Metabolite_name RefMet_name 1B 2B 3B 4B 6B 10B 11B 12B 7B 9B Factors - Group:Sham-operated Group:Sham-operated Group:Sham-operated Group:Sham-operated Group:Sham-operated Group:TAC-operated Group:TAC-operated Group:TAC-operated Group:TAC-operated Group:TAC-operated 10-Hydroxydecanoate 10-Hydroxydecanoic acid 1-Aminoethylphosphonate 2^_3^-cCMP 2',3' cyclic CMP 2_3-DPG 2,3-Diphosphoglyceric acid 44 79 30 34 70 39 52 59 36 70 2_3-Pyridinedicarboxylate Quinolinic acid 2_4-Dihydroxypyrimidine-5-carboxylate Uracil-5-carboxylic acid 2_5-Dihydroxybenzoate Gentisic acid 2-Amino-3-phosphonopropionate 2-Aminoethylphosphonate Ciliatine 2-Deoxyglucose 6-phosphate 2-Deoxy-D-glucose 6-phosphate 2.2000 2.2000 1.7000 2.1000 2-Deoxyribose 1-phosphate Deoxyribose 1-phosphate 2-Furoate 2-Furoic acid 2-Hydroxy-4-methylpentanoate D-Leucic acid 2-Hydroxybutyrate 2-Hydroxybutyric acid 7.1000 4.1000 4.8000 7.9000 5.5000 7.2000 5.6000 6.1000 8.6000 2-Hydroxyglutarate 2-Hydroxyglutaric acid 17 7.5000 16 11 18 12 7.4000 14 8.6000 11 2-Hydroxyisobutyrate 2-Hydroxyisobutyric acid 2.7000 4.1000 3.7000 2.5000 4.5000 2.5000 4.5000 3.6000 2.9000 3.8000 2-Hydroxyoctanoate 2-Hydroxyoctanoic acid 2-Hydroxypentanoate 2-Hydroxyvaleric acid 2-Hydroxyphenylacetate 2-Hydroxyphenylacetic acid 2-Isopropylmalate 2-Isopropylmalic acid 2-Oxoadipate Oxoadipic acid 2-Oxobutyrate 3-Methyl pyruvic acid 2-Oxoglutarate 2-Oxoglutaric acid 2-Oxoisopentanoate Ketoisovaleric acid 2-Oxooctanoate 2PG 2-Phosphoglyceric acid 9 5.1000 2 3.9000 3.8000 2.7000 2-Quinolinecarboxylate Quinaldic acid 2-Thiopheneacetate 2-Thienylacetic acid 3-(2-Hydroxyphenyl)propionate 3-(2-Hydroxyphenyl)propanoic acid 3-(4-Hydroxyphenyl)propionate Desaminotyrosine 3^_5^-Cyclic dAMP 3-Acetylacrylate 3^-AMP 3'-AMP 3-Hydroxy-3-methylglutarate 3-Hydroxymethylglutaric acid 0.7400 1.3000 3-Hydroxybutyrate 3-Hydroxybutyric acid 202 153 139 141 235 213 272 230 233 251 3-Hydroxypropionate Hydroxypropionic acid 3-Indolebutyrate 3-Indolebutyric acid 3-Indoxyl sulfate Indoxyl sulfate 3-Methylbutanoate Isovaleric acid 3PG 3-Phosphoglyceric acid 41 23 17 18 23 17 20 26 14 24 3-Phenyllactate Phenyllactic acid 3-Phenylpropionate Hydrocinnamic acid 3-Ureidopropionate Ureidopropionic acid 4-Acetylbutyrate 5-Ketocaproic acid 2.7000 2.1000 2.5000 2.9000 3.1000 4-Hydroxy-3-methoxymandelate Vanillylmandelic acid 4-Hydroxymandelate 4-Hydroxymandelic acid 4-Methyl-2-oxopentanoate Ketoleucine 6.6000 1.7000 3 2.6000 3.5000 2.4000 2.4000 3.8000 2.3000 2.1000 4-Methylthio-2-oxobutyrate 2-Oxo-4-methylthiobutanoic acid 4-Oxohexanoate 4-Oxopentanoate Levulinic acid 7.8000 9.3000 8.8000 7.7000 11 9.1000 8.2000 9.1000 9.6000 8.9000 4-Pyridoxate 4-Pyridoxic acid 5-Oxoproline Pyroglutamic acid 66 16 19 17 23 14 18 18 14 27 6-Hydroxyhexanoate 6-Hydroxycaproic acid 6-Phosphogluconate 6-Phosphogluconic acid 4 4.3000 3.2000 3.7000 3.9000 4.4000 3.4000 3.6000 3.8000 Acetyl CoA Acetyl-CoA 28 22 13 18 18 11 22 16 12 17 Adenosine 3^_5^-diphosphate Adenosine 3',5'-diphosphate 10 17 11 12 14 12 8 8.8000 5.2000 13 Adenosine 5^-phosphosulfate Adenosine phosphosulfate Adenylosuccinate Adenylsuccinic acid 59 50 52 50 47 36 20 38 38 51 Adipate Adipic acid ADP ADP 394 240 198 252 264 182 220 220 177 241 ADP-glucose ADP-glucose 12 11 8.6000 6.6000 8.3000 8.3000 10 8.3000 9.6000 11 ADP-ribose ADP-ribose 26 34 29 25 41 28 32 31 36 30 Allantoate Allantoic acid AMP AMP 1488 1555 1420 1350 1509 1101 1012 1421 930 1312 ATP ATP 640 69 44 164 96 48 79 81 86 66 Azelate Azelaic acid 4.7000 2.5000 2.2000 2 3.1000 2.3000 2.4000 1.8000 2.6000 3.7000 Barbiturate Barbituric acid Benzoate Benzoic acid Benzoylformate Phenylglyoxylic acid Benzylsuccinate (R)-2-Benzylsuccinic acid Biotin Biotin Butanoate Butyric acid cAMP 3',5' cyclic AMP Carbamoylaspartate Carbamoylaspartate Carbamoylphosphate Carbamoylphosphate CDP CDP 3 1.3000 1.1000 1.4000 1.9000 0.9800 1.3000 1.4000 0.9700 1.4000 CDP-choline CDP-choline 48 55 40 37 46 39 40 40 30 42 cGMP 3',5' cyclic GMP Cholate Cholic acid cIMP cis-Aconitate cis-Aconitic acid 11 7.8000 7.7000 8.4000 7.7000 6 7.4000 7.7000 7.2000 8.2000 Citraconate Citraconic acid Citramalate Citramalic acid Citrate Citric acid 279 159 171 168 158 134 150 172 156 197 CMP CMP 20 19 17 17 18 15 13 17 11 17 CMP-N-acetylneuraminate CMP-N-acetylneuraminic acid 12 12 11 9.8000 13 9.8000 8.5000 10 7.6000 10 CoA Coenzyme A 33 33 12 14 15 23 9.1000 25 15 43 Crotonate Crotonic acid CTP CTP Cysteate Cysteic acid Cysteine S-sulfate Cysteine-S-sulfate Cysteine sulfinate 3-Sulfino-alanine dADP dADP dAMP dAMP dATP dATP dCDP dCDP dCMP dCMP 0.7400 0.7600 0.7200 dCTP dCTP Deamido-NAD+ Nicotinic acid adenine dinucleotide Decanoate Capric acid 2.2000 3.7000 1.7000 4.1000 2.5000 3.1000 3.2000 3.2000 dGTP dGTP DHAP Dihydroxyacetone phosphate Digalacturonate Digalacturonic acid Dihydroorotate 4,5-Dihydroorotic acid dITP dITP Dodecanedioate Dodecanedioic acid 0.4100 0.3900 0.2600 Dodecanoate Lauric acid 11 19 19 13 22 19 21 17 20 15 dTDP dTDP dTMP dTMP dTTP dTTP dUDP dUDP dUMP dUMP dUTP dUTP Ethanolamine phosphate Phosphoethanolamine 320 284 265 249 301 245 235 258 240 298 F1_6P Fructose 1,6-bisphosphate 54 62 30 48 34 29 42 30 24 38 F6P Fructose 6-phosphate 36 14 10 24 6 20 2.2000 7.7000 1.8000 FAD FAD 88 91 73 75 82 71 69 64 65 93 Folate Folic acid Fumarate Fumaric acid 182 104 117 103 127 122 64 107 126 158 G1P Glucose 1-phosphate 11 7.9000 4.8000 9.4000 3.9000 1.5000 6.6000 3.3000 4.6000 3.4000 G3P Glyceraldehyde 3-phosphate G6P Glucose 6-phosphate 203 75 44 149 26 5.4000 99 6.2000 47 7.5000 Galacturonate 1-phosphate GDP GDP 62 51 43 39 52 39 44 48 31 54 GDP-mannose GDP-mannose 11 11 7.8000 6.9000 9.4000 8.2000 9.9000 9.3000 7.9000 13 Gluconate Gluconic acid Glucosamine 6-phosphate Glucosamine 6-phosphate Glucuronate Glucuronic acid Glutarate Glutaric acid 4.8000 4.2000 4 4.3000 4 5.7000 4.5000 5.1000 8.1000 6.6000 Glycerate Glyceric acid Glycerophosphate sn-Glycero-3-phosphate 459 588 302 394 477 454 472 449 299 499 Glycocholate Glycocholic acid Glycolate Glycolic acid 58 42 Glyoxylate Glyoxylic acid GMP GMP 237 246 207 181 220 207 227 244 188 269 GTP GTP 76 48 27 28 35 26 35 30 21 40 Heptanoate Heptylic acid 3 Hexanoate Caproic acid 4.4000 3.2000 Hippurate Hippuric acid Homovanillate Homovanillic acid IDP IDP IMP IMP 341 393 288 328 254 500 716 318 430 507 Isethionate 2-Hydroxyethanesulfonate 3.4000 2 2 3.5000 3.2000 2.5000 2.5000 Isobutyryl CoA Isobutyryl-CoA 4.9000 4.6000 3.3000 3.6000 4.9000 2.7000 4.8000 3.2000 4 3.9000 Isocitrate Isocitric acid 38 33 29 27 29 19 26 23 30 28 Itaconate Itaconic acid ITP ITP Lactate Lactic acid 4145 2803 2465 2807 2472 2314 2479 2593 2462 3010 Malate Malic acid 500 300 381 339 417 280 201 246 377 397 Malonate Malonic acid 5.3000 4.6000 2.9000 2.5000 6.3000 5.1000 7.1000 5.2000 20 6.7000 Malonyl CoA Malonyl-CoA 1.3000 1.8000 1.1000 Methanesulfonate Methanesulfonic acid Methyl sulfate Methyl sulfate (Methylthio)acetate (Methylthio)acetic acid m-Hydroxybenzoate 3-Hydroxybenzoic acid Mucate Galactaric acid 4.9000 5.1000 5.4000 5.3000 7.9000 3.9000 5.6000 6.6000 6.8000 5.4000 N-Acetylaspartate N-Acetylaspartic acid 26 21 10 17 16 12 12 12 20 32 N-Acetyl-beta-alanine N-Acetyl-beta-alanine N-Acetylglucosamine 1-phosphate N-Acetyl-D-glucosamine 1-phosphate 4.1000 3.1000 2.4000 2.1000 2.7000 2.9000 2.6000 3 2.8000 5.1000 N-Acetylglucosamine 6-phosphate N-Acetyl-glucosamine 6-phosphate 3.6000 3.8000 3.1000 2.9000 3.4000 4 2.1000 3.4000 3.5000 3.5000 N-Acetylglutamate N-Acetylglutamic acid 12 15 14 17 21 8.3000 7.1000 22 1.9000 12 N-Acetylleucine N-Acetylleucine N-Acetylmethionine N-Acetylmethionine N-Acetylmuramate N-Acetylmuramic acid N-Acetylneuraminate N-Acetylneuraminic acid 4 3.5000 3.1000 3.1000 3.5000 2.6000 1.5000 2.5000 2.7000 4.9000 N-Acetylphenylalanine N-Acetylphenylalanine NAD+ NAD+ 603 549 464 499 605 463 484 415 424 556 NADH NADH 83 81 66 83 93 59 56 71 58 68 NADP+ NADP+ 84 91 71 74 82 54 59 69 48 77 NADPH NADPH 62 46 39 45 45 36 24 62 22 48 N-Carbamylglutamate Carglumic acid N-Formylaspartate N-Formyl-aspartic acid N-Formylmethionine N-Formylmethionine Nicotinate Nicotinic acid o-Coumarate trans-o-Coumaric acid Octanoate Caprylic acid 1.6000 3 4.9000 o-Hydroxybenzoate Salicylic acid o-Hydroxyhippurate Salicyluric acid O-Phosphoserine Phosphoserine Orotate Orotic acid Orotidine 5^-monophosphate Orotidylic acid 2.4000 1.8000 1.3000 1.5000 1.2000 1.5000 P1_ P4-Di(adenosine-5^) tetraphosphate Pantothenate Pantothenic acid 40 41 16 14 30 35 29 20 39 40 p-Coumarate cis-p-Coumaric acid Pelargonate Pelargonic acid 7.9000 12 13 8.9000 15 9.8000 12 7.3000 17 9.8000 Pentanoate Valeric acid PEP Phosphoenolpyruvic acid 4.3000 2.3000 2 2.7000 2.4000 2.2000 2.2000 Phenaceturate Phenylacetylglycine Phenyl phosphate Phenyl phosphate Phenylpyruvate Phenylpyruvic acid Phosphonoacetate Phosphonoacetate Phthalate Phthalic acid 1.5000 0.5900 0.4300 0.5700 0.5300 1.5000 0.4500 0.4700 0.8500 p-Hydroxybenzoate 4-Hydroxybenzoic acid p-Hydroxyphenylacetate 4-Hydroxyphenylacetic acid Phytate Myo-inositol hexakisphosphate Pimelate Pimelic acid Porphobilinogen Porphobilinogen Propionate Propionic acid Prostaglandin E2 PGE2 Prostaglandin F2alpha PGF2alpha PRPP Phosphoribosyl pyrophosphate 1.5000 1.2000 0.5900 1.2000 Pyrrole-2-carboxylate Pyrrole-2-carboxylic acid Pyruvate Pyruvic acid Quinate Quinic acid R5P Ribose 5-phosphate Ribulose 1_5-diphosphate Ribulose 1,5-bisphosphate Ru5P Ribulose 5-phosphate 46 54 41 35 49 43 43 55 37 61 S7P Sedoheptulose 7-phosphate 7.5000 7 6.6000 5.6000 8.2000 5.8000 7.8000 3.8000 6.7000 5.7000 Saccharate Glucaric acid Sebacate Sebacic acid 0.4800 0.3800 0.2700 0.3700 0.4200 0.5900 Serine O-sulfate Serine-O-sulfate Shikimate Shikimic acid Sinapate Sinapic acid Sorbitol 6-phosphate Pseudouridine Succinate Succinic acid 981 879 945 774 1007 450 646 773 739 669 Succinyl CoA Succinyl-CoA 2.2000 1.7000 2.2000 3.2000 1.5000 2.2000 4.7000 Syringate Syringic acid Tartrate Tartaric acid Taurocholate Taurocholic acid TDP-glucose dTDP-glucose Terephthalate Terephthalic acid 2.1000 2 1.5000 1.1000 1.9000 1.5000 2.5000 1.4000 2 2 threo-beta-methylaspartate + Glu 705 891 484 553 754 551 762 784 526 589 Threonate Threonic acid 105 151 124 124 177 89 136 123 126 104 Tiglate Tiglic acid trans-4-Hydroxy-3-methoxycinnamate trans-Ferulic acid trans-Aconitate trans-Aconitic acid trans-Cinnamate trans-Cinnamic acid Trehalose 6-phosphate Trehalose 6-phosphate 2.7000 5.1000 7.8000 6.7000 2 1.7000 1.9000 UDP UDP 14 4.9000 3.5000 5.7000 7.9000 3.7000 4.8000 7.6000 3.6000 4.3000 UDP-glucose UDP-glucose 66 52 48 33 41 37 41 39 41 55 UDP-glucuronate UDP-glucuronic acid 11 12 13 14 13 13 10 11 6.2000 11 UDP-N-acetylglucosamine UDP-N-acetylglucosamine 97 91 77 74 87 72 70 69 68 84 UMP UMP 189 223 178 171 201 174 154 195 117 193 Undecanoate Undecylic acid 0.6700 Urate Uric acid 38 25 24 30 30 27 24 34 25 29 UTP UTP 12 1.6000 3.4000 1.3000 1.9000 1.6000 Xanthurenate Xanthurenic acid XMP XMP XTP Xanthosine 5-triphosphate