Metabolite_name RefMet_name 1B 2B 3B 4B 6B 10B 11B 12B 7B 9B Factors - Group:Sham-operated Group:Sham-operated Group:Sham-operated Group:Sham-operated Group:Sham-operated Group:TAC-operated Group:TAC-operated Group:TAC-operated Group:TAC-operated Group:TAC-operated 1_3-Diaminopropane 1,3-Diaminopropane 1-Amino-1-cyclopentanecarboxylate 1-Azaniumylcyclopentane-1-carboxylate 1-Aminocyclopropane-1-carboxylate 1-Aminocyclopropanecarboxylic acid 1-Methyl-2-pyrrolidinone N-Methylpyrrolidin-2-one 1-Methyladenosine 1-Methyladenosine 1-Methylhistamine 1-Methylhistamine 7.2000 6.3000 4.4000 5.8000 7.9000 7 4.5000 6.7000 5.3000 6.7000 1-Methylnicotinamide 1-Methyl nicotinamide 3.7000 3.6000 2.4000 1.6000 2.4000 3.3000 3.5000 2.3000 4.4000 3.9000 2_3-Diaminopropionate 2,3-Diaminopropionic acid 2_4-Diaminobutyrate 2,4-Diaminobutyric acid 2_4-Dimethylaniline 2,4-Dimethylaniline 2AB 2S-Aminobutyric acid 6.5000 4.7000 3.4000 3.5000 5.4000 5.5000 4.8000 5.9000 4.4000 6.4000 2-Aminobenzimidazole 2-Aminophenol 2-Aminophenol 2^-Deoxycytidine Deoxycytidine 0.7900 2^-Deoxyguanosine Deoxyguanosine 2^-Deoxyinosine Deoxyinosine 2-Deoxystreptamine 2-Deoxystreptamine 2-Guanidinobenzimidazole 2-Guanidinobenzimidazole 3_3^_5-Triiodothyronine Liothyronine 3_5-Diiodo-tyrosine 3,5-Diiodo-L-tyrosine 3-Aminoisobutyrate 3-Aminoisobutanoic acid 3-Aminopropane-1_2-diol (S)-3-Amino-1,2-propanediol 3-Aminopropionitrile 3-Chloroalanine 3-Hydroxyanthranilate 3-Hydroxyanthranilic acid 3-Hydroxykynurenine Hydroxykynurenine 3-Iodotyrosine Iodotyrosine 3-Methoxytyramine 3-Methoxytyramine 3-Methyladenine 3-Methyladenine 3-Methylguanine 3-Methylguanine 3-Methylhistidine 3-Methylhistidine 6 4.6000 3.7000 4.8000 3.7000 5.2000 4.7000 4.8000 7.9000 6 4-Amino-3-hydroxybutyrate 4-Aminosalicylate Aminosalicylic acid 4-(beta-Acetylaminoethyl)imidazole N-Acetylhistamine 4-Hydroxymethylimidazole Imidazole-4-methanol 4-Methyl-5-thiazoleethanol 5-(2-Hydroxyethyl)-4-methylthiazole 5_6-Dimethylbenzimidazole Dimethylbenzimidazole 5-Aminolevulinate 5-Amino-levulinic acid 5-Aminovalerate 5-Aminopentanoic acid 5^-Deoxyadenosine 5'-Deoxyadenosine 5-Hydroxyindoleacetate 5-Hydroxyindoleacetic acid 5-Hydroxylysine 5-Hydroxylysine 5-Hydroxytryptophan 5-Hydroxy-tryptophan 5-Methoxyindoleacetate 5-Methoxyindoleacetic acid 5-Methoxy-N_N-dimethyltryptamine 5-Methoxytryptamine 5-Methoxytryptamine 5-Methyl-2^-deoxycytidine 5-Methyl-2'-deoxycytidine 5-Methylcytosine 5-Methylcytosine 5-Methyltetrahydrofolate 5-Methyl-THF 5-Methylthioadenosine 5'-Methylthioadenosine 3.2000 2.9000 3.4000 2.5000 3 2.3000 2.4000 2.7000 2.1000 2.1000 6-Aminohexanoate Aminocaproic acid 6-Hydroxynicotinate 6-Hydroxynicotinic acid 6-Methylaminopurine 6-Methyladenine 7_8-Dihydrobiopterin 7,8-Dihydrobiopterin 7_8-Dihydroneopterin 7,8-Dihydroneopterin 7-Methylguanine 7-Methylguanine Acetylcholine Acetylcholine 0.7700 0.2300 0.2700 0.2600 Adenine Adenine 2.7000 3 2.4000 2.5000 3 2.4000 2.5000 2.9000 2 2.7000 Adenosine Adenosine 17 15 15 12 16 7.4000 9.9000 9.7000 9.1000 11 ADMA Dimethylarginine Agmatine Agmatine AICAR (5-Aminoimidazole-4-carboxamide ribotide) AICAR Ala Alanine 1462 1325 598 953 1293 911 1061 850 532 885 Ala-Ala Ala-Ala Allantoin Allantoin 355 366 371 274 395 461 390 366 456 385 Alliin Alliin alpha-Aminoadipate Aminoadipic acid 12 13 8.9000 9.8000 12 9.8000 9.3000 9 7.4000 9.7000 alpha-Methylbenzylamine Alpha-Methylserine Alpha-Methylserine Amantadine Loratadine Aniline Aniline Anserine Anserine 125 29 21 43 16 29 22 23 17 Anthranilate 2-Aminobenzoic acid Arg Arginine 95 45 41 38 41 40 46 47 44 46 Arginine ethyl ester Ethyl arginate Argininosuccinate Argininosuccinic acid 3.9000 2.2000 2.8000 2.7000 2.6000 3.6000 3.3000 Asn Asparagine 46 40 27 28 30 33 44 29 38 30 Asp Aspartic acid 481 578 284 377 501 557 463 401 484 472 Benzamide Benzamide Benzamidine Benzamidine Benzimidazole 1H-Benzimidazole beta-Ala beta-Alanine 27 18 13 15 18 24 12 16 19 16 beta-Ala-Lys beta-Cyanoalanine Cyanoalanine beta-Imidazolelactate Imidazolelactic acid Betaine Betaine 557 536 385 358 340 320 119 287 117 224 Betaine aldehyde Betaine aldehyde beta-Leucine beta-Leucine Betonicine Betonicine Bis(3-aminopropyl)amine Norspermidine Cadaverine Cadaverine Canavanine Canavanine Carnitine Carnitine 1154 1305 1155 1141 1346 1295 1026 1476 1026 1351 Carnosine Carnosine 58 12 9.6000 16 6.8000 6.1000 9.4000 11 12 8.4000 Castanospermine Castanospermine Choline Choline 293 234 219 239 279 365 254 332 336 406 Citrulline Citrulline 45 30 27 26 24 22 21 32 28 24 Creatine Creatine 5008 3221 3157 3809 3144 2387 3129 3135 2307 2663 Creatinine Creatinine 13 7.8000 6.5000 8.1000 6.9000 6.5000 7.3000 7.1000 6.9000 7 Cyclohexylamine Cyclohexylamine Cys Cysteine Cys-Gly Cys-Gly Cystathionine Cystathionine Cysteamine Cysteamine Cysteine-glutathione disulphide -Divalent 2.9000 Cystine Cystine Cytidine Cytidine 6.7000 5.6000 4.7000 5.2000 5.7000 6.3000 5.6000 6.3000 5.2000 5.6000 Cytosine Cytosine Desthiobiotin Dethiobiotin Diethanolamine Diethanolamine 26 9.2000 5.1000 3.4000 5.9000 4.5000 11 10 8 5.9000 Dihydrouracil Dihydrouracil Diphenylamine Diphenylamine DOPA DOPA Dopamine Dopamine Ectoine Ectoine Epinephrine Epinephrine GABA gamma-Aminobutyric acid 2.8000 2 3.8000 1.8000 3.1000 4.1000 2.7000 3.6000 1.5000 gamma-Butyrobetaine 3-Dehydroxycarnitine 19 19 17 18 18 14 13 18 15 14 gamma-Glu-2AB gamma-Glutamyl-2-aminobutanoate gamma-Glu-cys gamma-Glutamylcysteine gamma-Guanidinobutyrate 4-Guanidinobutanoic acid 0.5400 0.8700 Gln Glutamine 1569 978 1412 1100 1178 787 966 1349 705 797 Glu Glutamic acid 1051 1431 707 852 1145 815 1165 1174 795 848 Glucosaminate Glucosaminic acid Glucosamine Glucosamine 1.1000 1.7000 1.3000 1 1.1000 0.8200 1.3000 0.8700 Glu-Glu Glu-Glu Glutathione(ox) Oxidized glutathione 301 283 273 275 287 200 243 251 155 235 Glutathione(red) Glutathione 103 135 58 87 85 129 57 127 59 192 Gly Glycine 1015 692 521 571 593 497 591 531 484 569 Glycerophosphorylcholine sn-Glycero-3-phosphocholine 2289 2224 1508 1230 1842 2580 3590 1856 5310 2910 Gly-Gly Gly-Gly 4.4000 5.1000 4.7000 4.7000 4.2000 4.8000 4.4000 5.2000 1.9000 3.9000 Gly-Leu Gly-Leu 3.3000 5.9000 4.8000 4 3.1000 1.6000 4.6000 1.8000 3.1000 2.3000 Gramine Guanidinoacetate Guanidoacetic acid 5.7000 5.2000 5.8000 4.4000 5.9000 6.9000 Guanidinosuccinate Guanidinosuccinic acid Guanine Guanine Guanosine Guanosine 2.5000 2.4000 3.1000 1.5000 2.4000 2.8000 3.1000 1.5000 3.7000 3 Harman Harman Hexylamine Hexylamine His Histidine 84 44 39 38 45 40 45 48 43 46 Histamine Histamine 38 29 16 19 27 34 25 24 24 30 Histidinol L-Histidinol Homocarnosine Homocarnosine Homocysteine Homocysteine Homocystine Homocystine Homoserine Homoserine Hydroxyproline Hydroxyproline 52 33 28 27 21 21 23 21 24 20 Hydroxyurea Hydroxyurea Hypotaurine Hypotaurine 325 276 252 332 205 79 62 188 31 69 Hypoxanthine Hypoxanthine 36 39 36 25 41 55 45 48 46 51 Ibotenate Ile Isoleucine 59 44 34 33 44 45 66 48 45 44 Imidazole-4-acetate Imidazoleacetic acid Indole-3-acetaldehyde Indoleacetaldehyde Indole-3-acetamide 1H-Indole-3-acetamide Indole-3-acetate Indoleacetic acid Indole-3-ethanol Tryptophanol Inosine Inosine 32 37 36 23 40 40 43 30 46 37 Isoamylamine 3-Methyl-1-butylamine Isobutylamine Isonicotinamide Isopropanolamine Isopropanolamine Kynurenine Kynurenine Leu Leucine 101 84 62 69 87 87 121 90 88 86 Leu-Leu-Tyr Leu-Leu-Tyr Lys Lysine 255 118 98 101 102 95 106 107 105 112 Lysinamide Lysinamide Mannosamine 2-Amino-2-deoxy-D-mannose Melamine Melamine Melatonin Melatonin Met Methionine 43 35 29 24 23 25 27 24 25 28 Metformin Metformin Methionine sulfoxide Methionine sulfoxide 5.1000 2.5000 Methionine sulfoximine Methionine sulfoximine Methylguanidine Methylguanidine Muramate Muramic acid Muscimol Muscimol N1-Acetylspermidine N1-Acetylspermidine N1-Acetylspermine N1-Acetylspermine N1-Acetylspermine_divalent N1-Acetylspermine N1_N12-Diacetylspermine N1,N12-Diacetylspermine N1_N8-Diacetylspermidine N1,N8-Diacetylspermidine N6-Methyl-2^-deoxyadenosine N6-Methyl-2'-deoxyadenosine N6_N6_N6-Trimethyllysine N-6-Trimethyllysine 5.2000 4.8000 2.6000 2.9000 4.9000 3.4000 5.2000 4.1000 3.8000 4.3000 N8-Acetylspermidine N8-Acetylspermidine N-Acetylglucosamine N-Acetyl-D-glucosamine N-Acetylglucosylamine N-Acetyl-beta-glucosaminylamine N-Acetylhistidine N-Acetylhistidine N-Acetylornithine N-Acetylornithine N-Acetylputrescine N-Acetylputrescine N-Acetylvaline N-Acetylvaline N-alpha-Benzenolarginine ethylester Bz-Arg-OEt N-alpha_N-alpha-Dimethylhistidine N,N-Dimethylhistidine n-Butyl a-Picolinate N-epsilon-Acetyllysine N6-Acetyllysine N-gamma-Ethylglutamine N(5)-Ethyl-glutamine 2.1000 2.2000 1.3000 1.5000 2 1.7000 0.8700 2 2.4000 1.8000 Nicotinamide Niacinamide 271 372 348 294 304 340 325 401 265 331 Nicotine Nicotine N-Methylalanine N-Methylalanine N-Methylaniline N-Methylaniline N-Methylglutamate N-Methyl-glutamic acid N_N-Dimethylglycine Dimethylglycine 4.5000 4.1000 3.2000 3.2000 4.5000 4.2000 4.6000 4.9000 N-omega-Methyltryptamine N-Methyltryptamine Noradrenaline Xi-Norepinephrine 2.9000 3.5000 3.4000 3.8000 2.6000 2.8000 2.4000 2.2000 Nornicotine Nornicotine o-Acetylcarnitine CAR 2:0 297 261 164 261 240 124 247 204 147 149 O-Acetylserine O-Acetylserine Octopine Octopine Octylamine Octylamine Ophthalmate Ophthalmic acid Ornithine Ornithine 22 11 7.4000 6.7000 9.4000 6.3000 9.5000 8.2000 8.3000 10 o-Succinylhomoserine o-Succinylhomoserine p-Aminobenzoate p-Aminobenzoic acid Phe Phenylalanine 56 43 38 38 42 42 45 44 41 44 Phenethylamine Phenylethylamine Phenylethanolamine 2-Hydroxyphenethylamine Phe-Phe Phe-Phe Phosphorylcholine Choline phosphate 280 63 145 158 119 55 32 144 60 81 Picolinamide Picolinamide Pipecolate Pipecolic acid 3.1000 3.1000 2.9000 2.6000 2.5000 3.4000 2.9000 2.9000 5 3.5000 Pro Proline 100 71 60 55 59 53 61 61 55 56 Proline betaine Proline betaine 2.8000 3.8000 2.5000 3.2000 2.3000 2.6000 3.7000 2.8000 5.3000 3.4000 Pseudopelletierine psi-Pelletierine Pterin Pterin Purine Purine Purine riboside Nebularine Putrescine(1_4-Butanediamine) Putrescine 2.2000 2.1000 1.6000 2 2.1000 1.6000 2.2000 2 Pyrazole 1H-pyrazole Pyridoxal Pyridoxal Pyridoxamine Pyridoxamine Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 3.3000 3.3000 1.9000 2.5000 2.5000 2.3000 2.9000 Pyridoxine Pyridoxine Riboflavin Riboflavin Saccharopine Saccharopine SAH S-Adenosylhomocysteine 3.1000 3.7000 2.6000 3 3.6000 4.6000 3.4000 4.4000 3 4 SAM+ S-Adenosylmethionine 12 12 9.7000 9.5000 9.6000 9.1000 9.1000 10 6.5000 9.3000 Sarcosine Sarcosine SDMA Symmetric dimethylarginine Sepiapterin Sepiapterin Ser Serine 360 200 171 160 180 152 149 185 112 165 Serotonin Serotonin S-Lactoylglutathione S-Lactoylglutathione S-Methylmethionine S-Methylmethionine Spermidine Spermidine 11 10 5.9000 7.4000 8 4.4000 5.1000 9.8000 4.9000 5.9000 Spermine Spermine Synephrine Synephrine Taurine Taurine 11202 9480 8903 9406 9239 7779 8043 9774 6532 8365 Taurocyamine Taurocyamine Tetrahydropalmatine Tetrahydropalmatine Thiamine Thiamine Thiamine monophosphate Thiamine monophosphate 5.9000 8.6000 6.1000 5.3000 6.4000 9.2000 7.6000 7 8 8.1000 Thr Threonine 253 153 165 139 175 117 134 166 93 127 Thymidine Thymidine 88 92 105 79 115 78 96 83 100 71 Thymine Thymine trans-Zeatin trans-Zeatin TRH Thyrotropin releasing hormone Trientine Trientine Trigonelline Trigonelline Trimethylamine N-oxide Trimethylamine N-oxide 4.2000 2.5000 2 2.3000 2.3000 1.2000 2.1000 1.8000 1.7000 4.5000 Trimethylsulfonium Trimethyl sulfonium Tropine Pseudotropine Tropinone Tropinone Trp Tryptophan 22 23 19 20 21 20 21 21 19 20 Tryptamine Tryptamine Tyr Tyrosine 69 49 42 41 39 41 42 45 40 40 Tyramine Tyramine Tyrosine methyl ester Methyl tyrosinate Uracil Uracil Urea Urea 3983 3592 2759 2924 3254 2823 2824 3071 3813 3667 Uridine Uridine 30 40 39 36 37 56 47 49 49 47 Urocanate Urocanic acid 12 4.6000 Val Valine 152 123 86 98 123 118 151 120 113 116 Xanthine Xanthine Xanthopterin Xanthopterin Xanthosine Xanthosine