Metabolite_name RefMet_name Controlinvitro_1 Controlinvitro_2 Controlinvitro_3 Controlinvitro_4 Controlinvitro_5 Controlinvitro_6 Controlinvitro_7 Controlinvitro_8 Controlinvitro_9 DRB18invitro_1 DRB18invitro_2 DRB18invitro_3 DRB18invitro_4 DRB18invitro_5 DRB18invitro_6 DRB18invitro_7 DRB18invitro_8 DRB18invitro_9 Factors - Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 Treatment:DRB18 19-Hydroxyandrost-4-ene-3_17-dione 19-Hydroxyandrost-4-ene-3,17-dione 52135.3450 32432.4704 38685.9920 179671.0411 142814.4582 140545.8945 238189.3129 217252.3826 285552.2389 197442.0441 144135.7617 133412.9579 2-Ethylacrylic acid 203.6859 157.7859 136.7230 172.3918 161.8511 161.5712 94.4844 131.5561 104.4832 135.8286 3-Hydroxy-3-methylglutaryl-CoA 3-Hydroxy-3-methylglutaryl-CoA 122.0452 240.1171 310.9986 190.0529 212.8799 163.2853 41.2799 84.0246 28.0464 131.6518 104.2590 102.2044 4-Methylpentanal 4-Methylpentanal 131.8877 17.3516 41.0299 185.2739 123.4678 66.8103 388.1326 217.9225 258.2099 153.9408 142.0073 112.0209 5b-Cyprinol sulfate 152224.1663 144389.9572 133774.1687 154121.4489 116623.1307 112697.8840 218346.4326 188703.0444 218500.8458 235590.0560 187397.0789 186056.1982 Acetyl CoA Acetyl-CoA 211.2388 175.8678 339.7638 307.5907 300.3797 365.3187 113.2251 239.3231 101.4657 102.5980 53.8416 Adenosine Adenosine 1057.5498 1094.7976 852.4556 1406.9625 1303.4613 1361.7769 780.7770 503.6287 621.5687 1068.4487 865.4739 660.6624 ADP ADP 320.0673 372.1529 248.2556 245.1456 200.2326 172.0180 74.4455 39.5666 70.0764 259.7314 190.1361 230.9016 AICAR AICAR 535.3775 487.2138 338.9680 265.3917 257.5343 198.7242 But-2-enoic acid Crotonic acid 4325.1879 4156.1924 3907.7083 3467.9854 4480.0522 3661.8638 11135.4321 12923.4084 14280.0949 13123.0855 10878.2658 8623.0184 dCTP dCTP 489.1794 253.6156 273.7920 200.9784 193.0023 153.2118 228.8649 380.1766 280.8408 181.8929 115.0014 93.3130 Deoxycytidine Deoxycytidine 9020.2880 6888.3562 7135.2829 7180.6435 6211.6622 5639.5073 4926.3740 6390.1144 5096.0040 5778.4010 Deoxyguanosine Deoxyguanosine 177696.5433 181414.6053 168131.5586 87683.5867 97960.2879 91649.1231 dGDP dGDP 2179.7260 1335.4346 1594.4421 3108.6521 2850.0482 2660.2268 616.7701 995.6563 1191.6456 960.7862 2074.1829 2054.3279 D-glucose Glucose 12417.7330 14138.1121 11228.2942 10280.3744 10426.8620 9252.1556 dGTP dGTP 4297.0226 3659.7889 3138.3626 2947.8009 2511.1731 2506.9972 2965.5811 1931.4016 2113.8605 2541.3899 1984.9850 Dihydroxyacetone phosphate Dihydroxyacetone phosphate 10625.6503 7970.1889 9136.6514 9433.4340 8132.7883 8667.4456 7227.8216 5954.8329 6571.9646 6613.5095 8308.7112 7700.4497 dUTP dUTP 2158.6101 1979.4812 1867.8888 1734.3306 1326.3119 1201.6213 Fructose 6-phosphate Fructose 6-phosphate 18074.4042 14612.2088 16689.3449 30418.1359 26289.4574 25308.2963 16761.1939 14881.2063 18023.4684 15930.4248 12626.4621 12115.3651 Galabiosylceramide (d18:1/22:0) 233.7466 242.4215 114.8117 173.1987 170.0704 39.8022 503.2134 558.1437 340.0320 185.9032 241.1463 188.4118 Glucosamine Glucosamine 330673.7136 306766.2295 286985.8251 172252.4716 113992.6061 127721.3844 296023.3202 208496.6374 217311.9263 Glucose-6-Phosphate Glucose 6-phosphate 8657.6254 10388.4822 8463.5033 6597.9132 7736.5652 7909.6711 7418.6858 6297.3516 7874.3600 5265.0133 4389.5185 4196.6908 Glycerol Glycerol 35.9145 15.5784 23.5783 15.8735 24.7242 22.6447 13.1463 25.1219 26.0781 15.7860 30.0127 20.4515 Glycine Glycine 179.9046 219.9041 179.7641 84.5589 154.8683 59.0925 Glycineamideribotide GAR 206.3139 513.2952 245.8945 154.1056 175.8054 47.2459 176.2163 161.7510 302.2777 3.3216 31.9988 11.3727 GSH Glutathione 290916.2315 41287.4412 22800.1628 244609.8057 248516.1016 33218.8207 212222.8467 193922.3752 103271.8262 12900.1901 9312.5327 10085.8432 GSSG Oxidized glutathione 9650.6898 1083.8614 844.7292 7667.8608 7857.0255 738.3212 9848.4313 12438.9424 13288.1321 1021.3399 865.0413 943.6214 Hypoxanthine Hypoxanthine 299264.1631 203812.9637 238847.1003 355269.7348 317169.5432 242260.9268 251758.0125 192841.7415 215269.7237 295278.1170 294694.2018 230220.4218 Inosinic acid IMP 253.7605 336.0038 355.6893 349.7325 251.1511 304.2540 333.9265 406.7719 582.4126 140.8031 290.9100 258.8002 Lactaldehyde Lactaldehyde 151501.4152 107246.1122 109827.0794 41025.7281 29855.7426 29614.5024 137851.2761 102127.9514 106123.6291 167470.5537 144583.1671 125167.3365 L-Arginine Arginine 484.2625 391.8409 391.4125 239.6608 176.6740 161.5576 576.3189 603.6985 647.1006 225.5678 190.5831 158.4292 L-Aspartic acid Aspartic acid 1303.6855 1673.1298 947.1351 266.9315 1845.1905 1998.5445 335.7400 1047.7174 528.5768 249.1098 1420.1524 1572.1023 Leukotriene D4 LTD4 22445.5301 18920.1507 16597.8875 26563.8821 22502.7775 23738.1505 46677.9135 49483.7213 48814.8216 47595.7253 44949.2862 38547.6125 L-glutamine Glutamine 24588.9925 17211.5454 23978.0115 14074.7079 11401.2489 15601.9593 L-Histidine Histidine 2410.8995 1992.4861 2417.1010 3413.2916 2876.7888 2534.7098 3338.3357 2807.0916 2957.6287 2626.7919 2379.6601 2265.2480 L-Isoleucine Isoleucine 924107.9323 850143.8399 917897.9620 812355.4693 658631.8594 634549.1217 467042.0783 349069.0718 384433.7857 711465.4120 596092.4205 609468.3483 L-Lactic acid Lactic acid 101.4474 91.8891 106.3264 92.0831 101.1398 98.4627 81.2225 75.4162 72.4030 71.8654 79.1726 50.7165 L-Leucine Leucine 240288.8498 220812.1034 232438.1692 254683.3982 206248.6218 196947.6858 370648.5229 320218.5498 351955.2181 262884.1220 207182.1924 208918.7360 L-Lysine Lysine 26299.0305 28640.4277 19047.8707 38335.1933 39059.3738 24618.7589 19608.6231 21497.8588 17827.5385 23194.8488 25538.4253 15477.9853 L-Palmitoylcarnitine CAR 16:0 17754.6075 32737.0208 32121.7736 25058.0133 35916.8013 42074.5019 33886.2667 58048.5237 69466.1448 56119.6998 52461.9631 65909.0511 L-Proline Proline 663839.0363 548084.1198 616877.9893 673162.4627 560486.3713 529121.8368 581052.6137 460981.9967 518715.4228 750602.4895 623632.9582 625578.0643 Malic acid Malic acid 349008.0251 387086.0308 400899.3729 263050.7233 240012.8767 226806.1335 N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine 2792.1710 1210.2709 1273.5692 1401.6815 997.7744 952.6245 354.7246 337.9815 562.5047 1164.7070 778.2817 1113.9294 N-Acetyl-D-Glucosamine 6-Phosphate N-Acetyl-glucosamine 6-phosphate 9785.7701 7939.6505 9179.0312 10574.7069 8736.7756 8200.4691 8582.5482 7126.9905 7681.1717 7809.4871 7933.6727 NADPH NADPH 2127.6237 1959.7380 2535.1929 1682.4922 1862.2758 1580.6750 710.1503 744.6448 660.9101 1655.3195 1535.7884 2190.7918 Niacinamide Niacinamide 257789.3665 157972.5242 147391.3356 158299.7670 138911.2944 106715.4058 228210.8975 178069.5848 184422.0378 198068.9569 183216.2101 144545.4132 Orotidine 5^-phosphate Orotidylic acid 516.3351 520.4740 532.5650 466.7854 509.7513 395.1012 1008.3528 1293.9264 1169.0903 529.2010 737.3660 516.0338 Phenylpyruvic acid Phenylpyruvic acid 31158.4703 26521.4471 27483.6319 38166.9798 30155.5989 24675.6301 33327.0952 22664.4621 23790.9947 29415.4987 20558.2691 21926.0071 Phosphoribosyl formamidocarboxamide 22049.2107 19321.4357 22930.8101 38297.9600 36779.9570 36143.9216 7570.7782 6529.2418 8882.2003 19285.3326 17952.1554 17938.9006 Phosphoserine Phosphoserine 99887.1981 79610.3536 84942.1886 61800.9165 49458.9550 46136.1347 75868.9436 59968.8424 65584.0506 82247.8069 69414.8091 64616.8707 Prostaglandin E2 PGE2 366343.9000 362942.4788 327548.8557 481975.2387 438153.2411 422940.4559 534849.0869 511933.7929 519309.8224 1115594.1960 1015490.8570 1064320.8890 Pyrroline hydroxycarboxylic acid Pyrroline hydroxycarboxylic acid 9125.8344 5843.6420 6578.8954 6264.2335 5678.8397 4475.1144 9869.4009 6630.1477 9019.3804 6530.1078 6563.9052 4820.7729 Pyruvic acid Pyruvic acid 94904.0750 70142.2816 82976.7765 62171.3422 54761.8649 44555.1152 43104.7312 32958.4179 35072.0075 54505.7908 52911.5411 41713.5629 (R)-3-Hydroxybutyric acid 3R-Hydroxybutyric acid 10625.6503 7970.1889 9136.6514 9433.4340 8132.7883 8667.4456 7227.8216 5954.8329 6571.9646 6613.5095 8308.7112 7700.4497 (R)-3-Hydroxydodecanoic acid 3-Hydroxydodecanoic acid 49151.7257 33535.0031 42247.5851 78073.6391 57582.9741 58651.7596 19249.7802 17803.0688 16773.2185 77346.1531 59232.9351 60577.5809 (R)-3-Hydroxyhexanoic acid 3-Hydroxycaproic acid 26795.8273 23994.0704 23742.1218 23079.1544 22201.5090 22372.0226 51654.1492 46001.8320 43338.8316 36205.3297 27924.2235 33483.8046 Spermidine Spermidine 37.1587 32.9208 23.3985 50.5452 17.3314 105.8678 61.3060 96.0639 61.1852 Sphingosine Sphingosine 9604.5041 7760.4221 7302.7575 16951.7046 15444.4971 12830.2855 28280.1228 29796.4590 30166.6532 28426.3453 29107.9622 28093.2271 Succinic acid Succinic acid 506175.2320 510528.5420 546304.6315 335031.5426 358512.0899 388564.0972 Sucrose Sucrose 146.1148 129.3771 178.8225 120.1794 79.4238 94.5057 35.7168 84.9315 19.4820 40.6711 21.7457 113.8876 Thymidine Thymidine 3797.5138 3761.4234 2805.9311 2693.7882 2314.8558 1100.0761 2439.7565 2310.0999 trans-Dodec-2-enoic acid 2E-Dodecenoyl-CoA 7764.7404 9484.3813 8849.3552 7138.4919 6763.4322 6477.1504 12411.4115 11172.8486 11960.8469 7341.7434 8286.5843 7151.1008 Ureidosuccinic acid N-Carbamoylaspartic acid 18981.4943 18578.1750 19111.4519 17725.9433 18052.7238 18011.9802 Uridine 5^-diphosphate UDP 1068.7172 1659.8925 1042.2733 1076.7637 1304.5980 1042.2497 916.7809 1162.0811 341.1287 777.2588 Uridine diphosphate-N-acetylglucosamine UDP-N-acetylglucosamine 698432.2806 557448.1378 654605.9585 497235.2255 387654.1157 428432.1014 UTP UTP 512.0564 642.5223 421.7158 496.1782 461.6947 314.0562 296.4637 376.4109 Vanillylmandelic acid Vanillylmandelic acid 5988.7402 4261.9508 4559.9768 7633.2727 5804.3024 4872.9292 13959.3064 11172.4487 13057.5042 13335.3722 10960.7339 10374.9719