Metabolite_name RefMet_name I2_17 I2_224 I2_229 I2_31 I2_34 I2_39 I4_13 I4_15 I4_18 I4_202 I4_211 I4_215 I6_201 I6_209 I6_216 I6_218 I6_230 I6_232 I8_101b I8_14 I8_98b I8_99b LD10_200 LD10_204 LD10_213 LD10_236 LD10_237 LD10_240 NP_220 NP_221 NP_222 NP_225 NP_226 NP_227 R4_203 R4_214 R4_232 R4_239 R4_243 Factors - time_point:I2 time_point:I2 time_point:I2 time_point:I2 time_point:I2 time_point:I2 time_point:I4 time_point:I4 time_point:I4 time_point:I4 time_point:I4 time_point:I4 time_point:I6 time_point:I6 time_point:I6 time_point:I6 time_point:I6 time_point:I6 time_point:I8 time_point:I8 time_point:I8 time_point:I8 time_point:LD10 time_point:LD10 time_point:LD10 time_point:LD10 time_point:LD10 time_point:LD10 time_point:NP time_point:NP time_point:NP time_point:NP time_point:NP time_point:NP time_point:R4 time_point:R4 time_point:R4 time_point:R4 time_point:R4 11(R)-HPETE/Leukotriene B4 (isobars) 11-HpETE 10500 5130 5130 2280 5830 6930 1030 3610 573 7640 12200 12500 6400 5890 3390 2000 726 7970 7780 4630 7330 1160 1960 3740 1110 7650 9730 9730 1010 5360 6060 15100 1580 2830 8440 5520 4820 4700 3520 13(S)-HODE 13S-HODE 11500 2560 2560 2560 4200 7050 2920 3590 699 10300 13300 15900 7130 3350 3040 2270 1430 9840 5150 3060 4960 2580 4340 4770 2850 7040 4510 4510 1560 7050 4370 306 3060 2400 8850 5240 4310 8020 4090 1-4-beta-D-Xylan 877000 684000 684000 663000 620000 840000 755000 820000 890000 818000 1080000 980000 1160000 1030000 825000 540000 675000 850000 957000 717000 993000 783000 1020000 991000 784000 1180000 770000 770000 254000 776000 766000 345000 817000 869000 844000 663000 670000 930000 678000 2/3-Phospho-D-glycerate 2-Phosphoglyceric acid 149000 110000 110000 187000 118000 122000 287000 192000 120000 218000 221000 197000 352000 274000 274000 64100 141000 242000 438000 295000 168000 162000 376000 324000 58900 656000 256000 256000 39200 103000 270000 29600 228000 184000 616000 77900 204000 540000 309000 2-Oxoglutarate 2-Oxoglutaric acid 156000 148000 148000 124000 122000 122000 124000 138000 156000 169000 158000 154000 138000 91900 100000 54800 98300 139000 168000 111000 102000 107000 163000 128000 127000 204000 152000 152000 31100 127000 149000 40200 144000 94700 108000 106000 88800 144000 109000 3alpha-7alpha-12alpha-Trihydroxy-5beta-cholanate Cholic acid 56600 17100 17100 94400 20100 3750 107000 64700 2500 7380 3650 21600 186000 12500 7290 2190 20600 5670 7030 2830 4530 50600 27400 13100 16800 4750 4750 795 5700 1460 25300 20400 1790 3150 3600 5640 4-Pyridoxate 4-Pyridoxic acid 82700 67200 67200 52800 52900 70700 25700 46600 75100 84600 152000 80700 97500 80000 66700 22000 54400 87100 129000 83400 104000 71300 249000 223000 151000 446000 103000 103000 61300 57300 101000 6160 116000 160000 88500 92000 30200 127000 42000 6-Phospho-D-gluconate 6-Phosphogluconic acid 232000 404000 404000 230000 329000 171000 359000 350000 230000 402000 407000 350000 500000 415000 329000 50900 243000 483000 977000 824000 705000 387000 462000 384000 53800 1060000 291000 291000 26800 120000 137000 22600 276000 277000 745000 157000 170000 692000 368000 9(S)-HODE 9S-HODE 3180 201 201 194 528 4090 442 340 242 5890 5450 5780 5720 1340 1080 645 7230 6960 3300 3110 1740 1090 953 276 6050 2850 2850 874 871 2740 313 11200 1110 2400 4660 2550 Acetoacetate Acetoacetic acid 2650000 1790000 1790000 1940000 1930000 2350000 2440000 2450000 2590000 2190000 2890000 3020000 3190000 3210000 2390000 1770000 2100000 2630000 2770000 2200000 2860000 2280000 2930000 3060000 2380000 3360000 2200000 2200000 984000 2290000 2150000 1270000 2420000 2830000 2330000 2030000 1930000 2470000 2140000 alhpa-tocopheronolactone Alhpa-tocopheronolactone 11100 20200 20200 8710 6320 11300 10400 10400 7980 10400 10500 8000 9750 7740 21300 11600 14800 11100 9710 12300 13100 14100 9260 9300 11200 17800 8310 8310 6290 8120 9180 7640 12800 6930 11700 22900 10300 11200 12800 AMP AMP 20200000 15500000 15500000 21400000 14300000 17700000 16100000 12600000 24800000 21000000 20700000 25700000 20800000 18400000 14800000 5950000 15800000 26700000 31500000 25300000 23500000 18400000 21200000 25100000 11400000 30500000 20000000 20000000 2050000 15600000 25300000 2900000 28700000 19200000 32900000 18300000 13800000 26200000 22300000 Catechin Catechin 2430000 2170000 2170000 1590000 1880000 2500000 2050000 2270000 2020000 2000000 2600000 2810000 2180000 1940000 1450000 1220000 1360000 2220000 2010000 1640000 2510000 1970000 2500000 1830000 2010000 2580000 2780000 2780000 539000 2210000 1780000 884000 1510000 1790000 1410000 1610000 1330000 1830000 1520000 Citrate Citric acid 1570000 1280000 1280000 1060000 1520000 1550000 1260000 983000 899000 1840000 1490000 1640000 1770000 1540000 989000 832000 1380000 1540000 1220000 1140000 1570000 1510000 1430000 2560000 1420000 1880000 1540000 1540000 441000 1250000 971000 380000 1430000 1890000 1440000 922000 820000 1030000 1210000 Cortisol Cortisol 17700 33300 33300 5820 3090 8450 15800 13600 7080 49800 1520 5650 5470 1410 47200 107000 5650 43100 1650 6900 4950 40000 9090 62200 62200 4250 1510 6680 12900 1290 13500 5430 14200 16600 Dehydroascorbate L-Dehydroascorbic acid 2030000 1600000 1600000 1400000 1490000 1560000 1510000 1540000 1780000 2130000 2530000 2300000 1820000 1430000 972000 732000 1100000 1690000 2330000 1490000 1870000 1450000 2000000 1890000 1100000 2580000 2100000 2100000 257000 1440000 1770000 415000 1740000 1380000 1640000 1290000 1030000 1860000 1300000 D-Erythrose 4-phosphate Erythrose 4-phosphate 154000 156000 156000 88200 106000 131000 102000 110000 175000 115000 232000 107000 154000 172000 113000 35200 103000 182000 264000 210000 164000 145000 120000 142000 66500 183000 156000 156000 4480 84300 87200 14900 164000 82400 174000 100000 88700 166000 158000 D-Glucono-1-5-lactone 6-phosphate 6-Phosphonoglucono-D-lactone 186000 175000 175000 91300 142000 171000 136000 124000 262000 158000 295000 151000 201000 217000 119000 38800 100000 230000 314000 246000 200000 167000 187000 214000 82000 270000 170000 170000 3620 70600 98500 19700 170000 96400 231000 117000 99100 205000 189000 D-Glucose Glucose 29800000 19700000 19700000 21600000 19500000 25800000 26200000 26000000 28200000 24500000 33300000 33900000 34100000 33100000 25800000 17200000 23100000 29000000 31300000 25700000 31500000 24900000 34500000 32500000 25100000 38100000 24900000 24900000 8040000 25200000 23900000 11200000 27500000 28500000 24400000 22700000 21500000 28100000 23200000 D-Glucose 6-phosphate Glucose 6-phosphate 22300000 21900000 21900000 11300000 16100000 19900000 17000000 16900000 29200000 18000000 31200000 20700000 21900000 26300000 14300000 5140000 13800000 25800000 35400000 28500000 23100000 19700000 19500000 20900000 10300000 31400000 20300000 20300000 1040000 9900000 10700000 2290000 20600000 10300000 26200000 14600000 11400000 24000000 21100000 D-Glyceraldehyde 3-phosphate/Glycerone phosphate Glyceraldehyde 3-phosphate 841000 704000 704000 387000 668000 659000 424000 351000 799000 606000 930000 555000 887000 1090000 729000 265000 546000 749000 921000 1050000 1470000 1180000 906000 590000 715000 916000 590000 590000 219000 750000 909000 220000 777000 384000 1080000 1160000 374000 1010000 769000 dihydroxy-hexadecanoic acid Dihydroxyhexadecanoic acid 11600 8030 8030 2590 1180 9940 8560 3090 9050 3020 8800 4480 13600 7470 3540 7160 6470 9720 13800 11700 2590 4490 28800 27100 16100 50100 14800 14800 3210 7400 14900 4490 6210 24400 21600 7010 6850 19200 7700 dihydroxy-octadecanoic acid 9630 4240 4240 9450 7550 8770 6580 7640 7400 7660 10100 8820 11600 9560 3960 9730 2480 10200 5640 5440 6130 4450 9030 7750 8670 8170 8270 8270 7530 9820 8630 5880 6420 6420 8540 4520 10400 9190 5780 Diphosphate Pyrophosphate 17300000 14000000 14000000 7540000 9250000 13500000 10200000 8520000 6530000 16400000 21300000 20100000 13500000 10200000 6750000 1390000 6890000 16300000 25600000 14400000 19500000 12600000 15800000 17400000 4880000 27900000 19400000 19400000 124000 9800000 12100000 309000 14500000 8250000 17300000 12800000 5830000 15100000 8920000 Dodecanedioic acid Dodecanedioic acid 129000 130000 130000 139000 142000 158000 145000 134000 136000 155000 167000 183000 173000 173000 103000 117000 115000 153000 173000 128000 120000 102000 151000 143000 129000 160000 148000 148000 159000 132000 150000 128000 124000 112000 146000 120000 117000 160000 124000 D-O-Phosphoserine 18000 26700 26700 83100 83100 44000 61000 68400 73300 42400 21200 20000 26200 65900 46900 137000 76200 56000 5880 35000 37000 26300 45600 44600 94500 11500 34500 34500 231000 63400 58700 200000 48200 71200 28700 16200 99900 33000 53100 D-Rhamnose Rhamnose 43200 37900 37900 32900 19300 55100 38900 37300 57600 33800 85400 24100 58100 65800 62800 46500 72100 69900 84700 125000 55800 100000 219000 187000 137000 319000 38000 38000 63500 70500 115000 45400 106000 155000 116000 75900 58200 105000 61800 D-Ribose Ribose 704000 433000 433000 513000 398000 598000 644000 613000 661000 592000 796000 824000 844000 714000 566000 349000 515000 718000 755000 579000 805000 524000 735000 783000 591000 1140000 591000 591000 168000 548000 600000 256000 596000 656000 666000 546000 501000 675000 481000 epoxy-octadecanoic acid 5050 3920 3920 4990 2840 7140 3700 3480 1630 2510 6800 1740 10400 4100 1490 3250 1430 9530 9650 11200 3500 1530 6620 1190 928 6640 7450 7450 1540 3080 5620 1410 10700 1440 30200 3330 10200 14500 8720 Fumarate Fumaric acid 1300000 1170000 1170000 1120000 833000 1030000 967000 978000 1400000 1580000 2330000 1910000 1660000 1500000 920000 361000 846000 1280000 2360000 1350000 1300000 1160000 1980000 1630000 1000000 2760000 1660000 1660000 96900 981000 2000000 170000 1370000 919000 1390000 1200000 549000 1690000 1040000 Glycocholate Glycocholic acid 132000 47200 47200 51600 40800 89400 19800 17600 40900 45700 25600 50300 38400 114000 22100 1120 23500 42600 93500 34800 18600 32500 152000 136000 105000 93200 12300 12300 5390 3790 1660 50200 48000 3110 1870 13100 8360 Heptanoic acid Heptylic acid 49500 64500 64500 51100 38200 42900 55700 51200 31500 45000 28100 52500 53300 36400 52600 40800 63400 52100 81200 60300 73100 79600 44100 41700 44900 38700 66700 66700 47800 55800 45000 39200 60000 38900 61900 31500 44200 43300 58200 Hydroxyacetone phosphate Hydroxyacetone phosphate 207000 221000 221000 117000 113000 228000 241000 219000 106000 493000 299000 294000 197000 145000 122000 42200 124000 395000 649000 263000 348000 184000 556000 493000 142000 811000 485000 485000 10300 125000 113000 9750 209000 221000 201000 112000 137000 188000 161000 hydroxy-dodecanedioic acid Hydroxydodecanedioic acid 54800 78700 78700 51900 43800 49200 59600 55700 40400 51200 48900 59500 55500 46200 63400 46400 60300 74500 98000 70800 70500 81800 53200 51900 41200 59400 72400 72400 40400 56900 47200 40500 54400 46700 66200 78000 52500 73100 55300 Icosatetraenoic acid Eicosatetraenoic acid 6460 2990 2990 512 4490 3120 2950 2090 4440 7490 7690 4530 1440 1960 1110 1550 4000 5080 4520 1940 3360 1600 2510 1050 3460 3930 3930 2420 3540 229 4340 3400 4970 4050 2340 5590 2780 Lactate Lactic acid 60800000 41600000 41600000 41900000 42800000 47900000 41300000 39100000 38800000 45300000 58200000 58900000 52700000 58900000 45500000 21700000 41400000 55800000 61200000 54200000 55300000 60800000 73100000 73800000 47700000 86000000 59300000 59300000 9200000 49400000 63200000 12000000 62200000 59700000 75700000 48900000 43700000 79800000 51700000 Malate Malic acid 4680000 3850000 3850000 6420000 3180000 3400000 4370000 2410000 5590000 5240000 12800000 9410000 11600000 12200000 9240000 1970000 5230000 8260000 14200000 8690000 5360000 7280000 16700000 10200000 7910000 27600000 4520000 4520000 386000 6060000 17400000 638000 9060000 2930000 13700000 12100000 2300000 12000000 4900000 Maltose Maltose 1080000 597000 597000 139000 536000 734000 571000 595000 18900 695000 964000 816000 1530000 1240000 680000 539000 693000 1090000 1090000 894000 1290000 1110000 1540000 1440000 1540000 1230000 755000 755000 96000 758000 206000 148000 603000 947000 940000 972000 639000 873000 674000 Maltotriose Maltotriose 149000 91000 91000 16100 88600 117000 67700 103000 134000 165000 169000 263000 298000 143000 79400 109000 265000 203000 151000 245000 220000 231000 236000 238000 209000 147000 147000 2720 134000 36200 36900 133000 148000 182000 210000 145000 182000 146000 Mannitol Mannitol 224000 142000 142000 95900 85800 163000 224000 191000 227000 152000 230000 279000 264000 801000 221000 215000 190000 182000 154000 163000 228000 162000 207000 188000 206000 266000 152000 152000 99300 167000 145000 86700 158000 179000 141000 188000 139000 192000 157000 Octanoic acid (caprylate) Caprylic acid 57600 82700 82700 50100 53300 46400 62900 60600 55300 54700 50400 61700 49900 60000 80400 41800 72000 64900 74300 76400 70000 82100 56300 45600 48000 54100 69200 69200 36800 55000 55300 40000 62600 43900 65400 88800 56000 69400 64800 Oxaloacetate Oxaloacetic acid 269000 211000 211000 191000 213000 244000 211000 188000 268000 259000 276000 245000 273000 262000 194000 109000 201000 290000 338000 268000 249000 263000 299000 290000 199000 384000 256000 256000 45100 214000 277000 68800 268000 231000 276000 190000 182000 266000 221000 Pentose phosphates (isobars) Ribulose 5-phosphate 10000000 8580000 8580000 5050000 7190000 8350000 7890000 7490000 4420000 11000000 13400000 10200000 9710000 9840000 5170000 1610000 4550000 8740000 13000000 9390000 10600000 7590000 10600000 9790000 5000000 15900000 11000000 11000000 350000 7640000 6980000 732000 9100000 5770000 10100000 6230000 4920000 9580000 7240000 Pyruvate Pyruvic acid 2050000 1470000 1470000 1770000 1680000 1860000 1790000 1910000 1890000 2030000 2190000 2230000 2230000 2380000 1730000 1580000 1610000 1970000 1830000 1670000 2070000 1510000 2220000 2240000 1780000 2240000 1860000 1860000 1370000 1820000 1930000 1460000 1860000 2100000 1830000 1570000 1700000 1940000 1720000 Sedoheptulose 7-phosphate Sedoheptulose 7-phosphate 4420000 4850000 4850000 5290000 3550000 4480000 4540000 5920000 8130000 5350000 7470000 5570000 4990000 3900000 2760000 1370000 2740000 6830000 10800000 5850000 3950000 2780000 3610000 5420000 1260000 8260000 6660000 6660000 407000 1990000 3660000 522000 4270000 3180000 5220000 1440000 3690000 5330000 3890000 Succinate Succinic acid 383000 213000 213000 296000 334000 242000 264000 152000 7170000 239000 476000 461000 328000 526000 1050000 399000 255000 199000 274000 211000 178000 417000 554000 785000 578000 478000 205000 205000 321000 345000 667000 257000 550000 511000 413000 175000 223000 321000 222000 Sulfoglycolithocholate Sulfoglycolithocholic acid 8590 9050 8490 9810 10100 8270 8720 21300 1590 1480 1630 7840 1920 1900 15600 15600 9630 17800 7600 3800 13800 1430 1540 Taurochenodeoxycholate Taurochenodeoxycholic acid 154000 88800 88800 132000 532000 188000 237000 104000 11300 285000 172000 223000 179000 111000 84500 339000 248000 175000 320000 170000 463000 141000 142000 413000 233000 177000 192000 192000 155000 393000 100000 250000 175000 250000 148000 185000 80300 336000 107000 trihydroxy-octadecenoic acid Trihydroxyoctadecenoic acid 246000 189000 189000 214000 225000 200000 236000 249000 227000 232000 256000 251000 251000 228000 163000 232000 194000 227000 256000 219000 220000 209000 228000 210000 217000 249000 194000 194000 221000 262000 219000 190000 225000 240000 256000 232000 231000 252000 223000 Urate Uric acid 532000 206000 206000 2020000 435000 466000 2760000 716000 11400000 1000000 867000 1650000 3330000 1240000 1330000 1400000 710000 491000 802000 443000 205000 458000 290000 229000 182000 273000 276000 276000 860000 709000 3840000 658000 560000 511000 2150000 260000 1370000 2710000 803000