320 2978 Eicosapentaenoic acid Eicosapentaenoic acid 30007 31593 31727 29102 31720 15459 32411 25354 17899 26785 23328 19940 29906 41253 30623 36783 20045 27170 26130 Eicosatetraenoic acid Eicosatetraenoic acid 6649906 4538442 5501184 5843278 7818840 3727408 8778577 5817524 5660052 5413504 6311388 7448984 11026570 6366342 8408349 16867290 4927624 7814178 7077200 Ethanolamine phosphate Phosphoethanolamine 5658118 7984820 9510389 7767922 8159838 7419518 6045440 7577644 8091726 8253578 8669698 6135156 6139928 7159932 8330810 6864282 7903518 7954510 7471246 Fumarate Fumaric acid 617010 734220 878895 702226 1066418 955627 1168586 814567 733482 928517 1128853 1051066 1333552 1145712 1030934 1264691 1100628 834770 641027 gamma-L-Glutamyl-D-alanine gamma-L-Glutamyl-D-alanine 7981 13681 18138 11502 31400 24199 39612 27983 16154 18192 20651 27072 33825 17629 6490 38595 23117 21530 6213 Glycerol 3-phosphate sn-Glycero-3-phosphate 235350 319005 728553 164302 151745 130794 340027 307608 213699 304032 251564 213692 185400 178735 192643 187431 187562 153859 202394 Hexadecanoic acid Palmitic acid 6743124 7176504 7964956 6230430 8432108 5366705 11295570 9399421 11940610 8041390 7960582 8662827 8283690 7538520 15415560 9200345 7323042 5710924 11934330 Hexanoic acid (caproate) Caproic acid 340937 262716 310409 240528 196264 231344 228034 325061 330734 306259 245263 240753 348030 216418 501912 329315 197487 192211 421160 Homocarnosine Homocarnosine 105679 91278 89832 97489 130822 429534 444561 60520 183239 98819 121579 428252 380756 91857 71396 347727 79389 146952 103981 Lactate Lactic acid 41268480 54316350 72730740 60395190 74025780 44633340 71539750 59464400 61509420 61307820 63361280 75425370 70620610 60112810 50847200 85472360 70940740 65937840 63116520 Linoleate Linoleic acid 344461 798284 870816 667024 1009445 457027 650882 762524 717038 780930 744925 638757 711324 601433 949693 1480590 636097 885412 891145 Malate Malic acid 4315850 6075402 8339410 7025006 9060457 10078550 9595483 6461508 6720500 7847980 7971806 8917365 9871153 9279680 8511321 10066440 8795489 5880798 5055006 Maltose Maltose 5112 11277 14563 9385 16271 7905 25615 20268 28667 16915 9791 17416 18847 12946 23386 19525 11110 11251 34715 Mannitol Mannitol 169392 219145 194984 192191 192627 269635 210884 207802 267147 250142 223368 230467 252863 217237 185958 313102 194773 180967 182464 N-Acetylneuraminate N-Acetylneuraminic acid 1509302 1603202 1312844 1390564 1664129 2019253 1793048 1571337 1648077 1799026 1670683 1555132 1641787 1560220 1654627 1717922 1677837 1674758 1780650 N-Acetylornithine N-Acetylornithine 65087 13635 15008 9372 12531 26024 31017 26939 10784 18434 12864 23398 24221 25587 10825 30873 25962 18068 14711 N-Methylethanolamine phosphate N-Methylethanolamine phosphate 8742 28806 16787 10955 7748 11042 795 13595 23330 10152 16139 8883 9519 11375 8421 6001 25060 11735 7382 Octadecanoic acid Stearic acid 3240471 2976108 2428889 3332683 3661498 2273320 3691680 2803624 5052164 2706390 2222747 2505899 4375918 2641468 5243246 2851051 2895140 3894447 3423839 Octadecatrienoic acid Octadecatrienoic acid 46433 61735 64775 63660 70711 34847 62517 50411 37571 50365 51577 47501 53820 81538 64819 65898 51430 58828 52044 Octadecenoic acid Octadecenoic acid 3284460 3781596 4319114 5291938 4916312 3167321 5654198 3769320 4064665 4187412 4353150 5879838 5798886 5389770 5514896 8542063 5300146 4982924 5088892 Pantetheine Pantetheine 2992 3614 7199 11502 8059 3760 13145 7178 6630 4101 8873 5769 6746 9505 9078 12018 9861 8241 6797 Pantothenol Pantothenol 1567777 1779488 1626899 1573365 1314271 1724657 1169147 1714307 1922743 2058599 1468397 1326152 1467918 1741758 1822408 1667125 1298854 1499832 1813038 Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 5487 10554 3775 5842 5325 7095 16320 15397 5639 12619 7395 14753 6905 15664 12321 14612 8658 8063 16982 Pyruvate Pyruvic acid 835259 851445 761529 761349 789865 1918596 718970 867858 683058 1024821 878040 1169054 828945 1284593 592786 637054 894181 835335 658627 quinolinic acid Quinolinic acid 309466 401051 406741 351245 354253 331004 242563 409269 315719 389797 294309 302372 285473 416915 430830 290800 343538 355040 273490 (S)(+)-Allantoin Allantoin 408020 456428 504900 400672 392036 333683 222222 474487 318524 412001 487039 251168 331801 464562 296109 277814 394179 399987 378164 S-Glutathionyl-L-cysteine S-Glutathionyl-cysteine 62201 65141 164250 111190 117036 40698 154861 92554 60494 64763 84749 137725 192128 75972 100899 284346 87258 105609 80124 Sphingosine 1-phosphate Sphingosine 1-phosphate 10674 10363 14811 23434 23038 9725 21090 13137 17449 14418 17892 24045 20143 21271 21156 20547 17506 19078 20295 Succinate Succinic acid 2844581 2688528 1921556 626957 667462 4872072 670575 860569 1777237 1993547 770871 808324 640419 595362 626123 557418 755393 721522 894370 Taurine Taurine 147424700 170790500 150563200 164685500 159710000 149463900 167316100 182132100 164659800 187246700 147557100 158604500 162767600 186842500 163937100 171443900 185897900 165561300 165926300 Tetradecanoic acid Myristic acid 804657 771784 829414 636246 763444 499705 745208 806536 881928 670882 751467 658972 715395 680385 1280626 1035345 693430 849393 957210 Tetradecenoic acid Tetradecenoic acid 40627 44869 42792 42212 50603 31899 51203 41076 43358 34931 39698 34473 41966 47309 50133 32927 33756 54865 40243 Thymidine Thymidine 57219 76814 78830 35852 31475 62567 44443 61772 68848 81239 46984 23834 27501 32711 40667 50625 55077 46768 62248 trans-4-Hydroxy-L-proline trans-4-Hydroxyproline 3287842 3879434 3785388 4073681 4147197 5329945 4802766 3336089 3778387 3699713 3658208 4498072 4005296 4095633 3369591 4577290 3798711 3973180 3155142 UDP UDP 71144 312444 334756 119940 87272 222751 172818 202098 249883 325420 208373 155779 425101 89707 265055 221572 217664 140218 298987 UDP-glucose UDP-glucose 906755 1094009 1201408 890863 973649 1197260 888261 747962 797648 1043961 1013957 984135 885720 1009760 1092949 828834 913850 1206025 863360 UDP-N-acetyl-D-glucosamine UDP-N-acetylglucosamine 884453 958555 1017610 876626 1006344 1050004 880268 698975 757862 912785 924552 914199 821253 1141298 944465 877373 853318 1028126 806126 UMP UMP 2418894 2692203 1901694 2006782 1630021 2679521 1485859 1801532 2031066 2276923 2240977 1422959 1443761 1140998 2336480 1117313 1721796 1674128 1730714 Urate Uric acid 19441 19183 32213 36261 92860 27475 37166 27280 26896 33700 24903 28109 34499 39054 33799 34669 18226 37755 18778 Xanthine Xanthine 281537 298608 538716 392454 662415 419440 1070410 487166 386886 359160 510091 695741 839987 795738 641669 1708243 567921 585349 453784