Metabolite_name RefMet_name CTL-12_R14- CTL-4_R20- CTL-8_R13- 4T1-17_R4- 4T1-21_R22- 4T1-25_R16- CTL-1_R23- CTL-5_R2- CTL-9_R1- 4T1-15_R11- 4T1-1_R7- CTL-11_R21- CTL-3_R6- CTL-7_R3- 4T1-19_R15- 4T1-27_R18- Factors - Tissue:Lung | Treatment:Control Tissue:Lung | Treatment:Control Tissue:Lung | Treatment:Control Tissue:Lung | Treatment:Tumor Tissue:Lung | Treatment:Tumor Tissue:Lung | Treatment:Tumor Tissue:Tibialis_anterior | Treatment:Control Tissue:Tibialis_anterior | Treatment:Control Tissue:Tibialis_anterior | Treatment:Control Tissue:Tibialis_anterior | Treatment:Tumor Tissue:Tibialis_anterior | Treatment:Tumor Tissue:Upper_Arm_SkM | Treatment:Control Tissue:Upper_Arm_SkM | Treatment:Control Tissue:Upper_Arm_SkM | Treatment:Control Tissue:Upper_Arm_SkM | Treatment:Tumor Tissue:Upper_Arm_SkM | Treatment:Tumor 1-3-Bisphosphoglycerate 3-Phospho-D-glyceroyl dihydrogen phosphate 119000 100000 45800 7360 23100 4160 30000 5440 2^_3^-Cyclic CMP 2',3' cyclic CMP 24200 30200 27300 20100 24700 16900 14500 10500 13000 18900 20300 20200 15000 14000 16300 13100 2/3-Phospho-D-glycerate 2-Phosphoglyceric acid 1390000 1280000 1160000 873000 583000 1130000 551000 3170000 2000000 6150000 6100000 7660000 6220000 11300000 368000 7290000 2-Hydroxyglutarate 2-Hydroxyglutaric acid 452000 363000 554000 279000 493000 388000 464000 401000 328000 352000 225000 286000 378000 435000 443000 363000 2-Oxoglutaramate 2-Keto-glutaramic acid 49700 23300 49400 54700 21900 32600 6280 2510 50500 14600 53900 72400 63200 35900 41800 42100 2-Oxoglutarate 2-Oxoglutaric acid 190000 185000 240000 222000 159000 132000 260000 302000 236000 149000 177000 246000 357000 245000 94000 205000 3^_5^-Cyclic AMP 3',5' cyclic AMP 8760 4620 5290 8290 6850 5400 3770 4130 5400 6370 8940 6870 5510 5500 2640 5820 3-Fumarylpyruvate 45200 46200 50200 18700 33500 49800 48100 23400 18300 48900 37800 50500 28200 15000 51400 45200 3-Hydroxyisobutyrate 3-Hydroxyisobutyric acid 582000 2460000 1230000 2090000 4230000 580000 2360000 1460000 654000 1560000 101000 691000 834000 944000 7990000 1130000 3-Methyldioxyindole 3-Methyldioxyindole 33600 18600 36800 8110 6780 25800 2150 2100 3100 8730 5690 6150 2240 1380 13500 3280 3-Phosphonooxypyruvate Phosphohydroxypyruvic acid 52600 15000 23100 67800 33800 24800 28300 58500 69600 13800 86800 9950 19600 23100 34900 27700 4-Hydroxyphenylacetate 4-Hydroxyphenyl acetate 580000 450000 491000 571000 353000 410000 344000 495000 348000 801000 695000 449000 354000 369000 953000 1530000 5-Hydroxyindoleacetate 5-Hydroxyindoleacetic acid 422000 143000 242000 34700 115000 53100 47400 31000 29800 15800 45400 35500 25300 19200 86900 35300 5-L-Glutamyl-taurine 5-L-Glutamyl-taurine 44100 20100 62000 96000 43000 54300 19200 28300 23800 38600 51400 26000 66500 108000 5^-Phosphoribosyl-N-formylglycinamide FGAR 14500 7640 14900 25800 20400 15000 16300 3700 29100 2990 3360 5010 19400 6-Phospho-D-gluconate 6-Phosphogluconic acid 328000 405000 183000 245000 136000 228000 245000 253000 206000 416000 461000 182000 304000 165000 200000 403000 (7Z-10Z-13Z-16Z-19Z)-Docosa-7-10-13-16-19-pentaenoic acid DPA 422000 410000 566000 522000 505000 129000 410000 831000 744000 121000 315000 364000 227000 475000 325000 327000 (8Z-11Z-14Z)-Icosatrienoic acid Dihomo-gamma-linolenic acid 463000 585000 312000 474000 272000 331000 135000 145000 197000 72200 298000 105000 119000 143000 270000 219000 Acetoacetate Acetoacetic acid 504000 316000 785000 362000 370000 331000 625000 747000 592000 149000 54200 372000 176000 441000 998000 599000 Acetylcholine Acetylcholine 3510 1960 1120 921 480 449 535 1270 1540 Adenylosuccinic acid Adenylsuccinic acid 107000 276000 175000 329000 658000 186000 165000 88000 346000 365000 466000 319000 434000 258000 98400 317000 ADP ADP 489000 573000 431000 690000 473000 680000 1240000 1110000 851000 2670000 3000000 1070000 647000 440000 1350000 1380000 ADP-D-ribose ADP-ribose 1840000 2430000 2190000 3410000 1030000 2010000 4130000 7480000 9510000 3460000 7430000 5610000 5780000 5550000 4310000 6090000 alhpa-tocopheronolactone Alhpa-tocopheronolactone 24000 19100 46600 46600 21100 21500 17000 40200 81600 39600 42300 35700 24400 36900 35900 21000 alpha-D-Glucosamine 1-phosphate Glucosamine 1-phosphate 124000 116000 182000 178000 171000 174000 34700 66000 47900 145000 156000 11800 34300 58900 89600 197000 Anthranilate 2-Aminobenzoic acid 30200 19100 39000 14400 21100 17000 7970 15500 13700 16300 20900 11900 16000 15000 11000 16400 ATP ATP 114000 93600 42600 31300 56000 99400 267000 164000 147000 5370000 1190000 433000 735000 483000 196000 708000 Carbamoyl phosphate Carbamoylphosphate 49200 38400 29800 42300 45900 42300 32100 34600 31800 35100 52700 36100 46100 26400 37600 35400 CDP CDP 19500 23900 39000 48000 23300 24300 13800 12600 24500 66800 52400 9870 18400 4030 41100 18000 CDP-ethanolamine CDP-Ethanolamine 454000 403000 509000 707000 741000 535000 113000 208000 129000 298000 231000 97800 130000 105000 169000 430000 CerP 20700 15600 4060 2720 9720 1150 2000 11900 2190 2340 10500 1700 1400 2360 8930 Cholesterol sulfate Cholesterol sulfate 513000 827000 459000 1310000 621000 985000 56300 119000 107000 108000 484000 68800 106000 69900 116000 333000 cis-Aconitate cis-Aconitic acid 983000 1070000 1230000 2550000 1420000 1380000 358000 306000 422000 460000 570000 275000 343000 279000 574000 955000 Citrate Citric acid 10900000 10900000 12100000 8180000 4920000 6720000 2290000 3460000 3990000 4350000 5210000 2430000 2200000 2400000 5240000 6710000 CMP-N-acetylneuraminate CMP-N-acetylneuraminic acid 665000 607000 406000 556000 613000 507000 276000 273000 312000 444000 387000 195000 158000 201000 422000 531000 Creatine Creatine 549000 713000 815000 1420000 1150000 4060000 60500000 52300000 51600000 67800000 67000000 64300000 47100000 61300000 43700000 57100000 Creatinine Creatinine 67700 37700 99000 61600 61100 82500 880000 672000 961000 1020000 707000 1050000 862000 1110000 732000 969000 CTP CTP 11000 2550 9900 11600 11000 69300 75600 20900 23000 25400 10500 19900 D-Arabitol/Xylitol/Ribitol 217000 168000 143000 189000 250000 360000 353000 371000 411000 371000 481000 336000 208000 305000 419000 719000 Decanoic acid Capric acid 549000 789000 495000 379000 740000 432000 557000 411000 248000 503000 434000 484000 439000 406000 414000 341000 D-Erythrose 4-phosphate Erythrose 4-phosphate 397000 320000 403000 760000 471000 1080000 473000 1350000 824000 1380000 4110000 726000 1110000 1330000 907000 2340000 D-Fructose 1-6-bisphosphate Fructose 1,6-bisphosphate 2250000 2880000 2120000 1490000 2140000 1770000 1900000 2150000 527000 4860000 11500000 543000 2950000 5180000 355000 2990000 D-Glucono-1-5-lactone 6-phosphate 6-Phosphonoglucono-D-lactone 42000 31400 52500 11300 23400 43400 95000 150000 47400 63500 270000 37700 55700 179000 11100 153000 D-Glucoronate 142000 161000 184000 121000 231000 316000 3800 3730 105000 175000 264000 214000 D-Glucose Glucose 5430000 6750000 10800000 7130000 3180000 3810000 5940000 9660000 8410000 10100000 16200000 6510000 4410000 7570000 7940000 9780000 D-Glyceraldehyde 3-phosphate/Glycerone phosphate Glyceraldehyde 3-phosphate 3430000 3390000 3150000 2460000 2330000 2390000 3030000 3280000 1540000 4360000 8870000 1170000 3880000 5830000 662000 2980000 D-Hexose-phosphate 12300000 12400000 11600000 6590000 9800000 9660000 17100000 33600000 16600000 14600000 58200000 6660000 17100000 36100000 2580000 32800000 dihydroxy-octadecanoic acid 55700 52300 95100 65000 42500 68300 39600 25500 28600 76900 95000 49500 31900 33500 56700 32900 Dimethylglycine Dimethylglycine 193000 206000 88800 312000 358000 240000 176000 52200 115000 48200 3890 83400 104000 37700 247000 363000 Diphosphate Pyrophosphate 8370000 9260000 7280000 7620000 8210000 8640000 25100000 27300000 33800000 22500000 21100000 35000000 30900000 28800000 21900000 26800000 Docosahexaenoic acid Docosahexaenoic acid 804000 677000 1740000 1860000 989000 991000 918000 1060000 1860000 257000 1430000 849000 478000 1150000 1120000 797000 Dodecanoic acid Lauric acid 404000 177000 185000 172000 251000 205000 235000 413000 302000 352000 278000 180000 243000 178000 305000 206000 D-Rhamnose Rhamnose 39800 79900 74000 25300 32700 19200 138000 145000 209000 167000 126000 168000 107000 79000 90500 63300 D-Ribose Ribose 233000 187000 240000 176000 114000 112000 215000 153000 207000 292000 352000 145000 110000 119000 343000 765000 Eicosapentaenoic acid Eicosapentaenoic acid 373000 222000 286000 228000 94800 113000 547000 211000 296000 106000 234000 184000 156000 626000 157000 181000 Eicosatetraenoic acid Eicosatetraenoic acid 5870000 4500000 3540000 7260000 2470000 4560000 2470000 2590000 1890000 1220000 4070000 1410000 855000 860000 2960000 3060000 FAD FAD 131000 127000 111000 194000 136000 153000 202000 307000 174000 185000 430000 156000 186000 189000 182000 181000 FADH2 FADH2 9330 7000 6440 15500 11300 10700 18200 20000 15400 15900 34300 9920 10600 14400 13600 7560 Flavin mononucleotide FMN 24700 30600 25800 40300 29800 34500 74900 104000 65700 67100 104000 65400 84500 58700 49500 43300 Fumarate Fumaric acid 1530000 2380000 2100000 2330000 2790000 2120000 5800000 6170000 5970000 4290000 4270000 4390000 6820000 5000000 6950000 6990000 gamma-L-Glutamyl-L-cysteine gamma-Glutamylcysteine 61000 87200 126000 184000 125000 78900 1960 3910 15300 4700 16100 2910 7140 4400 44400 4020 GDP GDP 45600 89800 18500 57500 76900 46900 21700 15300 11400 41100 60200 11900 20000 2490 26300 56400 Glycerol 3-phosphate sn-Glycero-3-phosphate 1150000 674000 970000 2200000 1080000 2050000 483000 3300000 1260000 26100000 19900000 1110000 6910000 13900000 1130000 1310000 GTP GTP 5680 8420 33200 12500 8530 3530 3920 6850 HETE HETE 1710000 701000 1170000 212000 373000 467000 6110 89900 19500 27800 23200 1100 1220 10100 211000 29200 Hexadecanoic acid Palmitic acid 10300000 12800000 15800000 12400000 6200000 12000000 7870000 6990000 7530000 12100000 21600000 10100000 6660000 6390000 10300000 8120000 Hexadecenoic acid Hexadecenoic acid 1080000 555000 1200000 532000 660000 576000 912000 670000 2190000 637000 1040000 919000 597000 791000 1900000 875000 Hexanoic acid Caproic acid 435000 490000 537000 414000 567000 496000 553000 255000 407000 500000 1610000 582000 358000 310000 655000 554000 HODE HODE 417000 242000 251000 283000 167000 99500 16500 147000 45600 21800 74100 21500 12500 55900 212000 68900 Homocarnosine Homocarnosine 1290 3310 6030 12700 5050 107000 8720000 8850000 8600000 8970000 8160000 8510000 8460000 5320000 2990000 4290000 Homovanillate Homovanillic acid 18800 19100 33500 57700 55400 30900 78000 94800 137000 112000 231000 107000 72100 71400 139000 105000 IDP IDP 2750 23700 16600 10200 23400 13600 4010 1710 11900 23300 6540 115000 9150 34700 Indole-5-6-quinone 115000 153000 108000 143000 120000 132000 161000 94200 115000 136000 112000 184000 86500 99200 111000 91700 Itaconate Itaconic acid 733000 569000 152000 1030000 890000 676000 226000 240000 271000 264000 717000 200000 181000 154000 477000 424000 ITP ITP 38300 44100 46700 28300 28200 27900 2880 16700 45700 16400 19600 25300 6990 140000 Kynurenic acid Kynurenic acid 142000 49300 53500 1800 1550 1340 2230 5490 2000 1120 4150 1850 3680 4230 1890 1130 Lactate Lactic acid 30700000 28200000 67400000 83600000 67600000 77700000 856000000 947000000 901000000 464000000 1090000000 661000000 800000000 675000000 560000000 897000000 Leukotriene A4 LTA4 100000 93700 148000 11600 15700 11900 4180 2220 855 772 9650 1560 Malate Malic acid 13100000 12200000 13700000 14300000 23700000 16900000 39700000 45300000 42000000 29900000 38000000 32800000 36100000 36200000 41600000 59900000 Maltose/Sucrose 197000 160000 213000 277000 109000 168000 195000 331000 169000 102000 154000 172000 176000 218000 330000 483000 Maltotriose Maltotriose 14700 32400 11300 72700 15600 53500 40400 126000 60200 21800 96800 32000 44100 54400 67500 99700 Mannitol/Sorbitol/Glucitol/Iditol 272000 293000 226000 285000 904000 1050000 471000 659000 694000 636000 1250000 588000 359000 583000 654000 1150000 Mevalonate-P 5-Phosphomevalonic acid 7630 13300 13600 3930 4950 956 17000 3920 Mevalonate-PP 24400 15600 4200 32800 9820 9740 5830 10400 N-acetyl-D-glucosamine N-Acetyl-D-glucosamine 39300 36500 27000 12700 29800 8960 3190 3820 13900 10800 16900 5830 3000 3060 65700 62400 N-Acetyl-L-leucine N-Acetylleucine 17500 28000 26000 47700 29000 6710 14200 20900 14600 19600 53300 15500 8460 12400 39300 13200 N-Acetylneuraminate N-Acetylneuraminic acid 853000 761000 888000 1000000 735000 668000 287000 390000 313000 199000 533000 198000 319000 231000 783000 598000 NAD+ NAD+ 25200 17800 29400 63500 56800 14500 36100 NADP+ NADP+ 2230 18000 2610 6780 9380 25200 9510 7080 6630 N-Glycoloyl-neuraminate N-Glycoloylneuraminic acid 957000 795000 1090000 1590000 2010000 1680000 160000 192000 255000 742000 669000 68900 184000 225000 1830000 1010000 Nonanoic acid Pelargonic acid 527000 633000 762000 458000 621000 318000 515000 420000 836000 639000 898000 605000 366000 1120000 480000 276000 Octadecadienoic acid Octadecadienoic acid 4120000 3070000 5270000 3300000 3290000 2500000 3860000 5800000 7750000 2700000 4800000 7940000 3150000 3890000 12800000 4650000 Octadecanoic acid Stearic acid 4380000 6180000 4580000 3750000 3570000 3940000 2620000 3430000 1980000 5620000 6560000 1400000 3330000 1990000 3870000 2540000 Octadecatrienoic acid Octadecatrienoic acid 391000 217000 232000 212000 113000 77500 461000 643000 389000 172000 417000 227000 478000 676000 455000 302000 Octadecenoic acid Octadecenoic acid 4300000 3050000 3370000 4170000 5310000 3220000 2650000 3450000 4910000 3680000 3470000 3640000 1940000 3340000 11800000 5730000 Octanoic acid Caprylic acid 381000 379000 509000 375000 418000 245000 235000 194000 228000 214000 880000 357000 239000 196000 377000 306000 Oxaloacetate Oxaloacetic acid 39300 80500 50100 9720 20600 29400 14300 15400 23100 18800 24000 2750 14600 7550 12900 19400 Pantetheine Pantetheine 29900 42500 34300 32100 39100 39900 61700 78200 74800 27700 69400 50600 49200 60300 236000 183000 Pantetheine 4--phosphate Pantetheine 4'-phosphate 133000 51100 103000 77300 157000 122000 342000 335000 400000 124000 496000 421000 387000 258000 739000 415000 Pantothenate Pantothenic acid 656000 527000 695000 1040000 1680000 996000 1780000 1580000 2560000 910000 2500000 3210000 3360000 2420000 4040000 2070000 Pentanoate Valeric acid 99400 109000 106000 91800 73400 104000 41200 93800 60400 56800 79500 104000 55600 52300 90600 88400 Pentose phosphates (isobars) Ribulose 5-phosphate 8250000 6910000 8670000 6080000 7360000 10100000 5440000 7570000 8020000 8890000 8410000 5540000 4830000 4630000 11900000 9200000 Phosphate Phosphoric acid 16700000 16000000 306000 85000 14900000 66500000 11700000 239000 277000 525000 93300 14900000 17400 76500 25000000 955000 Phosphodimethyl-ethanolamine N,N-Dimethylethanolamine phosphate 3490000 3250000 3720000 4360000 1700000 3410000 39200 329000 289000 181000 432000 164000 167000 144000 713000 728000 Phosphoenolpyruvate Phosphoenolpyruvic acid 142000 122000 89500 215000 159000 280000 106000 435000 216000 352000 1180000 328000 246000 941000 271000 784000 Phosphoethanolamine Phosphoethanolamine 15900000 13200000 16700000 26700000 19700000 22200000 621000 1260000 1180000 1860000 4060000 788000 732000 724000 3420000 4850000 Prostaglandin A2/B2 48100 20300 45800 86200 49000 27800 13800 8180 12200 24300 28300 12800 22100 16100 17500 41100 Prostaglandin D2/Thromboxane A2 (isobars) 1390000 578000 1280000 1300000 766000 725000 48500 98100 69300 72500 175000 56900 84500 77300 112000 367000 Prostaglandin F2alpha/beta/D1 (isobars) 278000 173000 309000 371000 194000 149000 2590 7230 5810 4060 11500 597 2930 1350 18400 23500 Prostaglandin G2 PGG2 43100 43700 74100 93600 42500 77500 40300 53300 54900 61600 57900 54700 35400 37000 67900 42600 Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 29600 47000 46800 23300 24300 36100 35700 113000 70700 75000 46100 126000 106000 Pyruvate Pyruvic acid 1100000 2210000 1310000 2150000 1480000 2070000 24200000 30900000 17300000 11500000 18500000 21500000 31400000 26300000 9170000 21800000 Quinolinic acid Quinolinic acid 133000 172000 125000 202000 120000 108000 59600 132000 156000 109000 136000 166000 27900 116000 174000 141000 Sedoheptulose 7-phosphate Sedoheptulose 7-phosphate 1290000 1570000 1530000 1610000 1420000 1130000 81300 110000 79100 276000 399000 93200 23900 78300 459000 606000 Serine-Phosphoethanolamine 130000 166000 100000 89200 121000 125000 103000 62500 60900 113000 82800 114000 81200 67900 90600 74500 Sphinganine 1-phosphate Sphinganine 1-phosphate 17400 34300 18000 13800 8280 10800 5750 12400 20400 21100 20300 3930 15200 15500 11500 8050 Sphingosine 1-phosphate Sphingosine 1-phosphate 9190 2540 7430 11900 12600 9610 1950 10500 22200 7630 14300 7260 12900 19800 12700 Succinate Succinic acid 475000 1310000 1440000 2610000 1400000 943000 1380000 4420000 4790000 14000000 8370000 4790000 3640000 7510000 1770000 2520000 Taurochenodeoxycholate/Tauroursodeoxycholate 10900 67000 13200 9130 7650 13500 25600 4590 2420 2380 Taurocholate Taurocholic acid 45300 52200 1330000 95200 23200 28500 3520 182000 54500 144000 109000 26600 5120 130000 56800 23900 Tetradecanoic acid Myristic acid 1490000 1000000 617000 1000000 494000 1080000 513000 671000 569000 851000 1340000 950000 699000 542000 1040000 895000 Tetradecenoic acid Tetradecenoic acid 48800 43600 77100 47900 35900 61200 52800 43300 60600 60100 84100 86600 37700 57100 61700 59300 Thromboxane B2 TXB2 1150000 1180000 993000 1490000 1170000 954000 10400 37900 51500 9930 25600 2120 2020 2920 95300 51700 UDP UDP 1260000 1680000 1090000 903000 1910000 1540000 79200 83700 53000 421000 393000 124000 109000 86900 588000 360000 UDP-D-glucuronate UDP-glucuronic acid 270000 235000 284000 358000 455000 485000 44300 75800 134000 220000 372000 63100 59800 60000 256000 300000 UDP-glucose UDP-glucose 1940000 1920000 1130000 2060000 2970000 2060000 351000 301000 282000 933000 1070000 275000 337000 349000 1050000 1230000 UDP-N-acetyl-D-glucosamine UDP-N-acetylglucosamine 1810000 1580000 1140000 2070000 3380000 2740000 725000 1140000 1120000 1430000 1680000 529000 449000 568000 2140000 2200000 UTP UTP 5220 5080 4740 7590 6050 64700 26800 28200 431000 354000 77300 109000 95400 62900 89500