Metabolite_name RefMet_name LP11_post_CSF_F LP14_post_CSF_M LP15_post_CSF_F LP16_post_CSF_M LP18_post_CSF_M LP19_post_CSF_F LP20_post_CSF_F LP21_post_CSF_M LP22_post_CSF_M LP23_post_CSF_F LP24_post_CSF_M LP25_post_CSF_M LP26_post_CSF_M LP27_post_CSF_M LP28_post_CSF_M LP29_post_CSF_M LP30_post_CSF_F LP31_post_CSF_M LP32_post_CSF_M LP11_pre_CSF_F LP14_pre_CSF_M LP15_pre_CSF_F LP16_pre_CSF_M LP18_pre_CSF_M LP19_pre_CSF_F LP20_pre_CSF_F LP21_pre_CSF_M LP22_pre_CSF_M LP23_pre_CSF_F LP24_pre_CSF_M LP25_pre_CSF_M LP26_pre_CSF_M LP27_pre_CSF_M LP28_pre_CSF_M LP29_pre_CSF_M LP30_pre_CSF_F LP31_pre_CSF_M LP32_pre_CSF_M Factors - Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Post Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre DeoxyCer(m18:1/16:0) DeoxyCer(m18:1/18:0) DeoxyCer(m18:1/20:0) DeoxyCer(m18:1/22:0) DeoxyCer(m18:1/24:0) Cer 18:0;O/22:0 2120 9120 3200 1360 5740 13300 3030 5230 7140 3680 9790 2910 9860 13500 17800 7780 4760 6170 6730 4460 7280 5810 3250 9640 2010 3480 10100 6830 2590 15500 2460 5620 15200 5480 8650 620 8760 8670 DeoxyCer(m18:1/24:1) DeoxyCer(m18:1/26:0) DeoxyCer(m18:1/26:1) DeoxydihydroCer(m18:0/16:0) DeoxydihydroCer(m18:0/18:0) DeoxydihydroCer(m18:0/20:0) Cer 18:1;O/24:1 11300 10600 11700 14600 21100 17700 50000 37600 30000 38800 21600 28000 36300 53300 30300 18300 38400 16800 33700 20300 8280 9030 14500 14500 18300 46500 36600 34800 37400 19800 33400 16200 19100 29000 9100 24500 21100 41200 DeoxydihydroCer(m18:0/22:0) Cer 18:1;O/24:0 34300 18200 35900 63800 64900 41800 234000 291000 150000 104000 74800 98400 238000 232000 227000 67700 171000 167000 185000 75900 29400 62100 107000 62100 37700 305000 268000 263000 237000 76600 163000 62900 51900 185000 40100 127000 116000 217000 DeoxydihydroCer(m18:0/24:0) DeoxydihydroCer(m18:0/24:1) DeoxydihydroCer(m18:0/26:0) DeoxydihydroCer(m18:0/26:1) GD2(d18:1/16:0) GD2 18:1;O2/16:0 GD2(d18:1/18:0) GD2 18:1;O2/18:0 GD2(d18:1/18:1) GD2 18:1;O2/18:1* GD2(d18:1/19:0) GD2 18:1;O2/19:0* GD2(d18:1/20:0) GD2 18:1;O2/20:0 GD2(d18:1/21:0) GD2 18:1;O2/21:0* GD2(d18:1/22:0) GD2 18:1;O2/22:0 GD3(d18:1/14:0) GD3 18:1;O2/14:0* GD3(d18:1/15:0) GD3 18:1;O2/15:0* GD3(d18:1/16:0) GD3 18:1;O2/16:0 GD3(d18:1/16:1) GD3 18:1;O2/16:1* GD3(d18:1/17:0) GD3 18:1;O2/17:0* GD3(d18:1/18:0) GD3 18:1;O2/18:0 GD3(d18:1/18:1) GD3 18:1;O2/18:1* GD3(d18:1/19:0) GD3 18:1;O2/19:0* GD3(d18:1/20:0) GD3 18:1;O2/20:0 GD3(d18:1/21:0) GD3 18:1;O2/21:0* GD3(d18:1/22:0) GD3 18:1;O2/22:0 GD3(d18:1/23:0) GD3 18:1;O2/23:0* GD3(d18:1/24:0) GD3 18:1;O2/24:0 GD3(d18:1/25:0) GD3 18:1;O2/25:0* GM2(d18:1/16:0) GM2 18:1;O2/16:0 GM2(d18:1/16:1) GM2 18:1;O2/16:1* GM2(d18:1/18:1) GM2 18:1;O2/18:1* GM2(d18:1/20:0) GM2 18:1;O2/20:0 GM3(d18:1/16:0) GM3 18:1;O2/16:0 GM3(d18:1/16:1) GM3 18:1;O2/16:1* GM3(d18:1/18:0) GM3 18:1;O2/18:0 GM3(d18:1/18:1) GM3 18:1;O2/18:1* GM3(d18:1/20:0) GM3 18:1;O2/20:0 GM3(d18:1/22:0) GM3 18:1;O2/22:0 GM3(d18:1/24:0) GM3 18:1;O2/24:0 GM3(d18:1/24:1) GM3 18:1;O2/24:1 SM(d18:1/12:0) SM 18:1;O2/12:0 102000 107000 202000 89600 127000 145000 84400 104000 161000 134000 220000 77200 83500 161000 97800 219000 129000 84200 86000 153000 110000 198000 107000 137000 156000 95600 87000 149000 141000 161000 89000 70700 189000 90500 131000 148000 117000 82000 SM(d18:1/16:0) SM 18:1;O2/16:0 116000 159000 112000 112000 142000 138000 83800 152000 133000 101000 183000 115000 132000 182000 126000 200000 223000 154000 106000 190000 124000 128000 215000 178000 121000 72000 71700 103000 153000 196000 92400 162000 159000 140000 199000 149000 118000 161000 SM(d18:1/16:0 OH) SM 18:1;O2/16:0;O SM(d18:1/16:1) SM 18:1;O2/16:1 29000 47900 32400 36000 38400 42100 25300 28200 28200 32500 43600 28600 31700 34600 28100 41500 34100 35900 36400 38800 52800 39600 53000 47700 38000 21700 31600 33500 23400 40000 27600 38600 35900 42300 59700 31600 47700 36800 SM(d18:1/16:1 OH) SM 18:1;O2/16:1;O 165000 312000 198000 164000 216000 278000 222000 219000 192000 167000 458000 264000 218000 426000 229000 279000 276000 341000 256000 257000 361000 254000 306000 269000 242000 171000 205000 256000 220000 380000 219000 397000 231000 295000 338000 266000 269000 298000 SM(d18:1/16:2) SM 18:1;O2/16:2 SM(d18:1/16:2 OH) SM 18:1;O2/16:2;O 206000 325000 279000 182000 245000 240000 182000 156000 183000 213000 312000 179000 228000 307000 214000 319000 253000 294000 157000 340000 355000 259000 304000 302000 240000 141000 164000 204000 247000 267000 176000 252000 250000 282000 293000 250000 254000 220000 SM(d18:1/18:0) SM 18:1;O2/18:0 154000 228000 219000 84300 193000 99200 176000 235000 279000 221000 293000 165000 203000 273000 235000 352000 175000 142000 151000 159000 180000 162000 101000 174000 99100 122000 168000 252000 225000 201000 155000 131000 252000 231000 111000 147000 211000 96900 SM(d18:1/18:0 OH) SM 18:1;O2/18:0;O SM(d18:1/18:1) SM 18:1;O2/18:1 101000 143000 127000 71400 110000 70900 78800 130000 145000 131000 183000 78500 101000 184000 115000 130000 90800 85100 89900 80500 109000 106000 75800 118000 75600 69800 105000 174000 140000 154000 74100 66600 147000 121000 98300 60500 112000 69100 SM(d18:1/18:1 OH) SM 18:1;O2/18:1;O 119000 176000 110000 68600 133000 95600 127000 177000 208000 148000 389000 141000 157000 319000 204000 283000 166000 145000 141000 181000 124000 152000 139000 174000 120000 119000 145000 188000 145000 339000 195000 128000 307000 163000 137000 132000 150000 128000 SM(d18:1/18:2) SM 18:1;O2/18:2 24000 39900 35300 18000 23700 26100 26800 24900 36100 31000 102000 22400 29400 58000 35100 61600 34500 34100 25200 22500 22500 58300 28900 40700 29200 12900 35800 36500 38300 39800 12600 28700 53200 36000 65200 37100 37700 25800 SM(d18:1/18:2 OH) SM 18:1;O2/18:2;O SM(d18:1/20:0) SM 18:1;O2/20:0 SM(d18:1/20:0 OH) SM 18:1;O2/20:0;O SM(d18:1/20:1) SM 18:1;O2/20:1 SM(d18:1/20:1 OH) SM 18:1;O2/20:1;O SM(d18:1/20:2) SM 18:1;O2/20:2 40900 66700 32600 52200 46300 42500 54200 45200 42800 71000 72700 64000 60000 56100 62100 63200 70000 60800 69300 60700 61600 43500 60800 58300 53000 53000 71900 82900 61100 75500 54900 85900 54100 83700 89200 61000 74400 70700 SM(d18:1/20:2 OH) SM 18:1;O2/20:2;O 37800 60600 53700 20200 60200 59900 47000 49900 46900 35600 132000 30100 43600 81200 43700 98500 48800 33900 39500 58000 43800 63700 56200 93200 67800 35900 60700 61600 28800 163000 51400 37000 80200 61100 74600 58500 40800 37400 SM(d18:1/22:0) SM 18:1;O2/22:0 SM(d18:1/22:0 OH) SM 18:1;O2/22:0;O SM(d18:1/22:1) SM 18:1;O2/22:1 34800 44000 28700 31400 25600 29800 32100 42100 41800 27600 99200 26200 26200 43000 53800 55400 31300 40100 30200 43900 42000 48900 27700 29300 49900 35500 54600 40000 30500 100000 28400 32600 59900 40200 43200 56900 47200 43800 SM(d18:1/22:2) SM 18:1;O2/22:2 46400 80600 32000 63800 39500 45100 260000 204000 201000 270000 193000 252000 184000 200000 150000 223000 225000 268000 220000 74800 59000 54700 90600 62300 41300 111000 195000 202000 207000 174000 268000 282000 138000 240000 197000 228000 198000 233000 SM(d18:1/22:2 OH) SM 18:1;O2/22:2;O SM(d18:1/23:0) or SM(d18:1/22:1 OH) SM 18:1;O2/22:1;O 111000 116000 103000 64700 99200 107000 167000 220000 140000 146000 758000 147000 215000 296000 206000 385000 196000 171000 181000 156000 108000 131000 162000 119000 168000 120000 181000 199000 115000 526000 189000 151000 328000 153000 108000 197000 178000 218000 SM(d18:1/24:0) SM 18:1;O2/24:0 653000 762000 716000 488000 783000 572000 975000 1050000 1350000 994000 3390000 778000 1570000 1860000 1590000 2170000 1170000 849000 1020000 791000 898000 828000 761000 803000 831000 836000 1160000 1170000 700000 3080000 1030000 1000000 2010000 1350000 843000 925000 1190000 1160000 SM(d18:1/24:0 OH) SM 18:1;O2/24:0;O 28500 41900 55000 19600 37400 33800 28600 42400 36800 41100 67100 29800 70500 69300 65600 58700 28900 42000 49300 47300 46200 48200 26000 40200 20000 26500 48900 55000 47800 74500 32700 31800 65100 49700 14600 30300 32500 34800 SM(d18:1/24:1) SM 18:1;O2/24:1 91500 141000 109000 51000 101000 68200 87200 111000 165000 97900 422000 98600 157000 176000 172000 189000 111000 97400 91200 133000 101000 123000 134000 137000 131000 105000 147000 144000 90900 331000 91000 102000 247000 178000 103000 104000 140000 141000 SM(d18:1/24:2) SM 18:1;O2/24:2 55800 52200 42300 42100 75200 65000 226000 236000 216000 275000 172000 178000 199000 216000 241000 217000 220000 246000 265000 35900 45400 51100 75400 58600 51200 215000 228000 235000 231000 214000 195000 349000 239000 301000 231000 315000 219000 270000 SM(d18:1/24:2 OH) SM 18:1;O2/24:2;O SM(d18:1/25:0) or SM(d18:1/24:1 OH) SM(d18:1/26:0) SM 18:1;O2/26:0 10800 9700 8110 9400 10700 11300 60800 52700 53800 61500 46600 39500 46500 49700 44100 39500 60000 62500 43900 10800 12900 8480 8450 9710 9690 42400 56900 32400 53500 59400 48300 67900 43400 56100 56900 72800 38700 45800 SM(d18:1/26:0 OH) SM 18:1;O2/26:0;O 9950 11000 7600 12300 16500 14300 12700 7860 7270 13000 19000 14000 13000 12700 20100 22800 18600 21700 15700 11800 9950 10500 15000 11000 9170 7980 12200 14600 15800 12100 13100 15900 9920 16000 11800 13400 14900 16600 SM(d18:1/26:1) SM 18:1;O2/26:1 40900 40800 46000 20500 36300 27700 51900 62900 82800 43600 177000 46200 69200 84900 99800 94500 58700 57300 47400 36300 46500 35800 48500 32400 29800 47400 71600 67400 50200 156000 51600 40500 86400 95800 43700 42300 60400 61400 SM(d18:1/26:1 OH) SM 18:1;O2/26:1;O 11200 12100 10000 12300 8280 10300 23300 14300 17900 15200 18700 18600 8920 12300 14800 18500 32700 20100 21400 12000 21900 12700 17600 11700 12100 11600 16600 21300 16100 12600 13200 17500 17800 16000 17000 23300 17500 19300 SM(d18:1/26:2) SM 18:1;O2/26:2 SM(d18:1/26:2 OH) 1alpha,25-Dihydroxyvitamin D3