Metabolite_name	RefMet_name	HSC_sot_ND_1	HSC_sot_ND_2	HSC_sot_ND_3	HSC_sot_ND_0h_1	HSC_sot_ND_0h_2	HSC_sot_ND_0h_3	HSC_sot_ND_12h_1	HSC_sot_ND_12h_2	HSC_sot_ND_12h_3	HSC_sot_ND_6h_1	HSC_sot_ND_6h_2	HSC_sot_ND_6h_3	HSC_sot_NR_1	HSC_sot_NR_2	HSC_sot_NR_3	HSC_sot_NR_0h_1	HSC_sot_NR_0h_2	HSC_sot_NR_0h_3	HSC_sot_NR_12h_1	HSC_sot_NR_12h_2	HSC_sot_NR_12h_3	HSC_sot_NR_6h_1	HSC_sot_NR_6h_2	HSC_sot_NR_6h_3
Factors	-	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 1 h | Batch:1e | Note:[13C, 15N]AAs were used for AA uptake (FigS6.J)	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 1 h | Batch:1e | Note:[13C, 15N]AAs were used for AA uptake (FigS6.J)	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 1 h | Batch:1e | Note:[13C, 15N]AAs were used for AA uptake (FigS6.J)	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 0 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 0 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 0 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 12 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 12 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 12 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 6 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 6 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:Ctrl, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 6 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 1 h | Batch:1e | Note:[13C, 15N]AAs were used for AA uptake (FigS6.J)	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 1 h | Batch:1e | Note:[13C, 15N]AAs were used for AA uptake (FigS6.J)	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 1 h | Batch:1e | Note:[13C, 15N]AAs were used for AA uptake (FigS6.J)	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 0 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 0 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 0 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 12 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 12 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 12 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 6 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 6 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).	Source_Name[gating]:Lin– Scal1+ c-Kit+ CD48– CD150+ (HSC) | Treatment:NR 1 week, [13C, 15N] AAs were incorporated for 24 h and subsequently washed out for 6 h | Batch:1e | Note:[13C, 15N] AA levels and [13C]TCA substrate levels in different time point were calculated for AA catabolism (Fig5.L).
[13C_ 15N]Alanine_ 2TBDMS	Alanine	331000	317000	310000	3310000	3170000	3100000	875000	921000	830000	1600000	1410000	1360000	332000	299000	312000	3320000	2990000	3120000	753000	727000	691000	1330000	1240000	1290000
[13C_ 15N]Aspartic acid_ 3TBDMS	Aspartic acid	82500	83500	74300	825000	835000	743000	365000	321000	333000	599000	435000	509000	84000	76900	79700	840000	769000	797000	313000	303000	296000	543000	486000	423000
[13C_ 15N]Glutamic acid_ 3TBDMS	Glutamic acid	61300	63800	60700	613000	638000	607000	235000	244000	207000	395000	407000	385000	66700	57100	59100	667000	571000	591000	184000	182000	154000	310000	279000	288000
[13C_ 15N]Glycine_ 2TBDMS	Glycine	51100	63400	50800	6350000	5500000	5380000	3040000	3010000	2070000	3840000	4870000	4100000	58700	59500	57400	6710000	5780000	5350000	3130000	2930000	3380000	3880000	4920000	4900000
[13C_ 15N]Histidine_ 3TBDMS	Histidine	64800	56500	57700	648000	565000	577000	173000	127000	208000	314000	313000	354000	54600	54400	49500	546000	544000	495000	102000	136000	138000	221000	314000	242000
[13C_ 15N]Isoleucine_ 2TBDMS	Isoleucine	328000	306000	281000	3280000	3060000	2810000	1400000	1430000	1100000	2150000	2250000	2140000	296000	384000	357000	2960000	3840000	3570000	1370000	1040000	995000	2270000	2300000	2130000
[13C_ 15N]Leucine_ 2TBDMS	Leucine	369000	353000	318000	3690000	3530000	3180000	1040000	984000	1080000	2120000	2240000	2140000	302000	353000	321000	3020000	3530000	3210000	782000	810000	741000	1460000	1580000	1900000
[13C_ 15N]Lysine_ 3TBDMS	Lysine	148000	139000	133000	1480000	1390000	1330000	594000	551000	585000	813000	786000	796000	134000	142000	166000	1340000	1420000	1660000	466000	441000	464000	766000	780000	837000
[13C_ 15N]Methionine_ 2TBDMS	Methionine	197000	206000	182000	1970000	2060000	1820000	740000	680000	544000	1200000	1180000	927000	200000	220000	173000	2000000	2200000	1730000	501000	575000	607000	1010000	1270000	1040000
[13C_ 15N]Phenylalanine_ 2TBDMS	Phenylalanine	289000	297000	243000	2890000	2970000	2430000	1240000	1380000	1130000	1410000	1520000	1440000	246000	276000	222000	2460000	2760000	2220000	1000000	929000	926000	1360000	1240000	1360000
[13C_ 15N]Proline_ 2TBDMS	Proline	184000	168000	174000	1840000	1680000	1740000	450000	528000	423000	866000	829000	857000	176000	161000	160000	1760000	1610000	1600000	319000	275000	325000	750000	701000	731000
[13C_ 15N]Serine_ 3TBDMS	Serine	321000	324000	282000	3210000	3240000	2820000	964000	851000	886000	2120000	2190000	1860000	347000	311000	356000	3470000	3110000	3560000	712000	793000	822000	1940000	1880000	1650000
[13C_ 15N]Threonine_ 3TBDMS	Threonine	86000	79700	77200	860000	797000	772000	342000	313000	322000	510000	508000	413000	61200	67200	85200	612000	672000	852000	286000	244000	232000	362000	350000	368000
[13C_ 15N]Tyrosine_ 3TBDMS	Tyrosine	798000	774000	724000	7980000	7740000	7240000	2250000	2370000	2940000	4140000	4380000	3180000	730000	698000	740000	7300000	6980000	7400000	2210000	1830000	1850000	3120000	3970000	3320000
[13C_ 15N]Valine_ 2TBDMS	Valine	805000	762000	793000	8050000	7620000	7930000	3210000	2980000	2570000	5270000	4440000	4280000	822000	769000	787000	8220000	7690000	7870000	1790000	2280000	2610000	4020000	4230000	4080000
[13C]Alpha_Ketoglutarate	2-Oxoglutaric acid				2160000	1880000	2000000	34000	37400	41200	26100	28500	30100				23500	20500	21700	50900	51500	50900	33400	32100	35000
[13C]Citrate	Citric acid				45400	42100	39700	81800	80700	86800	70200	69300	69800				48900	55500	46700	107000	90600	95600	82200	84200	82400
[13C]Fumatate	Fumaric acid				173000	176000	142000	343000	315000	342000	244000	249000	275000				159000	138000	138000	364000	354000	367000	293000	276000	285000
[13C]Malate	Malic acid				84900	90700	104000	142000	162000	145000	116000	136000	133000				108000	137000	119000	164000	178000	184000	141000	150000	156000
[13C]Succinate	Succinic acid				128000	135000	113000	213000	235000	231000	192000	160000	185000				108000	111000	123000	247000	246000	267000	209000	192000	206000